A novel synthetic compound, 3-amino-3-(4-fluoro-phenyl)-1H-quinoline-2,4-dione, inhibits cisplatin-induced hearing loss by the suppression of reactive oxygen species: In vitro and in vivo study

Neuroscience

Volumn 232, Issue , 2013, Pages 1-12

  Shin, Y S ^a   Song, S J ^b   Kang, S U ^a   Hwang, H S ^a   Choi, J W ^a   Lee, B H ^a   Jung, Y S ^b   Kim, C H ^a  

^a Ajou University School of Medicine   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

3 amino 3 (4 fluoro phenyl) 1H quinoline 2,4 dione (KR 22332); Cisplatin; Hearing preservation; Mitochondria; Ototoxicity; Reactive oxygen species

Indexed keywords

3 AMINO 3 (4 FLUOROPHENYL) 1H QUINOLINE 2,3 DIONE; CASPASE 3; CISPLATIN; KR 22332; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 3; PROTEIN P53; QUINOLINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 3-AMINO-3-(4-FLUOROPHENYL)-1H-QUINOLINE-2,4-DIONE; CASP3 PROTEIN, MOUSE; NEUROPROTECTIVE AGENT; NOX3 PROTEIN, RAT; QUINOLONE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUDITORY NEUROMAST; CELL LEVEL; CONTROLLED STUDY; CORTI ORGAN; DRUG CYTOTOXICITY; DRUG EFFECT; EVOKED AUDITORY RESPONSE; FEMALE; HEARING IMPAIRMENT; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; MULTICENTER STUDY; NERVE CELL; NICK END LABELING; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ZEBRA FISH; ANIMAL; CELL LINE; CHEMISTRY; DRUG EFFECTS; EVOKED BRAIN STEM AUDITORY RESPONSE; HEARING LOSS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; SYNTHESIS;

ANIMALS; APOPTOSIS; CASPASE 3; CELL LINE; CISPLATIN; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HEARING LOSS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; NADPH OXIDASE; NEUROPROTECTIVE AGENTS; ORGAN OF CORTI; QUINOLONES; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; TUMOR NECROSIS FACTOR-ALPHA; TUMOR SUPPRESSOR PROTEIN P53; ZEBRAFISH;

EID: 84872367429     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2012.12.008     Document Type: Article

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