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Volumn 54, Issue 2, 2013, Pages 310-324

Atypical antipsychotics alter cholesterol and fatty acid metabolism in vitro

Author keywords

Apolipoprotein B secretion; Cholesterol biosynthesis; Intracellular lipid traffic; Lipid synthesis; Second generation antipsychotic drugs

Indexed keywords

APOLIPOPROTEIN B; CLOZAPINE; HALOPERIDOL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHOSPHOLIPID; RISPERIDONE; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRIACYLGLYCEROL; ZIPRASIDONE;

EID: 84872440215     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M026948     Document Type: Article
Times cited : (89)

References (58)
  • 1
    • 12344326514 scopus 로고    scopus 로고
    • Treatments for schizophrenia: A critical review of pharmacology and mechanisms of action of antipsychotic drugs
    • DOI 10.1038/sj.mp.4001556
    • Miyamoto, S., G. E. Duncan, C. E. Marx, and J. A. Lieberman. 2005. Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs. Mol. Psychiatry. 10: 79-104. (Pubitemid 40139590)
    • (2005) Molecular Psychiatry , vol.10 , Issue.1 , pp. 79-104
    • Miyamoto, S.1    Duncan, G.E.2    Marx, C.E.3    Lieberman, J.A.4
  • 5
    • 42949118314 scopus 로고    scopus 로고
    • Acute and long-term adverse effects of antipsychotics
    • Correll, C. U. 2007. Acute and long-term adverse effects of antipsychotics. CNS Spectr. 12: 10-14.
    • (2007) CNS Spectr. , vol.12 , pp. 10-14
    • Correll, C.U.1
  • 6
    • 34248562315 scopus 로고    scopus 로고
    • Antipsychotic medications: Metabolic and cardiovascular risk
    • Newcomer, J. W. 2007. Antipsychotic medications: metabolic and cardiovascular risk. J. Clin. Psychiatry. 68 (Suppl 4) : 8-13. (Pubitemid 46762118)
    • (2007) Journal of Clinical Psychiatry , vol.68 , Issue.SUPPL. 4 , pp. 8-13
    • Newcomer, J.W.1
  • 8
    • 3142769794 scopus 로고    scopus 로고
    • The effects of antipsychotic therapy on serum lipids: A comprehensive review
    • DOI 10.1016/j.schres.2004.01.014, PII S0920996404000441
    • Meyer, J. M., and C. E. Koro. 2004. The effects of antipsychotic therapy on serum lipids: a comprehensive review. Schizophr. Res. 70: 1-17. (Pubitemid 38916622)
    • (2004) Schizophrenia Research , vol.70 , Issue.1 , pp. 1-17
    • Meyer, J.M.1    Koro, C.E.2
  • 10
    • 70350738289 scopus 로고    scopus 로고
    • Cardiometabolic risk of second-generation antipsychotic medications during first-time use in children and adolescents
    • Correll, C. U., P. Manu, V. Olshanskiy, B. Napolitano, J. M. Kane, and A. K. Malhotra. 2009. Cardiometabolic risk of second-generation antipsychotic medications during first-time use in children and adolescents. JAMA. 302: 1765-1773.
    • (2009) JAMA , vol.302 , pp. 1765-1773
    • Correll, C.U.1    Manu, P.2    Olshanskiy, V.3    Napolitano, B.4    Kane, J.M.5    Malhotra, A.K.6
  • 11
    • 77954141786 scopus 로고    scopus 로고
    • Effects of olanzapine and risperidone on lipid metabolism in chronic schizophrenic patients with long-term antipsychotic treatment: A randomized five month study
    • Smith, R. C., J. P. Lindenmayer, Q. Hu, E. Kelly, T. F. Viviano, J. Cornwell, S. Vaidhyanathaswamy, S. Marcovina, and J. M. Davis. 2010. Effects of olanzapine and risperidone on lipid metabolism in chronic schizophrenic patients with long-term antipsychotic treatment: a randomized five month study. Schizophr. Res. 120: 204-209.
    • (2010) Schizophr. Res. , vol.120 , pp. 204-209
    • Smith, R.C.1    Lindenmayer, J.P.2    Hu, Q.3    Kelly, E.4    Viviano, T.F.5    Cornwell, J.6    Vaidhyanathaswamy, S.7    Marcovina, S.8    Davis, J.M.9
  • 14
    • 67649516618 scopus 로고
    • The effect of a substituted fluorobutyrophenone(haloperidol) on the metabolism of sterols in rat skin
    • Summerly, R., and H. J. Yardley. 1965. The effect of a substituted fluorobutyrophenone(haloperidol) on the metabolism of sterols in rat skin. Biochem. J. 96: 30.
    • (1965) Biochem. J. , vol.96 , pp. 30
    • Summerly, R.1    Yardley, H.J.2
  • 17
    • 77957124138 scopus 로고    scopus 로고
    • Antipsychotic drugs upregulate lipogenic gene expression by disrupting intracellular trafficking of lipoprotein-derived cholesterol
    • Kristiana, I., L. J. Sharpe, V. S. Catts, L. H. Lutze-Mann, and A. J. Brown. 2010. Antipsychotic drugs upregulate lipogenic gene expression by disrupting intracellular trafficking of lipoprotein-derived cholesterol. Pharmacogenomics J. 10: 396-407.
    • (2010) Pharmacogenomics J , vol.10 , pp. 396-407
    • Kristiana, I.1    Sharpe, L.J.2    Catts, V.S.3    Lutze-Mann, L.H.4    Brown, A.J.5
  • 20
    • 0032563304 scopus 로고    scopus 로고
    • Circulation of cholesterol between lysosomes and the plasma membrane
    • DOI 10.1074/jbc.273.30.18915
    • Lange, Y., J. Ye, and T. L. Steck. 1998. Circulation of cholesterol between lysosomes and the plasma membrane. J. Biol. Chem. 273: 18915-18922. (Pubitemid 28366279)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.30 , pp. 18915-18922
    • Lange, Y.1    Ye, J.2    Steck, T.L.3
  • 22
    • 5444230078 scopus 로고    scopus 로고
    • Synergistic upregulation of low-density lipoprotein receptor activity by tamoxifen and lovastatin
    • DOI 10.1016/j.cardiores.2004.06.024, PII S0008636304002810
    • Suárez, Y., C. Fernández, D. Gómez-Coronado, A. J. Ferruelo, A. Dávalos, J. Martínez-Botas, and M. A. Lasunción. 2004. Synergistic upregulation of low-density lipoprotein receptor activity by tamoxifen and lovastatin. Cardiovasc. Res. 64: 346-355. (Pubitemid 39361697)
    • (2004) Cardiovascular Research , vol.64 , Issue.2 , pp. 346-355
    • Suarez, Y.1    Fernandez, C.2    Gomez-Coronado, D.3    Ferruelo, A.J.4    Davalos, A.5    Martinez-Botas, J.6    Lasuncion, M.A.7
  • 24
    • 33750980390 scopus 로고    scopus 로고
    • Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: Marked differences between various antipsychotic drugs
    • Ferno, J., S. Skrede, A. O. Vik-Mo, B. Havik, and V. M. Steen. 2006. Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs. BMC Neurosci. 7: 69.
    • (2006) BMC Neurosci. , vol.7 , pp. 69
    • Ferno, J.1    Skrede, S.2    Vik-Mo, A.O.3    Havik, B.4    Steen, V.M.5
  • 25
    • 60249089094 scopus 로고    scopus 로고
    • Common effect of antipsychotics on the biosynthesis and regulation of fatty acids and cholesterol supports a key role of lipid homeostasis in schizophrenia
    • Polymeropoulos, M. H., L. Licamele, S. Volpi, K. Mack, S. N. Mitkus, E. D. Carstea, L. Getoor, A. Thompson, and C. Lavedan. 2009. Common effect of antipsychotics on the biosynthesis and regulation of fatty acids and cholesterol supports a key role of lipid homeostasis in schizophrenia. Schizophr. Res. 108: 134-142.
    • (2009) Schizophr. Res. , vol.108 , pp. 134-142
    • Polymeropoulos, M.H.1    Licamele, L.2    Volpi, S.3    Mack, K.4    Mitkus, S.N.5    Carstea, E.D.6    Getoor, L.7    Thompson, A.8    Lavedan, C.9
  • 27
    • 0031957128 scopus 로고    scopus 로고
    • Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL
    • Calvo, D., D. Gómez-Coronado, Y. Suárez, M. A. Lasunción, and M. A. Vega. 1998. Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL. J. Lipid Res. 39: 777-788. (Pubitemid 28163280)
    • (1998) Journal of Lipid Research , vol.39 , Issue.4 , pp. 777-788
    • Calvo, D.1    Gomez-Coronado, D.2    Suarez, Y.3    Lasuncion, M.A.4    Vega, M.A.5
  • 28
    • 27244433832 scopus 로고    scopus 로고
    • Effects of distal cholesterol biosynthesis inhibitors on cell proliferation and cell cycle progression
    • Fernández, C., M. Martín, D. Gómez-Coronado, and M. A. Lasunción. 2005. Effects of distal cholesterol biosynthesis inhibitors on cell proliferation and cell cycle progression. J. Lipid Res. 46: 920-929.
    • (2005) J. Lipid Res. , vol.46 , pp. 920-929
    • Fernández, C.1    Martín, M.2    Gómez-Coronado, D.3    Lasunción, M.A.4
  • 29
    • 34250874423 scopus 로고    scopus 로고
    • Fast and easy in vitro screening assay for cholesterol biosynthesis inhibitors in the post-squalene pathway
    • DOI 10.1016/j.steroids.2007.04.005, PII S0039128X07000736
    • Giera, M., F. Plossl, and F. Bracher. 2007. Fast and easy in vitro screening assay for cholesterol biosynthesis inhibitors in the post-squalene pathway. Steroids. 72: 633-642. (Pubitemid 46978408)
    • (2007) Steroids , vol.72 , Issue.8 , pp. 633-642
    • Giera, M.1    Plossl, F.2    Bracher, F.3
  • 30
    • 78650901479 scopus 로고    scopus 로고
    • Huh-7 or HepG2 cells: Which is the better model for studying human apo-lipoprotein-B100 assembly and secretion?
    • Meex, S. J., U. Andreo, J. D. Sparks, and E. A. Fisher. 2011. Huh-7 or HepG2 cells: which is the better model for studying human apo-lipoprotein-B100 assembly and secretion? J. Lipid Res. 52: 152-158.
    • (2011) J. Lipid Res. , vol.52 , pp. 152-158
    • Meex, S.J.1    Andreo, U.2    Sparks, J.D.3    Fisher, E.A.4
  • 31
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • DOI 10.1172/JCI200215593
    • Horton, J. D., J. L. Goldstein, and M. S. Brown. 2002. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109: 1125-1131. (Pubitemid 34496588)
    • (2002) Journal of Clinical Investigation , vol.109 , Issue.9 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 32
    • 9544223310 scopus 로고    scopus 로고
    • Emopamil-binding protein, a mammalian protein that binds a series of structurally diverse neuroprotective agents, exhibits delta8-delta7 sterol isomerase activity in yeast
    • DOI 10.1074/jbc.271.37.22434
    • Silve, S., P. H. Dupuy, C. Labit-Lebouteiller, M. Kaghad, P. Chalon, A. Rahier, M. Taton, J. Lupker, D. Shire, and G. Loison. 1996. Emopamil-binding protein, a mammalian protein that binds a series of structurally diverse neuroprotective agents, exhibits delta8-delta7 sterol isomerase activity in yeast. J. Biol. Chem. 271: 22434-22440. (Pubitemid 26304678)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.37 , pp. 22434-22440
    • Silve, S.1    Dupuy, P.H.2    Labit-Lebouteiller, C.3    Kaghad, M.4    Chalon, P.5    Rahier, A.6    Taton, M.7    Lupker, J.8    Shire, D.9    Loison, G.10
  • 34
    • 0025759087 scopus 로고
    • Lanosterol 14 alpha-demethylase (P45014DM): Effects of P45014DM inhibitors on sterol biosynthesis downstream of lanosterol
    • Tuck, S. F., H. Patel, E. Safi, and C. H. Robinson. 1991. Lanosterol 14 alpha-demethylase (P45014DM): effects of P45014DM inhibitors on sterol biosynthesis downstream of lanosterol. J. Lipid Res. 32: 893-902.
    • (1991) J. Lipid Res. , vol.32 , pp. 893-902
    • Tuck, S.F.1    Patel, H.2    Safi, E.3    Robinson, C.H.4
  • 35
    • 0029939653 scopus 로고    scopus 로고
    • Sterol biosynthesis: Strong inhibition of maize delta 5,7-sterol delta 7-reductase by novel 6-aza-B-homosteroids and other analogs of a presumptive carbocationic intermediate of the reduction reaction
    • Rahier, A., and M. Taton. 1996. Sterol biosynthesis: strong inhibition of maize delta 5,7-sterol delta 7-reductase by novel 6-aza-B-homosteroids and other analogs of a presumptive carbocationic intermediate of the reduction reaction. Biochemistry. 35: 7069-7076.
    • (1996) Biochemistry , vol.35 , pp. 7069-7076
    • Rahier, A.1    Taton, M.2
  • 36
    • 79958137952 scopus 로고    scopus 로고
    • The interaction of antipsychotic drugs with lipids and subsequent lipid reorganization investigated using biophysical methods
    • Alves, I., G. Staneva, C. Tessier, G. F. Salgado, and P. Nuss. 2011. The interaction of antipsychotic drugs with lipids and subsequent lipid reorganization investigated using biophysical methods. Biochim. Biophys. Acta. 1808: 2009-2018.
    • (2011) Biochim. Biophys. Acta. , vol.1808 , pp. 2009-2018
    • Alves, I.1    Staneva, G.2    Tessier, C.3    Salgado, G.F.4    Nuss, P.5
  • 37
    • 52049107832 scopus 로고    scopus 로고
    • Psychotropic drugs interfere with the tight coupling of polyphosphoinositide cycle metabolites in human platelets: A result of receptor-independent drug intercalation in the plasma membrane?
    • Oruch, R., E. Hodneland, I. F. Pryme, and H. Holmsen. 2008. Psychotropic drugs interfere with the tight coupling of polyphosphoinositide cycle metabolites in human platelets: a result of receptor-independent drug intercalation in the plasma membrane? Biochim. Biophys. Acta. 1778: 2165-2176.
    • (2008) Biochim. Biophys. Acta. , vol.1778 , pp. 2165-2176
    • Oruch, R.1    Hodneland, E.2    Pryme, I.F.3    Holmsen, H.4
  • 38
    • 77954563005 scopus 로고    scopus 로고
    • An intercalation mechanism as a mode of action exerted by psychotropic drugs: Results of altered phospholipid substrate availabilities in membranes?
    • Oruch, R., A. Lund, I. F. Pryme, and H. Holmsen. 2010. An intercalation mechanism as a mode of action exerted by psychotropic drugs: results of altered phospholipid substrate availabilities in membranes? J. Chem. Biol. 3: 67-88.
    • (2010) J. Chem. Biol. , vol.3 , pp. 67-88
    • Oruch, R.1    Lund, A.2    Pryme, I.F.3    Holmsen, H.4
  • 41
    • 60449111934 scopus 로고    scopus 로고
    • Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver
    • Ferno, J., A. O. Vik-Mo, G. Jassim, B. Havik, K. Berge, S. Skrede, O. A. Gudbrandsen, J. Waage, N. Lunder, S. Mork, et al. 2009. Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver. Psychopharmacology (Berl.). 203: 73-84.
    • (2009) Psychopharmacology (Berl.). , vol.203 , pp. 73-84
    • Ferno, J.1    Vik-Mo, A.O.2    Jassim, G.3    Havik, B.4    Berge, K.5    Skrede, S.6    Gudbrandsen, O.A.7    Waage, J.8    Lunder, N.9    Mork, S.10
  • 42
    • 19944366619 scopus 로고    scopus 로고
    • Regulation of plasma triglycerides in insulin resistance and diabetes
    • DOI 10.1016/j.arcmed.2005.01.005, PII S0188440905000068, Current Trends in Diabetes
    • Ginsberg, H. N., Y. L. Zhang, and A. Hernandez-Ono. 2005. Regulation of plasma triglycerides in insulin resistance and diabetes. Arch. Med. Res. 36: 232-240. (Pubitemid 40755136)
    • (2005) Archives of Medical Research , vol.36 , Issue.3 , pp. 232-240
    • Ginsberg, H.N.1    Zhang, Y.-L.2    Hernandez-Ono, A.3
  • 43
    • 70350719357 scopus 로고    scopus 로고
    • Psychotropic drugs up-regulate the expression of cholesterol transport proteins including ApoE in cultured human CNS- And liver cells
    • Vik-Mo, A. O., J. Ferno, S. Skrede, and V. M. Steen. 2009. Psychotropic drugs up-regulate the expression of cholesterol transport proteins including ApoE in cultured human CNS- and liver cells. BMC Pharmacol. 9: 10.
    • (2009) BMC Pharmacol. , vol.9 , pp. 10
    • Vik-Mo, A.O.1    Ferno, J.2    Skrede, S.3    Steen, V.M.4
  • 47
    • 79961231465 scopus 로고    scopus 로고
    • A double blind, placebo-controlled, randomized crossover study of the acute metabolic effects of olanzapine in healthy volunteers
    • Albaugh, V. L., R. Singareddy, D. Mauger, and C. J. Lynch. 2011. A double blind, placebo-controlled, randomized crossover study of the acute metabolic effects of olanzapine in healthy volunteers. PLoS ONE. 6: e22662.
    • (2011) PLoS ONE , vol.6
    • Albaugh, V.L.1    Singareddy, R.2    Mauger, D.3    Lynch, C.J.4
  • 48
    • 79952996037 scopus 로고    scopus 로고
    • Mechanisms of amine accumulation in, and egress from, lysosomes
    • Goldman, S. D., R. S. Funk, R. A. Rajewski, and J. P. Krise. 2009. Mechanisms of amine accumulation in, and egress from, lysosomes. Bioanalysis. 1: 1445-1459.
    • (2009) Bioanalysis , vol.1 , pp. 1445-1459
    • Goldman, S.D.1    Funk, R.S.2    Rajewski, R.A.3    Krise, J.P.4
  • 49
    • 0031047587 scopus 로고    scopus 로고
    • Contribution of lysosomal trapping to the total tissue uptake of psychotropic drugs
    • Daniel, W. A., and J. Wojcikowski. 1997. Contribution of lysosomal trapping to the total tissue uptake of psychotropic drugs. Pharmacol. Toxicol. 80: 62-68. (Pubitemid 27078228)
    • (1997) Pharmacology and Toxicology , vol.80 , Issue.2 , pp. 62-68
    • Daniel, W.A.1    Wojcikowski, J.2
  • 50
    • 0342614869 scopus 로고    scopus 로고
    • Lysosomal trapping as an important mechanism involved in the cellular distribution of perazine and in pharmacokinetic interaction with antidepressants
    • DOI 10.1016/S0924-977X(99)00034-6, PII S0924977X99000346
    • Daniel, W. A., and J. Wojcikowski. 1999. Lysosomal trapping as an important mechanism involved in the cellular distribution of perazine and in pharmacokinetic interaction with antidepressants. Eur. Neuropsychopharmacol. 9: 483-491. (Pubitemid 30089061)
    • (1999) European Neuropsychopharmacology , vol.9 , Issue.6 , pp. 483-491
    • Daniel, W.A.1    Wojcikowski, J.2
  • 51
    • 0024312609 scopus 로고
    • The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one
    • Liscum, L., and J. R. Faust. 1989. The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-beta-[2-(diethylamino)ethoxy] androst-5-en-17-one. J. Biol. Chem. 264: 11796-11806. (Pubitemid 19185347)
    • (1989) Journal of Biological Chemistry , vol.264 , Issue.20 , pp. 11796-11806
    • Liscum, L.1    Faust, J.R.2
  • 52
    • 0025283040 scopus 로고
    • Pharmacological inhibition of the intracellular transport of low-density lipoprotein-derived cholesterol in Chinese hamster ovary cells
    • DOI 10.1016/0005-2760(90)90201-8
    • Liscum, L. 1990. Pharmacological inhibition of the intracellular transport of low-density lipoprotein-derived cholesterol in Chinese hamster ovary cells. Biochim. Biophys. Acta. 1045: 40-48. (Pubitemid 20205782)
    • (1990) Biochimica et Biophysica Acta - Lipids and Lipid Metabolism , vol.1045 , Issue.1 , pp. 40-48
    • Liscum, L.1
  • 53
    • 0027972084 scopus 로고
    • Cholesterol homeostasis. Modulation by amphiphiles
    • Lange, Y., and T. L. Steck. 1994. Cholesterol homeostasis. Modulation by amphiphiles. J. Biol. Chem. 269: 29371-29374. (Pubitemid 24365077)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.47 , pp. 29371-29374
    • Lange, Y.1    Steck, T.L.2
  • 54
    • 0026739685 scopus 로고
    • Intracellular cholesterol transport
    • Liscum, L., and N. K. Dahl. 1992. Intracellular cholesterol transport. J. Lipid Res. 33: 1239-1254.
    • (1992) J. Lipid Res. , vol.33 , pp. 1239-1254
    • Liscum, L.1    Dahl, N.K.2
  • 55
    • 0029996993 scopus 로고    scopus 로고
    • Quantitative analysis of hydrophobic amine inhibition of intracellular cholesterol transport
    • Underwood, K. W., B. Andemariam, G. L. McWilliams, and L. Liscum. 1996. Quantitative analysis of hydrophobic amine inhibition of intracellular cholesterol transport. J. Lipid Res. 37: 1556-1568. (Pubitemid 26249985)
    • (1996) Journal of Lipid Research , vol.37 , Issue.7 , pp. 1556-1568
    • Underwood, K.W.1    Andemariam, B.2    McWilliams, G.L.3    Liscum, L.4
  • 56
    • 67349166918 scopus 로고    scopus 로고
    • Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes
    • Cenedella, R. J. 2009. Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes. Lipids. 44: 477-487.
    • (2009) Lipids. , vol.44 , pp. 477-487
    • Cenedella, R.J.1
  • 57
    • 84886639906 scopus 로고
    • In vitro inhibition of animal and higher plants 2,3-oxidosqualene-sterol cyclases by 2-aza-2,3-dihydrosqualene and derivatives, and by other ammonium-containing molecules
    • DOI 10.1016/0006-2952(85)90578-7
    • Duriatti, A., P. Bouvier-Nave, P. Benveniste, F. Schuber, L. Delprino, G. Balliano, and L. Cattel. 1985. In vitro inhibition of animal and higher plants 2,3-oxidosqualene-sterol cyclases by 2-aza-2,3-dihydrosqualene and derivatives, and by other ammonium-containing molecules. Biochem. Pharmacol. 34: 2765-2777. (Pubitemid 15041763)
    • (1985) Biochemical Pharmacology , vol.34 , Issue.15 , pp. 2765-2777
    • Duriatti, A.1    Bouvier-Nave, P.2    Benveniste, P.3
  • 58
    • 0030858044 scopus 로고    scopus 로고
    • Cholesterol biosynthesis from lanosterol: Development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase
    • Bae, S. H., and Y. K. Paik. 1997. Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. Biochem. J. 326: 609-616.
    • (1997) Biochem. J. , vol.326 , pp. 609-616
    • Bae, S.H.1    Paik, Y.K.2


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