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Volumn 13, Issue 1, 2013, Pages 56-62

Metabolic syndrome in youth: Chimera or useful concept?

Author keywords

Adolescents; Cardiometabolic; Cardiovascular disease; Children; Definition; Insulin resistance; Metabolic syndrome; Obesity; Prevalence; Type 2 diabetes; Youth

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN SENSITIZING AGENT; METFORMIN; SIBUTRAMINE; TETRAHYDROLIPSTATIN; THIAZOLIDINE DERIVATIVE; TRIACYLGLYCEROL;

EID: 84872597990     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-012-0331-2     Document Type: Article
Times cited : (31)

References (50)
  • 1
    • 84856433589 scopus 로고    scopus 로고
    • Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010
    • 22253364 10.1001/jama.2012.40
    • Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010. JAMA. 2012;307:483-90.
    • (2012) JAMA , vol.307 , pp. 483-490
    • Ogden, C.L.1    Carroll, M.D.2    Kit, B.K.3    Flegal, K.M.4
  • 2
    • 77952323536 scopus 로고    scopus 로고
    • Childhood obesity
    • 20451244 10.1016/S0140-6736(10)60171-7
    • Han JC, Lawlor DA, Kimm SY. Childhood obesity. Lancet. 2010;375:1737-48.
    • (2010) Lancet , vol.375 , pp. 1737-1748
    • Han, J.C.1    Lawlor, D.A.2    Kimm, S.Y.3
  • 3
    • 0024160877 scopus 로고
    • Role of insulin resistance in human disease
    • Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988;37:1595-607. (Pubitemid 19004941)
    • (1988) Diabetes , vol.37 , Issue.12 , pp. 1595-1607
    • Reaven, G.M.1
  • 4
    • 17144380822 scopus 로고    scopus 로고
    • The metabolic syndrome
    • DOI 10.1016/S0140-6736(05)66378-7
    • Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet. 2005;365:1415-28. (Pubitemid 40523737)
    • (2005) Lancet , vol.365 , Issue.9468 , pp. 1415-1428
    • Eckel, R.H.1    Grundy, S.M.2    Zimmet, P.Z.3
  • 6
    • 70350245011 scopus 로고    scopus 로고
    • Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; And International Association for the Study of Obesity
    • 19805654 10.1161/CIRCULATIONAHA.109.192644 1:CAS:528:DC%2BD1MXht1OrtrrK
    • Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120:1640-5.
    • (2009) Circulation , vol.120 , pp. 1640-1645
    • Alberti, K.G.1    Eckel, R.H.2    Grundy, S.M.3    Zimmet, P.Z.4    Cleeman, J.I.5    Donato, K.A.6
  • 7
    • 58749115594 scopus 로고    scopus 로고
    • Insulin resistance and obesity in childhood
    • 18805916 10.1530/EJE-08-0245 1:CAS:528:DC%2BD1MXhtFOnsb0%3D
    • Chiarelli F, Marcovecchio ML. Insulin resistance and obesity in childhood. Eur J Endocrinol. 2008;159 Suppl 1:S67-74.
    • (2008) Eur J Endocrinol , vol.159 , Issue.SUPPL. 1 , pp. 67-74
    • Chiarelli, F.1    Marcovecchio, M.L.2
  • 8
    • 0028836569 scopus 로고
    • Central adiposity and its metabolic correlates in obese adolescent girls
    • 7631766 1:CAS:528:DyaK2MXnt1Giu7o%3D
    • Caprio S, Hyman LD, Limb C, McCarthy S, Lange R, Sherwin RS, et al. Central adiposity and its metabolic correlates in obese adolescent girls. Am J Physiol. 1995;269:E118-26.
    • (1995) Am J Physiol , vol.269 , pp. 118-126
    • Caprio, S.1    Hyman, L.D.2    Limb, C.3    McCarthy, S.4    Lange, R.5    Sherwin, R.S.6
  • 9
    • 0034496387 scopus 로고    scopus 로고
    • Pathophysiology and pharmacological treatment of insulin resistance
    • DOI 10.1210/er.21.6.585
    • Matthaei S, Stumvoll M, Kellerer M, Haring HU. Pathophysiology and pharmacological treatment of insulin resistance. Endocrine Rev. 2000;21:585-618. (Pubitemid 32113286)
    • (2000) Endocrine Reviews , vol.21 , Issue.6 , pp. 585-618
    • Matthaei, S.1    Stumvoll, M.2    Kellerer, M.3    Haring, H.-U.4
  • 10
    • 41149140806 scopus 로고    scopus 로고
    • Metabolic complications of childhood obesity: Identifying and mitigating the risk
    • 18227502 10.2337/dc08-s273
    • Weiss R, Kaufman FR. Metabolic complications of childhood obesity: identifying and mitigating the risk. Diabetes Care. 2008;31 Suppl 2:S310-6.
    • (2008) Diabetes Care , vol.31 , Issue.SUPPL. 2 , pp. 310-316
    • Weiss, R.1    Kaufman, F.R.2
  • 15
    • 0141615879 scopus 로고    scopus 로고
    • Fatty liver in type 2 diabetes mellitus: Relation to regional adiposity, fatty acids, and insulin resistance
    • 1:CAS:528:DC%2BD3sXosV2qsrg%3D
    • Kelley DE, McKolanis TM, Hegazi RA, Kuller LH, Kalhan SC. Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance. Am J Physiol. 2003;285:E906-16.
    • (2003) Am J Physiol , vol.285 , pp. 906-916
    • Kelley, D.E.1    McKolanis, T.M.2    Hegazi, R.A.3    Kuller, L.H.4    Kalhan, S.C.5
  • 17
    • 0043240339 scopus 로고    scopus 로고
    • Prevalence of a metabolic syndrome phenotype in adolescents: Findings from the Third National Health and Nutrition Examination Survey, 1988-1994
    • DOI 10.1001/archpedi.157.8.821
    • Cook S, Weitzman M, Auinger P, Nguyen M, Dietz WH. Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994. Arch Pediatr Adolesc Med. 2003;157:821-7. (Pubitemid 36988016)
    • (2003) Archives of Pediatrics and Adolescent Medicine , vol.157 , Issue.8 , pp. 821-827
    • Cook, S.1    Weitzman, M.2    Auinger, P.3    Nguyen, M.4    Dietz, W.H.5
  • 19
    • 4644290315 scopus 로고    scopus 로고
    • Prevalence and trends of a metabolic syndrome phenotype among U.S. adolescents, 1999-2000
    • DOI 10.2337/diacare.27.10.2438
    • Duncan GE, Li SM, Zhou XH. Prevalence and trends of a metabolic syndrome phenotype among U.S. Adolescents, 1999-2000. Diabetes Care. 2004;27:2438-43. (Pubitemid 39281398)
    • (2004) Diabetes Care , vol.27 , Issue.10 , pp. 2438-2443
    • Duncan, G.E.1    Li, S.M.2    Zhou, X.-H.3
  • 20
    • 33645462246 scopus 로고    scopus 로고
    • Metabolic syndrome in obese Caucasian children: Prevalence using WHO-derived criteria and association with nontraditional cardiovascular risk factors
    • 10.1038/sj.ijo.0803151 1:CAS:528:DC%2BD28XivFSmtb4%3D
    • Invitti C, Maffeis C, Gilardini L, Pontiggia B, Mazzilli G, Girola A, et al. Metabolic syndrome in obese Caucasian children: prevalence using WHO-derived criteria and association with nontraditional cardiovascular risk factors. Int J Obes. 2006;30:627-33.
    • (2006) Int J Obes , vol.30 , pp. 627-633
    • Invitti, C.1    Maffeis, C.2    Gilardini, L.3    Pontiggia, B.4    Mazzilli, G.5    Girola, A.6
  • 21
    • 37849002520 scopus 로고    scopus 로고
    • Epidemiology of paediatric metabolic syndrome and type 2 diabetes mellitus
    • 10.3132/dvdr.2007.055
    • De Ferranti SD, Osganian SK. Epidemiology of paediatric metabolic syndrome and type 2 diabetes mellitus. Diabetes Vasc Dis Res. 2007;4:285-96.
    • (2007) Diabetes Vasc Dis Res. , vol.4 , pp. 285-296
    • De Ferranti, S.D.1    Osganian, S.K.2
  • 22
    • 38149134307 scopus 로고    scopus 로고
    • Comparison of different definitions of pediatric metabolic syndrome: Relation to abdominal adiposity, insulin resistance, adiponectin, and inflammatory biomarkers
    • 18206686 10.1016/j.jpeds.2007.07.053 1:CAS:528:DC%2BD1cXptlWltQ%3D%3D
    • Lee S, Bacha F, Gungor N, Arslanian S. Comparison of different definitions of pediatric metabolic syndrome: relation to abdominal adiposity, insulin resistance, adiponectin, and inflammatory biomarkers. J Pediatr. 2008;152:177-84.
    • (2008) J Pediatr , vol.152 , pp. 177-184
    • Lee, S.1    Bacha, F.2    Gungor, N.3    Arslanian, S.4
  • 23
    • 5144224797 scopus 로고    scopus 로고
    • Contrasting prevalence of and demographic disparities in the World Health Organization and National Cholesterol Education Program Adult Treatment Panel III definitions of metabolic syndrome among adolescents
    • DOI 10.1016/j.jpeds.2004.04.059, PII S0022347604003804
    • Goodman E, Daniels SR, Morrison JA, Huang B, Dolan LM. Contrasting prevalence of and demographic disparities in the World Health Organization and National Cholesterol Education Program Adult Treatment Panel III definitions of metabolic syndrome among adolescents. J Pediatr. 2004;145:445-51. (Pubitemid 39345978)
    • (2004) Journal of Pediatrics , vol.145 , Issue.4 , pp. 445-451
    • Goodman, E.1    Daniels, S.R.2    Morrison, J.A.3    Huang, B.4    Dolan, L.M.5
  • 24
    • 34547699923 scopus 로고    scopus 로고
    • Comparison of metabolic syndrome prevalence using eight different definitions: A critical approach
    • DOI 10.1136/adc.2006.104588
    • Reinehr T, de Sousa G, Toschke AM, Andler W. Comparison of metabolic syndrome prevalence using eight different definitions: a critical approach. Arch Dis Child. 2007;92:1067-72. (Pubitemid 350221448)
    • (2007) Archives of Disease in Childhood , vol.92 , Issue.12 , pp. 1067-1072
    • Reinehr, T.1    De Sousa, G.2    Toschke, A.M.3    Andler, W.4
  • 26
    • 33751343668 scopus 로고    scopus 로고
    • Waist circumference, blood pressure, and lipid components of the metabolic syndrome
    • DOI 10.1016/j.jpeds.2006.08.075, PII S0022347606008365
    • Lee S, Bacha F, Arslanian SA. Waist circumference, blood pressure, and lipid components of the metabolic syndrome. J Pediatr. 2006;149:809-16. (Pubitemid 44809275)
    • (2006) Journal of Pediatrics , vol.149 , Issue.6 , pp. 809-816
    • Lee, S.1    Bacha, F.2    Arslanian, S.A.3
  • 27
    • 33344462343 scopus 로고    scopus 로고
    • Waist circumference is an independent predictor of insulin resistance in black and white youths
    • DOI 10.1016/j.jpeds.2005.10.001, PII S0022347605009820
    • Lee S, Bacha F, Gungor N, Arslanian SA. Waist circumference is an independent predictor of insulin resistance in black and white youths. J Pediatr. 2006;148:188-94. (Pubitemid 43286759)
    • (2006) Journal of Pediatrics , vol.148 , Issue.2 , pp. 188-194
    • Lee, S.1    Bacha, F.2    Gungor, N.3    Arslanian, S.A.4
  • 28
    • 74549159700 scopus 로고    scopus 로고
    • Metabolic risk varies according to waist circumference measurement site in overweight boys and girls
    • 19863969 10.1016/j.jpeds.2009.08.010
    • Johnson ST, Kuk JL, Mackenzie KA, Huang TT, Rosychuk RJ, Ball GD. Metabolic risk varies according to waist circumference measurement site in overweight boys and girls. J Pediatr. 2010;156:247-52e1.
    • (2010) J Pediatr , vol.156
    • Johnson, S.T.1    Kuk, J.L.2    MacKenzie, K.A.3    Huang, T.T.4    Rosychuk, R.J.5    Ball, G.D.6
  • 32
    • 77950622102 scopus 로고    scopus 로고
    • The possible role of liver steatosis in defining metabolic syndrome in prepubertal children
    • 19913850 10.1016/j.metabol.2009.09.012
    • D'Adamo E, Marcovecchio ML, Giannini C, Capanna R, Impicciatore M, Chiarelli F, et al. The possible role of liver steatosis in defining metabolic syndrome in prepubertal children. Metab Clin Exp. 2010;59:671-6.
    • (2010) Metab Clin Exp , vol.59 , pp. 671-676
    • D'Adamo, E.1    Marcovecchio, M.L.2    Giannini, C.3    Capanna, R.4    Impicciatore, M.5    Chiarelli, F.6
  • 34
    • 34247571404 scopus 로고    scopus 로고
    • Instability in the diagnosis of metabolic syndrome in adolescents
    • DOI 10.1161/CIRCULATIONAHA.106.669994
    • Goodman E, Daniels SR, Meigs JB, Dolan LM. Instability in the diagnosis of metabolic syndrome in adolescents. Circulation. 2007;115:2316-22. (Pubitemid 46691226)
    • (2007) Circulation , vol.115 , Issue.17 , pp. 2316-2322
    • Goodman, E.1    Daniels, S.R.2    Meigs, J.B.3    Dolan, L.M.4
  • 35
    • 70349434781 scopus 로고    scopus 로고
    • Persistence of the metabolic syndrome and its influence on carotid artery intima media thickness in overweight Latino children
    • 19446812 10.1016/j.atherosclerosis.2009.03.013 1:CAS:528: DC%2BD1MXht1aju7bF This study shows the association between MetS and sucliclinacal signs of atherosclerosis in youth wth MetS
    • • Toledo-Corral CM, Ventura EE, Hodis HN, Weigensberg MJ, Lane CJ, Li Y, et al. Persistence of the metabolic syndrome and its influence on carotid artery intima media thickness in overweight Latino children. Atherosclerosis. 2009;206:594-8. This study shows the association between MetS and subclinical signs of atherosclerosis in youth wth MetS.
    • (2009) Atherosclerosis , vol.206 , pp. 594-598
    • Toledo-Corral, C.M.1    Ventura, E.E.2    Hodis, H.N.3    Weigensberg, M.J.4    Lane, C.J.5    Li, Y.6
  • 36
    • 69449083990 scopus 로고    scopus 로고
    • Childhood predictors of the metabolic syndrome in middle-aged adults: The Muscatine study
    • 19732563 This study indicates that childhood BMI is the stringest predictor of MetS during adulthood In addition there is an additive effect of high BMI and triglicerides in predicting risk
    • •• Burns TL, Letuchy EM, Paulos R, Witt J. Childhood predictors of the metabolic syndrome in middle-aged adults: the Muscatine study. J Pediatr. 2009;155(S5):e17-26. This study indicates that childhood BMI is the strongest predictor of MetS during adulthood In addition, there is an additive effect of high BMI and triglycerides in predicting risk.
    • (2009) J Pediatr , vol.155 , Issue.S5 , pp. 17-26
    • Burns, T.L.1    Letuchy, E.M.2    Paulos, R.3    Witt, J.4
  • 37
    • 38149016732 scopus 로고    scopus 로고
    • Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later
    • 18206689 10.1016/j.jpeds.2007.09.010 1:CAS:528:DC%2BD1cXptlWlug%3D%3D This study indicates the predictive value of MetS during childhood on the same syndrome during adulthood
    • •• Morrison JA, Friedman LA, Wang P, Glueck CJ. Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later. J Pediatr. 2008;152:201-6. This study indicates the predictive value of MetS during childhood on the same syndrome during adulthood.
    • (2008) J Pediatr , vol.152 , pp. 201-206
    • Morrison, J.A.1    Friedman, L.A.2    Wang, P.3    Glueck, C.J.4
  • 38
    • 78049525387 scopus 로고    scopus 로고
    • Pediatric metabolic syndrome predicts adulthood metabolic syndrome, subclinical atherosclerosis, and type 2 diabetes mellitus but is no better than body mass index alone: The Bogalusa Heart Study and the Cardiovascular Risk in Young Finns Study
    • 20921439 10.1161/CIRCULATIONAHA.110.940809 Data from these 2 large longitudinal studies indicate a 2-3 fold increased risk of adult MetS for adolescents with the syndrome
    • •• Magnussen CG, Koskinen J, Chen W, Thomson R, Schmidt MD, Srinivasan SR, et al. Pediatric metabolic syndrome predicts adulthood metabolic syndrome, subclinical atherosclerosis, and type 2 diabetes mellitus but is no better than body mass index alone: the Bogalusa Heart Study and the Cardiovascular Risk in Young Finns Study. Circulation. 2010;122:1604-11. Data from these 2 large longitudinal studies indicate a 2-3 fold increased risk of adult MetS for adolescents with the syndrome.
    • (2010) Circulation , vol.122 , pp. 1604-1611
    • Magnussen, C.G.1    Koskinen, J.2    Chen, W.3    Thomson, R.4    Schmidt, M.D.5    Srinivasan, S.R.6
  • 39
    • 69249238105 scopus 로고    scopus 로고
    • Predictive ability of childhood metabolic components for adult metabolic syndrome and type 2 diabetes
    • In line with reference 36, this study highlights the predictive value of MetS in youth on future cardiometabolci outcomes during adulthood e1-7
    • • Schubert CM, Sun SS, Burns TL, Morrison JA, Huang TT. Predictive ability of childhood metabolic components for adult metabolic syndrome and type 2 diabetes. J Pediatr. 2009;155:S6 e1-7. In line with reference 36, this study highlights the predictive value of MetS in youth on future cardiometabolic outcomes during adulthood.
    • (2009) J Pediatr , vol.155 , pp. 6
    • Schubert, C.M.1    Sun, S.S.2    Burns, T.L.3    Morrison, J.A.4    Huang, T.T.5
  • 40
    • 84857651712 scopus 로고    scopus 로고
    • Metabolic syndrome in adolescence: Can it be predicted from natal and parental profile? the Prediction of Metabolic Syndrome in Adolescence (PREMA) study
    • 22247492 10.1161/CIRCULATIONAHA.111.034546 1:CAS:528:DC%2BC38Xls1Cjs74%3D This study highlights that the coexistence of low birth weight, small head circumference, and parental history of overweight or obesity may be helpful in targeting children at risk for developing MetS in adolescence
    • • Efstathiou SP, Skeva II, Zorbala E, Georgiou E, Mountokalakis TD. Metabolic syndrome in adolescence: can it be predicted from natal and parental profile? The Prediction of Metabolic Syndrome in Adolescence (PREMA) study. Circulation. 2012;125:902-10. This study highlights that the coexistence of low birth weight, small head circumference, and parental history of overweight or obesity may be helpful in targeting children at risk for developing MetS during adolescence.
    • (2012) Circulation , vol.125 , pp. 902-910
    • Efstathiou, S.P.1    Skeva, I.I.2    Zorbala, E.3    Georgiou, E.4    Mountokalakis, T.D.5
  • 41
    • 61349168366 scopus 로고    scopus 로고
    • Progress and challenges in metabolic syndrome in children and adolescents: A scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; And Council on Nutrition, Physical Activity, and Metabolism
    • 19139390 10.1161/CIRCULATIONAHA.108.191394 This is a nice update on the current state of the art of the MetS in children and adolescents
    • •• Steinberger J, Daniels SR, Eckel RH, Hayman L, Lustig RH, McCrindle B, et al. Progress and challenges in metabolic syndrome in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; and Council on Nutrition, Physical Activity, and Metabolism. Circulation. 2009;119:628-47. This is a nice update on the current state of the art on the MetS in children and adolescents.
    • (2009) Circulation , vol.119 , pp. 628-647
    • Steinberger, J.1    Daniels, S.R.2    Eckel, R.H.3    Hayman, L.4    Lustig, R.H.5    McCrindle, B.6
  • 42
    • 16244381805 scopus 로고    scopus 로고
    • Insulin sensitivity among obese children and adolescents, according to degree of weight loss
    • DOI 10.1542/peds.2003-0649-F
    • Reinehr T, Kiess W, Kapellen T, Andler W. Insulin sensitivity among obese children and adolescents, according to degree of weight loss. Pediatrics. 2004;114:1569-73. (Pubitemid 41754919)
    • (2004) Pediatrics , vol.114 , Issue.6 , pp. 1569-1573
    • Reinehr, T.1    Kiess, W.2    Kapellen, T.3    Andler, W.4
  • 43
    • 0035321014 scopus 로고    scopus 로고
    • The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes
    • 11335776 10.1542/peds.107.4.e55 1:STN:280:DC%2BD3M3ptVCisA%3D%3D
    • Freemark M, Bursey D. The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes. Pediatrics. 2001;107:E55.
    • (2001) Pediatrics , vol.107 , pp. 55
    • Freemark, M.1    Bursey, D.2
  • 44
  • 46
    • 43549109197 scopus 로고    scopus 로고
    • Addition of metformin to a lifestyle modification program in adolescents with insulin resistance
    • 18492523 10.1016/j.jpeds.2008.01.018 1:CAS:528:DC%2BD1cXlvFymtrs%3D
    • Love-Osborne K, Sheeder J, Zeitler P. Addition of metformin to a lifestyle modification program in adolescents with insulin resistance. J Pediatr. 2008;152:817-22.
    • (2008) J Pediatr , vol.152 , pp. 817-822
    • Love-Osborne, K.1    Sheeder, J.2    Zeitler, P.3
  • 50
    • 45949096738 scopus 로고    scopus 로고
    • On the use of a continuous metabolic syndrome score in pediatric research
    • DOI 10.1186/1475-2840-7-17
    • Eisenmann JC. On the use of a continuous metabolic syndrome score in pediatric research. Cardiovasc Diabetol. 2008;7:17. (Pubitemid 351891426)
    • (2008) Cardiovascular Diabetology , vol.7 , pp. 17
    • Eisenmann, J.C.1


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