Use of non-steroidal anti-inflammatory drugs for the treatment of canine osteoarthritis

In Practice

Volumn 32, Issue 4, 2010, Pages 126-137

  Innes, John ^a   O'Neill, Turlough ^a,b   Lascelles, Duncan ^c,d,e  

^a Department of Small Animal Surgery ^*

^b Europ Coll of Veterinary Surgeons   (United States)

^c NORTH CAROLINA STATE UNIVERSITY   (United States)

^d College of Veterinary Medicine ^*  (United States)

^e European and American Colleges of Veterinary Surgery   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; CANIS FAMILIARIS;

EID: 77951861754     PISSN: 0263841X     EISSN: 20427689     Source Type: Journal    
DOI: 10.1136/inp.c1436     Document Type: Article

References (31)

1. BENTON, H. P., VASSEUR, P. B., BRODERICK-VILLA, G. A. & KOOLPE, M. (1997) Effect of carprofen on sulfated glycosaminoglycan metabolism, protein synthesis, and prostaglandin release by cultured osteoarthritic canine chondrocytes. American Journal of Veterinary Research 58, 286-292
2. CREAMER, P., HUNT, M. & DIEPPE, P. (1996) Pain mechanisms in osteoarthritis of the knee: effect of intraarticular anesthetic. Journal of Rheumatology 23, 1031-1036
3. GARCIA-HERNANDEZ, L., DECIGA-CAMPOS, M., GUEVARA-LOPEZ, U. & LOPEZ-MUNOZ, F. J. (2007) Co-administration of rofecoxib and tramadol results in additive or sub-additive interaction during arthritic nociception in rat. Pharmacology Biochemistry Behavior 87, 331-340
4. GIRAUDEL, J. M., PEYROU, M., KING, J. N. & GRUET, P. (2009) Population pharmacokinetic analysis of blood robenacoxib data from two dose confirmation field studies in dogs with osteoarthritis. Journal of Veterinary Pharmacology and Therapeutics 32, 102-103
5. GOODMAN, L., TORRES, B., PUNKE, J., REYNOLDS, L., SPEAS, A., ELLIS, A. & BUDSBERG, S. (2009) Effects of firocoxib and tepoxalin on healing in a canine gastric mucosal injury model. Journal of Veterinary Internal Medicine 23, 56-62
6. HANSON, P. D., BROOKS, K. C., CASE, J., CONZEMIUS, M., GORDON, W., SCHUESSLER, J., SHELLEY, B., SIFFERMAN, R., DRAG, M., ALVA, R., BELL, L., ROMANO, D. & FLEISHMAN, C. (2006) Efficacy and safety of firocoxib in the management of canine osteoarthritis under field conditions. Veterinary Therapeutics 7, 127-140
7. INNES, J., CLAYTON, J. & LASCELLES, B. D. X. (2010) Review of the safety and efficacy of long-term NSAID use in the treatment of canine osteoarthritis. Veterinary Record 166, 226-230
8. JUNG, M., LEES, P., SEEWALD, W. & KING, J. N. (2009) Analytical determination and pharmacokinetics of robenacoxib in the dog. Journal of Veterinary Pharmacology and Therapeutics 32, 41-48
9. KUJUBU, D. A., FLETCHER, B. S., VARNUM, B. C., LIM, R. W. & HERSCHMAN, H. R. (1991) TISlO, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. Journal of Biological Chemistry 266, 12866-12872
10. LASCELLES, B. D., GAYNOR, J. S., SMITH, E. S., ROE, S. C., MARCELLIN-LITTLE, D. J., DAVIDSON, G., BOLAND, E. & CARR, J. (2008) Amantadine in a multimodal analgesic regimen for alleviation of refractory osteoarthritis pain in dogs. Journal of Veterinary Internal Medicine 22, 53-59
11. LASCELLES, B. D. X., KING, S., ROE, S., MARCELLIN-LITTLE, D. J. & JONES, S. (2009) Expression and activity of COX-1 and 2 and 5-LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis. Journal of Orthopaedic Research 27, 1204-1208
12. LEES, P., ALEXANDER-BOWMAN, S., HUMMEL, B., KUBIAK, T., MICHELS, G., KRAUTMANN, M., COX, S., TOUTAIN, P. L. & STEGEMANN, M. (2009) Pharmacokinetics and pharmacodynamics of mavacoxib in the dog. Journal of Veterinary Pharmacology and Therapeutics 32, 105-106
13. LI, J., DEMELLO, K. M. L., CHENG, H., SAKYA, S. M., BRONK, B. S., RAFKA, R. J., JAYNES, B. H., ZIEGLER, C. B., KILROY, C., MANN, D. W., NIMZ, E. L., LYNCH, M. P., HAVEN, M. L., KOLOSKO, N. L., MINICH, M. L., LI, C., DUTRA, J. K., RAST, B., CROSSON, R. M., MORTON, B. J., KIRK, G. W., CALLAGHAN, K. M., KOSS, D. A., SHAVNYA, A., LUND, L. A., SEIBEL, S. B., PETRAS, C. F. & SILVIA, A. (2004) Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenylpyrazol-1-yl)-5-methanesulfonyl-pyridine. Bioorganic and Medicinal Chemistry Letters 14, 95-98
14. MACRORY, L., VAUGHAN-THOMAS, A., CLEGG, P. D. & INNES, J. F. (2009) An exploration of the ability of tepoxalin to ameliorate the degradation of articular cartilage in a canine in vitro model. BMC Veterinary Research 5, 25
15. MANNION, R. J. & WOOLF, C. J. (2000) Pain mechanisms and management: a central perspective. Clinical Journal of Pain 16, S144-S156
16. MCCANN, M. E., ANDERSEN, D. R., ZHANG, D. H., BRIDEAU, C., BLACK, W. C., HANSON, P. D. & HICKEY, G. J. (2004) In vitro effects and in vivo efficacy of a novel cyclooxygenase-2 inhibitor in dogs with experimentally induced synovitis. American Journal of Veterinary Research 65, 503-512
17. MUIR, W. W., 3rd & WOOLF, C. J. (2001) Mechanisms of pain and their therapeutic implications. Journal of the American Veterinary Medical Association 219, 1346-1356
18. OSTROM, R. S., GREGORIAN, C., DRENAN, R. M., GABOT, K., RANA, B. K. & INSEL, P. A. (2001) Key role for constitutive cyclooxygenase-2 of MDCK cells in basal signaling and response to released ATP. American Journal of Physiology Cell Physiology 281, C524-C531
19. PELLETIER, J. P., LAJEUNESSE, D., JOVANOVIC, D. V., LASCAU-COMAN, V., JOLICOEUR, F. C., HILAL, G., FERNANDES, J. C. & MARTEL-PELLETIER, J. (2000) Carprofen simultaneously reduces progression of morphological changes in cartilage and subchondral bone in experimental dog osteoarthritis. Journal of Rheumatology 27, 2893-2902
20. PETERSON, K. D. & KEEFE, T. J. (2004) Effects of meloxicam on severity of lameness and other clinical signs of osteoarthritis in dogs. Journal of the American Veterinary Medical Association 225, 1056-1060
21. PUNKE, J. P., SPEAS, A. L., REYNOLDS, L. R. & BUDSBERG, S. C. (2008) Effects of firocoxib, meloxicam, and tepoxalin on prostanoid and leukotriene production by duodenal mucosa and other tissues of osteoarthritic dogs. American Journal of Veterinary Research 69, 203-1209
22. RAINSFORD, K. D., SKERRY, T. M., CHINDEMI, P. & DELANEY, K. (1999) Effects of the NSAIDs meloxicam and indomethacin on cartilage proteoglycan synthesis and joint responses to calcium pyrophosphate crystals in dogs. Veterinary Research Communications 23, 101-113
23. SANDERSON, R. O., BEATA, C. FLIPO, R. M., GENEVOIS, J. P., MACIAS, C. TACKE, S., VEZZONI, A. & INNES, J. F. (2009) Systematic review of the management of canine osteoarthritis. Veterinary Record 164, 418-424
24. SCHMASSMANN, A., ZOIDL, G., PESKAR, B. M., WASER, B., SCHMASSMANN-SUHIJAR, D., GEBBERS, J. O. & REUBI, J. C. (2006) Role of the different isoforms of cyclooxygenase and nitric oxide synthase during gastric ulcer healing in cyclooxygenase-1 and -2 knockout mice. American Journal of Physiology - Gastrointestinal and Liver Physiology 290, G747-G756
25. SCHNEIDER, T. A. & BUDSBERG, S. C. (2001) Plasma and synovial concentrations of carprofen in dogs with chronic osteoarthritis. Veterinary and Comparative Orthopaedics and Traumatology 14, 19-24
26. STREPPA, H. K., JONES, C. J. & BUDSBERG, S. C. (2002) Cyclooxygenase selectivity of nonsteroidal anti-inflammatory drugs in canine blood. American Journal of Veterinary Research 63, 91-94
27. TØRRING, M. L., RIIS, A., CHRISTENSEN, S., THOMSEN, R. W., JEPSEN, P., SØNDERGAARD, J. & SØRENSEN, H. T. (2008) Perforated peptic ulcer and short-term mortality among tramadol users. British Journal of Clinical Pharmacology 65, 565-572
28. VASSEUR, P. B., JOHNSON, A. L., BUDSBERG, S. C., LINCOLN, J. D., TOOMBS, J. P., WHITEHAIR, J. G. & LENTZ, E. L. (1995) Randomized, controlled trial of the efficacy of carprofen, a nonsteroidal anti-inflammatory drug, in the treatment of osteoarthritis in dogs. Journal of the American Veterinary Medical Association 206, 807-811
29. WOOLF, C.J. & SALTER, M. W. (2000) Neuronal plasticity: increasing the gain in pain. Science 288, 1765-1769
30. WOOTEN, J. G., BLIKSLAGER, A. T., RYAN, K. A., MARKS, S. L., LAW, J. M. & LASCELLES, B. D. (2008) Cyclooxygenase expression and prostanoid production in pyloric and duodenal mucosae in dogs after administration of nonsteroidal antiinflammatory drugs. American Journal of Veterinary Research 69, 457-464
31. XIE, W. L., CHIPMAN, J. G., ROBERTSON, D. L., ERIKSON, R. L. & SIMMONS, D. L. (1991) Expression of a mitogenresponsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proceedings of the National Academy of Sciences of the United States of America 88, 2692-2696