Quantitative prediction of CYP2B6 induction by estradiol during pregnancy: Potential explanation for increased methadone clearance during pregnancy

Drug Metabolism and Disposition

Volumn 41, Issue 2, 2013, Pages 270-274

  Dickmann, Leslie J ^a   Isoherranen, Nina ^b  

^a Department of Pharmacokinetics and Drug Metabolism ^*  (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMFEBUTAMONE; CARBAMAZEPINE; CYTOCHROME P450 2B6; ESTRADIOL; MESSENGER RNA; METHADONE; RIFAMPICIN;

ARTICLE; CONCENTRATION RESPONSE; DRUG CLEARANCE; DRUG HYDROXYLATION; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; LIMIT OF DETECTION; LIVER CELL; PREDICTION; PREGNANCY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; THIRD TRIMESTER PREGNANCY;

ANALGESICS, OPIOID; ARYL HYDROCARBON HYDROXYLASES; BIOTRANSFORMATION; BUPROPION; CARBAMAZEPINE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; ESTRADIOL; FEMALE; HEPATOCYTES; HUMANS; HYDROXYLATION; METABOLIC CLEARANCE RATE; METHADONE; OXIDOREDUCTASES, N-DEMETHYLATING; PREGNANCY; PRIMARY CELL CULTURE; RIFAMPIN; RNA, MESSENGER; SUBSTRATE SPECIFICITY; UP-REGULATION;

RODENTIA;

EID: 84872715726     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.047118     Document Type: Article

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