Blockade of 5-HT 2 receptor selectively prevents MDMA-induced verbal memory impairment

Neuropsychopharmacology

Volumn 36, Issue 9, 2011, Pages 1932-1939

  Van Wel, J H P ^a   Kuypers, K P C ^a   Theunissen, E L ^a   Bosker, W M ^a   Bakker, K ^a   Ramaekers, J G ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

5 HT 1; 5 HT 2; ketanserin; MDMA; pindolol; serotonin

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; KETANSERIN; PINDOLOL; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; PLACEBO; SEROTONIN 2 ANTAGONIST; SEROTONIN RECEPTOR AFFECTING AGENT;

ADULT; ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MEMORY DISORDER; NORMAL HUMAN; PERFORMANCE; PRIORITY JOURNAL; SPATIAL MEMORY; VERBAL MEMORY; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG ANTAGONISM;

ADULT; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MEMORY DISORDERS; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; PLACEBOS; SEROTONIN 5-HT2 RECEPTOR ANTAGONISTS; SEROTONIN AGENTS; YOUNG ADULT;

EID: 79960318582     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2011.80     Document Type: Article

References (35)

1. 1A receptor in relation to human cognition. Behav Brain Res 195: 103-111.
2. 1A receptor expression and cognitive functions-a strategy in translational psychopharma-cology. Psychopharmacology (Berl) 185: 389-394.
3. Brogden RN, Sorkin EM (1990). Ketanserin. A review of its pharmacodynamic and pharmacokinetic properties, and ther-apeutic potential in hypertension and peripheral vascular disease. Drugs 40: 903-949. (Pubitemid 120032437)
4. Cole JC, Sumnall H (2003). The pre-clinical behavioural pharma-cology of 3,4-methylenedioxymethamphetamine (MDMA). Neu-rosci Biobehav Rev 27: 199-217. (Pubitemid 36677429)
5. Deelman BG, Liebrand WB, Koning-Haanstra M, van den Burg W (1980). Measurements of aphasic disorders. A brief description of the SAN-battery. Gerontologie 11: 17-21.
6. Galizio M, Mc Kinney P, Cerutti DT, Pitts RC (2009). Effects of MDMA, methamphetamine and methylphenidate on repeated acquisition and performance in rats. Pharmacol Biochem Behav 94: 305-311.
7. Gouzoulis-Mayfrank E, Daumann J (2009). Neurotoxicity of drugs of abuse\-the case of methylenedioxyamphetamines (MDMA, ecstasy), and amphetamines. Dialogues Clin Neurosci 11: 305-317.
8. 1A receptor function in the human psychopharmacology of MDMA. J Psychopharmacol 23: 923-935.
9. 2A receptor in the hyperlocomotive and hyperthermic effects of (+)-3,4-methylenedioxymethampheta-mine. Psychopharmacology (Berl) 178: 505-513. (Pubitemid 40486991)
10. Kay C, Harper DN, Hunt M (2010). Differential effects of MDMA and scopolamine on working versus reference memory in the radial arm maze task. Neurobiol Learn Mem 93: 151-156.
11. Kuypers KP, Ramaekers JG (2005). Transient memory impairment after acute dose of 75mg 3.4-Methylene-dioxymethampheta-mine. J Psychopharmacol 19: 633-639. (Pubitemid 41578826)
12. Kuypers KPC, Samyn N, Ramaekers JG (2006). MDMA and alcohol effects, combined and alone, on objective and subjective measures of actual driving performance and psychomotor function. Psychopharmacology (Berl) 187: 467-475. (Pubitemid 44200518)
13. Kuypers KP, Ramaekers JG (2007). Acute dose of MDMA (75mg) impairs spatial memory for location but leaves contextual processing of visuospatial information unaffected. Psychophar-macology (Berl) 189: 557-563. (Pubitemid 44791224)
14. 2 receptors and uptake sites in the neocortex of the rhesus monkey. J Comp Neurol 280: 27-42. (Pubitemid 19052904)
15. 2 antagonist Ketanserin in healthy humans. Neuropsychopharmacology 23: 396-404.
16. Linden DE (2007). The working memory networks of the human brain. Neuroscientist 13: 257-267.
17. 2A/2B/2C) receptors involved in learning and memory processes? IDrugs 2: 796-801. (Pubitemid 29354507)
18. (2A/2B/2C) receptors on memory formation: simple agonism, antagonism, or inverse agonism? Cell Mol Biol 22: 675-688. (Pubitemid 36169216)
19. Meneses A (2007a). Do serotonin(1-7) receptors modulate short and long-term memory? Neurobiol Learn Mem 87: 561-572.
20. 3 and 5-HT4 receptors or 5-HT uptake inhibition: short-and long-term memory. Neurobiol Learn Mem 184: 81-90. (Pubitemid 47411590)
21. Morgan MJ (2000). Ecstasy (MDMA): a review of its possible persistent psychological effects. Psychopharmacology 152: 230-248.
22. Parrott AC (2001). Human psychopharmacology of Ecstasy (MDMA): a review of 15 years of empirical research. Hum Psychopharmacol Clin Exp 16: 557-577. (Pubitemid 34040989)
23. 1A) receptor in vivo: autoreceptor and postsynaptic receptor occupancy exam-ined with PET and [carbonyl-(11)C]WAY- 100635. Nucl Med Biol 27: 509-513. (Pubitemid 30658155)
24. Ramaekers JG, Kuypers KP, Wingen M, Heinecke A, Formisano E (2009). Involvement of inferior parietal lobules in prospective memory impairment during acute MDMA (ecstasy) intoxication: an event-related f MRI study. Neuropsychopharmacology 34: 1641-1648.
25. 2A receptors in rat and human brain. Neuropsychopharmacology 26: 387-396. (Pubitemid 34159216)
26. Reneman L, Lavalaye J, Schmand B, de Wolff FA, van den Brink W, den Heeten GJ et al (2001). Cortical serotonin transporter density and verbal memory in individuals who stopped using 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy'): preliminary findings. Arch Gen Psychiatry 58: 901-906. (Pubitemid 32937910)
27. Rey A (1958). The clinical examination in psychology/L'examen clinique en psychologie. Presses Universitaires de France: Oxford, England.
28. 2 receptors: implications for treating LSD-induced hallucino-genesis. Psychopharmacology 98: 495-499. (Pubitemid 19193897)
29. Schmitt JAJ, Kruizinga MJ, Riedel WJ (2001). Non-serotonergic pharmacological profiles and associated cognitive effects of serotonin reuptake inhibitors. J Psychopharmacol 15: 173-179. (Pubitemid 32808250)
30. Schott BH, Seidenbecher CI, Richter S, Wustenberg T, Debska-Vielhaber G, Schubert H et al (2011). Genetic variation of the serotonin 2A receptor affects hippocampal novelty processing in humans. PLoS One 6: e15984.
31. 2C receptors. Neuropharmacology 33: 467-471.
32. 2A locus reveals multiple episodic memory-related variants. Biol Psychol 79: 239-242.
33. Trigo JM, Cabrero-Castel A, Berrendero F, Maldonado R, Robledo P (2008). MDMA modifies active avoidance learning and recall in mice. Psychopharmacology 197: 391-400.
34. Vermeeren A, Jackson JL, Muntjewerff ND, Quint PJ, Harrison EM, O'Hanlon JF (1995). Comparison of acute alprazolam (0.25, 0.50 and 1.0mg) effects versus those of lorazepam 2mg and placebo on memory in healthy volunteers using laboratory and telephone tests. Psychopharmacology 118: 1-9.
35. 1A receptors on human explicit memory. Am J Psychiatry 160: 334-340. (Pubitemid 41110460)