Celastrol attenuates adipokine resistin-associated matrix interaction and migration of vascular smooth muscle cells

Journal of Cellular Biochemistry

Volumn 114, Issue 2, 2013, Pages 398-408

  Kang, Sang Wook ^a   Kim, Min Soo ^a   Kim, Hyun Sung ^a   Kim, Yunho ^a   Shin, Daekeun ^a   Park, Jung Han Yoon ^a   Kang, Young Hee ^a  

^a Hallym University   (South Korea)

Author keywords

Celastrol; Macrophage resistin; Smooth muscle cell migration; Toll like receptor 4

Indexed keywords

ADIPOCYTOKINE; BETA3 INTEGRIN; CD18 ANTIGEN; CELASTROL; COLLAGEN TYPE 1; COLLAGEN TYPE 4; CONNECTIVE TISSUE GROWTH FACTOR; GELATINASE A; RESISTIN; TOLL LIKE RECEPTOR 4;

ARTICLE; ATHEROSCLEROSIS; CELL INTERACTION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MACROPHAGE; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

AORTA; ATHEROSCLEROSIS; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; COLLAGEN TYPE IV; GENE EXPRESSION; HUMANS; INSULIN RESISTANCE; MACROPHAGES; MUSCLE, SMOOTH, VASCULAR; RESISTIN; TOLL-LIKE RECEPTOR 4; TRIPTERYGIUM; TRITERPENES;

TRIPTERYGIUM WILFORDII;

EID: 84872712463     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24374     Document Type: Article

References (34)

1. Burnett MS, Lee CW, Kinnaird TD, Stabile E, Durrani S, Dullum MK, Devaney JM, Fishman C, Stamou S, Canos D, Zbinden S, Clavijo LC, Jang GJ, Andrews JA, Zhu J, Epstein SE. 2005. The potential role of resistin in atherogenesis. Atherosclerosis 182:241-248.
2. Calabro P, Samudio I, Willerson JT, Yeh ET. 2004. Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways. Circulation 110:3335-3340.
3. Ding Q, Chai H, Mahmood N, Tsao J, Mochly-Rosen D, Zhou W. 2011. Matrix metalloproteinases modulated by protein kinase Ce mediate resistin-induced migration of human coronary artery smooth muscle cells. J Vasc Surg 53:1044-1051.
4. Espinola-Klein C, Gori T, Blankenberg S, Munzel T. 2011. Inflammatory markers and cardiovascular risk in the metabolic syndrome. Front Biosci 16:1663-1674.
5. Fantuzzi G. 2005. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 115:911-919.
6. Game BA, He L, Jarido V, Nareika A, Jaffa AA, Lopes-Virella MF, Huang Y. 2007. Pioglitazone inhibits connective tissue growth factor expression in advanced atherosclerotic plaques in low-density lipoprotein receptor-deficient mice. Atherosclerosis 192:85-91.
7. Hansen J, Palmfeldt J, Vang S, Corydon TJ, Gregersen N, Bross P. 2011. Quantitative proteomics reveals cellular targets of celastrol. PLoS ONE 6:e26634.
8. Ishigaki T, Imanaka-Yoshida K, Shimojo N, Matsushima S, Taki W, Yoshida T. 2011. Tenascin-C enhances crosstalk signaling of integrin αvβ3/PDGFR-β complex by SRC recruitment promoting PDGF-induced proliferation and migration in smooth muscle cells. J Cell Physiol 226:2617-2624.
9. Jean C, Gravelle P, Fournie JJ, Laurent G. 2011. Influence of stress on extracellular matrix and integrin biology. Oncogene 30:2697-2706.
10. Jiang C, Zhang H, Zhang W, Kong W, Zhu Y, Zhang H, Xu Q, Li Y, Wang X. Homocysteine promotes vascular smooth muscle cell migration by induction of the adipokine resistin. Am J Physiol Cell Physiol 297:C1466- C1476.
11. Jung HS, Park KH, Cho YM, Chung SS, Cho HJ, Cho SY, Kim SJ, Kim SY, Lee HK, Park KS. 2006. Resistin is secreted from macrophages in atheromas and promotes atherosclerosis. Cardiovasc Res 69:76-85.
12. Kannaiyan R, Shanmugam MK, Sethi G. 2011. Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer. Cancer Lett 303:9-20.
13. Leeuwis JW, Nguyen TQ, Theunissen MG, Peeters W, Goldschmeding R, Pasterkamp G, Vink A. 2010. Connective tissue growth factor is associated with a stable atherosclerotic plaque phenotype and is involved in plaque stabilization after stroke. Stroke 41:2979-2981.
14. Li C, Wang MH. 2011. Anti-inflammatory effect of the water fraction from hawthorn fruit on LPS-stimulated RAW 264.7 cells. Nutr Res Pract 5:101-106.
15. Li H, Wang QJ, Zhu DN, Yang Y, Reinioside C. 2008. A triterpene saponin of Polygala aureocauda Dunn, exerts hypolipidemic effect on hyperlipidemic mice. Phytother Res 22:159-164.
16. Li G, Jin R, Norris RA, Zhang L, Yu S, Wu F, Markwald RR, Nanda A, Conway SJ, Smyth SS, Granger DN. 2010. Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway. Atherosclerosis 208:358-365.
17. Liu Z, Ma L, Zhou GB. 2011. The main anticancer bullets of the Chinese medicinal herb, thunder god vine. Molecules 16:5283-5297.
18. Mangge H, Almer G, Truschnig-Wilders M, Schmidt A, Gasser R, Fuchs D. Inflammation, adiponectin, obesity and cardiovascular risk. Curr Med Chem 17:4511-4520.
19. Nagaev I, Bokarewa M, Tarkowski A, Smith U. 2006. Human resistin is a systemic immune-derived proinflammatory cytokine targeting both leukocytes and adipocytes. PLoS ONE 1:e31.
20. Paimela T, Hyttinen JM, Viiri J, Ryhänen T, Karjalainen RO, Salminen A, Kaarniranta K. 2011. Celastrol regulates innate immunity response via NF-κB and Hsp70 in human retinal pigment epithelial cells. Pharmacol Res 64:501-508.
21. Panchatcharam M, Miriyala S, Yang F, Leitges M, Chrzanowska-Wodnicka M, Quilliam LA, Anaya P, Morris AJ, Smyth SS. 2010. Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling. Int J Biochem Cell Biol 42:965-974.
22. Raines EW. 2004. PDGF and cardiovascular disease. Cytokine Growth Factor Rev 15:237-254.
23. Raines EW, Ferri N. 2005. Thematic review series: The immune system and atherogenesis. Cytokines affecting endothelial and smooth muscle cells in vascular disease. J Lipid Res 46:1081-1092.
24. Reilly MP, Lehrke M, Wolfe ML, Rohatgi A, Lazar MA, Rader DJ. 2005. Resistin is an inflammatory marker of atherosclerosis in humans. Circulation 111:932-939.
25. Salminen A, Lehtonen M, Paimela T, Kaarniranta K. 2010. Celastrol: Molecular targets of Thunder God Vine. Biochem Biophys Res Commun 394:439-442.
26. Schober A. 2008. Chemokines in vascular dysfunction and remodeling. Arterioscler Thromb Vasc Biol 28:1950-1959.
27. Schultz GS, Davidson JM, Kirsner RS, Bornstein P, Herman IM. 2011. Dynamic reciprocity in the wound microenvironment. Wound Repair Regen 19:134-148.
28. Silswal N, Singh AK, Aruna B, Mukhopadhyay S, Ghosh S, Ehtesham NZ. 2005. Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaB-dependent pathway. Biochem Biophys Res Commun 334:1092-1101.
29. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA. 2001. The hormone resistin links obesity to diabetes. Nature 409:307-312.
30. Ström A, Olin AI, Aspberg A, Hultgårdh-Nilsson A. 2006. Fibulin-2 is present in murine vascular lesions and is important for smooth muscle cell migration. Cardiovasc Res 69:755-763.
31. Tilg H, Moschen AR. 2006. Adipocytokines: Mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6:772-783.
32. Verma S, Li SH, Wang CH, Fedak PW, Li RK, Weisel RD, Mickle DA. 2003. Resistin promotes endothelial cell activation: Further evidence of adipokine-endothelial interaction. Circulation 108:736-740.
33. Yadav VR, Sung B, Prasad S, Kannappan R, Cho SG, Liu M, Chaturvedi MM, Aggarwal BB. 2010. Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor. J Mol Med (Berl) 88:1243-1253.
34. Yu X, Tao W, Jiang F, Li C, Lin J, Liu C. 2010. Celastrol attenuates hypertension-induced inflammation and oxidative stress in vascular smooth muscle cells via induction of heme oxygenase-1. Am J Hypertens 23:895-903.