Sesamin suppresses activation of microglia and p44/42 MAPK pathway, which confers neuroprotection in rat intracerebral hemorrhage

Neuroscience

Volumn 232, Issue , 2013, Pages 45-52

  Ohnishi, M ^a   Monda, A ^a   Takemoto, R ^a   Matsuoka, Y ^a   Kitamura, C ^a   Ohashi, K ^a   Shibuya, H ^a   Inoue, A ^a  

^a FUKUYAMA UNIVERSITY   (Japan)

Author keywords

Intracerebral hemorrhage; Microglia; Neuroprotection; P44 42 MAPK; Sesamin; Thrombin

Indexed keywords

GELATINASE A; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; SESAMIN; THROMBIN; 1,3 DIOXOLANE DERIVATIVE; ANTIOXIDANT; LIGNAN; NEUROPROTECTIVE AGENT; NOS2 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN HEMATOMA; BRAIN HEMORRHAGE; CELL ACTIVATION; CELL LOSS; CELL PROLIFERATION; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; MALE; MICROGLIA; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANIMAL; BRAIN; CELL CULTURE; CELL DEATH; CEREBRAL HEMORRHAGE; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; NERVE CELL; PATHOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; BRAIN; CELL DEATH; CELL PROLIFERATION; CELLS, CULTURED; CEREBRAL HEMORRHAGE; DIOXOLES; DISEASE MODELS, ANIMAL; LIGNANS; MALE; MAP KINASE SIGNALING SYSTEM; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEURONS; NEUROPROTECTIVE AGENTS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS, SPRAGUE-DAWLEY; RATS, WISTAR;

EID: 84872583617     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2012.11.057     Document Type: Article

References (22)

1. Fujimoto S., Katsuki H., Kume T., Akaike A. Thrombin-induced delayed injury involves multiple and distinct signaling pathways in the cerebral cortex and the striatum in organotypic slice cultures. Neurobiol Dis 2006, 22:130-142.
2. Fujimoto S., Katsuki H., Ohnishi M., Takagi M., Kume T., Akaike A. Thrombin induces striatal neurotoxicity depending on mitogen-activated protein kinase pathways in vivo. Neuroscience 2007, 144:694-701.
3. Fukuda Y., Osawa T., Namiki M., Ozaki T. Studies on antioxidant substances in sesame seed. Agric Biol Chem 1985, 49:301-306.
4. Hijioka M., Matsushita H., Hisatsune A., Isohama Y., Katsuki H. Therapeutic effect of nicotine in a mouse model of intracerebral hemorrhage. J Pharmacol Exp Ther 2011, 338:741-749.
5. Holland J.A., Meyer J.W., Chang M.M., O'Donnell R.W., Johnson D.K., Ziegler L.M. Thrombin stimulated reactive oxygen species production in cultured human endothelial cells. Endothelium 1998, 6:113-121.
6. Hsieh P.F., Hou C.W., Yao P.W., Wu S.P., Peng Y.F., Shen M.L., Lin C.H., Chao Y.Y., Chang M.H., Jeng K.C. Sesamin ameliorates oxidative stress and mortality in kainic acid-induced status epilepticus by inhibition of MAPK and COX-2 activation. J Neuroinflamm 2011, 8:57.
7. Jeng K.C., Hou R.C., Wang J.C., Ping L.I. Sesamin inhibits lipopolysaccharide-induced cytokine production by suppression of p38 mitogen-activated protein kinase and nuclear factor-κB. Immunol Lett 2005, 97:101-106.
8. Katsuki H., Okawara M., Shibata H., Kume T., Akaike A. Nitric oxide-producing microglia mediate thrombin-induced degeneration of dopaminergic neurons in rat midbrain slice culture. J Neurochem 2006, 97:1232-1242.
9. Khan M.N., Ishrat T., Ahmad A., Hoda M.N., Khan M.B., Khuwaja G., Srivastava P., Raza S.S., Islam F., Ahmad S. Sesamin attenuates behavioral, biochemical and histological alterations induced by reversible middle cerebral artery occlusion in the rat. Chem Biol Interact 2010, 183:255-263.
10. Lee C.C., Liu K.J., Wu Y.C., Lin S.J., Chang C.C., Huang T.S. Sesamin inhibits macrophage-induced vascular endothelial growth factor and matrix metalloprotease-9 expression and proangiogenic activity in breast cancer cells. Inflammation 2010, 34:209-221.
11. Morioka N., Tanabe H., Inoue A., Dohi T., Nakata Y. Noradrenaline reduces the ATP-stimulated phosphorylation of p38 MAP kinase via beta adrenergic receptors-cAMP-protein kinase A-dependent mechanism in cultured rat spinal microglia. Neurochem Int 2009, 55:226-234.
12. Nakai M., Harada M., Nakamura K., Akimoto K., Shibata H., Miki W., Kiso Y. Novel antioxidative metabolites in rat liver with ingested sesamin. J Agric Food Chem 2003, 51:1666-1670.
13. Noorbakhsh F., Vergnolle N., Hollenberg M.D., Power C. Proteinase-activated receptors in the nervous system. Nat Rev Neurosci 2003, 4:981-990.
14. Ohnishi M., Katsuki H., Fujimoto S., Takagi M., Kume T., Akaike A. Involvement of thrombin and mitogen-activated protein kinase pathways in hemorrhagic brain injury. Exp Neurol 2007, 206:43-52.
15. Ohnishi M., Katsuki H., Takagi M., Kume T., Akaike A. Long-term treatment with nicotine suppresses neurotoxicity of, and microglial activation by, thrombin in cortico-striatal slice cultures. Eur J Pharmacol 2009, 602:288-293.
16. Ohnishi M., Katsuki H., Izumi Y., Kume T., Takada-Takatori Y., Akaike A. Mitogen-activated protein kinases support survival of activated microglia that mediate thrombin-induced striatal injury in organotypic slice culture. J Neurosci Res 2010, 88:2155-2164.
17. Ohnishi M., Katsuki H., Unemura K., Izumi Y., Kume T., Takada-Takatori Y., Akaike A. Heme oxygenase-1 contributes to pathology associated with thrombin-induced striatal and cortical injury in organotypic slice culture. Brain Res 2010, 1347:170-178.
18. Ohnishi M., Katsuki H., Fukutomi C., Takahashi M., Motomura M., Fukunaga M., Matsuoka Y., Isohama Y., Izumi Y., Kume T., Inoue A., Akaike A. HMGB1 inhibitor glycyrrhizin attenuates intracerebral hemorrhage-induced injury in rat. Neuropharmacology 2011, 61:975-980.
19. Osawa T., Nagata M., Namiki M., Fukuda Y. Sesamolinol, a novel antioxidant isolated from sesame seed. Agric Biol Chem 1985, 49:3351-3352.
20. Patterson C., Ruef J., Madamanchi N.R., Barry-Lane P., Hu Z., Horaist C., Ballinger C.A., Brasier A.R., Bode C., Runge M.S. Stimulation of vascular smooth muscle cell NAD(P)H oxidase by thrombin. Evidence that p47 (phox) may participate in forming this oxidase in vitro and in vivo. J Biol Chem 1999, 274:19814-19822.
21. Ryu J., Pyo H., Jou I., Joe E. Thrombin induces NO release from cultured rat microglia via protein kinase C, mitogen-activated protein kinase, and NF-κB. J Biol Chem 2000, 275:29955-29959.
22. Yanari M.A., Kauppinen T.M., Swanson R.A. Microglial activation in stroke: therapeutic targets. Neurotherapeutics 2010, 7:378-391.