Biophysical and biochemical characterization of a liposarcoma-derived recombinant MnSOD protein acting as an anticancer agent

International Journal of Cancer

Volumn 123, Issue 11, 2008, Pages 2684-2695

  Mancini, Aldo ^a   Borrelli, Antonella ^a   Schiattarella, Antonella ^a   Aloj, Luigi ^a   Aurilio, Michela ^a   Morelli, Franco ^b   Pica, Alessandra ^c   Occhiello, Antonella ^c   Lorizio, Roberto ^c   Mancini, Roberto ^c   Sica, Alessandro ^c   Mazzarella, Lelio ^c   Sica, Filomena ^c   Grieco, Paolo ^c   Novellino, Ettore ^c   Pagnozzi, Daniela ^c   Pucci, Piero ^c   Rommelaere, Jean ^d  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Anticancer agent; Antioxidant; Free radicals; rMnSOD

Indexed keywords

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; ANTINEOPLASTIC AGENT; ESTROGEN; ESTROGEN RECEPTOR; GALLIUM 68; IODINE 125; IODINE 131; MANGANESE SUPEROXIDE DISMUTASE; PROTEIN BAX; PROTEIN BCL 2; SODIUM IODIDE I 125; SYNTHETIC PEPTIDE;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOCHEMISTRY; BIOPHYSICS; CELL STRAIN MCF 7; CONTROLLED STUDY; DOWN REGULATION; DRUG INHIBITION; FEMALE; FLUORESCENCE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; LIPOSARCOMA; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SCINTIGRAPHY; TUMOR CELL;

AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; BIOCHEMICAL PHENOMENA; BIOCHEMISTRY; BIOPHYSICAL PHENOMENA; BIOPHYSICS; CELL LINE, TUMOR; CHROMATOGRAPHY, AFFINITY; CIRCULAR DICHROISM; ESTRADIOL; HEALTH; HUMANS; HYDROGEN PEROXIDE; LIPOSARCOMA; MICE; MICE, NUDE; MOLECULAR SEQUENCE DATA; PEPTIDE MAPPING; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUPEROXIDE DISMUTASE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 57349198688     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.23791     Document Type: Article

References (34)

1. Bishop JM. The molecular genetics of cancer. Science 1987;235:305-11.
2. Rabbitts TH. Chromosomal translocations in human cancer. Nature 1994;372:143-9.
3. Mitelman F, Mertens F, Johansson B. A breakpoint map of recurrent chromosomal rearrangements in human neoplasia. Nat Genet 1997;15:417-74.
4. Doll R, Peto R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 1981;66:1191-308.
5. Sun J, Hemler ME. Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions. Cancer Res 2001;61:2276-81.
6. Folkman J. Tumor angiogenesis: a possible control point in tumor growth. Ann Intern Med 1975;82:96-100.
7. Konopka TE, Barker JE, Bamford TL, Guida E, Anderson RL, Stewart AG. Nitric oxide synthase II gene disruption: implications for tumor growth and vascular endothelial growth factor production. Cancer Res 2001;61:3182-7.
8. Arbiser JL, Petros J, Klafter R, Govindajaran B, McLaughlin ER, Brown LF, Cohen C, Moses M, Kilroy S, Arnold RS, Lambeth JD. Reactive oxygen generated by Nox1 trigger the angiogenic switch. Proc Natl Acad Sci USA 2002;99:715-20.
9. Mancini A, Garbi C, D'Armiento FP, Borrelli A, Ambesi-Impiombato FS. Culture and cloning of an adipocytes cell line froma human liposarcoma. Bollettino Istituto dei Tumori di Napoli 1991;38:43-49.
10. Mancini A, Borrelli A, Schiattarella A, Fasano S, Occhiello A, Pica A, Sehr P, Tommasino M, N€uesch JP, Rommelaere J. Tumor suppressive activity of a variant isoform of manganese superoxide dismutase released by a human liposarcoma cell line. Int J Cancer 2006;119:932-43.
11. McCord JM, Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 1969;244:6049-55.
12. Folz RJ, Guan J, Seldin MF, Oury TD, Enghild JJ, Crapo JD. Mouse extracellular superoxide dismutase: primary structure, tissue-specific gene expression, chromosomal localization, and lung in situ hybridization. Am J Respir Cell Mol Biol 1997;17:393-403.
13. Ookawara T, Kizaki T, Yakayama E, Imazeki N, Matsubara O, Ikeda Y, Suzuki K, Li Ji L, Tadakuma T, Taniguchi N, Ohno H. Nuclear translocation of extracellular superoxide dismutase. Biochem Biophys Res Comm 2002;296:54-61.
14. Borgstahl GE, Parge HE, Hickey MJ, Beyer WF, Jr, Hallewell RA, Tainer JA. The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles. Cell 1992;71:107-18.
15. Davis CA, Hearn AS, Fletcher B, Bickford J, Garcia JE, Leveque V, Melendez JA, Silverman DN, Zucali J, Agarwal A, Nick HS. Potent anti-tumor effects of an active site mutant of human manganese-superoxide dismutase. Evolutionary conservation of product inhibition. J Biol Chem 2004;279:12769-76.
16. Wispe JR, Clark JC, Burhans MS, Kropp KE, Korfhagen TR, Whitsett JA. Synthesis and processing of the precursor for human mangano-superoxide dismutase. Biochim Biophys Acta 1989;994:30-6.
17. Corbau R, Salomon N, Rommeleare J, Nuesch JP. Phosphorylation of the viral non structural protein NS1 during MVMp infection of A9 cells. Virology 1999;259:402-15.
18. Holgate CS, Jackson P, Cowen PN, Bird CC. Immunogold-silver staining: new method of immunostaining with enhanced sensitivity. J Histochem Cytochem 1983;31:938-44.
19. Stewart JM, Young JD. Solid phase peptide synthesis. Rockford, IL: Pierce Chemical, 1984.
20. Matthias M, Hendrickson RC, Pandey RC. Analysis of proteins and proteosomes by mass spectrometry. Annu Rev Biochem 2001;70:437-73.
21. Wagner UG, Pattridge KA, Ludwig ML, Stallings WC, Werber MM, Oefner C, Frolow F, Sussman JL. Comparison of the crystal structures of genetically engineered human manganese superoxide dismutase and manganese superoxide dismutase from Thermus thermophilus: differences in dimer-dimer interaction. Protein Sci 1993;2:814-25.
22. Mizuno K, Whittaker MM, Bächinger HP, Whittaker JW. Calorimetric studies on the tight binding metal interactions of Escherichia coli manganese superoxide dismutase. J Biol Chem 2004;279:27339-44.
23. Hsieh Y, Guan Y, Tu C, Bratt PJ, Angerhofer A, Lepock JR, Hickey MJ, Tainer JA, Nick HS, Silverman DN. Probing the active site of human manganese superoxide dismutase: the role of glutamine 143. Biochemistry 1998;37:4731-9.
24. Mashiba H, Matsunaga K. Device for intracellular increase of oxygen free radicals and inhibition of MethA tumour cell proliferation: in vitro and in vivo studies. Int J Tissue React 1988;10:273-80.
25. Schimmel M, Bauer G. Proapoptotic and redox state-related signaling of reactive oxygen species generated by transformed fibroblasts. Oncogene 2002;21:5886-96.
26. Mainous AG, III, Wells BJ, Koopman RJ, Everett CJ, Gill JM. Iron, lipids, and risk of cancer in the Framingham Offspring cohort Am J Epidemiol 2005;161:1115-22.
27. Wheeler MD, Smutney OM, Samulski RJ. Secretion of extracellular superoxide dismutase from muscle transduced with recombinant adenovirus inhibits the growth of B16 melanomas in mice. Mol Cancer Res 2003;1:871-81.
28. Mondola P, Annella T, Santillo M, Santangelo F, Mondola P, Annella T, Santillo M, Santangelo F. Evidence for secretion of cytosolic CuZn superoxide dismutase by Hep G2 cells and human fibroblasts. Int J Biochem Cell Biol 1996;28:677-81.
29. Janssen AM, Bosman CB, Kruidenier L, Griffioen G, Lamers CB, van Krieken JH, van de Velde CJ, Verspaget HW. Superoxide dismutases in the human colorectal cancer sequence. J Cancer Res Clin Oncol 1999;125:327-35.
30. Janssen AM, Bosman CB, van Duijn W, Oostendorp-van de Ruit MM, Kubben FJ, Griffioen G, Lamers CB, van Krieken JH, van de Velde CJ, Verspaget HW. Superoxide dismutases in gastric and esophageal cancer and the prognostic impact in gastric cancer. Clin Cancer Res 2000;6:3183-92.
31. Punnonen K, Ahotupa M, Asaishi K, Hy€oty M, Kudo R, Punnonen R. Antioxidant enzyme activities and oxidative stress in human breast cancer. J Cancer Res Clin Oncol 1994;120:374-7.
32. Nishiura T, Suzuki K, Kawaguchi T, Nakao H, Kawamura N, Taniguchi M, Kanayama Y, Yonezawa T, Lizuka S, Taniguchi N. Elevated serum manganese superoxide dismutase in acute leukemias. Cancer Lett 1992;62:211-5.
33. Church SL, Grant JW, Ridnour RA, Oberlay LW, Swanson PE, Meltzer PS, Trent JM. Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells. Proc Natl Acad Sci USA 1993;90:3113-17.
34. Hu Y, Rosen DG, Zhou Y, Feng L, Yang G, Liu J, Huang P. Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress. J Biol Chem 2005;280:39485-92.