Interleukin 10 knockout frail mice develop cardiac and vascular dysfunction with increased age

Experimental Gerontology

Volumn 48, Issue 2, 2013, Pages 128-135

  Sikka, Gautam ^a   Miller, Karen L ^a   Steppan, Jochen ^a   Pandey, Deepesh ^a   Jung, Sung M ^b   Fraser, Charles D ^c   Ellis, Carla ^a   Ross, Daniel ^a   Vandegaer, Koenraad ^a   Bedja, Djahida ^a   Gabrielson, Kathleen ^a   Walston, Jeremy D ^a   Berkowitz, Dan E ^a   Barouch, Lili A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Yeungnam University   (South Korea)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

Acetylcholine; Aging; Aorta; Cyclo oxygenase; Cytokines; Endothelial dysfunction; Frailty; Interleukin 10; Prostanoid; Thromboxane

Indexed keywords

ACETYLCHOLINE; CYCLOOXYGENASE 2; ICOSANOID; INTERLEUKIN 10; PROSTAGLANDIN SYNTHASE INHIBITOR; THROMBOXANE A2 RECEPTOR;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL COMPLIANCE; BODY MASS; CARDIOMEGALY; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; DOPPLER ECHOCARDIOGRAPHY; ECHOCARDIOGRAPHY; ENDOTHELIUM; FORCE TENSION MYOGRAPHY; FRACTIONAL SHORTENING; FRAIL ELDERLY; HEART DISEASE; HEART EJECTION FRACTION; HEART FUNCTION; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART LEFT VENTRICLE MASS; HISTOPATHOLOGY; ISOVOLUMIC RELAXATION TIME; KNOCKOUT MOUSE; MEAN ARTERIAL PRESSURE; MOUSE; MYOGRAPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PULSE WAVE; ULTRASOUND; VASCULAR DISEASE; VASCULAR RING; VASODILATATION; WILD TYPE;

AGE FACTORS; AGING; ANIMALS; AORTA; ARTERIAL PRESSURE; CARDIOVASCULAR DISEASES; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ECHOCARDIOGRAPHY, DOPPLER; ENDOTHELIUM, VASCULAR; GENOTYPE; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-10; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOGRAPHY; PHENOTYPE; PULSE WAVE ANALYSIS; STROKE VOLUME; THROMBOXANE A2; VASCULAR STIFFNESS; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS; VENTRICULAR FUNCTION, LEFT;

MUS;

EID: 84872419332     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2012.11.001     Document Type: Article

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