Therapeutic effect of nicotine in a mouse model of intracerebral hemorrhage

Journal of Pharmacology and Experimental Therapeutics

Volumn 338, Issue 3, 2011, Pages 741-749

  Hijioka, Masanori ^a   Matsushita, Hideaki ^a   Hisatsune, Akinori ^a   Isohama, Yoichiro ^a   Katsuki, Hiroshi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INHIBITOR; B CELL LYMPHOMA 2 PROTEIN; COLLAGENASE; NICOTINE TARTRATE; PROTEIN BAX; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN LEVEL; CELL COUNT; CONTROLLED STUDY; CORPUS STRIATUM; DRUG EFFICACY; DRUG MECHANISM; HISTOPATHOLOGY; IN VIVO STUDY; MACROPHAGE ACTIVATION; MALE; MICROGLIA; MOUSE; NERVE CELL; NEUROPROTECTION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSORIMOTOR FUNCTION; SURVIVAL RATE; SURVIVAL TIME;

ANIMALS; BCL-2-ASSOCIATED X PROTEIN; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; BODY WATER; BRAIN; BRAIN CHEMISTRY; BRAIN EDEMA; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INTRACRANIAL HEMORRHAGES; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICROGLIA; NEURONS; NEUTROPHILS; NICOTINE; NICOTINIC AGONISTS; OXIDATIVE STRESS; POSTURAL BALANCE; PSYCHOMOTOR PERFORMANCE; SURVIVAL;

EID: 80052153533     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.182519     Document Type: Article

References (35)

1. Akaike A, Takada-Takatori Y, Kume T, and Izumi Y (2010) Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection. J Mol Neurosci 40:211-216.
2. Beray-Berthat V, Delifer C, Besson VC, Girgis H, Coqueran B, Plotkine M, Marchand-Leroux C, and Margaill I (2010) Long-term histological and behavioural characterisation of a collagenase-induced model of intracerebral haemorrhage in rats. J Neurosci Methods 191:180-190.
3. Boue¨t V, Freret T, Toutain J, Divoux D, Boulouard M, and Schumann-Bard P (2007) Sensorimotor and cognitive deficits after transient middle cerebral artery occlusion in the mouse. Exp Neurol 203:555-567.
4. Gong C, Hoff JT, and Keep RF (2000) Acute inflammatory reaction following experimental intracerebral hemorrhage in rat. Brain Res 871:57-65. (Pubitemid 30406868)
5. Gonzalez CL, Gharbawie OA, and Kolb B (2006) Chronic low-dose administration of nicotine facilitates recovery and synaptic change after focal ischemia in rats. Neuropharmacology 50:777-787. (Pubitemid 43737013)
6. Hogg RC, Raggenbass M, and Bertrand D (2003) Nicotinic acetylcholine receptors: from structure to brain function. Rev Physiol Biochem Pharmacol 147:1-46.
7. Institute of Laboratory Animal Resources (1996) Guide for the Care and Use of Laboratory Animals 7th ed. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, Washington DC.
8. Jeong SW, Chu K, Jung KH, Kim SU, Kim M, and Roh JK (2003) Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhage. Stroke 34:2258-2263. (Pubitemid 37099846)
9. Kagitani F, Uchida S, Hotta H, and Sato A (2000) Effects of nicotine on blood flow and delayed neuronal death following intermittent transient ischemia in rat hippocampus. Jpn J Physiol 50:585-595. (Pubitemid 32299491)
10. Katsuki H (2010) Exploring neuroprotective drug therapies for intracerebral hemorrhage. J Pharmacol Sci 114:366-378.
11. Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, and Akaike A (2001) alpha7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity. J Biol Chem 276:13541-13546.
12. Lee JC, Cho GS, Choi BO, Kim HC, Kim YS, and Kim WK (2006) Intracerebral hemorrhage-induced brain injury is aggravated in senescence-accelerated prone mice. Stroke 37:216-222.
13. Lee MY, Chen L, and Toborek M (2009) Nicotine attenuates iNOS expression and contributes to neuroprotection in a compressive model of spinal cord injury. J Neurosci Res 87:937-947.
14. Matsushita H, Hijioka M, Hisatsune A, Isohama Y, Shudo K, and Katsuki H (2011) A retinoic acid receptor agonist Am80 rescues neurons, attenuates inflammatory reactions, and improves behavioral recovery after intracerebral hemorrhage in mice. J Cereb Blood Flow Metab 31:222-234.
15. Moxon-Emre I and Schlichter LC (2011) Neutrophil depletion reduces blood-brain barrier breakdown, axon injury, and inflammation after intracerebral hemorrhage. J Neuropathol Exp Neurol 70:218-235.
16. Mudo G, Belluardo N, and Fuxe K (2007) Nicotinic receptor agonists as neuroprotective/neurotrophic drugs. Progress in molecular mechanisms. J Neural Transm 114:135-147. (Pubitemid 46018681)
17. Nanri M, Yamamoto J, Miyake H, and Watanabe H (1998) Protective effect of GTS-21, a novel nicotinic receptor agonist, on delayed neuronal death induced by ischemia in gerbils. Jpn J Pharmacol 76:23-29. (Pubitemid 28068636)
18. Ohnishi M, Katsuki H, Fujimoto S, Takagi M, Kume T, and Akaike A (2007) Involvement of thrombin and mitogen-activated protein kinase pathways in hemorrhagic brain injury. Exp Neurol 206:43-52. (Pubitemid 46935121)
19. Ohnishi M, Katsuki H, Takagi M, Kume T, and Akaike A (2009) Long-term treatment with nicotine suppresses neurotoxicity of, and microglial activation by, thrombin in cortico-striatal slice cultures. Eur J Pharmacol 602:288-293.
20. Park HJ, Lee PH, Ahn YW, Choi YJ, Lee G, Lee DY, Chung ES, and Jin BK (2007) Neuroprotective effect of nicotine on dopaminergic neurons by anti-inflammatory action. Eur J Neurosci 26:79-89. (Pubitemid 47035441)
21. Paulson JR, Yang T, Selvaraj PK, Mdzinarishvili A, Van der Schyf CJ, Klein J, Bickel U, and Abbruscato TJ (2010) Nicotine exacerbates brain edema during in vitro and in vivo focal ischemic conditions. J Pharmacol Exp Ther 332:371-379.
22. Quik M, Huang LZ, Parameswaran N, Bordia T, Campos C, and Perez XA (2009) Multiple roles for nicotine in Parkinson's disease. Biochem Pharmacol 78:677-685.
23. Qureshi AI, Mendelow AD, and Hanley DF (2009) Intracerebral haemorrhage. Lancet 373:1632-1644.
24. Shytle RD, Mori T, Townsend K, Vendrame M, Sun N, Zeng J, Ehrhart J, Silver AA, Sanberg PR, and Tan J (2004) Cholinergic modulation of microglial activation by alpha7 nicotinic receptors. J Neurochem 89:337-343. (Pubitemid 38495982)
25. Song EC, Chu K, Jeong SW, Jung KH, Kim SH, Kim M, and Yoon BW (2003) Hyperglycemia exacerbates brain edema and perihematomal cell death after intracerebral hemorrhage. Stroke 34:2215-2220. (Pubitemid 37099839)
26. Suzuki T, Hide I, Matsubara A, Hama C, Harada K, Miyano K, Andrä M, Matsubayashi H, Sakai N, Kohsaka S, et al. (2006) Microglial alpha7 nicotinic acetylcholine receptors drive a phospholipase C/IP3 pathway and modulate the cell activation toward a neuroprotective role. J Neurosci Res 83:1461-1470. (Pubitemid 43844991)
27. Tait SW and Green DR (2010) Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol 11:621-632.
28. Taly A, Corringer PJ, Guedin D, Lestage P, and Changeux JP (2009) Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system. Nat Rev Drug Discov 8:733-750.
29. Tsujimoto Y (2003) Cell death regulation by the Bcl-2 protein family in the mitochondria. J Cell Physiol 195:158-167.
30. Wang H, Yu M, Ochani M, Amella CA, Tanovic M, Susarla S, Li JH, Wang H, Yang H, Ulloa L, et al. (2003) Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 421:384-388. (Pubitemid 36157937)
31. Wang J and Doré S (2007a) Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage. Brain 130:1643-1652. (Pubitemid 47355932)
32. Wang J and Doré S (2007b) Inflammation after intracerebral hemorrhage. J Cereb Blood Flow Metab 27:894-908. (Pubitemid 46659028)
33. Wang L, Kittaka M, Sun N, Schreiber SS, and Zlokovic BV (1997) Chronic nicotine treatment enhances focal ischemic brain injury and depletes free pool of brain microvascular tissue plasminogen activator in rats. J Cereb Blood Flow Metab 17:136-146. (Pubitemid 27085836)
34. Wasserman JK and Schlichter LC (2007) Minocycline protects the blood-brain barrier and reduces edema following intracerebral hemorrhage in the rat. Exp Neurol 207:227-237. (Pubitemid 47429657)
35. Xin M and Deng X (2005) Nicotine inactivation of the proapoptotic function of Bax through phosphorylation. J Biol Chem 280:10781-10789. (Pubitemid 40395941)