메뉴 건너뛰기




Volumn 16, Issue 23, 2012, Pages 2868-2878

Synthesis, crystal structure, characterization and DNA binding studies of novel copper (II) complex based on amino acid schiff base

Author keywords

Acylpyrazolone; Amino acid schiff base; Coordination polymer; DNA binding activity; DNA cleavage; Hyperchromism

Indexed keywords

AMINO ACIDS; BINDING ENERGY; CHELATION; COPPER COMPOUNDS; CRYSTAL STRUCTURE; DICHROISM; ELECTROPHORESIS; GAMMA RAYS; LIGANDS; SINGLE CRYSTALS; THERMOGRAVIMETRIC ANALYSIS;

EID: 84872522028     PISSN: 13852728     EISSN: None     Source Type: Journal    
DOI: 10.2174/138527212804546912     Document Type: Article
Times cited : (5)

References (47)
  • 3
    • 0040712319 scopus 로고    scopus 로고
    • Coordination behaviour of biologically active Schiff bases of amino acids towards stannous ion
    • Singh, H.; Sharma, L.M.; Gupta, M.K.; Varshney, A.K. Coordination behaviour of biologically active Schiff bases of amino acids towards stannous ion. Bull. Pol. Acad. Sci. Chem., 1999, 47(2), 103-110.
    • (1999) Bull. Pol. Acad. Sci. Chem , vol.47 , Issue.2 , pp. 103-110
    • Singh, H.1    Sharma, L.M.2    Gupta, M.K.3    Varshney, A.K.4
  • 4
    • 0035023902 scopus 로고    scopus 로고
    • Organotin (IV) complexes of amino acids and peptides
    • Nath, M.; Pokharia, S.; Yadav, R. Organotin (IV) complexes of amino acids and peptides. Coord. Chem. Rev., 2001, 215, 99-149.
    • (2001) Coord. Chem. Rev , vol.215 , pp. 99-149
    • Nath, M.1    Pokharia, S.2    Yadav, R.3
  • 5
    • 77953478745 scopus 로고    scopus 로고
    • Synthesis and characterization of tin (II) complexes of fluorinated Schiff bases derived from amino acids
    • Singh, H.L. Synthesis and characterization of tin (II) complexes of fluorinated Schiff bases derived from amino acids. Spectrochim. Acta, Part A, 2010, 76(2), 253-258.
    • (2010) Spectrochim. Acta, Part A , vol.76 , Issue.2 , pp. 253-258
    • Singh, H.L.1
  • 6
    • 0014171898 scopus 로고
    • Long-term survival of patients with Burkitt's lymphoma: An assessment of treatment and other factors which may relate to survival
    • Clifford, P.; Singh, S.; Stjernsward, J.; Klein, G. Long-term survival of patients with Burkitt's lymphoma: an assessment of treatment and other factors which may relate to survival. Cancer Res., 1967, 27(12), 2578-2615.
    • (1967) Cancer Res , vol.27 , Issue.12 , pp. 2578-2615
    • Clifford, P.1    Singh, S.2    Stjernsward, J.3    Klein, G.4
  • 7
    • 0031438611 scopus 로고    scopus 로고
    • Structural and biological behaviour of Co(II), Cu(II) and Ni(II) metal complexes of some amino acid derived Schiff-bases
    • Chohan, Z.H.; Praveen, M.; Ghaffar, A. Structural and biological behaviour of Co(II), Cu(II) and Ni(II) metal complexes of some amino acid derived Schiff-bases. Metal-Based Drugs, 1997, 4(5), 267-272.
    • (1997) Metal-Based Drugs , vol.4 , Issue.5 , pp. 267-272
    • Chohan, Z.H.1    Praveen, M.2    Ghaffar, A.3
  • 8
    • 0014681285 scopus 로고
    • Growth of microorganisms in the presence of transition metal complexes: The antibacterial activity of trans-dihalogentotetrapyridinerhodium(III) salts
    • Bromfield, R.J.; Dainty, R.H.; Gillard, R.D.; Heaton, B.T. Growth of microorganisms in the presence of transition metal complexes: the antibacterial activity of trans-dihalogentotetrapyridinerhodium(III) salts. Nature, 1969, 223(5207), 735-736.
    • (1969) Nature , vol.223 , Issue.5207 , pp. 735-736
    • Bromfield, R.J.1    Dainty, R.H.2    Gillard, R.D.3    Heaton, B.T.4
  • 9
    • 16244389281 scopus 로고    scopus 로고
    • Mapping nucleic acid structure by hydroxyl radical cleavage. Curr. Opin. Chem
    • Tullius, T.D.; Greenbaum, J.A. Mapping nucleic acid structure by hydroxyl radical cleavage. Curr. Opin. Chem. Biol., 2005, 9(2), 127-134.
    • (2005) Biol , vol.9 , Issue.2 , pp. 127-134
    • Tullius, T.D.1    Greenbaum, J.A.2
  • 10
    • 70449842295 scopus 로고
    • Chelating Polymers. I. Monomeric Hydroxyarylaminoacetic acids as prototype chelating compounds
    • D'Alelio, G.F.; Hofman, E.T.; Zeman, J.R. Chelating Polymers. I. Monomeric Hydroxyarylaminoacetic acids as prototype chelating compounds. J. Macromol. Sci. Chem., 1969, 3, 959-967.
    • (1969) J. Macromol. Sci. Chem , vol.3 , pp. 959-967
    • D'Alelio, G.F.1    Hofman, E.T.2    Zeman, J.R.3
  • 11
    • 0242582476 scopus 로고    scopus 로고
    • Theoretical study of cisplatin binding to purine bases: Why does cisplatin prefer guanine over adenine as substrate?
    • Baik, M.H.; Friesner, R.A.; Lippard, S.J. Theoretical study of cisplatin binding to purine bases: why does cisplatin prefer guanine over adenine as substrate?. J. Am. Chem. Soc., 2003, 125, 14082-14089.
    • (2003) J. Am. Chem. Soc , vol.125 , pp. 14082-14089
    • Baik, M.H.1    Friesner, R.A.2    Lippard, S.J.3
  • 12
    • 0001120760 scopus 로고    scopus 로고
    • Preorganization of DNA: Design principles for improving nucleic acid recognition by synthetic oligonucleotides
    • Kool, E.T. Preorganization of DNA: design principles for improving nucleic acid recognition by synthetic oligonucleotides. Chem. Rev., 1997, 97, 1473-1496.
    • (1997) Chem. Rev , vol.97 , pp. 1473-1496
    • Kool, E.T.1
  • 13
    • 0141730422 scopus 로고    scopus 로고
    • 3-donor macrocyclic ligands: Synthesis, protonation constants, metal-ion binding and asymmetric catalysis in the Henry reaction
    • 3-donor macrocyclic ligands: synthesis, protonation constants, metal-ion binding and asymmetric catalysis in the Henry reaction. Org. Biomol. Chem., 2003, 1, 2801-2803.
    • (2003) Org. Biomol. Chem , vol.1 , pp. 2801-2803
    • Gao, J.1    Martell, A.E.2
  • 15
    • 0032103928 scopus 로고    scopus 로고
    • Small-molecule-based strategies for controlling gene expression
    • Denison, C.; Kodadek, T. Small-molecule-based strategies for controlling gene expression. Chem. Biol., 1998, 5, 129-145.
    • (1998) Chem. Biol , vol.5 , pp. 129-145
    • Denison, C.1    Kodadek, T.2
  • 16
    • 27844598770 scopus 로고    scopus 로고
    • Acylpyrazolone ligands: Synthesis, structures, metal coordination chemistry and applications
    • Marchetti, F.; Pettinari, C.; Pettinari, R. Acylpyrazolone ligands: Synthesis, structures, metal coordination chemistry and applications. Coord. Chem. Rev., 2005, 249, 2909-2945.
    • (2005) Coord. Chem. Rev , vol.249 , pp. 2909-2945
    • Marchetti, F.1    Pettinari, C.2    Pettinari, R.3
  • 17
    • 69949099940 scopus 로고    scopus 로고
    • Synthesis, characterization and crystal structure of a Ni(II) complex derived from heterocyclic acylpyrazolone
    • Li, J.; Li, J.Z.; Zhang, H.Q. Zhang, Y.; Li, J.Q. Synthesis, characterization and crystal structure of a Ni(II) complex derived from heterocyclic acylpyrazolone. J. Coord. Chem., 2009, 62,2465-2471.
    • (2009) J. Coord. Chem , vol.62 , pp. 2465-2471
    • Li, J.1    Li, J.Z.2    Zhang, H.Q.3    Zhang, Y.4    Li, J.Q.5
  • 18
    • 57249093639 scopus 로고    scopus 로고
    • Homogeneous bioinspired copper-catalyzed oxidation reactions
    • Gamez, P.; Aubel, P.G.; Driessen, W.L.; Reedijk, J. Homogeneous bioinspired copper-catalyzed oxidation reactions. Chem. Soc. Rev., 2001, 30, 376-385.
    • (2001) Chem. Soc. Rev , vol.30 , pp. 376-385
    • Gamez, P.1    Aubel, P.G.2    Driessen, W.L.3    Reedijk, J.4
  • 19
    • 79951940072 scopus 로고    scopus 로고
    • Synthesis, spectral, thermal analyses, molecular modeling, and antimicrobial activities of Cu(II)-complexes with 1,3,4-oxadiazole Schiff-base derivatives
    • Abdalla, M.K.; Nadla, A.E.W.; Sudha, J.; Vipin, K. Synthesis, spectral, thermal analyses, molecular modeling, and antimicrobial activities of Cu(II)-complexes with 1,3,4-oxadiazole Schiff-base derivatives. J. Coord. Chem., 2011, 64(5), 851-862.
    • (2011) J. Coord. Chem , vol.64 , Issue.5 , pp. 851-862
    • Abdalla, M.K.1    Nadla, A.E.W.2    Sudha, J.3    Vipin, K.4
  • 21
    • 0029926195 scopus 로고    scopus 로고
    • Synthesis of a functionalized salen copper complex and its interaction with DNA
    • Routier, S.; Bernier, J.L.; Waring, M.J.; Colson, P.; Houssier, C.; Bailly, C. Synthesis of a functionalized salen copper complex and its interaction with DNA. J. Org. Chem., 1996, 61(7), 2326-2331.
    • (1996) J. Org. Chem , vol.61 , Issue.7 , pp. 2326-2331
    • Routier, S.1    Bernier, J.L.2    Waring, M.J.3    Colson, P.4    Houssier, C.5    Bailly, C.6
  • 22
    • 0033541031 scopus 로고    scopus 로고
    • III, free radical production and DNA cleavage by hydroxy-salen-copper complexes. Isomeric effects studied by ESR and electrochemistry
    • III, free radical production and DNA cleavage by hydroxy-salen-copper complexes. Isomeric effects studied by ESR and electrochemistry. J. Am. Chem. Soc., 1999, 121,1862-1869.
    • (1999) J. Am. Chem. Soc , vol.121 , pp. 1862-1869
    • Lamour, E.1    Routier, S.2    Bernier, J.L.3    Catteau, J.P.4    Bailly, C.5    Vezin, H.6
  • 23
    • 0001557370 scopus 로고
    • The synthesis of 1-phenyl-3-methyl-4-acyl-pyrazolones-5
    • Jensen, B.S. The synthesis of 1-phenyl-3-methyl-4-acyl-pyrazolones-5. Acta Chem. Scand., 1959, 13, 1668-1678.
    • (1959) Acta Chem. Scand , vol.13 , pp. 1668-1678
    • Jensen, B.S.1
  • 24
    • 0036308557 scopus 로고    scopus 로고
    • An unprecedented 1D ladder coordination polymer based on a pentanuclear copper(II) 2,4,6-tris(dipyridin-2-ylamino)-1,3,5-triazine building block
    • Gamez, P.; Hoog, P.; Roubeau, O.; Lutz, M.; Driessen, W.L.; Spek, A.L.; Reedijk, J. An unprecedented 1D ladder coordination polymer based on a pentanuclear copper(II) 2,4,6-tris(dipyridin-2-ylamino)-1,3,5-triazine building block. Chem. Commun., 2002, 1488-1489.
    • (2002) Chem. Commun , pp. 1488-1489
    • Gamez, P.1    Hoog, P.2    Roubeau, O.3    Lutz, M.4    Driessen, W.L.5    Spek, A.L.6    Reedijk, J.7
  • 26
    • 0015895751 scopus 로고
    • Quenching of protein fluorescence by oxygen. Detection of structural fluctuations in proteins on the nanosecond time scale
    • Lakowicz, J. R.; Weber, G. Quenching of protein fluorescence by oxygen. Detection of structural fluctuations in proteins on the nanosecond time scale. Biochem., 1973, 12, 4171-4179.
    • (1973) Biochem , vol.12 , pp. 4171-4179
    • Lakowicz, J.R.1    Weber, G.2
  • 28
    • 0000178498 scopus 로고    scopus 로고
    • An Azide-Bridged Copper(II) Ferromagnetic Chain Compound Exhibiting Metamagnetic behavior
    • Thompson, L.K.; Tandon, S.S.; Lloret, F. An Azide-Bridged Copper(II) Ferromagnetic Chain Compound Exhibiting Metamagnetic Behavior. Inorg. Chem., 1997, 36, 3301-3306.
    • (1997) Inorg. Chem , vol.36 , pp. 3301-3306
    • Thompson, L.K.1    Tandon, S.S.2    Lloret, F.3
  • 29
    • 75649151030 scopus 로고    scopus 로고
    • A twodimensional metal-organic framework based on a ferromagnetic pentanuclear copper(II)
    • Zhu, X.; Zhao, J.W.; Li, B.L.; Song, Y.; Zhang, Y.M. Zhang, Y. A twodimensional metal-organic framework based on a ferromagnetic pentanuclear copper(II), Inorg. Chem., 2010, 49, 1266-1270.
    • (2010) Inorg. Chem , vol.49 , pp. 1266-1270
    • Zhu, X.1    Zhao, J.W.2    Li, B.L.3    Song, Y.4    Zhang, Y.M.5    Zhang, Y.6
  • 30
    • 37049096497 scopus 로고
    • Synthesis, Structure, and spectroscopic properties of copper(II) compounds containing nitrogen-sulphur donor ligands; the crystal and molecular structure of aqua [l,7-bis(N-methylbenzimidazol-2'-yl)-2,6-dithiaheptane]copperperchlorate
    • (II)
    • Addison, A.W.; Rao, T.N.; Reedijk, J.; Rijn, J.V.; Verschoor, G.C. Synthesis, Structure, and spectroscopic properties of copper(II) compounds containing nitrogen-sulphur donor ligands; the crystal and molecular structure of aqua [l,7-bis(N-methylbenzimidazol-2'-yl)-2,6-dithiaheptane]copper(II)perchlorate. J. Chem. Soc. Dalton Trans., 1984, 1349-1356.
    • (1984) J. Chem. Soc. Dalton Trans , pp. 1349-1356
    • Addison, A.W.1    Rao, T.N.2    Reedijk, J.3    Rijn, J.V.4    Verschoor, G.C.5
  • 31
    • 1642549713 scopus 로고    scopus 로고
    • Nickel(II) and copper(II) complexes with pyridine-containing macrocycles bearing an aminopropyl pendant arm: Synthesis, characterization, and modifications of the pendant amino group
    • Herrera, A.M.; Staples, R.J.; Kryatov, S.V.; Nazarenko, A.Y.; Akimova, E. V. Nickel(II) and copper(II) complexes with pyridine-containing macrocycles bearing an aminopropyl pendant arm: synthesis, characterization, and modifications of the pendant amino group. Dalton Trans., 2003,846-854.
    • (2003) Dalton Trans , pp. 846-854
    • Herrera, A.M.1    Staples, R.J.2    Kryatov, S.V.3    Nazarenko, A.Y.4    Akimova, E.V.5
  • 32
    • 78650676700 scopus 로고    scopus 로고
    • DNA interaction, Enhanced DNA photocleavage, electrochemistry, thermal investigation and biopotencial properties of new mixed-ligand complexes of Cu(II)/VO(IV) based on Schiff bases
    • Raman, N.; Selvan, A. DNA interaction, Enhanced DNA photocleavage, electrochemistry, thermal investigation and biopotencial properties of new mixed-ligand complexes of Cu(II)/VO(IV) based on Schiff bases. J. Mol. Struct., 2011, 985, 173-183.
    • (2011) J. Mol. Struct , vol.985 , pp. 173-183
    • Raman, N.1    Selvan, A.2
  • 33
    • 0008199555 scopus 로고    scopus 로고
    • Ethidium bromide as a fluorescent probe for the interaction mode between titanocene dichloride and DNA
    • Yang, P.; Guo, M. L.; Yang, B. S. Ethidium bromide as a fluorescent probe for the interaction mode between titanocene dichloride and DNA. Chin. Sci. Bull, 1996, 41(13), 1098-1103.
    • (1996) Chin. Sci. Bull , vol.41 , Issue.13 , pp. 1098-1103
    • Yang, P.1    Guo, M.L.2    Yang, B.S.3
  • 34
    • 34247856045 scopus 로고    scopus 로고
    • A trinuclear copper(II) complex of 2,4,6-tris(di-2-pyridyl amine)-1,3,5-triazine shows prominent DNA cleavage activity
    • Chen, J.W.; Wang, X.Y.; Shao, Y.; Zhu, J.H.; Zhu, Y.G.; Li, Y.Z.; Xu, Q.; Guo, Z.J. A trinuclear copper(II) complex of 2,4,6-tris(di-2-pyridyl amine)-1,3,5-triazine shows prominent DNA cleavage activity. Inorg. Chem., 2007, 46(8), 3306-3312.
    • (2007) Inorg. Chem , vol.46 , Issue.8 , pp. 3306-3312
    • Chen, J.W.1    Wang, X.Y.2    Shao, Y.3    Zhu, J.H.4    Zhu, Y.G.5    Li, Y.Z.6    Xu, Q.7    Guo, Z.J.8
  • 35
    • 33845377584 scopus 로고
    • Design, synthesis, and DNA binding properties of bifunctional intercalators. Comparison of polymethylene and diphenyl ether chains connecting phenanthridine
    • Cory, M.; Mckee, D.D.; Kagan, J.; Hanry, D.W.; Miller, J.A. Design, synthesis, and DNA binding properties of bifunctional intercalators. Comparison of polymethylene and diphenyl ether chains connecting phenanthridine. J. Am. Chem. Soc., 1985, 107(8), 2528-2533.
    • (1985) J. Am. Chem. Soc , vol.107 , Issue.8 , pp. 2528-2533
    • Cory, M.1    Mckee, D.D.2    Kagan, J.3    Hanry, D.W.4    Miller, J.A.5
  • 36
    • 0036932185 scopus 로고    scopus 로고
    • Oxidative strand scission of nucleic acids by a multinuclear Copper(II) complex
    • Humphreys, K.J.; Johnson, A.E.; Karlin, K.D.; Rokita, S.E. Oxidative strand scission of nucleic acids by a multinuclear Copper(II) complex. J. Biol. Inorg. Chem., 2002, 7,835-842.
    • (2002) J. Biol. Inorg. Chem , vol.7 , pp. 835-842
    • Humphreys, K.J.1    Johnson, A.E.2    Karlin, K.D.3    Rokita, S.E.4
  • 37
    • 0014202608 scopus 로고
    • A fluorescent complex between ethidium bromide and nucleic acids: Physical-Chemical characterization
    • Lepecq, J.B.; Paoletti, C. A fluorescent complex between ethidium bromide and nucleic acids: Physical-Chemical characterization. J. Mol. Biol., 1967, 27(1), 87-106.
    • (1967) J. Mol. Biol , vol.27 , Issue.1 , pp. 87-106
    • Lepecq, J.B.1    Paoletti, C.2
  • 39
    • 0038620773 scopus 로고
    • DNA binding studies and site selective fluorescence sensitization of an anthryl probe
    • Kumar, C.V.; Asuncion, E.H. DNA binding studies and site selective fluorescence sensitization of an anthryl probe. J. Am. Chem. Soc., 1993, 115(19), 8547-8553.
    • (1993) J. Am. Chem. Soc , vol.115 , Issue.19 , pp. 8547-8553
    • Kumar, C.V.1    Asuncion, E.H.2
  • 40
    • 22844436753 scopus 로고    scopus 로고
    • Copper(II) complexes of tridentate pyridylmethylethylenediamines: Role of ligand steric hindrance on DNA binding and cleavage
    • Raja, A.; Rajendiran, V.; Maheswari, P.U.; Balamurugan, R.; Kilner, C.A.; Halcrow, M.A.; Palaniandavar, M. Copper(II) complexes of tridentate pyridylmethylethylenediamines: Role of ligand steric hindrance on DNA binding and cleavage. J. Inorg. Biochem. 2005, 99(8), 1717-1732.
    • (2005) J. Inorg. Biochem , vol.99 , Issue.8 , pp. 1717-1732
    • Raja, A.1    Rajendiran, V.2    Maheswari, P.U.3    Balamurugan, R.4    Kilner, C.A.5    Halcrow, M.A.6    Palaniandavar, M.7
  • 41
    • 38149109378 scopus 로고    scopus 로고
    • Interactions of polypyridyl cobalt complexes with DNA studied by rotating electrode methods
    • Selvi, P.T.; Evans, H.S.; Palaniandavar, M. Interactions of polypyridyl cobalt complexes with DNA studied by rotating electrode methods. J. Inorg. Biochem., 2005, 99, 2110-2116.
    • (2005) J. Inorg. Biochem , vol.99 , pp. 2110-2116
    • Selvi, P.T.1    Evans, H.S.2    Palaniandavar, M.3
  • 42
    • 74549208022 scopus 로고    scopus 로고
    • Synthesis and biophysical studies of bis-Macrocyclic Cobalt/Copper(II) complexes having a pyridine spacer with CT DNA and 5'-GMP
    • Arjmand, F.; Aziz, M. Synthesis and biophysical studies of bis-Macrocyclic Cobalt/Copper(II) complexes having a pyridine spacer with CT DNA and 5'-GMP. Chem. Biodiversity, 2009, 6, 2275-2289.
    • (2009) Chem. Biodiversity , vol.6 , pp. 2275-2289
    • Arjmand, F.1    Aziz, M.2
  • 43
    • 79954611887 scopus 로고    scopus 로고
    • DNA binding, oxidative DNA cleavage, cytotoxicity, and apoptosis-inducing activity of copper(II) complexes with1, 4-tpbd (N, N, N, N-tetrakis (2-yridylmethyl)benzene-1,4-diamine) ligand
    • Li, D.D.; Tian, J.L.; Gu, W.; Liu, X.; Zeng, H.H.; Yan, S.P. DNA binding, oxidative DNA cleavage, cytotoxicity, and apoptosis-inducing activity of copper(II) complexes with1, 4-tpbd (N, N, N, N-tetrakis (2-yridylmethyl)benzene-1,4-diamine) ligand. J. Inorg. Biochem., 2011, 105, 894-901.
    • (2011) J. Inorg. Biochem , vol.105 , pp. 894-901
    • Li, D.D.1    Tian, J.L.2    Gu, W.3    Liu, X.4    Zeng, H.H.5    Yan, S.P.6
  • 44
  • 45
    • 80053383917 scopus 로고    scopus 로고
    • Spectrophotometric study on the binding of two water soluble Schiff base complexes of Mn (III) with ct-DNA
    • Maryam, N.D.; Bordbar, A.K.; Mehrgardi, M.A.; Mirkhani, V. Spectrophotometric study on the binding of two water soluble Schiff base complexes of Mn (III) with ct-DNA. J. Fluoresc. 2011, 21(4), 1649-1658.
    • (2011) J. Fluoresc , vol.21 , Issue.4 , pp. 1649-1658
    • Maryam, N.D.1    Bordbar, A.K.2    Mehrgardi, M.A.3    Mirkhani, V.4
  • 46
    • 11944275553 scopus 로고
    • DNA photocleavage by phenanthrenequinone diimine complexes of rhodium (III):Shape-selective recognition and reaction
    • Sitlani, A.; Long, E.C.; Pyle, A.M.; Barton, J.K. DNA photocleavage by phenanthrenequinone diimine complexes of rhodium (III):shape-selective recognition and reaction. J. Am. Chem. Soc., 1992, 114(7), 2303-2308.
    • (1992) J. Am. Chem. Soc , vol.114 , Issue.7 , pp. 2303-2308
    • Sitlani, A.1    Long, E.C.2    Pyle, A.M.3    Barton, J.K.4
  • 47
    • 33845376015 scopus 로고
    • Nuclease activity of 1,10-phenanthroline-copper ion
    • Sigman, D.S. Nuclease activity of 1,10-phenanthroline-copper ion. Acc. Chem. Res., 1986, 19, 180-186.
    • (1986) Acc. Chem. Res , vol.19 , pp. 180-186
    • Sigman, D.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.