In vitro investigation on improvement in puerarin intestinal absorption

Chinese Traditional and Herbal Drugs

Volumn 42, Issue 11, 2011, Pages 2265-2269

  Li, Lin ^a,b   Zhang, Qiong ^c   Yang, Zhi Jian ^b   Lu, Yang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Unilever R and D   (China)

^c EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Bioavailability; Caco 2 cells; Intestinal absorption; Membrane permeability; Puerarin (PE)

Indexed keywords

BOVINE SERUM ALBUMIN; CHITOSAN; DODECYL SULFATE SODIUM; PENETRATION ENHANCING AGENT; POLIDOCANOL; PUERARIN;

ARTICLE; BIOAVAILABILITY; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; DRUG ABSORPTION; DRUG DIFFUSION; ELECTRIC RESISTANCE; IN VITRO STUDY; INCUBATION TEMPERATURE; INCUBATION TIME; INTESTINE ABSORPTION; INTESTINE MUCOSA PERMEABILITY; INTRACELLULAR TRANSPORT; MEMBRANE PERMEABILITY; MEMBRANE TRANSPORT; MOLECULAR WEIGHT; PROTEIN ISOLATION;

EID: 82855169556     PISSN: 02532670     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Mac Callum A, Hardy S P, Everest P H. Campylobacter jejuni inhibits the absorptive transport functions of Caco-2 cells and disrupts cellular tight junctions [J]. Microbiology, 2005, 151(7): 2451-2458. (Pubitemid 40984318)
2. Simons A L, Renouf M, Hendrich S, et al. Human gut microbial degradation of flavoniods: structure-function relationship [J]. J Agric Food Chem, 2005, 53(10): 4258-4263. (Pubitemid 40936793)
3. Xiao J B, Shi J, Cao H, et al. Analysis of binding interaction between puerarin and bovine serum albumin by multi-spectroscopic method [J]. J Pharm Biomed, 2007, 45(4): 609-615.
4. Schipper N G, Olsson S, Hooqstraate J A, et al. Chitosan as absorption enhancers for poorly absorbable drugs. 2: mechanism of absorption enhancement [J]. Pharm Res, 1997, 14(7): 923-929. (Pubitemid 27326989)
5. Fix J A. Strategies for delivery of peptides utilizing absorption-enhancing agents [J]. J Pharm Sci, 1996, 85(12): 1282-1285. (Pubitemid 27014180)