Histone H3 lysine 27 and 9 hypermethylation within the Bad promoter region mediates 5-Aza-2′-deoxycytidine-induced Leydig cell apoptosis: Implications of 5-Aza-2′-deoxycytidine toxicity to male reproduction

Apoptosis

Volumn 18, Issue 1, 2013, Pages 99-109

  Choi, Ji Young ^a   Lee, Sangmi ^a   Hwang, Soojin ^a   Jo, Sangmee Ahn ^b   Kim, Miji ^c   Kim, Young Ju ^a   Pang, Myung Geol ^d   Jo, Inho ^a  

^a Ewha Womans University School of Medicine   (South Korea)

^b Dankook University   (South Korea)

^c Ewha Womans University   (South Korea)

^d Chung Ang University   (South Korea)

Author keywords

5 Aza; Apoptosis; Histone methylation; Leydig cells; Male reproduction; Toxicity

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; 5 HYDROXYMETHYLCYTOSINE; BISULFITE; CASPASE 3; ENHANCER OF ZESTE HOMOLOGUE 2; EUCHROMATIC HISTONE METHYLTRANSFERASE 1; HISTONE H3; HISTONE METHYLTRANSFERASE; LYSINE; N (1 BENZYL 4 PIPERIDINYL) 2 (HEXAHYDRO 4 METHYL 1H 1,4 DIAZEPIN 1 YL) 6,7 DIMETHOXY 4 QUINAZOLINAMINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN; PROTEIN BAD; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DNA METHYLATION; ENZYME DEGRADATION; EPIGENETICS; FLOW CYTOMETRY; GENE CONTROL; GENE SILENCING; LEYDIG CELL; MALE; MALE GENITAL SYSTEM; MALE INFERTILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPRODUCTIVE TOXICITY; SEQUENCE ANALYSIS; SPERMATOGENESIS; TIME;

ANIMALS; APOPTOSIS; AZACITIDINE; BCL-ASSOCIATED DEATH PROTEIN; CPG ISLANDS; EPIGENESIS, GENETIC; HISTONES; LEYDIG CELLS; MALE; MICE; POLYCOMB REPRESSIVE COMPLEX 2; PROMOTER REGIONS, GENETIC; REPRODUCTION;

EID: 84872620889     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-012-0768-4     Document Type: Article

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