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Volumn 5, Issue , 2013, Pages 1-14

Safety and efficacy of ranolazine for the treatment of chronic angina pectoris

Author keywords

Chronic angina; Late Na+ current; Mitochondria; Ranolazine

Indexed keywords

AMLODIPINE; ANTIANGINA PECTORIS AGENT; ATENOLOL; DILTIAZEM; GLYCERYL TRINITRATE; PLACEBO; RANOLAZINE;

EID: 84872691105     PISSN: 1179559X     EISSN: None     Source Type: Journal    
DOI: 10.4137/CMT.S7824     Document Type: Review
Times cited : (10)

References (60)
  • 1
    • 84855396777 scopus 로고    scopus 로고
    • Executive summary: Heart disease and stroke statistics--2012 update: A report from the American Heart Association
    • Jan 3
    • Roger VL, Go AS, Lloyd-Jones DM, et al. Executive summary: heart disease and stroke statistics--2012 update: a report from the American Heart Association. Circulation. Jan 3, 2012;125(1):188-97.
    • (2012) Circulation , vol.125 , Issue.1 , pp. 188-197
    • Roger, V.L.1    Go, A.S.2    Lloyd-Jones, D.M.3
  • 2
    • 33745683654 scopus 로고    scopus 로고
    • Guidelines on the management of stable angina pectoris: Executive summary: The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology
    • Jun
    • Fox K, Garcia MA, Ardissino D, et al. Guidelines on the management of stable angina pectoris: executive summary: The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology. Eur Heart J. Jun 2006;27(11):1341-81.
    • (2006) Eur Heart J , vol.27 , Issue.11 , pp. 1341-1381
    • Fox, K.1    Garcia, M.A.2    Ardissino, D.3
  • 3
    • 0036847929 scopus 로고    scopus 로고
    • Angina 1 year after percutaneous coronary intervention: A report from the NHLBI Dynamic Registry
    • Nov
    • Holubkov R, Laskey WK, Haviland A, et al. Angina 1 year after percutaneous coronary intervention: a report from the NHLBI Dynamic Registry. Am. Heart J. Nov 2002;144(5):826-33.
    • (2002) Am. Heart J , vol.144 , Issue.5 , pp. 826-833
    • Holubkov, R.1    Laskey, W.K.2    Haviland, A.3
  • 4
    • 2442606694 scopus 로고    scopus 로고
    • The medicine, angioplasty, or surgery study (MASS-II): A randomized, controlled clinical trial of three therapeutic strategies for multivessel coronary artery disease: One-year results
    • May 19
    • Hueb W, Soares PR, Gersh BJ, et al. The medicine, angioplasty, or surgery study (MASS-II): a randomized, controlled clinical trial of three therapeutic strategies for multivessel coronary artery disease: one-year results. J Am Coll Cardiol. May 19, 2004;43(10):1743-51.
    • (2004) J Am Coll Cardiol , vol.43 , Issue.10 , pp. 1743-1751
    • Hueb, W.1    Soares, P.R.2    Gersh, B.J.3
  • 7
    • 33646140572 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of ranolazine
    • Jerling M. Clinical pharmacokinetics of ranolazine. Clin Pharmacokinet. 2006;45(5):469-91.
    • (2006) Clin Pharmacokinet , vol.45 , Issue.5 , pp. 469-491
    • Jerling, M.1
  • 8
    • 0030032681 scopus 로고    scopus 로고
    • Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts
    • Jan 1
    • McCormack JG, Barr RL, Wolff AA, Lopaschuk GD. Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts. Circulation. Jan 1, 1996;93(1):135-42.
    • (1996) Circulation , vol.93 , Issue.1 , pp. 135-142
    • McCormack, J.G.1    Barr, R.L.2    Wolff, A.A.3    Lopaschuk, G.D.4
  • 9
    • 0348129532 scopus 로고    scopus 로고
    • Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: A randomized controlled trial
    • Jan 21
    • Chaitman BR, Pepine CJ, Parker JO, et al. Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial. JAMA. Jan 21, 2004;291(3):309-16.
    • (2004) JAMA , vol.291 , Issue.3 , pp. 309-316
    • Chaitman, B.R.1    Pepine, C.J.2    Parker, J.O.3
  • 10
    • 11144356285 scopus 로고    scopus 로고
    • Anti-ischemic effects and longterm survival during ranolazine monotherapy in patients with chronic severe angina
    • Apr 21
    • Chaitman BR, Skettino SL, Parker JO, et al. Anti-ischemic effects and longterm survival during ranolazine monotherapy in patients with chronic severe angina. J Am Coll Cardiol. Apr 21, 2004;43(8):1375-82.
    • (2004) J Am Coll Cardiol , vol.43 , Issue.8 , pp. 1375-1382
    • Chaitman, B.R.1    Skettino, S.L.2    Parker, J.O.3
  • 11
    • 0026680239 scopus 로고
    • Effects of a new metabolic modulator, ranolazine, on exercise tolerance in angina pectoris patients treated with beta-blocker or diltiazem
    • Jul
    • Cocco G, Rousseau MF, Bouvy T, et al. Effects of a new metabolic modulator, ranolazine, on exercise tolerance in angina pectoris patients treated with beta-blocker or diltiazem. J Cardiovasc Pharmacol. Jul 1992;20(1):131-8.
    • (1992) J Cardiovasc Pharmacol , vol.20 , Issue.1 , pp. 131-138
    • Cocco, G.1    Rousseau, M.F.2    Bouvy, T.3
  • 12
    • 0032983310 scopus 로고    scopus 로고
    • A controlled trial with a novel anti-ischemic agent, ranolazine, in chronic stable angina pectoris that is responsive to conventional antianginal agents
    • Jul 1
    • Pepine CJ, Wolff AA. A controlled trial with a novel anti-ischemic agent, ranolazine, in chronic stable angina pectoris that is responsive to conventional antianginal agents. Ranolazine Study Group. Am J Cardiol. Jul 1, 1999; 84(1):46-50.
    • (1999) Ranolazine Study Group. Am J Cardiol , vol.84 , Issue.1 , pp. 46-50
    • Pepine, C.J.1    Wolff, A.A.2
  • 13
    • 12844280008 scopus 로고    scopus 로고
    • Comparative efficacy of ranolazine versus atenolol for chronic angina pectoris
    • Feb 1
    • Rousseau MF, Pouleur H, Cocco G, Wolff AA. Comparative efficacy of ranolazine versus atenolol for chronic angina pectoris. Am J Cardiol. Feb 1, 2005;95(3):311-6.
    • (2005) Am J Cardiol , vol.95 , Issue.3 , pp. 311-316
    • Rousseau, M.F.1    Pouleur, H.2    Cocco, G.3    Wolff, A.A.4
  • 14
    • 33746192571 scopus 로고    scopus 로고
    • Antianginal efficacy of ranolazine when added to treatment with amlodipine: The ERICA (Efficacy of Ranolazine in Chronic Angina) trial
    • Aug 1
    • Stone PH, Gratsiansky NA, Blokhin A, Huang IZ, Meng L. Antianginal efficacy of ranolazine when added to treatment with amlodipine: the ERICA (Efficacy of Ranolazine in Chronic Angina) trial. J Am Coll Cardiol. Aug 1, 2006;48(3):566-75.
    • (2006) J Am Coll Cardiol , vol.48 , Issue.3 , pp. 566-575
    • Stone, P.H.1    Gratsiansky, N.A.2    Blokhin, A.3    Huang, I.Z.4    Meng, L.5
  • 15
    • 0027241659 scopus 로고
    • Protective effects of ranolazine in guinea-pig hearts during low-flow ischaemia and their association with increases in active pyruvate dehydrogenase
    • Jul
    • Clarke B, Spedding M, Patmore L, McCormack JG. Protective effects of ranolazine in guinea-pig hearts during low-flow ischaemia and their association with increases in active pyruvate dehydrogenase. Br J Pharmacol. Jul 1993;109(3):748-50.
    • (1993) Br J Pharmacol , vol.109 , Issue.3 , pp. 748-750
    • Clarke, B.1    Spedding, M.2    Patmore, L.3    McCormack, J.G.4
  • 16
    • 33846804167 scopus 로고    scopus 로고
    • Ranolazine for the management of coronary artery disease
    • Dec
    • Cheng JW. Ranolazine for the management of coronary artery disease. Clin Ther. Dec 2006;28(12):1996-2007.
    • (2006) Clin Ther , vol.28 , Issue.12 , pp. 1996-2007
    • Cheng, J.W.1
  • 17
    • 0025319665 scopus 로고
    • Role of calcium ions in regulation of mammalian intramitochondrial metabolism
    • Apr
    • McCormack JG, Halestrap AP, Denton RM. Role of calcium ions in regulation of mammalian intramitochondrial metabolism. Physiol Rev. Apr 1990; 70(2):391-425.
    • (1990) Physiol Rev , vol.70 , Issue.2 , pp. 391-425
    • McCormack, J.G.1    Halestrap, A.P.2    Denton, R.M.3
  • 18
    • 0022802645 scopus 로고
    • Fuel selection in animals
    • Oct
    • Randle PJ. Fuel selection in animals. Biochem Soc Trans. Oct 1986;14(5): 799-806.
    • (1986) Biochem Soc Trans , vol.14 , Issue.5 , pp. 799-806
    • Randle, P.J.1
  • 19
    • 4344577023 scopus 로고    scopus 로고
    • Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties
    • Aug 24
    • Antzelevitch C, Belardinelli L, Zygmunt AC, et al. Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation. Aug 24, 2004;110(8):904-10.
    • (2004) Circulation , vol.110 , Issue.8 , pp. 904-910
    • Antzelevitch, C.1    Belardinelli, L.2    Zygmunt, A.C.3
  • 20
    • 3242778566 scopus 로고    scopus 로고
    • Antagonism by ranolazine of the pro-arrhythmic effects of increasing late INa in guinea pig ventricular myocytes
    • Aug
    • Song Y, Shryock JC, Wu L, Belardinelli L. Antagonism by ranolazine of the pro-arrhythmic effects of increasing late INa in guinea pig ventricular myocytes. J Cardiovasc Pharmacol. Aug 2004;44(2):192-9.
    • (2004) J Cardiovasc Pharmacol , vol.44 , Issue.2 , pp. 192-199
    • Song, Y.1    Shryock, J.C.2    Wu, L.3    Belardinelli, L.4
  • 21
    • 3342882854 scopus 로고    scopus 로고
    • Antiarrhythmic effects of ranolazine in a guinea pig in vitro model of long- QT syndrome
    • Aug
    • Wu L, Shryock JC, Song Y, Li Y, Antzelevitch C, Belardinelli L. Antiarrhythmic effects of ranolazine in a guinea pig in vitro model of long- QT syndrome. J Pharmacol Exp Ther. Aug 2004;310(2):599-605.
    • (2004) J Pharmacol Exp Ther , vol.310 , Issue.2 , pp. 599-605
    • Wu, L.1    Shryock, J.C.2    Song, Y.3    Li, Y.4    Antzelevitch, C.5    Belardinelli, L.6
  • 22
    • 33646386662 scopus 로고    scopus 로고
    • Molecular basis of ranolazine block of LQT-3 mutant sodium channels: Evidence for site of action
    • May
    • Fredj S, Sampson KJ, Liu H, Kass RS. Molecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of action. Br J Pharmacol. May 2006;148(1):16-24.
    • (2006) Br J Pharmacol , vol.148 , Issue.1 , pp. 16-24
    • Fredj, S.1    Sampson, K.J.2    Liu, H.3    Kass, R.S.4
  • 23
    • 0242266970 scopus 로고    scopus 로고
    • + exchange inhibitor, inhibits the mitochondrial death pathway
    • Nov 4
    • + exchange inhibitor, inhibits the mitochondrial death pathway. Circulation. Nov 4, 2003;108(18):2275-81.
    • (2003) Circulation , vol.108 , Issue.18 , pp. 2275-2281
    • Teshima, Y.1    Akao, M.2    Jones, S.P.3    Marbán, E.4
  • 24
    • 0026666057 scopus 로고
    • Inward sodium current at resting potentials in single cardiac myocytes induced by the ischemic metabolite lysophosphatidylcholine
    • Nov
    • Undrovinas AI, Fleidervish IA, Makielski JC. Inward sodium current at resting potentials in single cardiac myocytes induced by the ischemic metabolite lysophosphatidylcholine. Circ Res. Nov 1992;71(5):1231-41.
    • (1992) Circ Res , vol.71 , Issue.5 , pp. 1231-1241
    • Undrovinas, A.I.1    Fleidervish, I.A.2    Makielski, J.C.3
  • 25
    • 0028325970 scopus 로고
    • Palmitoyl carnitine modifies sodium currents and induces transient inward current in ventricular myocytes
    • Mar
    • Wu J, Corr PB. Palmitoyl carnitine modifies sodium currents and induces transient inward current in ventricular myocytes. Am J Physiol. Mar 1994; 266(3 Pt 2):H1034-46.
    • (1994) Am J Physiol , vol.266 , Issue.2-3 PART.
    • Wu, J.1    Corr, P.B.2
  • 26
    • 0030957101 scopus 로고    scopus 로고
    • Ionic mechanism of the effects of hydrogen peroxide in rat ventricular myocytes
    • May 1
    • Ward CA, Giles WR. Ionic mechanism of the effects of hydrogen peroxide in rat ventricular myocytes. J Physiol. May 1, 1997; 500(Pt 3):631-42.
    • (1997) J Physiol , vol.500 , Issue.3 PART. , pp. 631-642
    • Ward, C.A.1    Giles, W.R.2
  • 27
    • 33745251122 scopus 로고    scopus 로고
    • Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction
    • Jul
    • Song Y, Shryock JC, Wagner S, Maier LS, Belardinelli L. Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction. J Pharmacol Exp Ther. Jul 2006;318(1):214-22.
    • (2006) J Pharmacol Exp Ther , vol.318 , Issue.1 , pp. 214-222
    • Song, Y.1    Shryock, J.C.2    Wagner, S.3    Maier, L.S.4    Belardinelli, L.5
  • 28
    • 80052963908 scopus 로고    scopus 로고
    • 2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts
    • Oct
    • 2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts. Pharmacol Res. Oct 2011;64(4):381-92.
    • (2011) Pharmacol Res , vol.64 , Issue.4 , pp. 381-392
    • Aldakkak, M.1    Camara, A.K.2    Heisner, J.S.3    Yang, M.4    Stowe, D.F.5
  • 29
    • 84861867021 scopus 로고    scopus 로고
    • Ranolazine Decreases Mechanosensitivity of the Voltage-gated Sodium Ion Channel Na(v)1.5: A Novel Mechanism of Drug Action
    • Jun 5
    • Beyder A, Strege PR, Reyes S, et al. Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel Na(v)1.5: a novel mechanism of drug action. Circulation. Jun 5, 2012;125(22):2698-706.
    • (2012) Circulation , vol.125 , Issue.22 , pp. 2698-2706
    • Beyder, A.1    Strege, P.R.2    Reyes, S.3
  • 30
    • 0028841015 scopus 로고
    • The antianginal agent ranolazine is a weak inhibitor of the respiratory complex I, but with greater potency in broken or uncoupled than in coupled mitochondria
    • Nov 9
    • Wyatt KM, Skene C, Veitch K, Hue L, McCormack JG. The antianginal agent ranolazine is a weak inhibitor of the respiratory complex I, but with greater potency in broken or uncoupled than in coupled mitochondria. Biochem Pharmacol. Nov 9, 1995;50(10):1599-606.
    • (1995) Biochem Pharmacol , vol.50 , Issue.10 , pp. 1599-1606
    • Wyatt, K.M.1    Skene, C.2    Veitch, K.3    Hue, L.4    McCormack, J.G.5
  • 32
    • 29244441132 scopus 로고    scopus 로고
    • Blockade of electron transport before cardiac ischemia with the reversible inhibitor amobarbital protects rat heart mitochondria
    • Jan
    • Chen Q, Hoppel CL, Lesnefsky EJ. Blockade of electron transport before cardiac ischemia with the reversible inhibitor amobarbital protects rat heart mitochondria. J Pharmacol Exp Ther. Jan 2006;316(1):200-7.
    • (2006) J Pharmacol Exp Ther , vol.316 , Issue.1 , pp. 200-207
    • Chen, Q.1    Hoppel, C.L.2    Lesnefsky, E.J.3
  • 33
    • 84855809495 scopus 로고    scopus 로고
    • Damage to mitochondrial complex I during cardiac ischemia reperfusion injury is reduced indirectly by anti-anginal drug ranolazine
    • Mar
    • Gadicherla AK, Stowe DF, Antholine WE, Yang M, Camara AK. Damage to mitochondrial complex I during cardiac ischemia reperfusion injury is reduced indirectly by anti-anginal drug ranolazine. Biochim Biophys Acta. Mar 2012;1817(3):419-29.
    • (2012) Biochim Biophys Acta , vol.1817 , Issue.3 , pp. 419-429
    • Gadicherla, A.K.1    Stowe, D.F.2    Antholine, W.E.3    Yang, M.4    Camara, A.K.5
  • 34
    • 0033565557 scopus 로고    scopus 로고
    • The mitochondrial permeability transition pore and its role in cell death
    • Jul 15
    • Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem J. Jul 15, 1999;341(Pt 2):233-49.
    • (1999) Biochem J. Jul , vol.341 , Issue.2 PART. , pp. 233-249
    • Crompton, M.1
  • 35
    • 1142273368 scopus 로고    scopus 로고
    • Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection
    • Feb 15
    • Halestrap AP, Clarke SJ, Javadov SA. Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection. Cardiovasc Res. Feb 15, 2004;61(3):372-85.
    • (2004) Cardiovasc Res , vol.61 , Issue.3 , pp. 372-385
    • Halestrap, A.P.1    Clarke, S.J.2    Javadov, S.A.3
  • 36
    • 0019814286 scopus 로고
    • The role of calcium in the ischemic myocardium
    • Feb
    • Nayler WG. The role of calcium in the ischemic myocardium. Am J Pathol. Feb 1981;102(2):262-70.
    • (1981) Am J Pathol , vol.102 , Issue.2 , pp. 262-270
    • Nayler, W.G.1
  • 37
    • 84864476166 scopus 로고    scopus 로고
    • Calcium handling in human heart failure-abnormalities and target for therapy
    • Jul
    • Reuter H, Schwinger RH. Calcium handling in human heart failure-abnormalities and target for therapy. Wien Med Wochenschr. Jul 2012;162(13-4): 297-301.
    • (2012) Wien Med Wochenschr , vol.162 , Issue.4-13 , pp. 297-301
    • Reuter, H.1    Schwinger, R.H.2
  • 39
    • 70349786605 scopus 로고    scopus 로고
    • Ranolazine as a cardioplegia additive improves recovery of diastolic function in isolated rat hearts
    • Sep 15
    • Hwang H, Arcidi JM Jr, Hale SL, et al. Ranolazine as a cardioplegia additive improves recovery of diastolic function in isolated rat hearts. Circulation. Sep 15, 2009;120(Suppl 11):S16-21.
    • (2009) Circulation , vol.120 , Issue.11 SUPPL.
    • Hwang, H.1    Arcidi Jr., J.M.2    Hale, S.L.3
  • 40
    • 57049182027 scopus 로고    scopus 로고
    • Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure
    • Nov
    • Rastogi S, Sharov VG, Mishra S, et al. Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure. Am J Physiol Heart Circ Physiol. Nov 2008;295(5):H2149-55.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295 , Issue.5
    • Rastogi, S.1    Sharov, V.G.2    Mishra, S.3
  • 41
    • 0036936426 scopus 로고    scopus 로고
    • Ranolazine, a partial fatty acid oxidation (pFOX) inhibitor, improves left ventricular function in dogs with chronic heart failure
    • Dec
    • Sabbah HN, Chandler MP, Mishima T, et al. Ranolazine, a partial fatty acid oxidation (pFOX) inhibitor, improves left ventricular function in dogs with chronic heart failure. J Card Fail. Dec 2002;8(6):416-22.
    • (2002) J Card Fail , vol.8 , Issue.6 , pp. 416-422
    • Sabbah, H.N.1    Chandler, M.P.2    Mishima, T.3
  • 42
    • 45549105581 scopus 로고    scopus 로고
    • Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation
    • Jul
    • Sossalla S, Wagner S, Rasenack EC, et al. Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation. J Mol Cell Cardiol. Jul 2008;45(1):32-43.
    • (2008) J Mol Cell Cardiol , vol.45 , Issue.1 , pp. 32-43
    • Sossalla, S.1    Wagner, S.2    Rasenack, E.C.3
  • 43
    • 33646007982 scopus 로고    scopus 로고
    • Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current
    • May
    • Undrovinas AI, Belardinelli L, Undrovinas NA, Sabbah HN. Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current. J Cardiovasc Electrophysiol. May 2006;17 Suppl 1:S169-77.
    • (2006) J Cardiovasc Electrophysiol , vol.17 , Issue.1 SUPPL.
    • Undrovinas, A.I.1    Belardinelli, L.2    Undrovinas, N.A.3    Sabbah, H.N.4
  • 44
    • 0028134824 scopus 로고
    • Effects of ranolazine on left ventricular regional diastolic function in patients with ischemic heart disease
    • Oct
    • Hayashida W, van Eyll C, Rousseau MF, Pouleur H. Effects of ranolazine on left ventricular regional diastolic function in patients with ischemic heart disease. Cardiovasc Drugs Ther. Oct 1994;8(5):741-7.
    • (1994) Cardiovasc Drugs Ther , vol.8 , Issue.5 , pp. 741-747
    • Hayashida, W.1    van Eyll, C.2    Rousseau, M.F.3    Pouleur, H.4
  • 45
    • 53049104215 scopus 로고    scopus 로고
    • Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-QT syndrome
    • Dec
    • Moss AJ, Zareba W, Schwarz KQ, Rosero S, McNitt S, Robinson JL. Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-QT syndrome. J Cardiovasc Electrophysiol. Dec 2008;19(12):1289-93.
    • (2008) J Cardiovasc Electrophysiol , vol.19 , Issue.12 , pp. 1289-1293
    • Moss, A.J.1    Zareba, W.2    Schwarz, K.Q.3    Rosero, S.4    McNitt, S.5    Robinson, J.L.6
  • 46
    • 84862776882 scopus 로고    scopus 로고
    • Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity
    • Mar 16
    • Lovelock JD, Monasky MM, Jeong EM, et al. Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity. Circ Res. Mar 16, 2012;110(6):841-50.
    • (2012) Circ Res , vol.110 , Issue.6 , pp. 841-850
    • Lovelock, J.D.1    Monasky, M.M.2    Jeong, E.M.3
  • 47
    • 34247526904 scopus 로고    scopus 로고
    • Effects of ranolazine on recurrent cardiovascular events in patients with non-ST- elevation acute coronary syndromes: The MERLIN-TIMI 36 randomized trial
    • Apr 25
    • Morrow DA, Scirica BM, Karwatowska-Prokopczuk E, et al. Effects of ranolazine on recurrent cardiovascular events in patients with non-ST- elevation acute coronary syndromes: the MERLIN-TIMI 36 randomized trial. JAMA. Apr 25, 2007;297(16):1775-83.
    • (2007) JAMA , vol.297 , Issue.16 , pp. 1775-1783
    • Morrow, D.A.1    Scirica, B.M.2    Karwatowska-Prokopczuk, E.3
  • 48
    • 84862577191 scopus 로고    scopus 로고
    • A pilot randomized study of ranolazine for reduction of myocardial damage during elective percutaneous coronary intervention
    • Jun
    • Pelliccia F, Pasceri V, Marazzi G, Rosano G, Greco C, Gaudio C. A pilot randomized study of ranolazine for reduction of myocardial damage during elective percutaneous coronary intervention. Am Heart J. Jun 2012; 163(6):1019-23.
    • (2012) Am Heart J , vol.163 , Issue.6 , pp. 1019-1023
    • Pelliccia, F.1    Pasceri, V.2    Marazzi, G.3    Rosano, G.4    Greco, C.5    Gaudio, C.6
  • 49
    • 84862138606 scopus 로고    scopus 로고
    • Costs and clinical outcomes associated with use of ranolazine for treatment of angina
    • Jun
    • Phelps CE, Buysman EK, Gomez Rey G. Costs and clinical outcomes associated with use of ranolazine for treatment of angina. Clin Ther. Jun 2012;34(6):1395-407.
    • (2012) Clin Ther , vol.34 , Issue.6 , pp. 1395-1407
    • Phelps, C.E.1    Buysman, E.K.2    Gomez, R.G.3
  • 50
    • 4944222848 scopus 로고    scopus 로고
    • Efficacy and safety of a metabolic modulator drug in chronic stable angina: Review of evidence from clinical trials
    • Sep
    • Chaitman BR. Efficacy and safety of a metabolic modulator drug in chronic stable angina: review of evidence from clinical trials. J Cardiovasc Pharmacol Ther. Sep 2004;9 Suppl 1:S47-64.
    • (2004) J Cardiovasc Pharmacol Ther , vol.9 , Issue.1 SUPPL.
    • Chaitman, B.R.1
  • 51
    • 21044458297 scopus 로고    scopus 로고
    • Effect of hepatic impairment on the multiple-dose pharmacokinetics of ranolazine sustained-release tablets
    • Jul
    • Abdallah H, Jerling M. Effect of hepatic impairment on the multiple-dose pharmacokinetics of ranolazine sustained-release tablets. J Clin Pharmacol. Jul 2005;45(7):802-9.
    • (2005) J Clin Pharmacol , vol.45 , Issue.7 , pp. 802-809
    • Abdallah, H.1    Jerling, M.2
  • 52
    • 77953027146 scopus 로고    scopus 로고
    • Ranolazine (Ranexa) in the treatment of chronic stable angina
    • Aslam S, Gray D. Ranolazine (Ranexa) in the treatment of chronic stable angina. Adv Ther. Apr 2010;27(4):193-201.
    • (2010) Adv Ther , vol.27 , Issue.4 , pp. 193-201
    • Aslam, S.1    Gray, D.2
  • 53
    • 0025217267 scopus 로고
    • Ranolazine (RS- 43285): A preliminary study of a new anti-anginal agent with selective effect on ischaemic myocardium
    • Jain D, Dasgupta P, Hughes LO, Lahiri A, Raftery EB. Ranolazine (RS- 43285): a preliminary study of a new anti-anginal agent with selective effect on ischaemic myocardium. Eur J Clin Pharmacol. 1990;38(2):111-4.
    • (1990) Eur J Clin Pharmacol , vol.38 , Issue.2 , pp. 111-114
    • Jain, D.1    Dasgupta, P.2    Hughes, L.O.3    Lahiri, A.4    Raftery, E.B.5
  • 54
    • 0028016058 scopus 로고
    • Double-blind efficacy and safety study of a novel anti-ischemic agent, ranolazine, versus placebo in patients with chronic stable angina pectoris
    • Aug
    • Thadani U, Ezekowitz M, Fenney L, Chiang YK. Double-blind efficacy and safety study of a novel anti-ischemic agent, ranolazine, versus placebo in patients with chronic stable angina pectoris. Ranolazine Study Group. Circulation. Aug 1994;90(2):726-34.
    • (1994) Ranolazine Study Group. Circulation , vol.90 , Issue.2 , pp. 726-734
    • Thadani, U.1    Ezekowitz, M.2    Fenney, L.3    Chiang, Y.K.4
  • 55
    • 0028900204 scopus 로고
    • Intermittent transdermal nitroglycerin therapy in angina pectoris. Clinically effective without tolerance or rebound
    • Mar 1
    • Parker JO, Amies MH, Hawkinson RW, et al. Intermittent transdermal nitroglycerin therapy in angina pectoris. Clinically effective without tolerance or rebound. Minitran Efficacy Study Group. Circulation. Mar 1, 1995;91(5): 1368-74.
    • (1995) Minitran Efficacy Study Group. Circulation , vol.91 , Issue.5 , pp. 1368-1374
    • Parker, J.O.1    Amies, M.H.2    Hawkinson, R.W.3
  • 56
    • 8944230649 scopus 로고    scopus 로고
    • Comparison of subgroups assigned to medical regimens used to suppress cardiac ischemia (the Asymptomatic Cardiac Ischemia Pilot [ACIP] Study)
    • Jun 15
    • Pratt CM, McMahon RP, Goldstein S, et al. Comparison of subgroups assigned to medical regimens used to suppress cardiac ischemia (the Asymptomatic Cardiac Ischemia Pilot [ACIP] Study). Am J Cardiol. Jun 15, 1996;77(15):1302-9.
    • (1996) Am J Cardiol , vol.77 , Issue.15 , pp. 1302-1309
    • Pratt, C.M.1    McMahon, R.P.2    Goldstein, S.3
  • 57
    • 84872713788 scopus 로고    scopus 로고
    • A National Clinical Guideline, Accessed Aug 6
    • Management of Stable Angina. A National Clinical Guideline. http://www.Guideline.Gov/Content.Aspx?Id=34825&Search=Chronic+Angina. Accessed Aug 6, 2012.
    • (2012) Management of Stable Angina
  • 58
    • 35148850168 scopus 로고    scopus 로고
    • Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non ST-segment elevation acute coronary syndrome: Results from the Metabolic Efficiency With Ranolazine for Less Ischemia in Non ST-Elevation Acute Coronary Syndrome Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) randomized controlled trial
    • Oct 9
    • Scirica BM, Morrow DA, Hod H, et al. Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non ST-segment elevation acute coronary syndrome: results from the Metabolic Efficiency With Ranolazine for Less Ischemia in Non ST-Elevation Acute Coronary Syndrome Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) randomized controlled trial. Circulation. Oct 9, 2007;116(15):1647-52.
    • (2007) Circulation , vol.116 , Issue.15 , pp. 1647-1652
    • Scirica, B.M.1    Morrow, D.A.2    Hod, H.3
  • 59
    • 65449149816 scopus 로고    scopus 로고
    • Evaluation of the glycometabolic effects of ranolazine in patients with and without diabetes mellitus in the MERLIN-TIMI 36 randomized controlled trial
    • Apr 21
    • Morrow DA, Scirica BM, Chaitman BR, et al. Evaluation of the glycometabolic effects of ranolazine in patients with and without diabetes mellitus in the MERLIN-TIMI 36 randomized controlled trial. Circulation. Apr 21, 2009;119(15):2032-9.
    • (2009) Circulation , vol.119 , Issue.15 , pp. 2032-2039
    • Morrow, D.A.1    Scirica, B.M.2    Chaitman, B.R.3
  • 60
    • 84871692739 scopus 로고    scopus 로고
    • ACCF/AHA/ACP/AATS/ PCNA/SCAI/STS Guideline for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the American College of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons, Nov 19, [Epub ahead of print.]
    • Fihn SD, Gardin JM, Abrams J, et al. 2012 ACCF/AHA/ACP/AATS/ PCNA/SCAI/STS Guideline for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the American College of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. Circulation. Nov 19, 2012. [Epub ahead of print.]
    • (2012) Circulation
    • Fihn, S.D.1    Gardin, J.M.2    Abrams, J.3


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