Human neural stem cells genetically modified to overexpress Akt1 provide neuroprotection and functional improvement in mouse stroke model

PLoS ONE

Volumn 4, Issue 5, 2009, Pages

  Lee, Hong J ^a,b   Kim, Mi K ^a   Kim, Hee J ^a,c   Kim, Seung U ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Chung Ang University College of Medicine   (South Korea)

^c Dankook University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN PEROXIDE; PROTEIN KINASE B; RETROVIRUS VECTOR; AKT1 PROTEIN, HUMAN;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BRAIN FUNCTION; BRAIN HEMORRHAGE; CELL DIFFERENTIATION; CELL FUNCTION; CELL SURVIVAL; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; CYTOTOXICITY; DNA MODIFICATION; DRUG MECHANISM; FETUS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MOUSE; NEURAL STEM CELL TRANSPLANTATION; NEUROPROTECTION; NONHUMAN; SURVIVAL TIME; ANIMAL; ASTROCYTE; CELL CULTURE; CELL LINE; CYTOLOGY; DISEASE MODEL; DRUG EFFECT; GENETICS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; METABOLISM; METHODOLOGY; NERVE CELL; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; STEM CELL TRANSPLANTATION; STROKE; WESTERN BLOTTING;

ANIMALIA;

ANIMALS; ASTROCYTES; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL HEMORRHAGE; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; HUMANS; HYDROGEN PEROXIDE; IMMUNOHISTOCHEMISTRY; MICE; NEURONS; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELL TRANSPLANTATION; STEM CELLS; STROKE;

EID: 65949084698     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005586     Document Type: Article

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