Improved detection methods by genetic and immunological techniques for botulinum C/D and D/C mosaic neurotoxins

Veterinary Microbiology

Volumn 162, Issue 2-4, 2013, Pages 881-890

  Nakamura, Keiji ^a   Kohda, Tomoko ^a   Seto, Yoshiyuki ^a   Mukamoto, Masafumi ^a   Kozaki, Shunji ^a  

^a Osaka Prefecture University   (Japan)

Author keywords

Botulinum neurotoxin; Immunochromatography; Mosaic toxin; Multiplex PCR

Indexed keywords

BOTULINUM TOXIN; BOTULINUM TOXIN C; BOTULINUM TOXIN D; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BINDING AFFINITY; BOTULISM; CLOSTRIDIUM BOTULINUM TYPE C; CLOSTRIDIUM BOTULINUM TYPE D; GENE SEQUENCE; GENETIC PROCEDURES; IMMUNOAFFINITY CHROMATOGRAPHY; IMMUNOLOGICAL TECHNIQUE; LIMIT OF DETECTION; MULTIPLEX POLYMERASE CHAIN REACTION; NONHUMAN; NUCLEOTIDE SEQUENCE; SUPERNATANT;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BIRD DISEASES; BOTULINUM TOXINS; BOTULISM; CATTLE; CATTLE DISEASES; CHROMATOGRAPHY; CLOSTRIDIUM BOTULINUM; IMMUNOLOGIC TECHNIQUES; MALE; MICE; POLYMERASE CHAIN REACTION;

AVES; BOVINAE; CLOSTRIDIUM BOTULINUM;

EID: 84872497750     PISSN: 03781135     EISSN: 18732542     Source Type: Journal    
DOI: 10.1016/j.vetmic.2012.11.009     Document Type: Article

References (33)

1. Anniballi F., Auricchio B., Delibato E., Antonacci M., De Medici D., Fenicia L. Multiplex real-time PCR SYBR green for detection and typing of group III Clostridium botulinum. Vet. Microbiol. 2011, 154:332-338.
2. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
3. Brooks C.E., Clarke H.J., Graham D.A., Ball H.J. Diagnosis of botulism types C and D in cattle by a monoclonal antibody-based sandwich ELISA. Vet. Rec. 2011, 168:455.
4. Dahlenborg M., Borch E., Radstrom P. Prevalence of Clostridium botulinum types B, E and F in faecal samples from Swedish cattle. Int. J. Food Microbiol. 2003, 82:105-110.
5. Gessler F., Hampe K., Schmidt M., Bohnel H. Immunomagnetic beads assay for the detection of botulinum neurotoxin types C and D. Diagn. Microbiol. Infect. Dis. 2006, 56:225-232.
6. Gu S., Rumpel S., Zhou J., Strotmeier J., Bigalke H., Perry K., Shoemaker C.B., Rummel A., Jin R. Botulinum neurotoxin is shielded by NTNHA in an interlocked complex. Science 2012, 335:977-981.
7. Hasegawa K., Watanabe T., Suzuki T., Yamano A., Oikawa T., Sato Y., Kouguchi H., Yoneyama T., Niwa K., Ikeda T., Ohyama T. A novel subunit structure of Clostridium botulinum serotype D toxin complex with three extended arms. J. Biol. Chem. 2007, 282:24777-24783.
8. Hauser D., Eklund M.W., Boquet P., Popoff M.R. Organization of the botulinum neurotoxin C1 gene and its associated non-toxic protein genes in Clostridium botulinum C 468. Mol. Gen. Genet. 1994, 243:631-640.
9. Hill K.K., Smith T.J., Helma C.H., Ticknor L.O., Foley B.T., Svensson R.T., Brown J.L., Johnson E.A., Smith L.A., Okinaka R.T., Jackson P.J., Marks J.D. Genetic diversity among botulinum neurotoxin-producing clostridial strains. J. Bacteriol. 2007, 189:818-832.
10. Inoue K., Fujinaga Y., Watanabe T., Ohyama T., Takeshi K., Moriishi K., Nakajima H., Oguma K. Molecular composition of Clostridium botulinum type A progenitor toxins. Infect. Immun. 1996, 64:1589-1594.
11. Ito H., Sagane Y., Miyata K., Inui K., Matsuo T., Horiuchi R., Ikeda T., Suzuki T., Hasegawa K., Kouguchi H., Oguma K., Niwa K., Ohyama T., Watanabe T. HA-33 facilitates transport of the serotype D botulinum toxin across a rat intestinal epithelial cell monolayer. FEMS Immunol. Med. Microbiol. 2011, 61:323-331.
12. Kouguchi H., Watanabe T., Sagane Y., Sunagawa H., Ohyama T. In vitro reconstitution of the Clostridium botulinum type D progenitor toxin. J. Biol. Chem. 2002, 277:2650-2656.
13. Kozaki S., Nakaue S., Kamata Y. Immunological characterization of the neurotoxin produced by Clostridium botulinum type A associated with infant botulism in Japan. Microbiol. Immunol. 1995, 39:767-774.
14. Lindberg A., Skarin H., Knutsson R., Blomqvist G., Baverud V. Real-time PCR for Clostridium botulinum type C neurotoxin (BoNTC) gene, also covering a chimeric C/D sequence - application on outbreaks of botulism in poultry. Vet. Microbiol. 2010, 146:118-123.
15. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
16. Moriishi K., Koura M., Fujii N., Fujinaga Y., Inoue K., Syuto B., Oguma K. Molecular cloning of the gene encoding the mosaic neurotoxin, composed of parts of botulinum neurotoxin types C1 and D, and PCR detection of this gene from Clostridium botulinum type C organisms. Appl. Environ. Microbiol. 1996, 62:662-667.
17. Moriishi K., Syuto B., Saito M., Oguma K., Fujii N., Abe N., Naiki M. Two different types of ADP-ribosyltransferase C3 from Clostridium botulinum type D lysogenized organisms. Infect. Immun. 1993, 61:5309-5314.
18. Nakajima H., Inoue K., Ikeda T., Fujinaga Y., Sunagawa H., Takeshi K., Ohyama T., Watanabe T., Oguma K. Molecular composition of the 16S toxin produced by a Clostridium botulinum type D strain, 1873. Microbiol. Immunol. 1998, 42:599-605.
19. Nakamura K., Kohda T., Shibata Y., Tsukamoto K., Arimitsu H., Hayashi M., Mukamoto M., Sasakawa N., Kozaki S. Unique biological activity of botulinum D/C mosaic neurotoxin in murine species. Infect. Immun. 2012, 80:2886-2893.
20. Nakamura K., Kohda T., Umeda K., Yamamoto H., Mukamoto M., Kozaki S. Characterization of the D/C mosaic neurotoxin produced by Clostridium botulinum associated with bovine botulism in Japan. Vet. Microbiol. 2010, 140:147-154.
21. Raffestin S., Marvaud J.C., Cerrato R., Dupuy B., Popoff M.R. Organization and regulation of the neurotoxin genes in Clostridium botulinum and Clostridium tetani. Anaerobe 2004, 10:93-100.
22. Sagane Y., Kouguchi H., Watanabe T., Sunagawa H., Inoue K., Fujinaga Y., Oguma K., Ohyama T. Role of C-terminal region of HA-33 component of botulinum toxin in hemagglutination. Biochem. Biophys. Res. Commun. 2001, 288:650-657.
23. Sakaguchi Y., Hayashi T., Kurokawa K., Nakayama K., Oshima K., Fujinaga Y., Ohnishi M., Ohtsubo E., Hattori M., Oguma K. The genome sequence of Clostridium botulinum type C neurotoxin-converting phage and the molecular mechanisms of unstable lysogeny. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:17472-17477.
24. Skarin H., Hafstrom T., Westerberg J., Segerman B. Clostridium botulinum group III: a group with dual identity shaped by plasmids, phages and mobile elements. BMC Genomics 2011, 12:185.
25. Sugawara Y., Matsumura T., Takegahara Y., Jin Y., Tsukasaki Y., Takeichi M., Fujinaga Y. Botulinum hemagglutinin disrupts the intercellular epithelial barrier by directly binding E-cadherin. J. Cell Biol. 2010, 189:691-700.
26. Sunagawa H., Ohyama T., Watanabe T., Inoue K. The complete amino acid sequence of the Clostridium botulinum type D neurotoxin, deduced by nucleotide sequence analysis of the encoding phage d-16 phi genome. J. Vet. Med. Sci. 1992, 54:905-913.
27. Takeda M., Tsukamoto K., Kohda T., Matsui M., Mukamoto M., Kozaki S. Characterization of the neurotoxin produced by isolates associated with avian botulism. Avian Dis. 2005, 49:376-381.
28. Tsukamoto K., Mukamoto M., Kohda T., Ihara H., Wang X., Maegawa T., Nakamura S., Karasawa T., Kozaki S. Characterization of Clostridium butyricum neurotoxin associated with food-borne botulism. Microb. Pathog. 2002, 33:177-184.
29. Umeda K., Seto Y., Kohda T., Mukamoto M., Kozaki S. Genetic characterization of Clostridium botulinum associated with type B infant botulism in Japan. J. Clin. Microbiol. 2009, 47:2720-2728.
30. Umeda K., Seto Y., Kohda T., Mukamoto M., Kozaki S. A novel multiplex PCR method for Clostridium botulinum neurotoxin type A gene cluster typing. Microbiol. Immunol. 2010, 54:308-312.
31. Woudstra C., Skarin H., Anniballi F., Fenicia L., Bano L., Drigo I., Koene M., Bayon-Auboyer M.H., Buffereau J.P., De Medici D., Fach P. Neurotoxin gene profiling of Clostridium botulinum types C and D native to different countries within Europe. Appl. Environ. Microbiol. 2012, 78:3120-3127.
32. Yoneyama T., Miyata K., Chikai T., Mikami A., Suzuki T., Hasegawa K., Ikeda T., Watanabe T., Ohyama T., Niwa K. Clostridium botulinum serotype D neurotoxin and toxin complex bind to bovine aortic endothelial cells via sialic acid. FEMS Immunol. Med. Microbiol. 2008, 54:290-298.
33. Zhao H., Nakamura K., Kohda T., Mukamoto M., Kozaki S. Characterization of the monoclonal antibody response to botulinum neurotoxin type A in the complexed and uncomplexed forms. Jpn. J. Infect. Dis. 2012, 65:138-145.