Echocardiographic Evidence of Left Ventricular Hypertrophy in Obese Dogs

Journal of Veterinary Internal Medicine

Volumn 27, Issue 1, 2013, Pages 62-68

  Mehlman, E ^a   Bright, J M ^a   Jeckel, K ^a   Porsche, C ^a   Veeramachaneni, D N R ^a   Frye, M ^a  

^a Department of Ecosystem Science and Sustainability   (United States)

Author keywords

Blood pressure; Cardiomyopathy; Diastolic function; Obesity; Overweight

Indexed keywords

ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD PRESSURE; CASE CONTROL STUDY; DOG; DOG DISEASE; DOPPLER ECHOCARDIOGRAPHY; ECHOGRAPHY; FEMALE; HEART LEFT VENTRICLE HYPERTROPHY; HEART RATE; MALE; OBESITY; PATHOPHYSIOLOGY; PROSPECTIVE STUDY;

ANIMALS; BLOOD PRESSURE; CASE-CONTROL STUDIES; DOG DISEASES; DOGS; ECHOCARDIOGRAPHY, DOPPLER; FEMALE; HEART RATE; HYPERTROPHY, LEFT VENTRICULAR; MALE; OBESITY; PROSPECTIVE STUDIES;

ANIMALIA; CANIS FAMILIARIS;

EID: 84872390094     PISSN: 08916640     EISSN: 19391676     Source Type: Journal    
DOI: 10.1111/jvim.12018     Document Type: Article

References (55)

1. Burkholder W, Toll P. Obesity. In: Hand M, Thatcher C, Reimillard R, et al. eds. Small Animal Clinical Nutrition, 4th ed. Topeka, KS: Mark Morris Institute; 2000.
2. Lund E, Armstrong P, Kirk C, Klausner J. Prevalence and risk factors for obesity in adult dogs from private US veterinary practices. Int J Appl Res Vet Med 2006;4:177-186.
3. McGreevy PD, Thomson PC, Pride C, et al. Prevalence of obesity in dogs examined by Australian veterinary practices and the risk factors involved. Vet Rec 2005;156:695-702.
4. Edney AT, Smith PM. Study of obesity in dogs visiting veterinary practices in the United Kingdom. Vet Rec 1986;118:391-396.
5. Mason E. Obesity in pet dogs. Vet Rec 1970;86:612-616.
6. Colliard L, Ancel J, Benet JJ, et al. Risk factors for obesity in dogs in France. J Nutr 2006;136:1951S-1954S.
7. Lampman TJ, Lund EM, Lipowitz AJ. Cranial cruciate disease: Current status of diagnosis, surgery, and risk for disease. Vet Comp Orthop Traumatol 2003;16:122-126.
8. Smith GK, Mayhew PD, Kapatkin AS, et al. Evaluation of risk factors for degenerative joint disease associated with hip dysplasia in German Shepherd Dogs, Golden Retrievers, Labrador Retrievers, and Rottweilers. J Am Vet Med Assoc 2001;219:1719-1724.
9. Mattheeuws D, Rottiers R, Kaneko JJ, Vermeulen A. Diabetes mellitus in dogs: Relationship of obesity to glucose tolerance and insulin response. Am J Vet Res 1984;45:98-103.
10. Lekcharoensuk C, Lulich JP, Osborne CA, et al. Patient and environmental factors associated with calcium oxalate urolithiasis in dogs. J Am Vet Med Assoc 2000;217:515-519.
11. Henegar JR, Bigler SA, Henegar LK, et al. Functional and structural changes in the kidney in the early stages of obesity. J Am Soc Nephrol 2001;12:1211-1217.
12. Mizelle HL, Edwards TC, Montani JP. Abnormal cardiovascular responses to exercise during the development of obesity in dogs. Am J Hypertens 1994;7(4 Pt 1):374-378.
13. Rider OJ, Petersen SE, Francis JM, et al. Ventricular hypertrophy and cavity dilatation in relation to body mass index in women with uncomplicated obesity. Heart 2011;97:203-208.
14. Tumuklu MM, Etikan I, Kisacik B, Kayikcioglu M. Effect of obesity on left ventricular structure and myocardial systolic function: assessment by tissue Doppler imaging and strain/strain rate imaging. Echocardiography 2007;24:802-809.
15. Wong CY, O'Moore-Sullivan T, Leano R, et al. Alterations of left ventricular myocardial characteristics associated with obesity. Circulation 2004;110:3081-3087.
16. Peterson LR, Waggoner AD, Schechtman KB, et al. Alterations in left ventricular structure and function in young healthy obese women: Assessment by echocardiography and tissue Doppler imaging. J Am Coll Cardiol 2004;43:1399-1404.
17. Lind L, Siegbahn A, Ingelsson E, et al. A detailed cardiovascular characterization of obesity without the metabolic syndrome. Arterioscler Thromb Vasc Biol 2011;31:e27-e34.
18. Park J, Kim SH, Cho GY, et al. Obesity phenotype and cardiovascular changes. J Hypertens 2011;29:1765-1772.
19. Gardin JM, McClelland R, Kitzman D, et al. M-mode echocardiographic predictors of six- to seven-year incidence of coronary heart disease, stroke, congestive heart failure, and mortality in an elderly cohort (the Cardiovascular Health Study). Am J Cardiol 2001;87:1051-1057.
20. Levy D, Garrison RJ, Savage DD, et al. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med 1990;322:1561-1566.
21. Kardys I, Deckers JW, Stricker BH, et al. Echocardiographic parameters and all-cause mortality: The Rotterdam study. Int J Cardiol 2008;133:198-204.
22. Duflou J, Virmani R, Rabin I, et al. Sudden death as a result of heart disease in morbid obesity. Am Heart J 1995;130:306-313.
23. Amad KH, Brennan JC, Alexander JK. The cardiac pathology of chronic exogenous obesity. Circulation 1965;32:740-745.
24. Sharma S, Adrogue JV, Golfman L, et al. Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart. FASEB J 2004;18:1692-1700.
25. Kortelainen ML, Porvari K. Extreme obesity and associated cardiovascular disease verified at autopsy: Time trends over 3 decades. Am J Forensic Med Pathol 2011;32:372-377.
26. Laflamme D. Development and validation of body condition score system for dogs. Canine Pract 1997;22:10-15.
27. Weiser MG, Spangler WL, Gribble DH. Blood pressure measurement in the dog. J Am Vet Med Assoc 1977;171:364-368.
28. Valtonen MH, Eriksson LM. The effect of cuff width on accuracy of indirect measurement of blood pressure in dogs. Res Vet Sci 1970;11:358-362.
29. Schober KE, Hart TM, Stern JA, et al. Detection of congestive heart failure in dogs by Doppler echocardiography. J Vet Intern Med 2010;24:1358-1368.
30. Schober KE, Stern JA, DaCunha DN, et al. Estimation of left ventricular filling pressure by Doppler echocardiography in dogs with pacing-induced heart failure. J Vet Intern Med 2008;22:578-585.
31. Goncalves AC, Orton EC, Boon JA, Salman MD. Linear, logarithmic, and polynomial models of M-mode echocardiographic measurements in dogs. Am J Vet Res 2002;63:994-999.
32. Schober KE, Fuentes VL. Effects of age, body weight, and heart rate on transmitral and pulmonary venous flow in clinically normal dogs. Am J Vet Res 2001;62:1447-1454.
33. Switzer BR, Summer GK. Improved method for hydroxyproline analysis in tissue hydrolyzates. Anal Biochem 1971;39:487-491.
34. Sharma N, Okere IC, Duda MK, et al. High fructose diet increases mortality in hypertensive rats compared to a complex carbohydrate or high fat diet. Am J Hypertens 2007;20:403-409.
35. Bordoni A, Astolfi A, Morandi L, et al. N-3 PUFAs modulate global gene expression profile in cultured rat cardiomyocytes. Implications in cardiac hypertrophy and heart failure. FEBS Lett 2007;581:923-929.
36. Jeckel KM, Miller KE, Chicco AJ, et al. The role of dietary fatty acids in predicting myocardial structure in fat-fed rats. Lipids Health Dis 2011;10:92.
37. Chalifoux A, Dallaire A, Blais D, et al. Evaluation of the arterial blood pressure of dogs by two noninvasive methods. Can J Comp Med 1985;49:419-423.
38. Remillard RL, Ross JN, Eddy JB. Variance of indirect blood pressure measurements and prevalence of hypertension in clinically normal dogs. Am J Vet Res 1991;52:561-565.
39. Brown S, Atkins C, Bagley R, et al. Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats. J Vet Intern Med 2007;21:542-558.
40. Verkest KR, Rand JS, Fleeman LM, Morton JM. Spontaneously obese dogs exhibit greater postprandial glucose, triglyceride, and insulin concentrations than lean dogs. Domest Anim Endocrinol 2012;42:103-112.
41. Serisier S, Gayet C, Leray V, et al. Hypertriglyceridaemic insulin-resistant obese dog model: Effects of high-fat diet depending on age. J Anim Physiol Anim Nutr 2008;92:419-425.
42. Ishioka K, Omachi A, Sagawa M, et al. Canine adiponectin: cDNA structure, mRNA expression in adipose tissues and reduced plasma levels in obesity. Res Vet Sci 2006;80:127-132.
43. Stepien RL, Hinchcliff KW, Constable PD, Olson J. Effect of endurance training on cardiac morphology in Alaskan sled dogs. J Appl Physiol 1998;85:1368-1375.
44. Martin MW, Stafford Johnson MJ, Celona B. Canine dilated cardiomyopathy: A retrospective study of signalment, presentation and clinical findings in 369 cases. J Small Anim Pract 2009;50:23-29.
45. Shapiro LM, McKenna WJ. Left ventricular hypertrophy. Relation of structure to diastolic function in hypertension. Br Heart J 1984;51:637-642.
46. Myreng Y, Smiseth OA. Assessment of left ventricular relaxation by Doppler echocardiography. Comparison of isovolumic relaxation time and transmitral flow velocities with time constant of isovolumic relaxation. Circulation 1990;81:260-266.
47. Mantero A, Gentile F, Gualtierotti C, et al. Left ventricular diastolic parameters in 288 normal subjects from 20 to 80 years old. Eur Heart J 1995;16:94-105.
48. Choong CY, Herrmann HC, Weyman AE, Fifer MA. Preload dependence of Doppler-derived indexes of left ventricular diastolic function in humans. J Am Coll Cardiol 1987;10:800-808.
49. Farias CA, Rodriguez L, Garcia MJ, et al. Assessment of diastolic function by tissue Doppler echocardiography: Comparison with standard transmitral and pulmonary venous flow. J Am Soc Echocardiogr 1999;12:609-617.
50. Nagueh SF, Middleton KJ, Kopelen HA, et al. Doppler tissue imaging: A noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures. J Am Coll Cardiol 1997;30:1527-1533.
51. Killich M, Hartmann K, Wess G. [Tissue velocity imaging in healthy dogs]. Tierarztl Prax Ausg K Kleintiere Heimtiere 2011;39:69-78.
52. Cornell CC, Kittleson MD, Della Torre P, et al. Allometric scaling of M-mode cardiac measurements in normal adult dogs. J Vet Intern Med 2004;18:311-321.
53. Szczepaniak LS, Dobbins RL, Metzger GJ, et al. Myocardial triglycerides and systolic function in humans: In vivo evaluation by localized proton spectroscopy and cardiac imaging. Magn Reson Med 2003;49:417-423.
54. Sabbah HN, Sharov VG, Gupta RC, et al. Reversal of chronic molecular and cellular abnormalities due to heart failure by passive mechanical ventricular containment. Circ Res 2003;93:1095-1101.
55. Morita H, Suzuki G, Mishima T, et al. Effects of long-term monotherapy with metoprolol CR/XL on the progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure. Cardiovasc Drugs Ther 2002;16:443-449.