The application of radiation therapy to the pediatric preclinical testing program (PPTP): Results of a pilot study in rhabdomyosarcoma

Pediatric Blood and Cancer

Volumn 60, Issue 3, 2013, Pages 377-382

  Kaplon, Rita ^a   Hadziahmetovic, Mersiha ^a   Sommerfeld, Jim ^a   Bondra, Kathryn ^a   Lu, Lanchun ^a   Leasure, Justin ^a   Nguyen, Phuong ^a   McHugh, Kelsey ^a   Li, Ning ^a   Chronowski, Christopher ^a   Sebastian, Nikhil ^a   Singh, Mamta ^a   Kurmasheva, Raushan ^b   Houghton, Peter ^b   Pelloski, Christopher E ^a,b  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^b NATIONWIDE CHILDREN S HOSPITAL   (United States)

Author keywords

Fractionated radiotherapy; PPTP; Preclinical testing; Rhabdomyosarcoma; Xenograft

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER RADIOTHERAPY; CONTROLLED STUDY; EMBRYONAL RHABDOMYOSARCOMA; EVENT FREE SURVIVAL; FEASIBILITY STUDY; FEMALE; MOUSE; NONHUMAN; PEDIATRIC PRECLINICAL TESTING PROGRAM; PILOT STUDY; PRIORITY JOURNAL; RADIATION DOSE; RADIOSENSITIVITY; RHABDOMYOSARCOMA; SURVIVAL TIME; TREATMENT FAILURE; TREATMENT OUTCOME; TREATMENT RESPONSE; TUMOR GROWTH; TUMOR XENOGRAFT;

ANIMALS; DOSE FRACTIONATION; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICE; PILOT PROJECTS; RADIOTHERAPY; RHABDOMYOSARCOMA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84872447742     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.24210     Document Type: Article

References (28)

1. Houghton PJ, Morton CL, Tucker C, et al. The pediatric preclinical testing program: Description of models and early testing results. Pediatr Blood Cancer 2007; 49: 928-940.
2. Houghton PJ, Morton CL, Kolb EA, et al. Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program. Pediatr Blood Cancer 2008; 50: 799-805.
3. Houghton PJ, Morton CL, Kolb EA, et al. Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program. Pediatr Blood Cancer 2008; 50: 37-45.
4. Kolb EA, Gorlick R, Houghton PJ, et al. Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program. Pediatr Blood Cancer 2008; 50: 1190-1197.
5. Yu L, Baxter PA, Voicu H, et al. A clinically relevant orthotopic xenograft model of ependymoma that maintains the genomic signature of the primary tumor and preserves cancer stem cells in vivo. Neuro Oncol 2010; 12: 580-594.
6. Shu Q, Wong KK, Su JM, et al. Direct orthotopic transplantation of fresh surgical specimen preserves CD133+ tumor cells in clinically relevant mouse models of medulloblastoma and glioma. Stem Cells 2008; 26: 1414-1424.
7. Hoffman RM. In vitro sensitivity assays in cancer: A review, analysis, and prognosis. J Clin Lab Anal 1991; 5: 133-143.
8. Carney DN, Winkler CF. In vitro assays of chemotherapeutic sensitivity. Important Adv Oncol 1985; 78-103.
9. Yung WK. In vitro chemosensitivity testing and its clinical application in human gliomas. Neurosurg Rev 1989; 12: 197-203.
10. Neale G, Su X, Morton CL, et al. Molecular characterization of the pediatric preclinical testing panel. Clin Cancer Res 2008; 14: 4572-4583.
11. Whiteford CC, Bilke S, Greer BT, et al. Credentialing preclinical pediatric xenograft models using gene expression and tissue microarray analysis. Cancer Res 2007; 67: 32-40.
12. Deschavanne PJ, Fertil B. A review of human cell radiosensitivity in vitro. Int J Radiat Oncol Biol Phys 1996; 34: 251-266.
13. Ross DT, Perou CM. A comparison of gene expression signatures from breast tumors and breast tissue derived cell lines. Dis Markers 2001; 17: 99-109.
14. Lee J, Kotliarova S, Kotliarov Y, et al. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 2006; 9: 391-403.
15. Tsai MH, Cook JA, Chandramouli GV, et al. Gene expression profiling of breast, prostate, and glioma cells following single versus fractionated doses of radiation. Cancer Res 2007; 67: 3845-3852.
16. Hamilton J, Higgins G, Bernhard EJ. Conventional radiotherapy or hypofractionation? A study of molecular changes resulting from different radiation fractionation schemes. Cancer Biol Ther 2009; 8: 774-776.
17. Zelefsky MJ, Greco C, Motzer R, et al. Tumor control outcomes after hypofractionated and single-dose stereotactic image-guided intensity-modulated radiotherapy for extracranial metastases from renal cell carcinoma. Int J Radiat Oncol Biol Phys 2011; 82: 1744-1748.
18. Blanquicett C, Saif MW, Buchsbaum DJ, et al. Antitumor efficacy of capecitabine and celecoxib in irradiated and lead-shielded, contralateral human BxPC-3 pancreatic cancer xenografts: Clinical implications of abscopal effects. Clin Cancer Res 2005; 11: 8773-8781.
19. Jarnagin WR, Zager JS, Hezel M, et al. Treatment of cholangiocarcinoma with oncolytic herpes simplex virus combined with external beam radiation therapy. Cancer Gene Ther 2006; 13: 326-334.
20. Moyer JS, Li J, Wei S, et al. Intratumoral dendritic cells and chemoradiation for the treatment of murine squamous cell carcinoma. J Immunother 2008; 31: 885-895.
21. Sarkaria JN, Carlson BL, Schroeder MA, et al. Use of an orthotopic xenograft model for assessing the effect of epidermal growth factor receptor amplification on glioblastoma radiation response. Clin Cancer Res 2006; 12: 2264-2271.
22. Thames HD, Suit HD. Tumor radioresponsiveness versus fractionation sensitivity. Int J Radiat Oncol Biol Phys 1986; 12: 687-691.
23. Brenner DJ. Dose, volume, and tumor-control predictions in radiotherapy. Int J Radiat Oncol Biol Phys 1993; 26: 171-179.
24. Ishida Y, Sakamoto N, Kamibeppu K, et al. Late effects and quality of life of childhood cancer survivors: Part 2. Impact of radiotherapy. Int J Hematol 2010; 92: 95-104.
25. Armstrong GT, Stovall M, Robison LL. Long-term effects of radiation exposure among adult survivors of childhood cancer: Results from the childhood cancer survivor study. Radiat Res 2010; 174: 840-850.
26. Skowronska-Gardas A. A literature review of the recent radiotherapy clinical trials in pediatric brain tumors. Rev Recent Clin Trials 2009; 4: 42-55.
27. Ognjanovic S, Linabery AM, Charbonneau B, et al. Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975-2005. Cancer 2009; 115: 4218-4226.
28. Crist WM, Anderson JR, Meza JL, et al. Intergroup rhabdomyosarcoma study-IV: Results for patients with nonmetastatic disease. J Clin Oncol 2001; 19: 3091-3102.