Effects of interleukin-6 (IL-6) and an anti-IL-6 monoclonal antibody on drug-metabolizing enzymes in human hepatocyte culture

Drug Metabolism and Disposition

Volumn 39, Issue 8, 2011, Pages 1415-1422

  Dickmann, Leslie J ^a   Patel, Sonal K ^a   Rock, Dan A ^a   Wienkers, Larry C ^a   Slatter, J Greg ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; CYTOCHROME P450 4A11; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; MESSENGER RNA; OMEPRAZOLE; RIFAMPICIN;

ACUTE PHASE RESPONSE; ARTICLE; CELL ISOLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYOPRESERVATION; CYTOKINE RESPONSE; DRUG CONCENTRATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME REPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIVER CELL; LIVER CELL CULTURE; MEDIAN EFFECTIVE CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION;

ANTIBODIES, MONOCLONAL; C-REACTIVE PROTEIN; CELL CULTURE TECHNIQUES; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP3A; HEK293 CELLS; HEPATOCYTES; HUMANS; INTERLEUKIN-6; ISOENZYMES; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; RECEPTORS, INTERLEUKIN-6; SERUM AMYLOID A PROTEIN; TANDEM MASS SPECTROMETRY; TIME FACTORS; TRANSFECTION;

EID: 79960606980     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.038679     Document Type: Article

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