Stem cell based glioblastoma gene therapy

Neoplasma

Volumn 59, Issue 6, 2012, Pages 756-760

  Altaner, C ^a   Altanerova, V ^a  

^a INSTITUTE OF CHEMISTRY   (Slovakia)

Author keywords

Chemoresistance; Glioblastoma; Glioblastoma stem cells; Preclinical studies; Prodrug gene therapy; Radio resistance; Stem cell driven gene therapy

Indexed keywords

3 METHYLADENINE; 7 METHYLGUANINE; CARBOXYLESTERASE; CYTOSINE DEAMINASE; FLUCYTOSINE; FLUOROURACIL; GAMMA INTERFERON; GANCICLOVIR; HERPES SIMPLEX VIRUS THYMIDINE KINASE; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 2; IRINOTECAN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; TEMOZOLOMIDE; THYMIDINE KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; CANCER STEM CELL; GENE THERAPY; GLIOBLASTOMA; HUMAN; MESENCHYMAL STEM CELL; NEURAL STEM CELL; NONHUMAN; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; STEM CELL; ANIMAL; ENZYMOLOGY; GENETICS; MESENCHYMAL STROMA CELL; METABOLISM; PATHOLOGY; SIMPLEXVIRUS;

ANIMALS; CYTOSINE DEAMINASE; FLUCYTOSINE; GANCICLOVIR; GENETIC THERAPY; GLIOBLASTOMA; HUMANS; MESENCHYMAL STROMAL CELLS; SIMPLEXVIRUS; THYMIDINE KINASE;

EID: 84872678401     PISSN: 00282685     EISSN: 13384317     Source Type: Journal    
DOI: 10.4149/neo_2012_95     Document Type: Review

References (37)

1. LOUIS DN, OHGAKI H, WIESTLER OD, WIESTLER OD, CAVENEE WK, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007; 114: 97-109. http://dx.doi.org/10.1007/s00401-007-0243-4
2. ALTANER C. Glioblastoma and stem cells Review. Neoplasma 2008; 55: 369-374.
3. ISCHENKO I, SEELIGER H, SCHAFFER M, JAUCH KW, BRUNS CJ. Cancer stem cells: How can we target them? Curr Med Chem 2008; 15: 3171-3184. http://dx.doi.org/10.2174/092986708786848541
4. AGNIHOTRI S, GAJADHAR AS, TERNAMIAN C, GORLIA T, DIEFES KL et al. Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients. J Clin Invest. 2011 Dec 12. pii: 59334. doi: 10.1172/ JCI59334
5. CHAMBERLAIN MC, BOTA DA, LINSKEY ME, SCHWARTZ PH. Neural stem/progenitors and glioma stem-like cells have differential sensitivity to chemotherapy. Neurology. 2011 Nov 29;77(22): e135-6. http://dx.doi.org/10.1212/WNL.0b013e318239ba7c
6. PULKKANEN K. J., Yla-Herttuala S. Gene therapy for malignant glioma: current clinical status. Mol. Ther. 2005; 12: 585-598. http://dx.doi.org/10.1016/j.ymthe.2005.07.357
7. ABOODY KS, NAJBAUER J, DANKS M K. Stem and progenitor cell-mediated tumor selective gene therapy Cell-mediated anticancer therapy. Gene Therapy 2008; 15: 739-752.
8. DVORAK HF. Tumors: wound that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 1986; 315: 1650-1659.
9. BEXELL D, SCHEDING S, BENGZON J. Toward brain tumor gene therapy using multipotent mesenchymal stromal cells vectors. Mol. Ther. 2010; 18: 1067-1075. http://dx.doi.org/10.1038/mt.2010.58
10. BEXELL D, GUNNARSSON S, TORMIN A, DARABI A, GISSELSSON D, et al. Bone marrow multipotent mesenchymal stroma cells act as pericyte like migratory vehicles in experimental gliomas. Mol Ther 2009; 17: 183-190. http://dx.doi.org/10.1038/mt.2008.229
11. CIHOVA M, ALTANEROVA V, ALTANER C. Stem Cell Based Cancer Gene Therapy. Mol. Pharmaceutics 2011; 8: 1480-1487. http://dx.doi.org/10.1021/mp200151a
12. LE BLANC K. Immunomodulatory effects of fetal and adult mesenchymal stem cells. Cytotherapy 2003; 5: 485-489. http://dx.doi.org/10.1080/14653240310003611
13. KOPPULA P. R., CHELLURI L. K., POLISETTI N., VEMUGANTI G. K. Histocompatibility testing of cultivated human bone marrow stromal cells-a promising step towards pre-clinical screening for allogeneic stem cell therapy. Cell. Immunol. 2009; 259: 61-65. http://dx.doi.org/10.1016/j.cellimm.2009.05.014
14. GRIFFIN MD, RITTER T, MAHON BP. Immunological aspects of allogeneic mesenchymal stem cell therapies. Hum. Gene Ther. 2010; 21: 1641-1655. http://dx.doi.org/10.1089/hum.2010.156
15. KUCEROVA L, ALTANEROVA, V, MATUSKOVA M, TYCIAKOVA S, ALTANER C. Adipose tissue-derived human mesenchymal stem cells mediated prodrug cancer gene therapy. Cancer Res. 2007; 67: 6304-6313. http://dx.doi.org/10.1158/0008-5472.CAN-06-4024
16. KUCEROVA L, MATUSKOVA M, PASTORAKOVA A. TYCIAKOVA S, JAKUBIKOVA J. et al. Cytosine deaminase expressing human mesenchymal stem cells mediated tumour regression in melanoma bearing mice. J. Gene Med. 2008; 10: 1071-1082. http://dx.doi.org/10.1002/jgm.1239
17. CAVARRETTA IT, ALTANEROVA V, MATUSKOVA M, KUCEROVA L, CULIG Z. et al Adipose tissue derived mesenchymal stem cells expressing prodrug-converting enzyme inhibit human prostate tumor growth. Mol. Ther. 2010; 18: 223-231. http://dx.doi.org/10.1038/mt.2009.237
18. KONDO T, SETOGUCHI T, TAGA T. Persistence of a small subpopulation of cancer stemlike cells in the C6 glioma cell line. Proc Natl Acad Sci USA 2004; 101: 781-786. http://dx.doi.org/10.1073/pnas.0307618100
19. ZHENG X, SHEN G, YANG X, LIU W. Most C6 cells are cancer stem cells: evidence from clonal and population analyses. Cancer Res 2007; 67: 3691-3697. http://dx.doi.org/10.1158/0008-5472.CAN-06-3912
20. ZHOU XD, WANG XY, QU FJ, ZHONG YH, LU XD. et al. Detection of cancer stem cells from the C6 glioma cell line. J Int Med Res 2009; 37: 503-510.
21. ALTANEROVA V, CIHOVA M, BABIC M, RYCHLY B, ONDICOVA K. et al. Human adipose tissue-derived mesenchymal stem cells expressing yeast cytosinedeaminase: uracilphosphoribosyltransferase inhibit intracerebral rat glioblastoma, Int J Cancer. 2012;130: 2455-2463. http://dx.doi.org/10.1002/ijc.26278
22. MATUSKOVA M, HLUBINOVA K, PASTORAKOVA A, HUNAKOVA L, ALTANEROVA V. et al. HSV-tk expressing mesenchymal stem cellsexert bystander effect on human glioblastoma cells. Cancer Lett. 2010; 290: 58-67. http://dx.doi.org/10.1016/j.canlet.2009.08.028
23. LI S, GAO Y, TOKUYAMA T, YAMAMOTO J, YOKOTA N. et al. Genetically engineered neural stem cells migrate and suppress glioma cell growth at distant intracranial sites. Cancer Lett 2007; 251: 220-227. http://dx.doi.org/10.1016/j.canlet.2006.11.024
24. AMANO S, LI S, GU C, GAO Y, KOIZUMI S. et al. Use of genetically engineered bone marrowderived mesenchymal stem cells for glioma gene therapy. Int. J. Oncol. 2009; 35: 1265-1270.
25. SONG C, XIANG J, TANG J, HIRST DG ZHOU J et al. Thymidine kinase gene modified bone marrow mesenchymal stem cells as vehicles for antitumor therapy. Hum. Gene Ther 2011; 22: 439-449. http://dx.doi.org/10.1089/hum.2010.116
26. HUANG Q, LIU XZ, KANG C S, WANG GX. ZHONG Y et al. The anti-glioma effect of suicide gene therapy using BMSC expressing HSV/TK combined with overexpression of Cx43 in glioma cells. Cancer Gene Ther. 2010; 17: 192-202. http://dx.doi.org/10.1038/cgt.2009.64
27. MORI K, IWATA J, MIYAZAKI M, OSADA H, TANGE Y et al. Bystander killing effect of thymidine kinase genetransduced bone marrow stromal cells with ganciclovir on malignant glioma cells. Neurol. Med.-Chir. (Tokyo) 2010; 50: 545-553. http://dx.doi.org/10.2176/nmc.50.545
28. BAK XY, YANG J, WANG S. Baculovirus-transduced bone marrow mesenchymal stem cells for systemic cancer therapy. Cancer Gene Ther. 2010; 17: 721-729. http://dx.doi.org/10.1038/cgt.2010.32
29. CHOI SA, LEE JL, WANG KC, PHI JH, SONG SH et al. Human adipose tissue-derived mesenchymal stem cells: Characteristics and therapeutic potential as cellular vehicles for prodrug gene therapy against brainstem gliomas. Eur. J. Cancer 2012; 48: 129-137. http://dx.doi.org/10.1016/j.ejca.2011.04.033
30. XU G, JIANG XD, XU Y, ZHANG J, HUANG FH. et al. Adenoviral-mediated interleukin-18 expression in mesenchymal stem cells effectively suppresses the growth of glioma in rats. Cell Biol. Int. 2009; 33: 466-474. http://dx.doi.org/10.1016/j.cellbi.2008.07.023
31. STAGG J, LEJEUNE L, PAQUIN A, GALIPEAU J. Marrow stromal cells for interleukin-2 delivery in cancer immunotherapy. Hum. Gene Ther. 2004; 75: 597-608. http://dx.doi.org/10.1089/104303404323142042
32. EHTESHAM M, KABOS P, NEUMAN T, BLACK KL, YU JS. The use of interleukin-12-secreting neural stem cells for the treatment of intracranial glioma. Cancer Res. 2002; 62: 5657-5663.
33. GUNNARSSON S, BEXELL D, SVENSSON A, SIESJO P, DARABI A. et al. Intratumoral IL-7 delivery by mesenchymal stromal cells potentiates IFN-γ-transduced tumor cell immunotherapy of experimental glioma. J. Neuroimmunol. 2010; 218: 140-144. http://dx.doi.org/10.1016/j.jneuroim.2009.10.017
34. RYU CH, PARK SH, PARK SA, KIM SM. LIM JY. et al. Gene Therapy of intracranial glioma using interleukin 12-secreting umbilical cord blood derived mesenchymal stem cells. Hum. Gene Ther. 2011; 22: 733-743. http://dx.doi.org/10.1089/hum.2010.187
35. MENON LG, KELLY K, YANG HW, KIM SK, BLACK PM. et al. Human bone marrow-derived mesenchymal stromal cells expressing S-TRAIL as a cellular delivery vehicle for human glioma therapy. Stem Cells. 2009; 27: 2320-2330. http://dx.doi.org/10.1002/stem.136
36. MOHR A, ALBARENQUE SM, DEEDIGAN LYU R, REIDY M. et al. Targeting of XIAP Combined with Systemic Mesenchymal Stem Cell-Mediated Delivery of sTRAIL Ligand Inhibits Metastatic Growth of Pancreatic Carcinoma Cells. Stem Cells 2010; 28: 2109-2120. http://dx.doi.org/10.1002/stem.533
37. KAUER TM, FIGUEIREDO J, HINGTGEN S, SHAH K. Encapsulated therapeutic stem cells implanted in the tumor resection cavity induce cell death in gliomas. Nat Neurosci. 2011; 15: 197-264. http://dx.doi.org/10.1038/nn.3019