Clinical experience of granulocyte transfusion in the management of neutropenic patients with haematological malignancies and severe infection

Scandinavian Journal of Infectious Diseases

Volumn 45, Issue 2, 2013, Pages 112-116

  Cherif, Honar ^a   Axdorph, Ulla ^b   Kalin, Mats ^b   Björkholm, Magnus ^b  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Febrile neutropenia; Granulocyte transfusion; Haematological malignancies

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADENOVIRUS INFECTION; ADOLESCENT; ADULT; AGED; ALPHA HEMOLYTIC STREPTOCOCCUS; ARTICLE; BACTEREMIA; CHILD; CLINICAL ARTICLE; COAGULASE NEGATIVE STAPHYLOCOCCUS; CRITICALLY ILL PATIENT; CYTOMEGALOVIRUS INFECTION; DETERIORATION; DISEASE DURATION; ENTEROCOCCUS; ENTEROCOLITIS; EPSTEIN BARR VIRUS INFECTION; ESCHERICHIA COLI; FEMALE; FEVER; GRANULOCYTE TRANSFUSION; HEMATOLOGIC MALIGNANCY; HERPES SIMPLEX; HUMAN; INFECTION; KLEBSIELLA; MALE; MENINGOENCEPHALITIS; MORTALITY; NEUTROPENIA; NONHODGKIN LYMPHOMA; OUTCOME ASSESSMENT; PNEUMONIA; PRESCHOOL CHILD; PSEUDOMONAS AERUGINOSA; RETROSPECTIVE STUDY; SCHOOL CHILD; SEPSIS; SINUSITIS; SOFT TISSUE INFECTION; STAPHYLOCOCCUS AUREUS; STENOTROPHOMONAS MALTOPHILIA; STREPTOCOCCUS PNEUMONIAE; SURVIVAL TIME; SURVIVOR; SYSTEMIC MYCOSIS; THROMBOCYTOPENIA; TREATMENT INDICATION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; BACTEREMIA; BACTERIA; CHI-SQUARE DISTRIBUTION; CHILD; CHILD, PRESCHOOL; FEMALE; GRANULOCYTES; HEMATOLOGIC NEOPLASMS; HUMANS; LEUKEMIA, LYMPHOID; LEUKOCYTE TRANSFUSION; LYMPHOMA, NON-HODGKIN; MALE; MIDDLE AGED; NEUTROPENIA; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84872352751     PISSN: 00365548     EISSN: 16511980     Source Type: Journal    
DOI: 10.3109/00365548.2012.714906     Document Type: Article

References (30)

1. Hughes WT, Armstrong D, Bodey GP, Brown AE, Edwards JE, Feld R, et al. 1997 guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever. Infectious Diseases Society of America. Clin Infect Dis 1997;25:551-73.
2. Klastersky J. Empirical treatment of sepsis in neutropenic patients. Hosp Med 2001;62:101-3.
3. Pizzo PA. Management of fever in patients with cancer and treatment-induced neutropenia. NEngl JMed 1993;328: 1323-32.
4. Cherif H, Martling C-R, Hansen J, Kalin M, Bjö rkholm M. Predictors of short and long-term outcome in patients with hematological disorders admitted to the intensive care unit for alife-threatening complication. Support Care Cancer 2007;15:1393-8.
5. Freireich EJ, Levin RH, Whang J, Carbone PP, Bronson W, Morse EE. The function and fate of transfused leukocytes from donors with chronic myelocytic leukemia in leukopenic recipients. Ann NY Acad Sci 1964;113:1081-9.
6. Cesaro S, Chinello P, De Silvestro G, Marson P, Picco G, Varotto S, et al. Granulocyte transfusions from G-CSFstimulated donors for the treatment of severe infections in neutropenic pediatric patients with onco-hematological diseases. Support Care Cancer 2003;11:101-6.
7. Oza A, Hallemeier C, Goodnough L, Khoury H, Shenoy S, Devine S, et al. Granulocyte-colony-stimulating factormobilized prophylactic granulocyte transfusions given after allogeneic peripheral blood progenitor cell transplantation result in amodest reduction of febrile days and intravenous antibiotic usage. Transfusion 2006;46:14-23.
8. Grigull L, Pulver N, Goudeva L, Sykora KW, Linderkamp C, Beilken A, et al. G-CSF mobilised granulocyte transfusions in 32 paediatric patients with neutropenic sepsis. Support Care Cancer 2006;14:910-6.
9. Sachs UJ, Reiter A, Walter T, Bein G, Woessmann W. Safety and effi cacy of therapeutic early onset granulocyte transfusions in pediatric patients with neutropenia and severe infections. Transfusion 2006;46:1909-14.
10. Stanworth SJ, Massey E, Hyde C, Brunskill S, Lucas G, Navarrete C, et al. Granulocyte transfusions for treating infections in patients with neutropenia or neutrophil dysfunction. Cochrane Database Syst Rev 2005;(3): CD005339.
11. Price TH. Granulocyte transfusion therapy: it' stime for an answer. Transfusion 2006;46:1-5.
12. Strauss RG. Role of granulocyte/neutrophil transfusions for haematology/oncology patients in the modern era. Br JHaematol 2012;158:299-306.
13. Seidel MG, Peters C, Wacker A, Northoff H, Moog R, Boehme A, et al. Randomized phase III study of granulocyte transfusions in neutropenic patients. Bone Marrow Transplant 2008;42:679-84.
14. Massey E, Paulus U, Doree C, Stanworth S. Granulocyte transfusions for preventing infections in patients with neutropenia or neutrophil dysfunction. Cochrane Database Syst Rev 2009;(1):CD005341.
15. Price TH, Bowden RA, Boeckh M, Bux J, Nelson K, Liles WC, et al. Phase I/II trial of neutrophil transfusions from donors stimulated with G-CSF and dexamethasone for treatment of patients with infections in hematopoietic stem cell transplantation. Blood 2000;95:3302-9.
16. Adkins D, Spitzer G, Johnston M, Velasquez W, Dunphy F, Petruska P. Transfusions of granulocyte-colony-stimulating actor-mobilized granulocyte components to allogeneic transplant recipients: analysis of kinetics and factors determining post transfusion neutrophil and platelet counts. Transfusion 1997;37:737-48.
17. Kerr JP, Liakopolou E, Brown J, Cornish JM, Fleming D, Massey E, et al. The use of stimulated granulocyte transfusions to prevent recurrence of past severe infections after allogeneic stem cell transplantation. Br JHaematol 2003; 123:114-8.
18. Rosenshein MS, Farewell VT, Price TH, Larson EB, Dale DC. The cost effectiveness of therapeutic and prophylactic leukocyte transfusion. NEngl JMed 1980;302:1058-62.
19. Hü bel K, Carter RA, Liles WC, Dale DC, Price TH, Bowden RA, et al. Granulocyte transfusion therapy for infections in candidates and recipients of HPC transplantation: acomparative analysis of feasibility and outcome for community donors versus related donors. Transfusion 2002;42:1414-21.
20. Safdar A, Hanna HA, Boktour M, Kontoyiannis DP, Hachem R, Lichtiger B, et al. Impact of high-dose granulocyte transfusions in patients with cancer with candidemia: retrospective case-control analysis of 491 episodes of Candida species bloodstream infections. Cancer 2004;101: 2859-65.
21. Hü bel K, Dale DC, Engert A, Liles WC. Current status of granulocyte (neutrophil) transfusion therapy for infectious diseases. JInfect Dis 2001;183:321-8.
22. O' Donghaile D, Childs RW, Leitman SF. Blood consult: granulocyte transfusions to treat invasive aspergillosis in apatient with severe aplastic anemia awaiting mismatched hematopoietic progenitor cell transplantation. Blood 2012; 119:1353-5.
23. Engelfriet CP, Reesink HW, Klein HG, Murphy MF, Pamphilon D, Devereux S, et al. International forum: granulocyte transfusions. Vox Sang 2000;79:59-66.
24. Vamvakas EC, Pineda AA. Meta-analysis of clinical studies of the effi cacy of granulocyte transfusions in the treatment of bacterial sepsis. JClin Apher 1996;11:1-9.
25. Stroncek D, Shawker T, Follmann D, Leitman SF. GCSF-induced spleen size changes in peripheral blood progenitor cell donors. Transfusion 2003;43:609-13.
26. Tassi C, Tazzari PL, Bonifazi F, Giudice V, Nannetti A, Ricci F, et al. Short-and long-term haematological surveillance of healthy donors of allogeneic peripheral haematopoietic progenitors mobilized with G-CSF: asingle institution prospective study. Bone Marrow Transplant 2005;36:289-94.
27. Sakamaki S, Matsunaga T, Hirayama Y, Kuga T, Niitsu Y. Haematological study of healthy volunteers 5 years after G-CSF. Lancet 1995;346:1432-3.
28. Cavallaro AM, Lilleby K, Majolino I, Storb R, Appelbaum FR, Rowley SD, et al. Three to six year follow-up of normal donors who received recombinant human granulocyte colonystimulating factor. Bone Marrow Transplant 2000;25:85-9.
29. Winston DJ, Ho WG, Gale RP. Therapeutic granulocyte transfusions for documented infections. Acontrolled trial in ninety-fi ve infectious granulocytopenic episodes. Ann Intern Med 1982;97:509-15.
30. Strauss RG, Connett JE, Gale RP, Bloomfi eld CD, Herzig GP, McCullough J, et al. Acontrolled trial of prophylactic granulocyte transfusions during initial induction chemotherapy for acute myelogenous leukemia. NEngl JMed 1981; 305:597-603.