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Volumn 302, Issue 10, 2012, Pages

Expression and functional significance of NADPH oxidase 5 (Nox5) and its splice variants in human blood vessels

Author keywords

Extracellular signalregulated kinase; Nox5 splice variants; Reactive oxygen species

Indexed keywords

ANGIOTENSIN II; CASPASE 3; ENDOTHELIN 1; HYDROGEN PEROXIDE; ISOPROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN VARIANT; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 5; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 5 ALPHA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 5 BETA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 5 DELTA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 5 EPSILON; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 5 GAMMA; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84861143531     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00910.2011     Document Type: Article
Times cited : (64)

References (37)
  • 3
    • 33846794822 scopus 로고    scopus 로고
    • The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
    • Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 87: 245-313, 2007.
    • (2007) Physiol Rev , vol.87 , pp. 245-313
    • Bedard, K.1    Krause, K.H.2
  • 5
    • 0034625073 scopus 로고    scopus 로고
    • Investigation into the sources of superoxide in human blood vessels: Angiotensin II increases superoxide production in human internal mammary arteries
    • Berry C, Hamilton CA, Brosnan MJ, Magill FG, Berg GA, McMurray JJ, Dominiczak AF. Investigation into the sources of superoxide in human blood vessels: angiotensin II increases superoxide production in human internal mammary arteries. Circulation 101: 2206-2212, 2000.
    • (2000) Circulation , vol.101 , pp. 2206-2212
    • Berry, C.1    Hamilton, C.A.2    Brosnan, M.J.3    Magill, F.G.4    Berg, G.A.5    McMurray, J.J.6    Dominiczak, A.F.7
  • 6
    • 11144338749 scopus 로고    scopus 로고
    • Vascular NADPH oxidases: Molecular mechanisms of activation
    • Brandes RP, Kreuzer J. Vascular NADPH oxidases: molecular mechanisms of activation. Cardiovasc Res 65: 16-27, 2005.
    • (2005) Cardiovasc Res , vol.65 , pp. 16-27
    • Brandes, R.P.1    Kreuzer, J.2
  • 7
    • 0030976142 scopus 로고    scopus 로고
    • Mechanisms of enhanced macrophage apoE secretion by oxidized LDL
    • Cader AA, Steinberg FM, Mazzone T, Chait A. Mechanisms of enhanced macrophage apoE secretion by oxidized LDL. J Lipid Res 38: 981-991, 1997.
    • (1997) J Lipid Res , vol.38 , pp. 981-991
    • Cader, A.A.1    Steinberg, F.M.2    Mazzone, T.3    Chait, A.4
  • 8
    • 0042379916 scopus 로고    scopus 로고
    • The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases
    • Cai H, Griendling KK, Harrison DG. The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases. Trends Pharmacol Sci 24: 471-478, 2003.
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 471-478
    • Cai, H.1    Griendling, K.K.2    Harrison, D.G.3
  • 9
    • 26844522807 scopus 로고    scopus 로고
    • NADPH oxidase-derived superoxide anion mediates angiotensin II-induced pressor effect via activation of p38 mitogen-activated protein kinase in the rostral ventrolateral medulla
    • Chan SH, Hsu KS, Huang CC, Wang LL, Ou CC, Chan JY. NADPH oxidase-derived superoxide anion mediates angiotensin II-induced pressor effect via activation of p38 mitogen-activated protein kinase in the rostral ventrolateral medulla. Circ Res 97: 772-780, 2005.
    • (2005) Circ Res , vol.97 , pp. 772-780
    • Chan, S.H.1    Hsu, K.S.2    Huang, C.C.3    Wang, L.L.4    Ou, C.C.5    Chan, J.Y.6
  • 10
    • 74549155206 scopus 로고    scopus 로고
    • An inhibitor of protein arginine methyltransferases, 7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalene-2-sulfonic acid) (AMI-1), is a potent scavenger of NADPH-oxidase-derived superoxide
    • Chen F, Fulton DJ. An inhibitor of protein arginine methyltransferases, 7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalene-2-sulfonic acid) (AMI-1), is a potent scavenger of NADPH-oxidase-derived superoxide. Mol Pharmacol 77: 280-287, 2010.
    • (2010) Mol Pharmacol , vol.77 , pp. 280-287
    • Chen, F.1    Fulton, D.J.2
  • 11
    • 79956113905 scopus 로고    scopus 로고
    • Hsp90 regulates NADPH oxidase activity and is necessary for superoxide but not hydrogen peroxide production
    • Chen F, Pandey D, Chadli A, Catravas JD, Chen T, Fulton DJ. Hsp90 regulates NADPH oxidase activity and is necessary for superoxide but not hydrogen peroxide production. Antioxid Redox Signal 14: 2107-2119.
    • Antioxid Redox Signal , vol.14 , pp. 2107-2119
    • Chen, F.1    Pandey, D.2    Chadli, A.3    Catravas, J.D.4    Chen, T.5    Fulton, D.J.6
  • 12
    • 46249108461 scopus 로고    scopus 로고
    • Regulation of ROS signal transduction by NADPH oxidase 4 localization
    • Chen K, Kirber MT, Xiao H, Yang Y, Keaney JF Jr. Regulation of ROS signal transduction by NADPH oxidase 4 localization. J Cell Biol 181: 1129-1139, 2008.
    • (2008) J Cell Biol , vol.181 , pp. 1129-1139
    • Chen, K.1    Kirber, M.T.2    Xiao, H.3    Yang, Y.4    Keaney Jr., J.F.5
  • 13
    • 0035897653 scopus 로고    scopus 로고
    • Homologs of gp91phox: Cloning and tissue expression of Nox3, Nox4, and Nox5
    • Cheng G, Cao Z, Xu X, van Meir EG, Lambeth JD. Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene 269: 131-140, 2001.
    • (2001) Gene , vol.269 , pp. 131-140
    • Cheng, G.1    Cao, Z.2    Xu, X.3    van Meir, E.G.4    Lambeth, J.D.5
  • 14
    • 33644971702 scopus 로고    scopus 로고
    • Differences in eNOS activity because of subcellular localization are dictated by phosphorylation state rather than the local calcium environment
    • Church JE, Fulton D. Differences in eNOS activity because of subcellular localization are dictated by phosphorylation state rather than the local calcium environment. J Biol Chem 281: 1477-1488, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 1477-1488
    • Church, J.E.1    Fulton, D.2
  • 15
    • 33745978446 scopus 로고    scopus 로고
    • cAMPresponse element-binding protein mediates acid-induced NADPH oxidase NOX5-S expression in Barrett esophageal adenocarcinoma cells
    • Fu X, Beer DG, Behar J, Wands J, Lambeth D, Cao W. cAMPresponse element-binding protein mediates acid-induced NADPH oxidase NOX5-S expression in Barrett esophageal adenocarcinoma cells. J Biol Chem 281: 20368-20382, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 20368-20382
    • Fu, X.1    Beer, D.G.2    Behar, J.3    Wands, J.4    Lambeth, D.5    Cao, W.6
  • 16
    • 70349316712 scopus 로고    scopus 로고
    • Nox5 and the regulation of cellular function
    • Fulton DJ. Nox5 and the regulation of cellular function. Antioxid Redox Signal 11: 2443-2452, 2009.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 2443-2452
    • Fulton, D.J.1
  • 19
    • 33847697219 scopus 로고    scopus 로고
    • Novel mechanism of activation of NADPH oxidase 5 calcium sensitization via phosphorylation
    • Jagnandan D, Church JE, Banfi B, Stuehr DJ, Marrero MB, Fulton DJ. Novel mechanism of activation of NADPH oxidase 5 calcium sensitization via phosphorylation. J Biol Chem 282: 6494-6507, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 6494-6507
    • Jagnandan, D.1    Church, J.E.2    Banfi, B.3    Stuehr, D.J.4    Marrero, M.B.5    Fulton, D.J.6
  • 20
    • 26444511064 scopus 로고    scopus 로고
    • Intracellular location regulates calcium-calmodulin-dependent activation of organelle-restricted eNOS
    • Jagnandan D, Sessa WC, Fulton D. Intracellular location regulates calcium-calmodulin-dependent activation of organelle-restricted eNOS. Am J Physiol Cell Physiol 289: C1024-C1033, 2005.
    • (2005) Am J Physiol Cell Physiol , vol.289
    • Jagnandan, D.1    Sessa, W.C.2    Fulton, D.3
  • 22
    • 0032889677 scopus 로고    scopus 로고
    • Redox regulation of cellular signalling
    • Kamata H, Hirata H. Redox regulation of cellular signalling. Cell Signal 11: 1-14, 1999.
    • (1999) Cell Signal , vol.11 , pp. 1-14
    • Kamata, H.1    Hirata, H.2
  • 23
    • 79952945592 scopus 로고    scopus 로고
    • Nox5 forms a functional oligomer mediated by self-association of its dehydrogenase domain
    • Kawahara T, Jackson HM, Smith SM, Simpson PD, Lambeth JD. Nox5 forms a functional oligomer mediated by self-association of its dehydrogenase domain. Biochemistry 50: 2013-2025.
    • Biochemistry , vol.50 , pp. 2013-2025
    • Kawahara, T.1    Jackson, H.M.2    Smith, S.M.3    Simpson, P.D.4    Lambeth, J.D.5
  • 24
    • 36849064316 scopus 로고    scopus 로고
    • Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes
    • Kawahara T, Lambeth JD. Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes. BMC Evol Biol 7: 178, 2007.
    • (2007) BMC Evol Biol , vol.7 , pp. 178
    • Kawahara, T.1    Lambeth, J.D.2
  • 25
    • 0032546259 scopus 로고    scopus 로고
    • The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension. Bosentan Hypertension Investigators
    • Krum H, Viskoper RJ, Lacourciere Y, Budde M, Charlon V. The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension. Bosentan Hypertension Investigators. N Engl J Med 338: 784-790, 1998.
    • (1998) N Engl J Med , vol.338 , pp. 784-790
    • Krum, H.1    Viskoper, R.J.2    Lacourciere, Y.3    Budde, M.4    Charlon, V.5
  • 26
    • 9344259718 scopus 로고    scopus 로고
    • Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors
    • Kwon J, Lee SR, Yang KS, Ahn Y, Kim YJ, Stadtman ER, Rhee SG. Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors. Proc Natl Acad Sci U S A 101: 16419-16424, 2004.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 16419-16424
    • Kwon, J.1    Lee, S.R.2    Yang, K.S.3    Ahn, Y.4    Kim, Y.J.5    Stadtman, E.R.6    Rhee, S.G.7
  • 27
    • 0042810670 scopus 로고    scopus 로고
    • Vascular NAD(P)H oxidases: Specific features, expression, and regulation
    • Lassegue B, Clempus RE. Vascular NAD(P)H oxidases: specific features, expression, and regulation. Am J Physiol Regul Integr Comp Physiol 285: R277-R297, 2003.
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.285
    • Lassegue, B.1    Clempus, R.E.2
  • 28
    • 6344285417 scopus 로고    scopus 로고
    • Endothelial cell superoxide generation: Regulation and relevance for cardiovascular pathophysiology
    • Li JM, Shah AM. Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. Am J Physiol Regul Integr Comp Physiol 287: R1014-R1030, 2004.
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.287
    • Li, J.M.1    Shah, A.M.2
  • 29
    • 0027365599 scopus 로고
    • Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells
    • Marui N, Offermann MK, Swerlick R, Kunsch C, Rosen CA, Ahmad M, Alexander RW, Medford RM. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J Clin Invest 92: 1866-1874, 1993.
    • (1993) J Clin Invest , vol.92 , pp. 1866-1874
    • Marui, N.1    Offermann, M.K.2    Swerlick, R.3    Kunsch, C.4    Rosen, C.A.5    Ahmad, M.6    Alexander, R.W.7    Medford, R.M.8
  • 30
    • 77952489013 scopus 로고    scopus 로고
    • Nicotinamide adenine dinucleotide phosphate reduced oxidase 5 (Nox5) regulation by angiotensin II and endothelin-1 is mediated via calcium/calmodulin-dependent, rac-1-independent pathways in human endothelial cells
    • Montezano AC, Burger D, Paravicini TM, Chignalia AZ, Yusuf H, Almasri M, He Y, Callera GE, He G, Krause KH, Lambeth D, Quinn MT, Touyz RM. Nicotinamide adenine dinucleotide phosphate reduced oxidase 5 (Nox5) regulation by angiotensin II and endothelin-1 is mediated via calcium/calmodulin-dependent, rac-1-independent pathways in human endothelial cells. Circ Res 106: 1363-1373, 2010.
    • (2010) Circ Res , vol.106 , pp. 1363-1373
    • Montezano, A.C.1    Burger, D.2    Paravicini, T.M.3    Chignalia, A.Z.4    Yusuf, H.5    Almasri, M.6    He, Y.7    Callera, G.E.8    He, G.9    Krause, K.H.10    Lambeth, D.11    Quinn, M.T.12    Touyz, R.M.13
  • 32
    • 0034625079 scopus 로고    scopus 로고
    • Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction
    • Ridker PM, Rifai N, Pfeffer M, Sacks F, Lepage S, Braunwald E. Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction. Circulation 101: 2149-2153, 2000.
    • (2000) Circulation , vol.101 , pp. 2149-2153
    • Ridker, P.M.1    Rifai, N.2    Pfeffer, M.3    Sacks, F.4    Lepage, S.5    Braunwald, E.6
  • 33
    • 56149117753 scopus 로고    scopus 로고
    • NOX5, a new "radical" player in human atherosclerosis?
    • Schulz E, Munzel T. NOX5, a new "radical" player in human atherosclerosis? J Am Coll Cardiol 52: 1810-1812, 2008.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1810-1812
    • Schulz, E.1    Munzel, T.2
  • 34
    • 34447525016 scopus 로고    scopus 로고
    • NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-kappaB in Barrett's esophageal adenocarcinoma cells
    • Si J, Fu X, Behar J, Wands J, Beer DG, Souza RF, Spechler SJ, Lambeth D, Cao W. NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-kappaB in Barrett's esophageal adenocarcinoma cells. J Biol Chem 282: 16244-16255, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 16244-16255
    • Si, J.1    Fu, X.2    Behar, J.3    Wands, J.4    Beer, D.G.5    Souza, R.F.6    Spechler, S.J.7    Lambeth, D.8    Cao, W.9
  • 35
    • 15444380462 scopus 로고    scopus 로고
    • NADPH oxidase-derived reactive oxygen species-mediated activation of ERK1/2 is required for apoptosis of human neutrophils induced by Entamoeba histolytica
    • Sim S, Yong TS, Park SJ, Im KI, Kong Y, Ryu JS, Min DY, Shin MH. NADPH oxidase-derived reactive oxygen species-mediated activation of ERK1/2 is required for apoptosis of human neutrophils induced by Entamoeba histolytica. J Immunol 174: 4279-4288, 2005.
    • (2005) J Immunol , vol.174 , pp. 4279-4288
    • Sim, S.1    Yong, T.S.2    Park, S.J.3    Im, K.I.4    Kong, Y.5    Ryu, J.S.6    Min, D.Y.7    Shin, M.H.8
  • 36
    • 0035909997 scopus 로고    scopus 로고
    • Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS)
    • Wallace AM, McMahon AD, Packard CJ, Kelly A, Shepherd J, Gaw A, Sattar N. Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circulation 104: 3052-3056, 2001.
    • (2001) Circulation , vol.104 , pp. 3052-3056
    • Wallace, A.M.1    McMahon, A.D.2    Packard, C.J.3    Kelly, A.4    Shepherd, J.5    Gaw, A.6    Sattar, N.7
  • 37
    • 0035584538 scopus 로고    scopus 로고
    • Upregulation of the vascular NAD(P)H-oxidase isoforms Nox1 and Nox4 by the renin-angiotensin system in vitro and in vivo
    • Wingler K, Wunsch S, Kreutz R, Rothermund L, Paul M, Schmidt HH. Upregulation of the vascular NAD(P)H-oxidase isoforms Nox1 and Nox4 by the renin-angiotensin system in vitro and in vivo. Free Radic Biol Med 31: 1456-1464, 2001.
    • (2001) Free Radic Biol Med , vol.31 , pp. 1456-1464
    • Wingler, K.1    Wunsch, S.2    Kreutz, R.3    Rothermund, L.4    Paul, M.5    Schmidt, H.H.6


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