Phenotypic Switch in Blood: Effects of Pro-Inflammatory Cytokines on Breast Cancer Cell Aggregation and Adhesion

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Geng, Yue ^a   Chandrasekaran, Siddarth ^a   Hsu, Jong Wei ^a   Gidwani, Mishka ^a   Hughes, Andrew D ^a   King, Michael R ^a  

^a Cornell University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD44V ANTIGEN; CYTOKINE; CYTOKINE RECEPTOR; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERLEUKIN 6; METFORMIN; SELECTIN; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BREAST CANCER; BREAST CARCINOMA; CANCER CELL; CANCER GROWTH; CELL ADHESION; CELL AGGREGATION; CULTURE MEDIUM; FLOW CYTOMETRY; HUMAN; IMMUNOFLUORESCENCE; METASTASIS; PHENOTYPE; POSITIVE FEEDBACK; SHEAR STRESS; TRIPLE NEGATIVE BREAST CANCER; TUMOR SPHEROID; UPREGULATION;

ANTI-INFLAMMATORY AGENTS; ANTIGENS, CD44; BREAST NEOPLASMS; CELL ADHESION; CELL AGGREGATION; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOKINES; E-SELECTIN; ENDOTHELIUM; FEMALE; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; METFORMIN; NEOPLASM METASTASIS; NEOPLASTIC CELLS, CIRCULATING; OLIGOSACCHARIDES; PHENOTYPE; SPHEROIDS, CELLULAR; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84872769109     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054959     Document Type: Article

References (47)

1. Stockler M, Wilcken NR, Ghersi D, Simes RJ, (2000) Systematic reviews of chemotherapy and endocrine therapy in metastatic breast cancer. Cancer Treat Rev 26: 151-168.
2. Ramaswamy S, Ross KN, Lander ES, Golub TR, (2003) A molecular signature of metastasis in primary solid tumors. Nat Genet 33: 49-54.
3. Poste G, Fidler IJ, (1980) The pathogenesis of cancer metastasis. Nature 283: 139-146.
4. Pandit TS, Kennette W, Mackenzie L, Zhang G, Al-Katib W, et al. (2009) Lymphatic metastasis of breast cancer cells is associated with differential gene expression profiles that predict cancer stem cell-like properties and the ability to survive, establish and grow in a foreign environment. Int J Oncol 35: 297-308.
5. Geng Y, Marshall JR, King MR, (2012) Glycomechanics of the metastatic cascade: tumor cell-endothelial cell interactions in the circulation. Ann Biomed Eng 40: 790-805.
6. Thorlacius H, Prieto J, Raud J, Gautam N, Patarroyo M, et al. (1997) Tumor cell arrest in the microcirculation: lack of evidence for a leukocyte-like rolling adhesive interaction with vascular endothelium in vivo. Clin Immunol Immunopathol 83: 68-76.
7. Geng Y, Narasipura S, Seigel GM, King MR, (2010) Vascular Recruitment of Human Retinoblastoma Cells by Multi-Cellular Adhesive Interactions with Circulating Leukocytes. Cellular and Molecular Bioengineering 3: 361-368.
8. Yin XY, Rana K, Ponmudi V, King MR, (2010) Knockdown of fucosyltransferase III disrupts the adhesion of circulating cancer cells to E-selectin without affecting hematopoietic cell adhesion. Carbohydrate Research 345: 2334-2342.
9. Goetz DJ, ElSabban ME, Hammer DA, Pauli BU, (1996) Lu-ECAM-1-mediated adhesion of melanoma cells to endothelium under conditions of flow. International Journal of Cancer 65: 192-199.
10. Kim YJ, Borsig L, Han HL, Varki NM, Varki A, (1999) Distinct selectin ligands on colon carcinoma mucins can mediate pathological interactions among platelets, leukocytes, and endothelium. American Journal of Pathology 155: 461-472.
11. Kozlowski L, Zakrzewska I, Tokajuk P, Wojtukiewicz MZ, (2003) Concentration of interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin-10 (IL-10) in blood serum of breast cancer patients. Roczniki Akademii Medycznej w Bialymstoku (1995) 48: 82-84.
12. Berberoglu U, Yildirim E, Celen O, (2004) Serum levels of tumor necrosis factor alpha correlate with response to neoadjuvant chemotherapy in locally advanced breast cancer. International Journal of Biological Markers 19: 130-134.
13. Bates RC, Mercurio AM, (2003) Tumor Necrosis Factor-α Stimulates the Epithelial-to-Mesenchymal Transition of Human Colonic Organoids. Molecular Biology of the Cell 14: 1790-1800.
14. Lee SO, Lou W, Hou M, de Miguel F, Gerber L, et al. (2003) Interleukin-6 promotes androgen-independent growth in LNCaP human prostate cancer cells. Clin Cancer Res 9: 370-376.
15. Muller A, Homey B, Soto H, Ge N, Catron D, et al. (2001) Involvement of chemokine receptors in breast cancer metastasis. Nature 410: 50-56.
16. Zen K, Liu D-Q, Guo Y-L, Wang C, Shan J, et al. (2008) CD44v4 Is a Major E-Selectin Ligand that Mediates Breast Cancer Cell Transendothelial Migration. PLoS ONE 3: e1826.
17. x/E-selectin. Breast Cancer 3: 19-23.
18. Minn AJ, Kang YB, Serganova I, Gupta GP, Giri DD, et al. (2005) Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. Journal of Clinical Investigation 115: 44-55.
19. Witz IP, (2008) The selectin-selectin ligand axis in tumor progression. Cancer Metastasis Rev 27: 19-30.
20. Laubli H, Borsig L, (2010) Selectins promote tumor metastasis. Seminars in Cancer Biology 20: 169-177.
21. Deng XS, Wang S, Deng A, Liu B, Edgerton SM, et al. (2012) Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers. Cell Cycle 11: 367-376.
22. Luque-Ramirez M, Escobar-Morreale HF, (2010) Treatment of polycystic ovary syndrome (PCOS) with metformin ameliorates insulin resistance in parallel with the decrease of serum interleukin-6 concentrations. Horm Metab Res 42: 815-820.
23. Fidler IJ, (1973) The relationship of embolic homogeneity, number, size and viability to the incidence of experimental metastasis. European Journal of Cancer (1965) 9: 223-227.
24. Glinsky GV, Glinsky VV, (1996) Apoptosis and metastasis: a superior resistance of metastatic cancer cells to programmed cell death. Cancer Letters 101: 43-51.
25. Coussens LM, Werb Z, (2002) Inflammation and cancer. Nature 420: 860-867.
26. Grivennikov SI, Greten FR, Karin M, (2010) Immunity, Inflammation, and Cancer. Cell 140: 883-899.
27. Condeelis J, Pollard JW, (2006) Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 124: 263-266.
28. Ben-Baruch A Host microenvironment in breast cancer development: inflammatory cells, cytokines and chemokines in breast cancer progression: reciprocal tumor-microenvironment interactions.
29. Lyon DE, McCain NL, Walter J, Schubert C, (2008) Cytokine comparisons between women with breast cancer and women with a negative breast biopsy. Nurs Res 57: 51-58.
30. Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, et al. (2011) Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 121: 2750-2767.
31. Marui N, Offermann MK, Swerlick R, Kunsch C, Rosen CA, et al. (1993) Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. The Journal of Clinical Investigation 92: 1866-1874.
32. Lagow EL, Carson DD, (2002) Synergistic stimulation of MUC1 expression in normal breast epithelia and breast cancer cells by interferon-gamma and tumor necrosis factor-alpha. J Cell Biochem 86: 759-772.
33. Zhang P, Ozdemir T, Chung CY, Robertson GP, Dong C, (2011) Sequential binding of αVβ3 and ICAM-1 determines fibrin-mediated melanoma capture and stable adhesion to CD11b/CD18 on neutrophils. J Immunol 186: 242-254.
34. Sullivan NJ, Sasser AK, Axel AE, Vesuna F, Raman V, et al. (2009) Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells. Oncogene 28: 2940-2947.
35. Muthukumaran N, Miletti-Gonzalez KE, Ravindranath AK, Rodriguez-Rodriguez L, (2006) Tumor necrosis factor-alpha differentially modulates CD44 expression in ovarian cancer cells. Mol Cancer Res 4: 511-520.
36. Davril M, Degroote S, Humbert P, Galabert C, Dumur V, et al. (1999) The sialylation of bronchial mucins secreted by patients suffering from cystic fibrosis or from chronic bronchitis is related to the severity of airway infection. Glycobiology 9: 311-321.
37. Groux-degroote S, Krzewinski-recchi M-A, Cazet A, Vincent A, Lehoux S, et al. (2008) IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewisx epitopes in the human bronchial mucosa. Biochem J 410: 213-223.
38. Geng Y, Yeh K, Takatani T, King MR, (2012) Three to Tango: MUC1 as a Ligand for Both E-Selectin and ICAM-1 in the Breast Cancer Metastatic Cascade. Front Oncol 2: 76.
39. Hughes AD, Mattison J, Western LT, Powderly JD, Greene BT, et al. (2012) Microtube device for selectin-mediated capture of viable circulating tumor cells from blood. Clin Chem 58: 846-853.
40. Hughes AD, Mattison J, Powderly JD, Greene BT, King MR (2012) Rapid Isolation of Viable Circulating Tumor Cells from Patient Blood Samples. J Vis Exp: e4248.
41. Agastin S, Giang UBT, Geng Y, DeLouise LA, King MR (2011) Continuously perfused microbubble array for 3D tumor spheroid model. Biomicrofluidics 5.
42. Hou J-M, Krebs M, Ward T, Morris K, Sloane R, et al. (2010) Circulating Tumor Cells, Enumeration and Beyond. Cancers 2: 1236-1250.
43. Paterlini-Brechot P, Benali NL, (2007) Circulating tumor cells (CTC) detection: Clinical impact and future directions. Cancer Letters 253: 180-204.
44. Hirschhaeuser F, Menne H, Dittfeld C, West J, Mueller-Klieser W, et al. (2010) Multicellular tumor spheroids: An underestimated tool is catching up again. Journal of Biotechnology 148: 3-15.
45. Chandrasekaran S, Geng Y, Delouise LA, King MR, (2012) Effect of homotypic and heterotypic interaction in 3D on the E-selectin mediated adhesive properties of breast cancer cell lines. Biomaterials 33: 9037-9048.
46. Chandrasekaran S, Giang UB, King MR, DeLouise LA, (2011) Microenvironment induced spheroid to sheeting transition of immortalized human keratinocytes (HaCaT) cultured in microbubbles formed in polydimethylsiloxane. Biomaterials 32: 7159-7168.
47. Lee D, Schultz JB, Knauf PA, King MR, (2007) Mechanical shedding of L-selectin from the neutrophil surface during rolling on sialyl Lewis x under flow. Journal of Biological Chemistry 282: 4812-4820.