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Volumn 19, Issue 2, 2013, Pages 109-116

Pifithrin-α Enhances the Survival of Transplanted Neural Stem Cells in Stroke Rats by Inhibiting p53 Nuclear Translocation

Author keywords

Cell survival; Cell transplantation; P53; Stem cells

Indexed keywords

PIFITHRIN ALPHA; PROTEIN P53; PUMA PROTEIN;

EID: 84872681231     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12045     Document Type: Article
Times cited : (13)

References (43)
  • 1
    • 33746367427 scopus 로고    scopus 로고
    • Stroke research priorities for the next decade - a representative view of the European scientific community
    • Meairs S, Wahlgren N, Dirnagl U, et al. Stroke research priorities for the next decade - a representative view of the European scientific community. Cerebrovasc Dis 2006;22:75-82.
    • (2006) Cerebrovasc Dis , vol.22 , pp. 75-82
    • Meairs, S.1    Wahlgren, N.2    Dirnagl, U.3
  • 2
    • 39749191084 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2008 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • Rosamond W, Flegal K, Furie K, et al. Heart disease and stroke statistics-2008 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2008;117:e25-e146.
    • (2008) Circulation , vol.117
    • Rosamond, W.1    Flegal, K.2    Furie, K.3
  • 3
    • 20444363057 scopus 로고    scopus 로고
    • Neurofibromin regulates neural stem cell proliferation, survival, and astroglial differentiation in vitro and in vivo
    • Dasgupta B, Gutmann DH. Neurofibromin regulates neural stem cell proliferation, survival, and astroglial differentiation in vitro and in vivo. J Neurosci 2005;25:5584-5594.
    • (2005) J Neurosci , vol.25 , pp. 5584-5594
    • Dasgupta, B.1    Gutmann, D.H.2
  • 4
    • 33745601099 scopus 로고    scopus 로고
    • Stem cells for the treatment of neurological disorders
    • Lindvall O, Kokaia Z. Stem cells for the treatment of neurological disorders. Nature 2006;441:1094-1096.
    • (2006) Nature , vol.441 , pp. 1094-1096
    • Lindvall, O.1    Kokaia, Z.2
  • 7
    • 43449102157 scopus 로고    scopus 로고
    • Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's disease
    • Bjugstad KB, Teng YD, Redmond DE Jr, et al. Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's disease. Exp Neurol 2008;211:362-369.
    • (2008) Exp Neurol , vol.211 , pp. 362-369
    • Bjugstad, K.B.1    Teng, Y.D.2    Redmond Jr., D.E.3
  • 8
    • 78650860359 scopus 로고    scopus 로고
    • Cell number and timing of transplantation determine survival of human neural stem cell grafts in stroke-damaged rat brain
    • Darsalia V, Allison SJ, Cusulin C, et al. Cell number and timing of transplantation determine survival of human neural stem cell grafts in stroke-damaged rat brain. J Cereb Blood Flow Metab 2011;31:235-242.
    • (2011) J Cereb Blood Flow Metab , vol.31 , pp. 235-242
    • Darsalia, V.1    Allison, S.J.2    Cusulin, C.3
  • 9
    • 0034065380 scopus 로고    scopus 로고
    • Improving the survival of grafted dopaminergic neurons: A review over current approaches
    • Brundin P, Karlsson J, Emgard M, et al. Improving the survival of grafted dopaminergic neurons: A review over current approaches. Cell Transplant 2000;9:179-195.
    • (2000) Cell Transplant , vol.9 , pp. 179-195
    • Brundin, P.1    Karlsson, J.2    Emgard, M.3
  • 10
    • 4143071470 scopus 로고    scopus 로고
    • Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex
    • Kelly S, Bliss TM, Shah AK, et al. Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex. Proc Natl Acad Sci USA 2004;101:11839-11844.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 11839-11844
    • Kelly, S.1    Bliss, T.M.2    Shah, A.K.3
  • 11
    • 29144460856 scopus 로고    scopus 로고
    • Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice
    • Munoz JR, Stoutenger BR, Robinson AP, Spees JL, Prockop DJ. Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice. Proc Natl Acad Sci USA 2005;102:18171-18176.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18171-18176
    • Munoz, J.R.1    Stoutenger, B.R.2    Robinson, A.P.3    Spees, J.L.4    Prockop, D.J.5
  • 12
    • 34547630679 scopus 로고    scopus 로고
    • Survival, migration and neuronal differentiation of human fetal striatal and cortical neural stem cells grafted in stroke-damaged rat striatum
    • Darsalia V, Kallur T, Kokaia Z. Survival, migration and neuronal differentiation of human fetal striatal and cortical neural stem cells grafted in stroke-damaged rat striatum. Eur J Neurosci 2007;26:605-614.
    • (2007) Eur J Neurosci , vol.26 , pp. 605-614
    • Darsalia, V.1    Kallur, T.2    Kokaia, Z.3
  • 13
    • 17444393951 scopus 로고    scopus 로고
    • Perinatal hypoxia/ischemia damages and depletes progenitors from the mouse subventricular zone
    • Brazel CY, Rosti RT III, Boyce S, Rothstein RP, Levison SW. Perinatal hypoxia/ischemia damages and depletes progenitors from the mouse subventricular zone. Dev Neurosci 2004;26:266-274.
    • (2004) Dev Neurosci , vol.26 , pp. 266-274
    • Brazel, C.Y.1    Rosti III, R.T.2    Boyce, S.3    Rothstein, R.P.4    Levison, S.W.5
  • 14
    • 33645873905 scopus 로고    scopus 로고
    • Hypoxia/ischemia expands the regenerative capacity of progenitors in the perinatal subventricular zone
    • Yang Z, Levison SW. Hypoxia/ischemia expands the regenerative capacity of progenitors in the perinatal subventricular zone. Neuroscience 2006;139:555-564.
    • (2006) Neuroscience , vol.139 , pp. 555-564
    • Yang, Z.1    Levison, S.W.2
  • 16
    • 2342491481 scopus 로고    scopus 로고
    • The role of p53-induced apoptosis in cerebral ischemia: Effects of the p53 inhibitor pifithrin alpha
    • Leker RR, Aharonowiz M, Greig NH, Ovadia H. The role of p53-induced apoptosis in cerebral ischemia: Effects of the p53 inhibitor pifithrin alpha. Exp Neurol 2004;187:478-486.
    • (2004) Exp Neurol , vol.187 , pp. 478-486
    • Leker, R.R.1    Aharonowiz, M.2    Greig, N.H.3    Ovadia, H.4
  • 17
    • 18144374206 scopus 로고    scopus 로고
    • Maintaining appearances-the role of p53 in adult neurogenesis
    • Medrano S, Scrable H. Maintaining appearances-the role of p53 in adult neurogenesis. Biochem Biophys Res Commun 2005;331:828-833.
    • (2005) Biochem Biophys Res Commun , vol.331 , pp. 828-833
    • Medrano, S.1    Scrable, H.2
  • 19
    • 79251625952 scopus 로고    scopus 로고
    • Novel perspectives on p53 function in neural stem cells and brain tumors
    • Hede SM, Nazarenko I, Nister M, Lindstrom MS. Novel perspectives on p53 function in neural stem cells and brain tumors. J Oncol 2011;2011:852970.
    • (2011) J Oncol , vol.2011 , pp. 852970
    • Hede, S.M.1    Nazarenko, I.2    Nister, M.3    Lindstrom, M.S.4
  • 20
    • 13944273471 scopus 로고    scopus 로고
    • p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression
    • Lin T, Chao C, Saito S, et al. p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat Cell Biol 2005;7:165-171.
    • (2005) Nat Cell Biol , vol.7 , pp. 165-171
    • Lin, T.1    Chao, C.2    Saito, S.3
  • 21
    • 58549090153 scopus 로고    scopus 로고
    • Regenerative capacity of neural precursors in the adult mammalian brain is under the control of p53
    • Medrano S, Burns-Cusato M, Atienza MB, Rahimi D, Scrable H. Regenerative capacity of neural precursors in the adult mammalian brain is under the control of p53. Neurobiol Aging 2009;30:483-497.
    • (2009) Neurobiol Aging , vol.30 , pp. 483-497
    • Medrano, S.1    Burns-Cusato, M.2    Atienza, M.B.3    Rahimi, D.4    Scrable, H.5
  • 22
    • 67249139255 scopus 로고    scopus 로고
    • Delayed treatment with a p53 inhibitor enhances recovery in stroke brain
    • Luo Y, Kuo CC, Shen H, et al. Delayed treatment with a p53 inhibitor enhances recovery in stroke brain. Ann Neurol 2009;65:520-530.
    • (2009) Ann Neurol , vol.65 , pp. 520-530
    • Luo, Y.1    Kuo, C.C.2    Shen, H.3
  • 23
    • 33751418926 scopus 로고    scopus 로고
    • Neural stem cell isolation and characterization
    • Rietze RL, Reynolds BA. Neural stem cell isolation and characterization. Methods Enzymol 2006;419:3-23.
    • (2006) Methods Enzymol , vol.419 , pp. 3-23
    • Rietze, R.L.1    Reynolds, B.A.2
  • 24
    • 44949149311 scopus 로고    scopus 로고
    • Production of neurons, astrocytes and oligodendrocytes from mammalian CNS stem cells
    • Chojnacki A, Weiss S. Production of neurons, astrocytes and oligodendrocytes from mammalian CNS stem cells. Nat Protoc 2008;3:935-940.
    • (2008) Nat Protoc , vol.3 , pp. 935-940
    • Chojnacki, A.1    Weiss, S.2
  • 25
    • 33747178923 scopus 로고    scopus 로고
    • Glutamate enhances proliferation and neurogenesis in human neural progenitor cell cultures derived from the fetal cortex
    • Suzuki M, Nelson AD, Eickstaedt JB, Wallace K, Wright LS, Svendsen CN. Glutamate enhances proliferation and neurogenesis in human neural progenitor cell cultures derived from the fetal cortex. Eur J Neurosci 2006;24:645-653.
    • (2006) Eur J Neurosci , vol.24 , pp. 645-653
    • Suzuki, M.1    Nelson, A.D.2    Eickstaedt, J.B.3    Wallace, K.4    Wright, L.S.5    Svendsen, C.N.6
  • 26
    • 73049105131 scopus 로고    scopus 로고
    • Hypoxia stimulates proliferation of rat neural stem cells with influence on the expression of cyclin D1 and c-Jun N-terminal protein kinase signaling pathway in vitro
    • Chen X, Tian Y, Yao L, Zhang J, Liu Y. Hypoxia stimulates proliferation of rat neural stem cells with influence on the expression of cyclin D1 and c-Jun N-terminal protein kinase signaling pathway in vitro. Neuroscience 2010;165:705-714.
    • (2010) Neuroscience , vol.165 , pp. 705-714
    • Chen, X.1    Tian, Y.2    Yao, L.3    Zhang, J.4    Liu, Y.5
  • 27
    • 0022545394 scopus 로고
    • A model of focal ischemic stroke in the rat: Reproducible extensive cortical infarction
    • Chen ST, Hsu CY, Hogan EL, Maricq H, Balentine JD. A model of focal ischemic stroke in the rat: Reproducible extensive cortical infarction. Stroke 1986;17:738-743.
    • (1986) Stroke , vol.17 , pp. 738-743
    • Chen, S.T.1    Hsu, C.Y.2    Hogan, E.L.3    Maricq, H.4    Balentine, J.D.5
  • 28
    • 0028841482 scopus 로고
    • Regulation of brain-derived neurotrophic factor gene expression after transient middle cerebral artery occlusion with and without brain damage
    • Kokaia Z, Zhao Q, Kokaia M, et al. Regulation of brain-derived neurotrophic factor gene expression after transient middle cerebral artery occlusion with and without brain damage. Exp Neurol 1995;136:73-88.
    • (1995) Exp Neurol , vol.136 , pp. 73-88
    • Kokaia, Z.1    Zhao, Q.2    Kokaia, M.3
  • 29
    • 0035167706 scopus 로고    scopus 로고
    • Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats
    • Chen J, Sanberg PR, Li Y, et al. Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke 2001;32:2682-2688.
    • (2001) Stroke , vol.32 , pp. 2682-2688
    • Chen, J.1    Sanberg, P.R.2    Li, Y.3
  • 30
    • 77957593752 scopus 로고    scopus 로고
    • Neurons and neuronal stem cells survive in glucose-free lactate and in high glucose cell culture medium during normoxia and anoxia
    • Wohnsland S, Burgers HF, Kuschinsky W, Maurer MH. Neurons and neuronal stem cells survive in glucose-free lactate and in high glucose cell culture medium during normoxia and anoxia. Neurochem Res 2010;35:1635-1642.
    • (2010) Neurochem Res , vol.35 , pp. 1635-1642
    • Wohnsland, S.1    Burgers, H.F.2    Kuschinsky, W.3    Maurer, M.H.4
  • 31
    • 0141569519 scopus 로고    scopus 로고
    • Reciprocal inhibition of p53 and nuclear factor-kappaB transcriptional activities determines cell survival or death in neurons
    • Culmsee C, Siewe J, Junker V, et al. Reciprocal inhibition of p53 and nuclear factor-kappaB transcriptional activities determines cell survival or death in neurons. J Neurosci 2003;23:8586-8595.
    • (2003) J Neurosci , vol.23 , pp. 8586-8595
    • Culmsee, C.1    Siewe, J.2    Junker, V.3
  • 32
    • 32544441224 scopus 로고    scopus 로고
    • Loss of p53 induces changes in the behavior of subventricular zone cells: Implication for the genesis of glial tumors
    • Gil-Perotin S, Marin-Husstege M, Li J, et al. Loss of p53 induces changes in the behavior of subventricular zone cells: Implication for the genesis of glial tumors. J Neurosci 2006;26:1107-1116.
    • (2006) J Neurosci , vol.26 , pp. 1107-1116
    • Gil-Perotin, S.1    Marin-Husstege, M.2    Li, J.3
  • 33
    • 26844552847 scopus 로고    scopus 로고
    • Increasing transplanted cell survival with cell-based angiogenic gene therapy
    • Yau TM, Kim C, Ng D, et al. Increasing transplanted cell survival with cell-based angiogenic gene therapy. Ann Thorac Surg 2005;80:1779-1786.
    • (2005) Ann Thorac Surg , vol.80 , pp. 1779-1786
    • Yau, T.M.1    Kim, C.2    Ng, D.3
  • 34
    • 65949084698 scopus 로고    scopus 로고
    • Human neural stem cells genetically modified to overexpress Akt1 provide neuroprotection and functional improvement in mouse stroke model
    • Lee HJ, Kim MK, Kim HJ, Kim SU. Human neural stem cells genetically modified to overexpress Akt1 provide neuroprotection and functional improvement in mouse stroke model. PLoS ONE 2009;4:e5586.
    • (2009) PLoS ONE , vol.4
    • Lee, H.J.1    Kim, M.K.2    Kim, H.J.3    Kim, S.U.4
  • 35
    • 79955946614 scopus 로고    scopus 로고
    • Human embryonic stem cell neural differentiation and enhanced cell survival promoted by hypoxic preconditioning
    • Francis KR, Wei L. Human embryonic stem cell neural differentiation and enhanced cell survival promoted by hypoxic preconditioning. Cell Death Dis 2010;1:e22.
    • (2010) Cell Death Dis , vol.1
    • Francis, K.R.1    Wei, L.2
  • 36
    • 77649276002 scopus 로고    scopus 로고
    • Transplantation of human neural precursor cells in Matrigel scaffolding improves outcome from focal cerebral ischemia after delayed postischemic treatment in rats
    • Jin K, Mao X, Xie L, et al. Transplantation of human neural precursor cells in Matrigel scaffolding improves outcome from focal cerebral ischemia after delayed postischemic treatment in rats. J Cereb Blood Flow Metab 2010;30:534-544.
    • (2010) J Cereb Blood Flow Metab , vol.30 , pp. 534-544
    • Jin, K.1    Mao, X.2    Xie, L.3
  • 37
    • 0035085210 scopus 로고    scopus 로고
    • A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide
    • Culmsee C, Zhu X, Yu QS, et al. A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide. J Neurochem 2001;77:220-228.
    • (2001) J Neurochem , vol.77 , pp. 220-228
    • Culmsee, C.1    Zhu, X.2    Yu, Q.S.3
  • 38
    • 0033807957 scopus 로고    scopus 로고
    • Time course of apoptotic cell death within mesencephalic cell suspension grafts: Implications for improving grafted dopamine neuron survival
    • Sortwell CE, Pitzer MR, Collier TJ. Time course of apoptotic cell death within mesencephalic cell suspension grafts: Implications for improving grafted dopamine neuron survival. Exp Neurol 2000;165:268-277.
    • (2000) Exp Neurol , vol.165 , pp. 268-277
    • Sortwell, C.E.1    Pitzer, M.R.2    Collier, T.J.3
  • 39
    • 33748978945 scopus 로고    scopus 로고
    • Neurorestorative treatment of stroke: Cell and pharmacological approaches
    • Chen J, Chopp M. Neurorestorative treatment of stroke: Cell and pharmacological approaches. NeuroRx 2006;3:466-473.
    • (2006) NeuroRx , vol.3 , pp. 466-473
    • Chen, J.1    Chopp, M.2
  • 41
    • 10744228800 scopus 로고    scopus 로고
    • Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
    • Jeffers JR, Parganas E, Lee Y, et al. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 2003;4:321-328.
    • (2003) Cancer Cell , vol.4 , pp. 321-328
    • Jeffers, J.R.1    Parganas, E.2    Lee, Y.3
  • 42
    • 7744244181 scopus 로고    scopus 로고
    • p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death
    • Cregan SP, Arbour NA, Maclaurin JG, et al. p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death. J Neurosci 2004;24:10003-10012.
    • (2004) J Neurosci , vol.24 , pp. 10003-10012
    • Cregan, S.P.1    Arbour, N.A.2    Maclaurin, J.G.3
  • 43
    • 33745726662 scopus 로고    scopus 로고
    • Targeted deletion of Puma attenuates cardiomyocyte death and improves cardiac function during ischemia-reperfusion
    • Toth A, Jeffers JR, Nickson P, et al. Targeted deletion of Puma attenuates cardiomyocyte death and improves cardiac function during ischemia-reperfusion. Am J Physiol Heart Circ Physiol 2006;291:H52-H60.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291
    • Toth, A.1    Jeffers, J.R.2    Nickson, P.3


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