Immunoregulation of myelin-specific CD4+ T cell response by neural stem/progenitor cells: Role of prostaglandin E2

Journal of Neuroimmunology

Volumn 255, Issue 1-2, 2013, Pages 32-38

  Liu, Mingyuan ^a   Xiao, Lin ^b   Liu, Shuxun ^b   Hu, Yiping ^a   Tian, Jun ^b   Gao, Guoqiang ^b   Xie, Shanshan ^a   Guan, Yangtai ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Experimental autoimmune encephalomyelitis; Immunoregulation; Neural stem cell; Prostaglandin E2; T cell

Indexed keywords

PROSTAGLANDIN E2;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; EMBRYO; FEMALE; HORMONE ACTION; HORMONE RELEASE; IMMUNE RESPONSE; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; MOUSE; NEURAL STEM CELL; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH17 CELL;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; COCULTURE TECHNIQUES; DINOPROSTONE; EMBRYONIC STEM CELLS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; MALE; MICE; MICE, INBRED C57BL; MYELIN SHEATH; NEURAL STEM CELLS; PREGNANCY;

EID: 84872648110     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2012.10.013     Document Type: Article

References (23)

1. Aggarwal S., Pittenger M.F. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005, 105:1815-1822.
2. Aharonowiz M., Einstein O., Fainstein N., Lassmann H., Reubinoff B., Ben-Hur T. Neuroprotective effect of transplanted human embryonic stem cell-derived neural precursors in an animal model of multiple sclerosis. PLoS One 2008, 3:e3145.
3. Fletcher J.M., Lalor S.J., Sweeney C.M., Tubridy N., Mills K.H. T cells in multiple sclerosis and experimental autoimmune encephalomyelitis. Clin. Exp. Immunol. 2010, 162:1-11.
4. Guan Y., Jiang Z., Ciric B., Rostami A.M., Zhang G.X. Upregulation of chemokine receptor expression by IL-10/IL-4 in adult neural stem cells. Exp. Mol. Pathol. 2008, 85:232-236.
5. Guerette D., Khan P.A., Savard P.E., Vincent M. Molecular evolution of type VI intermediate filament proteins. BMC Evol. Biol. 2007, 7:164.
6. Harris S.G., Padilla J., Koumas L., Ray D., Phipps R.P. Prostaglandins as modulators of immunity. Trends Immunol. 2002, 23:144-150.
7. Hirst C., Swingler R., Compston D.A., Ben-Shlomo Y., Robertson N.P. Survival and cause of death in multiple sclerosis: a prospective population-based study. J. Neurol. Neurosurg. Psychiatry 2008, 79:1016-1021.
8. Kleiter I., Song J., Lukas D., Hasan M., Neumann B., Croxford A.L., Pedre X., Hovelmeyer N., Yogev N., Mildner A., Prinz M., Wiese E., Reifenberg K., Bittner S., Wiendl H., Steinman L., Becker C., Bogdahn U., Neurath M.F., Steinbrecher A., Waisman A. Smad7 in T cells drives T helper 1 responses in multiple sclerosis and experimental autoimmune encephalomyelitis. Brain 2010, 133:1067-1081.
9. Leung S., Liu X., Fang L., Chen X., Guo T., Zhang J. The cytokine milieu in the interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease. Cell. Mol. Immunol. 2010, 7:182-189.
10. Meisel R., Zibert A., Laryea M., Gobel U., Daubener W., Dilloo D. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood 2004, 103:4619-4621.
11. Michalczyk K., Ziman M. Nestin structure and predicted function in cellular cytoskeletal organisation. Histol. Histopathol. 2005, 20:665-671.
12. Muls N., Jnaoui K., Dang H.A., Wauters A., Van Snick J., Sindic C.J., van Pesch V. Upregulation of IL-17, but not of IL-9, in circulating cells of CIS and relapsing MS patients. Impact of corticosteroid therapy on the cytokine network. J. Neuroimmunol. 2012, 243:73-80.
13. Murugaiyan G., Mittal A., Weiner H.L. Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis. J. Immunol. 2008, 181:7480-7488.
14. O'Connor R.A., Malpass K.H., Anderton S.M. The inflamed central nervous system drives the activation and rapid proliferation of Foxp3+ regulatory T cells. J. Immunol. 2007, 179:958-966.
15. Ourednik J., Ourednik V., Lynch W.P., Schachner M., Snyder E.Y. Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons. Nat. Biotechnol. 2002, 20:1103-1110.
16. Pluchino S., Quattrini A., Brambilla E., Gritti A., Salani G., Dina G., Galli R., Del Carro U., Amadio S., Bergami A., Furlan R., Comi G., Vescovi A.L., Martino G. Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature 2003, 422:688-694.
17. Pluchino S., Zanotti L., Brambilla E., Rovere-Querini P., Capobianco A., Alfaro-Cervello C., Salani G., Cossetti C., Borsellino G., Battistini L., Ponzoni M., Doglioni C., Garcia-Verdugo J.M., Comi G., Manfredi A.A., Martino G. Immune regulatory neural stem/precursor cells protect from central nervous system autoimmunity by restraining dendritic cell function. PLoS One 2009, 4:e5959.
18. Sinha S., Subramanian S., Proctor T.M., Kaler L.J., Grafe M., Dahan R., Huan J., Vandenbark A.A., Burrows G.G., Offner H. A promising therapeutic approach for multiple sclerosis: recombinant T-cell receptor ligands modulate experimental autoimmune encephalomyelitis by reducing interleukin-17 production and inhibiting migration of encephalitogenic cells into the CNS. J. Neurosci. 2007, 27:12531-12539.
19. Stromnes I.M., Goverman J.M. Active induction of experimental allergic encephalomyelitis. Nat. Protoc. 2006, 1:1810-1819.
20. Tjabringa G.S., Vezeridis P.S., Zandieh-Doulabi B., Helder M.N., Wuisman P.I., Klein-Nulend J. Polyamines modulate nitric oxide production and COX-2 gene expression in response to mechanical loading in human adipose tissue-derived mesenchymal stem cells. Stem Cells 2006, 24:2262-2269.
21. Wang L., Shi J., van Ginkel F.W., Lan L., Niemeyer G., Martin D.R., Snyder E.Y., Cox N.R. Neural stem/progenitor cells modulate immune responses by suppressing T lymphocytes with nitric oxide and prostaglandin E2. Exp. Neurol. 2009, 216:177-183.
22. Xiao B.G., Link H. Antigen-specific T cells in autoimmune diseases with a focus on multiple sclerosis and experimental allergic encephalomyelitis. Cell. Mol. Life Sci. 1999, 56:5-21.
23. Yang J., Rostami A., Zhang G.X. Cellular remyelinating therapy in multiple sclerosis. J. Neurol. Sci. 2009, 15(276):1-5.