Epidemiology and host spectrum of Borna disease virus infections

Journal of General Virology

Volumn 94, Issue PART2, 2013, Pages 247-262

  Kinnunen, Paula M ^a,b,d   Palva, Airi ^a   Vaheri, Antti ^b,c   Vapalahti, Olli ^a,b,c  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d CENTRE FOR MILITARY MEDICINE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE SULFATE; RIBAVIRIN; VIRUS VECTOR;

ANTIVIRAL THERAPY; BORNA DISEASE; CAT; CLINICAL FEATURE; CLINICAL TRIAL (TOPIC); COW; DOG; ECOLOGY; GENE SEQUENCE; GEOGRAPHIC DISTRIBUTION; HORSE; HUMAN; IMMUNE RESPONSE; INFECTION PREVENTION; MOLECULAR EPIDEMIOLOGY; MOLECULAR PHYLOGENY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RABBIT; REVIEW; SEROPREVALENCE; SHEEP; SPECIES DIFFERENTIATION; SPECIES DIVERSITY; TREATMENT DURATION; TREATMENT INDICATION; TREATMENT PLANNING; UNSPECIFIED SIDE EFFECT; VACCINATION; VIRUS CHARACTERIZATION; VIRUS DETECTION; VIRUS GENOME; VIRUS TRANSMISSION;

ANIMALS; BORNA DISEASE; BORNA DISEASE VIRUS; HUMANS; TOPOGRAPHY, MEDICAL; ZOONOSES;

BORNA DISEASE VIRUS; EQUIDAE; MAMMALIA; OVIS ARIES; PRIMATES; VERTEBRATA;

EID: 84872459032     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.046961-0     Document Type: Review

References (165)

1. Acha, P. N. (1987). Zoonoses and Communicable Diseases Common to Man and Animals, 2nd edn. Washington, DC: Pan American Health Organization, World Health Organization.
2. Ackermann, A., Kugel, D., Schneider, U. & Staeheli, P. (2007). Enhanced polymerase activity confers replication competence of Borna disease virus in mice. J Gen Virol 88, 3130-3132.
3. Ackermann, A., Guelzow, T., Staeheli, P., Schneider, U. & Heimrich, B. (2010). Visualizing viral dissemination in the mouse nervous system, using a green fluorescent protein-expressing Borna disease virus vector. J Virol 84, 5438-5442.
4. Allmang, U., Hofer, M., Herzog, S., Bechter, K. & Staeheli, P. (2001). Low avidity of human serum antibodies for Borna disease virus antigens questions their diagnostic value. Mol Psychiatry 6, 329-333.
5. Amori, G., Henttonen, H., Vohralík, V., Zagorodnyuk, I., Zima, J., Kry̌tufek, B., Juškaitis, R., Meinig, H. & Bertolino, S. (2006). Myodes glareolus. IUCN Red List of Threatened Species, version 2010.4, 5-0.
6. Arias, I., Sorlozano, A., Villegas, E., de Dios Luna, J., McKenney, K., Cervilla, J., Gutierrez, B. & Gutierrez, J. (2012). Infectious agents associated with schizophrenia: a meta-analysis. Schizophr Res 136, 128-136.
7. Bajramovic, J. J., Volmer, R., Syan, S., Pochet, S. & Gonzalez-Dunia, D. (2004) 29-Fluoro-29-deoxycytidine inhibits Borna disease virus replication and spread. Antimicrob Agents Chemother 48, 1422-1425.
8. Basso, W., Schares, S., Minke, L., Barwald, A., Maksimov, A., Peters, M., Schulze, C., Muller, M., Conraths, F. J. & Schares, G. (2010). Microsatellite typing and avidity analysis suggest a common source of infection in herds with epidemic Neospora caninum-associated bovine abortion. Vet Parasitol 173, 24-31.
9. Baur, K., Rauer, M., Richter, K., Pagenstecher, A., Gotz, J., Hausmann, J. & Staeheli, P. (2008). Antiviral CD8 T cells recognize Borna disease virus antigen transgenically expressed in either neurons or astrocytes. J Virol 82, 3099-3108.
10. Belyi, V. A., Levine, A. J. & Skalka, A. M. (2010). Unexpected inheritance: multiple integrations of ancient bornavirus and ebola-virus/marburgvirus sequences in vertebrate genomes. PLoS Pathog 6, e1001030.
11. Berg, A. L., Reid-Smith, R., Larsson, M. & Bonnett, B. (1998). Case control study of feline Borna disease in Sweden. Vet Rec 142, 715-717.
12. Berg, A. L., Dorries, R. & Berg, M. (1999). Borna disease virus infection in racing horses with behavioral and movement disorders. Arch Virol 144, 547-559.
13. Berg, M., Johansson, M., Montell, H. & Berg, A. L. (2001). Wild birds as a possible natural reservoir of Borna disease virus. Epidemiol Infect 127, 173-178.
14. Billich, C., Sauder, C., Frank, R., Herzog, S., Bechter, K., Takahashi, K., Peters, H., Staeheli, P. & Schwemmle, M. (2002). High-avidity human serum antibodies recognizing linear epitopes of Borna disease virus proteins. Biol Psychiatry 51, 979-987.
15. Bilzer, T., Grabner, A. & Stitz, L. (1996). Immunpathologie der Borna-Krankheit beim Pferd: klinische, virologische und neuropathologische Befunde. Tierarztl Prax 24, 567-576 (in German)
16. Bode, L. (2008). Human bornavirus infection-towards a valid diagnostic system. APMIS Suppl 116, 21-39.
17. Bode, L. & Ludwig, H. (2003). Borna disease virus infection, a human mental-health risk. Clin Microbiol Rev 16, 534-545.
18. Bode, L., Durrwald, R., Koeppel, P. & Ludwig, H. (1994). Neue Aspekte der equinen Borna-Virus-Infektion mit und ohne Krankheit. Tierarztl Prax 12, 1065-1068 (in German)
19. Bode, L., Dietrich, D. E., Stoyloff, R., Emrich, H. M. & Ludwig, H. (1997). Amantadine and human Borna disease virus in vitro and in vivo in an infected patient with bipolar depression. Lancet 349, 178-179.
20. Bode, L., Reckwald, P., Severus, W. E., Stoyloff, R., Ferszt, R., Dietrich, D. E. & Ludwig, H. (2001). Borna disease virus-specific circulating immune complexes, antigenemia, and free antibodies-the key marker triplet determining infection and prevailing in severe mood disorders. Mol Psychiatry 6, 481-491.
21. Bonthius, D. J. & Perlman, S. (2007). Congenital viral infections of the brain: lessons learned from lymphocytic choriomeningitis virus in the neonatal rat. PLoS Pathog 3, e149.
22. Briese, T., Schneemann, A., Lewis, A. J., Park, Y. S., Kim, S., Ludwig, H. & Lipkin, W. I. (1994). Genomic organization of Borna disease virus. Proc Natl Acad Sci U S A 91, 4362-4366.
23. Caplazi, P. & Ehrensperger, F. (1998). Spontaneous Borna disease in sheep and horses: immunophenotyping of inflammatory cells and detection of MHC-I and MHC-II antigen expression in Borna encephalitis lesions. Vet Immunol Immunopathol 61, 203-220.
24. Caplazi, P., Waldvogel, A., Stitz, L., Braun, U. & Ehrensperger, F. (1994). Borna disease in naturally infected cattle. J Comp Pathol 111, 65-72.
25. Carbone, K. M., Duchala, C. S., Griffin, J. W., Kincaid, A. L. & Narayan, O. (1987). Pathogenesis of Borna disease in rats: evidence that intra-axonal spread is the major route for virus dissemination and the determinant for disease incubation. J Virol 61, 3431-3440.
26. Chalmers, R. M., Thomas, D. R. & Salmon, R. L. (2005). Borna disease virus and the evidence for human pathogenicity: a systematic review. QJM 98, 255-274.
27. Cleaveland, S., Laurenson, M. K. & Taylor, L. H. (2001). Diseases of humans and their domestic mammals: pathogen characteristics, host range and the risk of emergence. Philos Trans R Soc Lond B Biol Sci 356, 991-999.
28. Clemente, R. & de la Torre, J. C. (2009). Cell entry of Borna disease virus follows a clathrin-mediated endocytosis pathway that requires Rab5 and microtubules. J Virol 83, 10406-10416.
29. Cubitt, B. & de la Torre, J. C. (1997). Amantadine does not have antiviral activity against Borna disease virus. Arch Virol 142, 2035-2042.
30. Cubitt, B., Oldstone, C. & de la Torre, J. C. (1994). Sequence and genome organization of Borna disease virus. J Virol 68, 1382-1396.
31. Danner, K. (1978). Bornasche Krankheit. Prakt Tierarzt 10, 748-752 (in German)
32. Danner, K. & Mayr, A. (1979). In vitro studies on Borna virus. II. Properties of the virus. Arch Virol 61, 261-271.
33. Danner, K., Heubeck, D. & Mayr, A. (1978). In vitro studies on Borna virus. I. The use of cell cultures for the demonstration, titration and production of Borna virus. Arch Virol 57, 63-75.
34. Dauphin, G., Legay, V., Sailleau, C., Smondack, S., Hammoumi, S. & Zientara, S. (2001). Evidence of Borna disease virus genome detection in French domestic animals and in foxes (Vulpes vulpes). J Gen Virol 82, 2199-2204.
35. De Bosschere, H., Roels, S., Vanopdenbosch, E., Bode, L. & Ludwig, H. (2004). Staggering disease in a cat: the first case of Borna disease virus infection in a Belgian cat. Intern J Appl Res Vet Med 2, 189-194.
36. de Jong, C., Field, H., Newman, S. H. & Epstein, J. H. (2011). Emerging infectious diseases. In Investigating the Role of Bats in Emerging Zoonoses, pp. 1-13. Edited by S. H. Newman, H. Field,
37. J. H. Epstein & C. de Jong. Rome: Food and Agriculture Organization of the United Nations.
38. de La Torre, J. C., Gonzalez-Dunia, D., Cubitt, B., Mallory, M., Mueller-Lantzsch, N., Grasser, F. A., Hansen, L. A. & Masliah, E. (1996). Detection of Borna disease virus antigen and RNA in human autopsy brain samples from neuropsychiatric patients. Virology 223, 272-282.
39. Degiorgis, M. P., Berg, A. L., Hârd Af Segerstad, C., Morner, T., Johansson, M. & Berg, M. (2000). Borna disease in a free-ranging lynx (Lynx lynx). J Clin Microbiol 38, 3087-3091.
40. Delnatte, P., Berkvens, C., Kummrow, M., Smith, D. A., Campbell, D., Crawshaw, G., Ojkic, D. & DeLay, J. (2011). New genotype of avian bornavirus in wild geese and trumpeter swans in Canada. Vet Rec 169, 108.
41. Dieckhofer, R. (2008). Infections in horses: diagnosis and therapy. APMIS Suppl 116, 40-43.
42. Dietrich, D. E., Bode, L., Spannhuth, C. W., Lau, T., Huber, T. J., Brodhun, B., Ludwig, H. & Emrich, H. M. (2000). Amantadine in depressive patients with Borna disease virus (BDV) infection: an open trial. Bipolar Disord 2, 65-70.
43. Durrwald, R. & Ludwig, H. (1997). Borna disease virus (BDV), a (zoonotic?) worldwide pathogen. A review of the history of the disease and the virus infection with comprehensive bibliography. Zentralbl Veterinarmed B 44, 147-184.
44. Durrwald, R., Kolodziejek, J., Muluneh, A., Herzog, S. & Nowotny, N. (2006a). Epidemiological pattern of classical Borna disease and regional genetic clustering of Borna disease viruses point towards the existence of to-date unknown endemic reservoir host populations. Microbes Infect 8, 917-929.
45. Durrwald, R., Kolodziejek, J. & Nowotny, N. (2006b). Borna disease virus (BDV) sequences derived from plasma samples of Australian cats contain multiple sequencing errors and are otherwise almost identical to strain V, a commonly used BDV laboratory strain. Microbes Infect 8, 1421-1422.
46. Durrwald, R., Kolodziejek, J., Herzog, S. & Nowotny, N. (2007). Meta-analysis of putative human bornavirus sequences fails to provide evidence implicating Borna disease virus in mental illness. Rev Med Virol 17, 181-203.
47. EDENext (2011). International consortium. Biology and control of vector-borne infections in Europe. Updated 15 March 2011; accessed 3 November 2012. http://www.edenext.eu/understanding-diseases/rodents
48. Enbergs, H. K., Vahlenkamp, T. W., Kipar, A. & Muller, H. (2001). Experimental infection of mice with Borna disease virus (BDV): replication and distribution of the virus after intracerebral infection. J Neurovirol 7, 272-277.
49. Formella, S., Jehle, C., Sauder, C., Staeheli, P. & Schwemmle, M. (2000). Sequence variability of Borna disease virus: resistance to superinfection may contribute to high genome stability in persistently infected cells. J Virol 74, 7878-7883.
50. Friedrich Loeffler Institut (2012). Tiergesundheitsjahresberichte 1999-2010 (in German). Updated 4 October 2012; accessed 18 November 2012. http://www.fli.bund.de/no_cache/de/startseite/publikationen/tiergesundheitsjahresberichte.html
51. Furrer, E., Bilzer, T., Stitz, L. & Planz, O. (2001a). High-dose Borna disease virus infection induces a nucleoprotein-specific cytotoxic T-lymphocyte response and prevention of immunopathology. J Virol 75, 11700-11708.
52. Furrer, E., Bilzer, T., Stitz, L. & Planz, O. (2001b). Neutralizing antibodies in persistent Borna disease virus infection: prophylactic effect of gp94-specific monoclonal antibodies in preventing encephalitis. J Virol 75, 943-951.
53. Galabru, J., Saron, M. F., Berg, M., Berg, A. L., Herzog, S., Labie, J. & Zientara, S. (2000). Borna disease virus antibodies in French horses. Vet Rec 147, 721-722.
54. Gavrilovskaya, I., Apekina, N., Okulova, N., Demina, V., Bernshtein, A. & Myasnikov, Y. (1993). IgG avidity assay for estimation of the time after onset of hantavirus infection in colonized and wild bank voles. Arch Virol 132, 359-367.
55. Geib, T., Sauder, C., Venturelli, S., Hassler, C., Staeheli, P. & Schwemmle, M. (2003). Selective virus resistance conferred by expression of Borna disease virus nucleocapsid components. J Virol 77, 4283-4290.
56. Grabner, A. & Fischer, A. (1991). Symptomatologie und Diagnostik der Borna-Enzephalitis des Pferdes. Eine Fallanalyse der letzten 13 Jahre. Tierarztl Prax 19, 68-73 (in German).
57. Habjan, M., Andersson, I., Klingstrom, J., Schumann, M., Martin, A., Zimmermann, P., Wagner, V., Pichlmair, A., Schneider, U. & other authors (2008). Processing of genome 59 termini as a strategy of negative-strand RNA viruses to avoid RIG-I-dependent interferon induction. PLoS ONE 3, e2032.
58. Hagiwara, K., Kamitani, W., Takamura, S., Taniyama, H., Nakaya, T., Tanaka, H., Kirisawa, R., Iwai, H. & Ikuta, K. (2000). Detection of Borna disease virus in a pregnant mare and her fetus. Vet Microbiol 72, 207-216.
59. Hagiwara, K., Asakawa, M., Liao, L., Jiang, W., Yan, S., Chai, J., Oku, Y., Ikuta, K. & Ito, M. (2001). Seroprevalence of Borna disease virus in domestic animals in Xinjiang, China. Vet Microbiol 80, 383-389.
60. Hagiwara, K., Tsuge, Y., Asakawa, M., Kabaya, H., Okamoto, M., Miyasho, T., Taniyama, H., Ishihara, C., de la Torre, J. C. & Ikuta, K. (2008). Borna disease virus RNA detected in Japanese macaques (Macaca fuscata). Primates 49, 57-64.
61. Hagiwara, K., Matoba, Y. & Asakawa, M. (2009). Borna disease virus in raccoons (Procyon lotor) in Japan. J Vet Med Sci 71, 1009-1015.
62. Hallensleben, W., Zocher, M. & Staeheli, P. (1997). Borna disease virus is not sensitive to amantadine. Arch Virol 142, 2043-2048.
63. Hardestam, J., Karlsson, M., Falk, K. I., Olsson, G., Klingstrom, J. & Lundkvist, (2008). Puumala hantavirus excretion kinetics in bank voles (Myodes glareolus). Emerg Infect Dis 14, 1209-1215.
64. Hausmann, J., Baur, K., Engelhardt, K. R., Fischer, T., Rziha, H. J. & Staeheli, P. (2005). Vaccine-induced protection against Borna disease in wild-type and perforin-deficient mice. J Gen Virol 86, 399-403.
65. Hedman, K., Lappalainen, M., Soderlund, M. & Hedman, L. (1993). Avidity of IgG in serodiagnosis of infectious diseases. Rev Med Microbiol 4, 123-129.
66. Herzog, S., Frese, K. & Rott, R. (1991). Studies on the genetic control of resistance of black hooded rats to Borna disease. J Gen Virol 72, 535-540.
67. Herzog, S., Frese, K. & Rott, R. (1994). Ein Beitrag zur Epizootologie der Bornaschen Krankheit der Pferd. Wien Tierarztl Monatsschr 81, 374-379 (in German)
68. Hilbe, M., Herrsche, R., Kolodziejek, J., Nowotny, N., Zlinszky, K. & Ehrensperger, F. (2006). Shrews as reservoir hosts of Borna disease virus. Emerg Infect Dis 12, 675-677.
69. Holmes, E. C., Woelk, C. H., Kassis, R. & Bourhy, H. (2002). Genetic constraints and the adaptive evolution of rabies virus in nature. Virology 292, 247-257.
70. Honkavuori, K. S., Shivaprasad, H. L., Williams, B. L., Quan, P. L., Hornig, M., Street, C., Palacios, G., Hutchison, S. K., Franca, M. & other authors (2008). Novel Borna virus in psittacine birds with proventricular dilatation disease. Emerg Infect Dis 14, 1883-1886.
71. Horie, M., Honda, T., Suzuki, Y., Kobayashi, Y., Daito, T., Oshida, T., Ikuta, K., Jern, P., Gojobori, T. & other authors (2010). Endogenous non-retroviral RNA virus elements in mammalian genomes. Nature 463, 84-87.
72. Hornig, M., Weissenbock, H., Horscroft, N. & Lipkin, W. I. (1999). An infection-based model of neurodevelopmental damage. Proc Natl Acad Sci U S A 96, 12102-12107.
73. Hornig, M., Briese, T., Licinio, J., Khabbaz, R. F., Altshuler, L. L., Potkin, S. G., Schwemmle, M., Siemetzki, U., Mintz, J. & other authors (2012). Absence of evidence for bornavirus infection in schizophrenia, bipolar disorder and major depressive disorder. Mol Psychiatry 17, 486-493.
74. Huebner, J., Bode, L. & Ludwig, H. (2001). Borna disease virus infection in FIV-positive cats in Germany. Vet Rec 149, 152.
75. Ikuta, K., Hagiwara, K., Taniyama, H. & Nowotny, N. (2002). Epidemiology and infection of natural animal hosts. In Borna Disease Virus and its Role in Neurobehavioral Disease, pp. 87-123. Edited by K. M. Carbone. Washington, DC: American Society for Microbiology.
76. Jacobsen, B., Algermissen, D., Schaudien, D., Venner, M., Herzog, S., Wentz, E., Hewicker-Trautwein, M., Baumgartner, W. & Herden, C. (2010). Borna disease in an adult alpaca stallion (Lama pacos). J Comp Pathol 143, 203-208.
77. Johansson, M., Berg, M. & Berg, A. L. (2002). Humoral immune response against Borna disease virus (BDV) in experimentally and naturally infected cats. Vet Immunol Immunopathol 90, 23-33.
78. Jones, K. E., Patel, N. G., Levy, M. A., Storeygard, A., Balk, D., Gittleman, J. L. & Daszak, P. (2008). Global trends in emerging infectious diseases. Nature 451, 990-993.
79. Jordan, I., Briese, T., Averett, D. R. & Lipkin, W. I. (1999). Inhibition of Borna disease virus replication by ribavirin. J Virol 73, 7903-7906.
80. Kamhieh, S., Hodgson, J. L., Bode, L., Ludwig, H. & Flower, R. L. (2008). Borna disease virus: evidence of naturally-occurring infection in cats in Australia. APMIS Suppl 116, 50-52.
81. Kao, M., Hamir, A. N., Rupprecht, C. E., Fu, Z. F., Shankar, V., Koprowski, H. & Dietzschold, B. (1993). Detection of antibodies against Borna disease virus in sera and cerebrospinal fluid of horses in the USA. Vet Rec 132, 241-244.
82. Katz, J. B., Alstad, D., Jenny, A. L., Carbone, K. M., Rubin, S. A. & Waltrip, R. W., II (1998). Clinical, serologic, and histopathologic characterization of experimental Borna disease in ponies. J Vet Diagn Invest 10, 338-343.
83. Kinnunen, P. M. (2011). Detection, epidemiology and host spectrum of cowpox and Borna disease virus infections. Doctoral dissertation, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
84. Kinnunen, P. M., Billich, C., Ek-Kommonen, C., Henttonen, H., Kallio, R. K., Niemimaa, J., Palva, A., Staeheli, P., Vaheri, A. & Vapalahti, O. (2007). Serological evidence for Borna disease virus infection in humans, wild rodents and other vertebrates in Finland. J Clin Virol 38, 64-69.
85. Kinnunen, P. M., Inkeroinen, H., Ilander, M., Kallio, E. R., Heikkila, H. P., Koskela, E., Mappes, T., Palva, A., Vaheri, A. & other authors (2011). Intracerebral Borna disease virus infection of bank voles leading to peripheral spread and reverse transcription of viral RNA. PLoS ONE 6, e23622.
86. Kistler, A. L., Gancz, A., Clubb, S., Skewes-Cox, P., Fischer, K., Sorber, K., Chiu, C. Y., Lublin, A., Mechani, S. & other authors (2008). Recovery of divergent avian bornaviruses from cases of proventricular dilatation disease: identification of a candidate etiologic agent. Virol J 5, 88.
87. Kohno, T., Goto, T., Takasaki, T., Morita, C., Nakaya, T., Ikuta, K., Kurane, I., Sano, K. & Nakai, M. (1999). Fine structure and morphogenesis of Borna disease virus. J Virol 73, 760-766.
88. Kolodziejek, J., Durrwald, R., Herzog, S., Ehrensperger, F., Lussy, H. & Nowotny, N. (2005). Genetic clustering of Borna disease virus natural animal isolates, laboratory and vaccine strains strongly reflects their regional geographical origin. J Gen Virol 86, 385-398.
89. Lebelt, J. & Hagenau, K. (1996). Die Verteilung des Bornavirus in naturlich infizierten Tieren mit klinischer Erkrankung. Berl Munch Tierarztl Wochenschr 109, 178-183 (in German).
90. Lee, B. J., Watanabe, M., Kamitani, W., Baba, S., Yamashita, M., Kobayashi, T., Tomonaga, K. & Ikuta, K. (2003). Age-and host-dependent control of Borna disease virus spread in the developing brains of gerbils and rats. Microbes Infect 5, 1195-1204.
91. Lee, B. J., Matsunaga, H., Ikuta, K. & Tomonaga, K. (2008). Ribavirin inhibits Borna disease virus proliferation and fatal neurological diseases in neonatally infected gerbils. Antiviral Res 80, 380-384.
92. Lieb, K., Hallensleben, W., Czygan, M., Stitz, L., Staeheli, P. &The Bornavirus Study Group (1997). No Borna disease virus-specific RNA detected in blood from psychiatric patients in different regions of Germany. Lancet 350, 1002.
93. Lipkin, W. I. & Briese, T. (2007). Bornaviridae. In Fields Virology, 5th edn, pp. 1829-1851. Edited by D. M. Knipe & P. M. Howley. Philadelphia, PA: Lippincott Williams & Wilkins.
94. Lipkin, W. I., Briese, T. & Hornig, M. (2011). Borna disease virus-fact and fantasy. Virus Res 162, 162-172.
95. Ludwig, H. & Bode, L. (2000). Borna disease virus: new aspects on infection, disease, diagnosis and epidemiology. Rev Sci Tech 19, 259-288.
96. Ludwig, H., Bode, L. & Gosztonyi, G. (1988). Borna disease: a persistent virus infection of the central nervous system. Prog Med Virol 35, 107-151.
97. Lundgren, A. L., Czech, G., Bode, L. & Ludwig, H. (1993). Natural Borna disease in domestic animals others than horses and sheep. Zentralbl Veterinarmed B 40, 298-303.
98. Lundgren, A.-L., Johannisson, A., Zimmermann, W., Bode, L., Rozell, B., Muluneh, A., Lindberg, R. & Ludwig, H. (1997). Neurological disease and encephalitis in cats experimentally infected with Borna disease virus. Acta Neuropathol 93, 391-401.
99. Malkinson, M., Weisman, Y., Perl, S. & Ashash, E. (1995). A Borna-like disease of ostriches in Israel. Curr Top Microbiol Immunol 190, 31-38.
100. Mashimo, T., Lucas, M., Simon-Chazottes, D., Frenkiel, M. P., Montagutelli, X., Ceccaldi, P. E., Deubel, V., Guenet, J. L. & Despres, P. (2002). A nonsense mutation in the gene encoding 29-59-oligoadenylate synthetase/L1 isoform is associated with West Nile virus susceptibility in laboratory mice. Proc Natl Acad Sci U S A 99, 11311-11316.
101. Matsumoto, Y., Hayashi, Y., Omori, H., Honda, T., Daito, T., Horie, M., Ikuta, K., Fujino, K., Nakamura, S. & other authors (2012). Bornavirus closely associates and segregates with host chromosomes to ensure persistent intranuclear infection. Cell Host Microbe 11, 492-503.
102. Mayr, A. & Danner, K. (1974). Persistent infections caused by Borna virus. Infection 2, 64-69.
103. Meerburg, B. G., Singleton, G. R. & Kijlstra, A. (2009). Rodent-borne diseases and their risks for public health. Crit Rev Microbiol 35, 221-270.
104. Metzler, A., Frei, U. & Danner, K. (1976). Virologically confirmed outbreak of Borna's disease in a Swiss herd of sheep. Schweiz Arch Tierheilkd 118, 483-492 (in German).
105. Metzler, A., Ehrensperger, F. & Wyler, R. (1978). Natural Borna virus infection in rabbits. Zentralbl Veterinarmed B 25, 161-164 (in German).
106. Metzler, A., Ehrensperger, F. & Danner, K. (1979). Bornavirus-infektion bei Schafen: Verlaufsuntersuchungen nach spontaner Infektion, unter besonderer Berucksichtigung der Antikörperkinetik im Serum und Liquor Cerebrospinalis. Schweiz Arch Tierheilkd 121, 37-48 (in German).
107. Mizutani, T., Kariwa, H., Yoshimatsu, K., Ogino, M., Morii, Y., Inagaki, H., Arikawa, J. & Takashima, I. (1999). A serosurvey of Borna disease virus infection in wild rats by a capture ELISA. J Vet Med Sci 61, 113-117.
108. Morales, J. A., Herzog, S., Kompter, C., Frese, K. & Rott, R. (1988). Axonal transport of Borna disease virus along olfactory pathways in spontaneously and experimentally infected rats. Med Microbiol Immunol (Berl) 177, 51-68.
109. Narayan, O., Herzog, S., Frese, K., Scheefers, H. & Rott, R. (1983). Pathogenesis of Borna disease in rats: immune-mediated viral ophthalmoencephalopathy causing blindness and behavioral abnor-malities. J Infect Dis 148, 305-315.
110. Nedorost, N., Maderner, C. A., Kolodziejek, J., Lussy, H., Nowotny, N. & Weissenbock, H. (2012). Identification of mixed infections with different genotypes of avian bornaviruses in psittacine birds with proventricular dilatation disease. Avian Dis 56, 414-417.
111. Nowotny, N., Kolodziejek, J., Jehle, C. O., Suchy, A., Staeheli, P. & Schwemmle, M. (2000). Isolation and characterization of a new subtype of Borna disease virus. J Virol 74, 5655-5658.
112. Okamoto, M., Taniyama, H., Hagiwara, K., Kirisawa, R., Furuoka, H., Kamitani, W. & Ikuta, K. (2002a). Borna disease in a heifer in Japan. Vet Rec 150, 16-18.
113. Okamoto, M., Kagawa, Y., Kamitani, W., Hagiwara, K., Kirisawa, R., Iwai, H., Ikuta, K. & Taniyama, H. (2002b). Borna disease in a dog in Japan. J Comp Pathol 126, 312-317.
114. Okamoto, M., Hagiwara, K., Kamitani, W., Sako, T., Hirayama, K., Kirisawa, R., Tsuji, M., Ishihara, C., Iwai, H. & other authors (2003). Experimental vertical transmission of Borna disease virus in the mouse. Arch Virol 148, 1557-1568.
115. Patti, A. M., Vulcano, A., Candelori, E., Donfrancesco, R., Ludwig, H. & Bode, L. (2008). Borna disease virus infection in Italian children. A potential risk for the developing brain? APMIS Suppl 116, 70-73.
116. Payne, S., Covaleda, L., Jianhua, G., Swafford, S., Baroch, J., Ferro, P. J., Lupiani, B., Heatley, J. & Tizard, I. (2011). Detection and characterization of a distinct bornavirus lineage from healthy Canada geese (Branta canadensis). J Virol 85, 12053-12056.
117. Planz, O., Pleschka, S. & Ludwig, S. (2001). MEK-specific inhibitor U0126 blocks spread of Borna disease virus in cultured cells. J Virol 75, 4871-4877.
118. Planz, O., Bechter, K. A. & Schwemmle, M. (2002). Human Borna disease infection. In Borna Disease Virus and its Role in Neurobehavioral Disease, pp. 179-225. Edited by K. M. Carbone. Washington, DC: American Society for Microbiology.
119. Planz, O., Rziha, H. J. & Stitz, L. (2003). Genetic relationship of Borna disease virus isolates. Virus Genes 26, 25-30.
120. Pletnikov, M. V., Gonzalez-Dunia, D. & Stitz, L. (2002). Experimental infection: pathogenesis of neurobehavioral disease. In Borna Disease Virus and its Role in Neurobehavioral Disease, pp. 125-178. Edited by K. M. Carbone. Washington, DC: American Society for Microbiology.
121. Poenisch, M., Burger, N., Staeheli, P., Bauer, G. & Schneider, U. (2009). Protein X of Borna disease virus inhibits apoptosis and promotes viral persistence in the central nervous systems of newborn-infected rats. J Virol 83, 4297-4307.
122. Prat, C. M., Schmid, S., Farrugia, F., Cenac, N., Le Masson, G., Schwemmle, M. & Gonzalez-Dunia, D. (2009). Mutation of the protein kinase C site in Borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity. PLoS Pathog 5, e1000425.
123. Priestnall, S. L., Schoniger, S., Ivens, P. A., Eickmann, M., Brachthauser, L., Kehr, K., Tupper, C., Piercy, R. J., Menzies-Gow, N. J. & Herden, C. (2011). Borna disease virus infection of a horse in Great Britain. Vet Rec 168, 380.
124. Puorger, M. E., Hilbe, M., Muller, J. P., Kolodziejek, J., Nowotny, N., Zlinszky, K. & Ehrensperger, F. (2010). Distribution of Borna disease virus antigen and RNA in tissues of naturally infected bicolored white-toothed shrews, Crocidura leucodon, supporting their role as reservoir host species. Vet Pathol 47, 236-244.
125. Qian, J., Zhai, A., Kao, W., Li, Y., Song, W., Fu, Y., Chen, X., Zhang, Q., Wu, J. & other authors (2010). Modulation of miR-122 on persistently Borna disease virus infected human oligodendroglial cells. Antiviral Res 87, 249-256.
126. Richt, J. A., Herzog, S., Haberzettl, K. & Rott, R. (1993). Demonstration of Borna disease virus-specific RNA in secretions of naturally infected horses by the polymerase chain reaction. Med Microbiol Immunol (Berl) 182, 293-304.
127. Richt, J. A., Grabner, A. & Herzog, S. (2000). Borna disease in horses. Vet Clin North Am Equine Pract 16, 579-595, xi.
128. Ritter, M., Bouloy, M., Vialat, P., Janzen, C., Haller, O. & Frese, M. (2000). Resistance to Rift Valley fever virus in Rattus norvegicus: genetic variability within certain 'inbred' strains. J Gen Virol 81, 2683-2688.
129. Rott, R. & Becht, H. (1995). Natural and experimental Borna disease in animals. Curr Top Microbiol Immunol 190, 17-30.
130. Rott, R., Herzog, S., Fleischer, B., Winokur, A., Amsterdam, J., Dyson, W. & Koprowski, H. (1985). Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders. Science 228, 755-756.
131. Rubin, S. A., Waltrip, R. W., II, Bautista, J. R. & Carbone, K. M. (1993). Borna disease virus in mice: host-specific differences in disease expression. J Virol 67, 548-552.
132. Sauder, C. & Staeheli, P. (2003). Rat model of Borna disease virus transmission: epidemiological implications. J Virol 77, 12886-12890.
133. Sauder, C., Mizutani, T. & Yamaguchi, K. (2002). Laboratory diagnosis. In Borna Disease Virus and its Role in Neurobehavioral Disease, pp. 45-85. Edited by K. M. Carbone. Washington, DC: American Society for Microbiology.
134. k-restricted cytotoxic T-cell epitope in the Borna disease virus nucleoprotein. J Virol 75, 8579-8588.
135. Schindler, A. R. (2004). Real-time RT-PCR for tracing and quantification of Borna disease virus RNA in diseased hosts compared to experimentally inoculated ticks. Inaugural dissertation, Vetsuisse-Fakultät, Universität Zurich, Zurich, Switzerland.
136. Schindler, A. R., Vogtlin, A., Hilbe, M., Puorger, M., Zlinszky, K., Ackermann, M. & Ehrensperger, F. (2007). Reverse transcription real-time PCR assays for detection and quantification of Borna disease virus in diseased hosts. Mol Cell Probes 21, 47-55.
137. Schneider, P. A., Briese, T., Zimmermann, W., Ludwig, H. & Lipkin, W. I. (1994). Sequence conservation in field and experimental isolates of Borna disease virus. J Virol 68, 63-68.
138. Schneider, U., Schwemmle, M. & Staeheli, P. (2005). Genome trimming: a unique strategy for replication control employed by Borna disease virus. Proc Natl Acad Sci U S A 102, 3441-3446.
139. Schwemmle, M., Jehle, C., Formella, S. & Staeheli, P. (1999). Sequence similarities between human bornavirus isolates and laboratory strains question human origin. Lancet 354, 1973-1974.
140. Shenbrot, G., Hutterer, R., Amori, G., Kryštufek, B., Yigit, N., Mitsain, G., Munõz, L. J. P. (2006). Crocidura leucodon. IUCN Red List of Threatened Species, version 2010.4, 5-0.
141. Solbrig, M. V. (2010). Animal models of CNS viral disease: examples from Borna disease virus models. Interdiscip Perspect Infect Dis 2010, 709791.
142. Solbrig, M. V., Schlaberg, R., Briese, T., Horscroft, N. & Lipkin, W. I. (2002). Neuroprotection and reduced proliferation of microglia in ribavirin-treated bornavirus-infected rats. Antimicrob Agents Chemother 46, 2287-2291.
143. Sprankel, H., Richarz, K., Ludwig, H. & Rott, R. (1978). Behavior alterations in tree shrews (Tupaia glis, Diard 1820) induced by Borna disease virus. Med Microbiol Immunol (Berl) 165, 1-18.
144. Staeheli, P., Sauder, C., Hausmann, J., Ehrensperger, F. & Schwemmle, M. (2000). Epidemiology of Borna disease virus. J Gen Virol 81, 2123-2135.
145. Stitz, L., Krey, H. & Ludwig, H. (1980). Borna disease in rhesus monkeys as a models for uveo-cerebral symptoms. J Med Virol 6, 333-340.
146. Stitz, L., Noske, K., Planz, O., Furrer, E., Lipkin, W. I. & Bilzer, T. (1998). A functional role for neutralizing antibodies in Borna disease: influence on virus tropism outside the central nervous system. J Virol 72, 8884-8892.
147. Stitz, L., Bilzer, T. & Planz, O. (2002). The immunopathogenesis of Borna disease virus infection. Front Biosci 7, d541-d555.
148. Tomonaga, K., Kobayashi, T. & Ikuta, K. (2002). Molecular and cellular biology of Borna disease virus infection. Microbes Infect 4, 491-500.
149. Tonteri, E., Jaaskelainen, A. E., Tikkakoski, T., Voutilainen, L., Niemimaa, J., Henttonen, H., Vaheri, A. & Vapalahti, O. (2011). Tick-borne encephalitis virus in wild rodents in winter, Finland, 2008-2009. Emerg Infect Dis 17, 72-75.
150. Vahlenkamp, T. W., Enbergs, H. K. & Muller, H. (2000). Experimental and natural Borna disease virus infections: presence of viral RNA in cells of the peripheral blood. Vet Microbiol 76, 229-244.
151. Vahlenkamp, T. W., Konrath, A., Weber, M. & Muller, H. (2002). Persistence of Borna disease virus in naturally infected sheep. J Virol 76, 9735-9743.
152. Volmer, R., Bajramovic, J. J., Schneider, U., Ufano, S., Pochet, S. & Gonzalez-Dunia, D. (2005). Mechanism of the antiviral action of 1-b-D-arabinofuranosylcytosine on Borna disease virus. J Virol 79, 4514-4518.
153. von Sind, J. B. (1770). Der im Feld und auf der Reise geschwind heilende Pferdearzt, welcher einen gründlichen Unterricht von den gewöhnlichsten Krankheiten der Pferde im Feld und auf der Reise wie auch einen auserlesenen Vorrath der nützlichsten und durch die Erfahrung bewährtesten Heilungsmitteln eröffnet. Frankfurt and Leipzig, Germany: Heinrich Ludwig Bönner (in German)
154. Walker, M. P., Jordan, I., Briese, T., Fischer, N. & Lipkin, W. I. (2000). Expression and characterization of the Borna disease virus polymerase. J Virol 74, 4425-4428.
155. Watanabe, M., Zhong, Q., Kobayashi, T., Kamitani, W., Tomonaga, K. & Ikuta, K. (2000). Molecular ratio between Borna disease viral-p40 and -p24 proteins in infected cells determined by quantitative antigen capture ELISA. Microbiol Immunol 44, 765-772.
156. Watanabe, M., Lee, B. J., Kamitani, W., Kobayashi, T., Taniyama, H., Tomonaga, K. & Ikuta, K. (2001). Neurological diseases and viral dynamics in the brains of neonatally Borna disease virus-infected gerbils. Virology 282, 65-76.
157. Weissenbock, H., Nowotny, N., Caplazi, P., Kolodziejek, J. & Ehrensperger, F. (1998). Borna disease in a dog with lethal meningoencephalitis. J Clin Microbiol 36, 2127-2130.
158. Weissenbock, H., Hornig, M., Hickey, W. F. & Lipkin, W. I. (2000). Microglial activation and neuronal apoptosis in bornavirus infected neonatal Lewis rats. Brain Pathol 10, 260-272.
159. Weissenbock, H., Bilzer, T., Ehrensperger, F., Gosztonyi, G., Herden, C., Staehli, P., Hausmann, J. & Pagenstecher, A. (2002). Equine Borna disease in Japan. Vet Rec 151, 712.
160. Wensman, J. J., Thorén, P., Hakhverdyan, M., Belák, S. & Berg, M. (2007). Development of a real-time RT-PCR assay for improved detection of Borna disease virus. J Virol Methods 143, 1-10.
161. Wensman, J. J., Berg, M. & Berg, A. L. (2008). Experiences of Borna disease virus infection in Sweden. APMIS Suppl 116, 46-49.
162. Wensman, J. J., Ilback, C., Hjertstrom, E., Blomstrom, A. L., Gustavsson, M. H., Jaderlund, K. H., Strom-Holst, B., Belák, S., Berg, A. L. & Berg, M. (2011). Expression of interferon gamma in the brain of cats with natural Borna disease virus infection. Vet Immunol Immunopathol 141, 162-167.
163. Wolff, T., Heins, G., Pauli, G., Burger, R. & Kurth, R. (2006). Failure to detect Borna disease virus antigen and RNA in human blood. J Clin Virol 36, 309-311.
164. Zwick, W. & Seifried, O. (1924). Untersuchungen ueber die in Hessen gehaeuft auftretende seuchenhafte Gehirn-und Rueckenmark-sentzuendung (Bornasche Krankheit) bei Pferden. Berl Tieraerztl Wochenscrift 40, 465-471 (in German).
165. Zwick, W., Seifried, O. & Witte, J. (1927). Experimentelle Untersuchungen uber die seuchenhafte Gehirn-und Ruckenmarksentzundung der Pferde (Bornasche Krankheit). Z Infkrankh Haustiere 30, 42-136 (in German).