Carbamate insecticide methomyl confers cytotoxicity through DNA damage induction

Food and Chemical Toxicology

Volumn 53, Issue , 2013, Pages 352-358

  Guanggang, Xiang ^a   Diqiu, Li ^a   Jianzhong, Yuan ^b   Jingmin, Guan ^b   Huifeng, Zhai ^c   Mingan, Shi ^b   Liming, Tao ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b INSTITUTE OF PLANT PHYSIOLOGY AND ECOLOGY   (China)

^c YANGZHOU UNIVERSITY   (China)

Author keywords

H2AX foci; Alkaline comet assay; Apoptosis; DNA damage; DNA fragmentation; Methomyl

Indexed keywords

GAMMA HISTONE H2AX; HISTONE H2AX; METHOMYL; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRAIN HEK293; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA DETERMINATION; DNA FRAGMENTATION; DOUBLE STRANDED DNA BREAK; DROSOPHILA; EMBRYO; GENOTOXICITY; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INSECT CELL; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS;

ANIMALS; APOPTOSIS; CARBAMATES; CELL LINE; CELL SURVIVAL; COMET ASSAY; DNA BREAKS, SINGLE-STRANDED; DNA DAMAGE; DNA FRAGMENTATION; DROSOPHILA; HEK293 CELLS; HELA CELLS; HISTONES; HUMANS; INSECTICIDES; METHOMYL;

EID: 84872425207     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.12.020     Document Type: Article

References (30)

1. Banáth J.P., Olive P.L. Expression of phosphorylated histone H2AX as a surrogate of cell killing by drugs that create DNA double-strand breaks. Cancer Research 2003, 63:4347-4350.
2. Baron R.L. Carbamate insecticides. Handbook of Pesticide Toxicology 1991, 1125-1189. Academic Press, New York. W.J. Hayes, R.L. Laws (Eds.).
3. Bassam B.J., Caetano-Anolles G., Gresshoff P.M. Fast and sensitive silver staining of DNA in polyacrylamide gels. Analytical Biochemistry 1991, 196:80-83.
4. Bolognesi C., Peluso M., Degan P., Rabboni R., Munnia A., Abbondandolo A. Genotoxic effects of the carbamate insecticide, methyomyl. II. In vivo studies with pure compound and the technical formulation, " Lannate 25" Environmental and Molecular Mutagenesis 1994, 24:235-242.
5. Bonatti S., Bolognesi C., Degan P., Abbondandolo A. Genotoxic effects of the carbamate insecticide methomyl. I. In vitro studies with pure compound and the technical formulation " Lannate 25" Environmental and Molecular Mutagenesis 1994, 23:306-311.
6. Calderon-Segura M.E., Gomez-Arroyo S., Molina-Alvarez B., Villalobos-Pietrini R., Calderon-Ezquerro C., Cortes-Eslava J., Valencia-Quintana P.R., Lopez-Gonzalez L., Zuniga-Reyes R., Sanchez-Rincon J. Metabolic activation of herbicide products by Vicia faba detected in human peripheral lymphocytes using alkaline single cell gel electrophoresis. Toxicology In Vitro 2007, 21:1143-1154.
7. Carbonell E., Valbuena A., Xamena N., Creus A., Marcos R. Temporary variations in chromosomal aberrations in a group of agricultural workers exposed to pesticides. Mutation Research 1995, 344:127-134.
8. Clavel J. Progress in the epidemiological understanding of gene-environment interactions in major diseases: cancer. Comptes Rendus Biologies 2007, 330:306-317.
9. Cotelle S., Ferard J.F. Comet assay in genetic ecotoxicology: a review. Environmental and Molecular Mutagenesis 1999, 34:246-255.
10. Fairbairn D.W., Olive P.L., O'Neill K.L. The comet assay: a comprehensive review. Mutation Research 1995, 339:37-59.
11. Falck G.C., Hirvonen A., Scarpato R., Saarikoski S.T., Migliore L., Norppa H. Micronuclei in blood lymphocytes and genetic polymorphism for GSTM1, GSTT1 and NAT2 in pesticide-exposed greenhouse workers. Mutation Research 1999, 441:225-237.
12. Fayez V., Bahig M. Short term toxicity of methomyl in rats. Chemosphere 1991, 23:375-381.
13. Guerzoni M.E., Del Cupolo L. Mutagenic activity of pesticides (author's transl). Rivista di Scienza e Tecnologia Degli Alimenti e di Nutrizione Umana 1976, 6:161-165.
14. Hemavathy K.C., Krishnamurthy N.B. Evaluation of lannate 20, a carbamate pesticide in the germ cells of male mice. Environmental Research 1987, 42:362-365.
15. Kaplan A.M., Sherman H. Toxicity studies with methyl N-[[(methylamino)carbonyl]oxy]- ethanimidothioate. Toxicology and Applied Pharmacology 1977, 40:1-17.
16. Kassie F., Parzefall W., Knasmuller S. Single cell gel electrophoresis assay: a new technique for human biomonitoring studies. Mutation Research 2000, 463:13-31.
17. Lander B.F., Knudsen L.E., Gamborg M.O., Jarventaus H., Norppa H. Chromosome aberrations in pesticide-exposed greenhouse workers. Scandinavian Journal of Work, Environment & Health 2000, 26:436-442.
18. Lin C.M., Wei L.Y., Wang T.C. The delayed genotoxic effect of N-nitroso N-propoxur insecticide in mammalian cells. Food Chemistry Toxicology 2007, 45:928-934.
19. Moriya M., Ohta T., Watanabe K., Miyazawa T., Kato K., Shirasu Y. Further mutagenicity studies on pesticides in bacterial reversion assay systems. Mutation Research 1983, 116:185-216.
20. Njagi G., Gopalan H. Mutagenicity testing of herbicides, fungicides and insecticides. I. Chromosome aberrations in Vicia faba. Cytologia 1981, 46:169-172.
21. Rogakou E.P., Pilch D.R., Orr A.H., Ivanova V.S., Bonner W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. The Journal of Biological Chemistry 1998, 273:5858-5868.
22. Rossman T.G. Inappropriate cytotoxicity measurements. Environmental and Molecular Mutagenesis 2009, 50:81.
23. Sokolov M.V., Smilenov L.B., Hall E.J., Panyutin I.G., Bonner W.M., Sedelnikova O.A. Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts. Oncogene 2005, 24:7257-7265.
24. Summer H., Grämer R., Dröge P. Denaturing urea polyacrylamide gel electrophoresis (Urea PAGE). Journal of Visualized Experiments 2009, 32:1485.
25. Sun X.Y., Jin Y.T., Wu B., Wang W.Q., Pang X.L., Wang J. Study on genotoxicity of aldicarb and methomyl. Huan Jing Ke Xue 2010, 31:2973-2980.
26. Tanaka T., Halicka D., Traganos F., Darzynkiewicz Z. Cytometric analysis of DNA damage: phosphorylation of histone H2AX as a marker of DNA double-strand breaks (DSBs). Methods in Molecular Biology 2009, 523:161-168.
27. Tanaka T., Huang X., Halicka H.D., Zhao H., Traganos F., Albino A.P., Dai W., Darzynkiewicz Z. Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents. Cytometry A 2007, 71:648-661.
28. Ward I.M., Minn K., Chen J. UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress. The Journal of Biological Chemistry 2004, 279:9677-9680.
29. Wojciechowski J.P., Kaur P., Sabharwal P.S. Induction of ouabain resistance in V-79 cells by four carbamate pesticides. Environmental Research 1982, 29:48-53.
30. Yu Y., Zhu W., Diao H., Zhou C., Chen F.F., Yang J. A comparative study of using comet assay and gammaH2AX foci formation in the detection of N-methyl-N'-nitro-N-nitrosoguanidine- induced DNA damage. Toxicology In Vitro 2006, 20:959-965.