Neutrophil gelatinase-associated lipocalin as an early biomarker of nephropathy in diabetic patients

Kidney and Blood Pressure Research

Volumn 32, Issue 2, 2009, Pages 91-98

  Bolignano, Davide ^a   Lacquaniti, Antonio ^a   Coppolino, Giuseppe ^a   Donato, Valentina ^a   Fazio, Maria Rosaria ^a   Nicocia, Giacomo ^a   Buemi, Michele ^a,b  

^a UNIVERSITY OF MESSINA   (Italy)

^b NONE   (Italy)

Author keywords

Chronic kidney disease; Diabetic nephropathy; Microalbuminuria; Neutrophil gelatinase associated lipocalin; Proteinuria

Indexed keywords

CREATININE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; SERUM ALBUMIN;

ADULT; ALBUMINURIA; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETIC NEPHROPATHY; DIABETIC PATIENT; DISEASE SEVERITY; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY INJURY; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN URINE LEVEL; PROTEINURIA;

ACUTE-PHASE PROTEINS; ADULT; BIOLOGICAL MARKERS; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; FEMALE; HUMANS; KIDNEY TUBULES; LIPOCALINS; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS; TIME FACTORS;

EID: 62849128223     PISSN: 14204096     EISSN: None     Source Type: Journal    
DOI: 10.1159/000209379     Document Type: Article

References (23)

1. Thomas MC, Burns WC, Cooper ME: Tubular changes in early diabetic nephropathy. Adv Chronic Kidney Dis 2005; 12: 177-186.
2. Abbate M, Zoja C, Remuzzi G: How does proteinuria cause progressive renal damage? J Am Soc Nephrol 2006; 17: 2974-2984.
3. Morii T, Fujita H, Narita T, et al: Association of monocyte chemoattractant protein-1 with renal tubular damage in diabetic nephropa- thy. J Diabetes Complications 2003; 17: 11-15.
4. Piwowar A, Knapik-Kordecka M, Fus I, Warwas M: Urinary activities of cathepsin B, N-acetyl-beta-D-glucosaminidase, and al- buminuria in patients with type 2 diabetes mellitus. Med Sci Monit 2006; 12:CR210- CR214.
5. Mohammadi-Karakani A, Asgharzadeh-Ha- ghighi S, Ghazi-Khansari M, Hosseini R: Determination of urinary enzymes as a marker of early renal damage in diabetic patients. J Clin Lab Anal 2007; 21: 413-417.
6. Phillips AO: The role of renal proximal tubular cells in diabetic nephropathy. Curr Diab Rep 2003; 3: 491-496.
7. Hirsch R, Dent C, Pfriem H, et al: NGAL is an early predictive biomarker of contrast-induced nephropathy in children. Pediatr Nephrol 2007; 22: 2089-2095.
8. Mishra J, Dent C, Tarabishi R, et al: Neutro- phil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 2005; 365: 1231-1238.
9. Trachtman H, Christen E, Cnaan A, et al; Investigators of the HUS-SYNSORB Pk Multi- center Clinical Trial: Urinary neutrophil gelatinase-associated lipocalcin in D+HUS: a novel marker of renal injury. Pediatr Nephrol 2006;21:989-994.
10. Mitsnefes MM, Kathman TS, Mishra J, et al: Serum neutrophil gelatinase-associated li- pocalin as a marker of renal function in children with chronic kidney disease. Pediatr Nephrol 2007; 22: 101-108.
11. Suzuki M, Wiers KM, Klein-Gitelman MS, et al: Neutrophil gelatinase-associated lipo- calin as a biomarker of disease activity in pediatric lupus nephritis. Pediatr Nephrol 2008; 23: 403-412.
12. Ding H, He Y, Li K, et al: Urinary neutrophil gelatinase-associated lipocalin (NGAL) is an early biomarker for renal tubulointerstitial injury in IgA nephropathy. Clin Immunol 2007; 123: 227-234.
13. Bolignano D, Coppolino G, Campo S, et al: Urinary neutrophil gelatinase-associated li- pocalin (NGAL) is associated with severity of renal disease in proteinuric patients. Nephrol Dial Transplant 2008; 23: 414-416.
14. Bolignano D, Coppolino G, Campo S, et al: Neutrophil gelatinase- associated lipocalin in patients with autosomal-dominant poly- cystic kidney disease. Am J Nephrol 2007; 27:373-378.
15. Kjeldsen L, Johnsen AH, Sengelov H, Bor- regaard N: Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem 1993; 268: 10425-10432.
16. Mori K, Nakao K: Neutrophil gelatinase-as- sociated lipocalin as the real-time indicator of active kidney damage. Kidney Int 2007;71: 967-970.
17. Bolignano D, Donato V, Coppolino G, et al: Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney damage. Am J Kidney Dis 2008; 52: 595-609.
18. Bonventre JV: Diagnosis of acute kidney injury: from classic parameters to new bio- markers. Contrib Nephrol 2007; 156: 213-219.
19. Ronco C: N-GAL: diagnosing AKI as soon as possible. Crit Care 2007; 11: 173.
20. Devarajan P: Emerging biomarkers of acute kidney injury. Contrib Nephrol 2007; 156: 203-212.
21. Swedenborg J, Eriksson P: The intraluminal thrombus as a source of proteolytic activity. Ann NY Acad Sci 2006; 1085: 133-138.
22. Leclercq A, Houard X, Philippe M, et al: Involvement of intraplaque hemorrhage in ath- erothrombosis evolution via neutrophil protease enrichment. J Leukoc Biol 2007; 82: 1420-1429.
23. Bolignano D, Lacquaniti A, Coppolino G, Campo S, Arena A, Buemi M: Neutrophil ge- latinase-associated lipocalin reflects the severity of renal impairment in subjects affected by chronic kidney disease. Kidney Blood Press Res 2008; 31: 255-258.