Bioequivalence in dogs of a meloxicam formulation administered as a transmucosal oral mist with an orally administered pioneer suspension product

Journal of Veterinary Pharmacology and Therapeutics

Volumn 36, Issue 1, 2013, Pages 78-84

  Lees, P ^a   Cheng, Z ^a   Keefe, T J ^b   Weich, E ^c   Bryd, J ^c   Cedergren, R ^d   Cozzi, E ^d  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b EnviroStat Associates   (United States)

^c Southwest Bio Labs   (United States)

^d ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MELOXICAM;

AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; DOG; DRUG ABSORPTION; DRUG FORMULATION; FEMALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PHARMACOKINETICS; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; SUSPENSION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; AEROSOLS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DOGS; FEMALE; THERAPEUTIC EQUIVALENCY; THIAZINES; THIAZOLES;

CANIS FAMILIARIS;

EID: 84872373876     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2012.01402.x     Document Type: Article

References (31)

1. Brideau, C., Van Staden, C. & Chan Chi, C. (2001) In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs and cats. American Journal of Veterinary Research, 62, 1755-1760.
2. Budsberg, S.C., Cross, A.R., Quandt, J.E., Pablo, L.S. & Runk, A.R. (2002) Evaluation of intravenous administration of meloxicam for perioperative pain management following stifle joint surgery in dogs. American Journal of Veterinary Research, 63, 1557-1563.
3. Busch, U., Schmid, J., Heinzel, G., Schmaus, H., Baierl, J., Huber, C. & Roth, W. (1998) Pharmacokinetics of meloxicam in animals and the relevance to humans. Drug Metabolism and Disposition, 16, 576-584.
4. Caulkett, N., Read, M., Fowler, D. & Waldner, C. (2003) A comparison of the analgesic effects of butorphanol with those of meloxicam after elective ovariohysterectomy in dogs. Canadian Veterinary Journal, 44, 565-570.
5. Deneuche, A.J., Dufayet, C., Goby, L., Fayolle, P. & Desbois, C. (2004) Analgesic comparison of meloxicam or ketoprofen for orthopaedic surgery in dogs. Veterinary Surgery, 33, 650-660.
6. Distel, M., Mueller, C., Bluhmki, E. & Fries, J. (1996) Safety of meloxicam: a global analysis of clinical trials. British Journal of Rheumatology, 35 (Suppl. 1), 68-77.
7. Engelhardt, G. (1996) Pharmacology of meloxicam, a new non-steroidal anti-inflammatory drug with an improved safety profile through preferential inhibition of COX-2. British Journal of Rheumatology, 35 (Suppl. 1), 4-12.
8. Engelhardt, G., Bögel, R., Schnitzler, C. & Utzmann, R. (1996) Meloxicam: influence on arachidonic acid metabolism Part 1. In Vitro findings. Biochemical Pharmacology, 51, 21-28.
9. Fowler, D., Isakow, K., Caulkett, N. & Waldner, C. (2003) An evaluation of the analgesic effects of meloxicam in addition to epidural morphine/mepivacaine in dogs undergoing cranial cruciate ligament repair. Canadian Veterinary Journal, 44, 643-648.
10. Giraudel, J.M., Toutain, P.L. & Lees, P. (2005) Development of in vitro assays for the evaluation of cyclooxygenase inhibitors and predicting selectivity of non-steroidal anti-inflammatory drugs in cats. American Journal of Veterinary Research, 66, 700-709.
11. Gruet, P., Seewald, W. & King, J.N. (2011) Evaluation of subcutaneous and oral administration of robenacoxib and meloxicam for the treatment of acute pain and inflammation associated with orthopedic surgery in dogs. American Journal of Veterinary Research, 72, 184-193.
12. Higgins, A.J. & Lees, P. (1984) The acute inflammatory process, arachidonic acid metabolism and the mode of action of anti-inflammatory drugs. Equine Veterinary Journal, 16, 163-175.
13. Innes, J., O'Neill, T. & Lascelles, D. (2010) Use of non-steroidal anti-inflammatory drugs for the treatment of canine osteoarthritis. In Practice, 32, 126-137.
14. Jones, C.J., Streppa, H.K. & Harmon, B.G. (2002) In vivo effects of meloxicam and aspirin on blood, gastric mucosal, and synovial fluid prostanoid synthesis in dogs. American Journal of Veterinary Research, 63, 1527-1531.
15. Kay-Mugford, P., Benn, S.J., LaMarre, J. & Conlon, P. (2000) In vitro effects of nonsteroidal anti-inflammatory drugs on cyclooxygenase activity in dogs. American Journal of Veterinary Research, 61, 802-810.
16. King, J.N., Rudaz, C., Borer, L., Jung, M., Seewald, W. & Lees, P. (2010) In vitro and ex vivo inhibition of canine cyclooxygenase isoforms by robenacoxib: a comparative study. Research in Veterinary Science, 88, 497-506.
17. Kujubu, D.A., Fletcher, B.S., Varnum, C., Lim, R.S. & Herschman, H.R. (1991) TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. Journal of Biological Chemistry, 266, 12866-12872.
18. Leece, E.A., Brearley, J.C. & Harding, E.F. (2005) Comparison of carprofen and meloxicam for 72hours following ovariohysterectomy in dogs. Veterinary Anaesthesia and Analgesia, 32, 184-192.
19. Lees, P. & Higgins, A.J. (1985) Clinical pharmacology and therapeutic uses of non-steroidal anti-inflammatory drugs in the horse. Equine Veterinary Journal, 17, 83-96.
20. Lees, P., Landoni, M.F., Giraudel, J. & Toutain, P.L. (2004) Pharmacodynamics and pharmacokinetics of non-steroidal anti-inflammatory drugs in species of veterinary interest. Journal of Veterinary Pharmacology and Therapeutics, 27, 479-490.
21. Luna, S.P.L., Basilio, A.C., Steagall, P.V.M., Machado, L.P., Moutinho, F.Q., Takahira, R.K. & Brandão, C.V.S. (2007) Evaluation of adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs. American Journal of Veterinary Research, 68, 258-264.
22. Matthews, K.A., Pettifer, G., Foster, R. & McDonnell, W. (2001) Safety and efficacy of preoperative administration of meloxicam, compared with that of ketoprofen and butorphanol in dogs undergoing abdominal surgery. American Journal of Veterinary Research, 62, 882-888.
23. Moreau, M., Dupuis, J., Bonneau, N.H. & Desnoyers, M. (2003) Clinical evaluation of nutraceutical, carprofen and meloxicam for the treatment of dogs with osteoarthritis. Veterinary Record, 152, 323-329.
24. Peterson, K.D. & Keefe, T.J. (2004) Effects of meloxicam on severity of lameness and other clinical signs of osteoarthritis in dogs. Journal of the American Veterinary Medical Association, 225, 1056-1060.
25. Ricketts, A.P., Lundy, K.M. & Seibel, S.B. (1998) Evaluation of selective inhibition of canine cyclooxygenase 1 and 2 by carprofen and other nonsteroidal anti-inflammatory drugs. American Journal of Veterinary Research, 59, 1441-1446.
26. Streppa, H.K., Jones, C.J. & Budsberg, C. (2002) Cyclooxygenase selectivity of nonsteroidal anti-inflammatory drugs in canine blood. American Journal of Veterinary Research, 63, 91-94.
27. Türck, D., Roth, W. & Busch, U. (1996) A review of the clinical pharmacokinetics of meloxicam. British Journal of Rheumatology, 35 (Suppl. 1), 13-16.
28. Vane, J.R. (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature (New Biology), 231, 232-235.
29. Warner, T.D., Giuliano, F., Vojnovic, I., Bukasa, A., Mitchell, J.A. & Vane, J.R. (1999) Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proceedings of the National Academy of Sciences of the USA, 96, 7563-7568.
30. Wooten, J.G., Blikslager, A.T., Marks, S.L., Law, J.M., Graeber, E.C. & Lascelles, D.X. (2009) Effect of nonsteroidal anti-inflammatory drugs with varied cyclooxygenase-2 selectivity on cyclooxygenase protein and prostanoid concentrations in pyloric and duodenal mucosa of dogs. American Journal of Veterinary Research, 70, 1243-1249.
31. Xie, W., Shipman, J.G., Robertson, D.L., Erikson, R.L. & Simmons, D.L. (1991) Expression of mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proceedings of the National Academy of Sciences of the USA, 88, 2692-2696.