G-CSF mobilised granulocyte transfusions in 32 paediatric patients with neutropenic sepsis

Supportive Care in Cancer

Volumn 14, Issue 9, 2006, Pages 910-916

  Grigull, Lorenz ^a   Pulver, Nicole ^a   Goudeva, Lilia ^a   Sykora, Karl Walter ^a   Linderkamp, Christin ^a   Beilken, Andreas ^a   Seidemann, Kathrin ^a   Schmid, Hansjörg ^a   Welte, Karl ^a   Heuft, Hans Gert ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

G CSF; Granulocyte transfusion; Neutropenia; Sepsis

Indexed keywords

C REACTIVE PROTEIN; CYTOMEGALOVIRUS ANTIBODY; DEXAMETHASONE; GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ADOLESCENT; ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; BACTERIUM ISOLATION; BLOOD TRANSFUSION; BREATHING RATE; FEMALE; FEVER; GRANULOCYTE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MORTALITY; MYCOSIS; NEUTROPENIA; NEUTROPHIL; NEUTROPHIL COUNT; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SEPSIS; TACHYCARDIA;

ACUTE DISEASE; ADOLESCENT; ANTINEOPLASTIC AGENTS; BIOLOGICAL MARKERS; BLOOD COMPONENT REMOVAL; C-REACTIVE PROTEIN; CHILD; CHILD, PRESCHOOL; FEMALE; FOLLOW-UP STUDIES; GERMANY; GRAM-NEGATIVE BACTERIAL INFECTIONS; GRAM-POSITIVE BACTERIAL INFECTIONS; GRANULOCYTE COLONY STIMULATING FACTOR, RECOMBINANT; GRANULOCYTES; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INFANT; LEUKEMIA, LYMPHOCYTIC, ACUTE; LEUKEMIA, MYELOID; LEUKOCYTE COUNT; LEUKOCYTE TRANSFUSION; MALE; MYCOSES; NEUTROPENIA; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RETROSPECTIVE STUDIES; SEPSIS; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 33747341612     PISSN: 09414355     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00520-006-0041-x     Document Type: Article

References (26)

1. Bhatia S, McCullough J, Perry EH, Clay M, Ramsay NK, Neglia JP (1994) Granulocyte transfusions: efficacy in treating fungal infections in neutropenic patients following bone marrow transplantation. Transfusion 34:226-232
2. Bindl L, Nicolai T (2005) Management of septic shock and acquired respiratory distress syndrome in pediatric cancer patients. Klin Padiatr 217(Suppl 1):S130-S142
3. Briones MA, Josephson CD, Hillyer CD (2003) Granulocyte transfusion: revisited. Curr Hematol Rep 2:522-527
4. Catalano L, Fontana R, Scarpato N, Picardi M, Rocco S, Rotoli B (1997) Combined treatment with amphotericin-B and granulocyte transfusion from G-CSF-stimulated donors in an aplastic patient with invasive aspergillosis undergoing bone marrow transplantation. Haematologica 82:71-72
5. Cesaro S, Chinello P, De Silvestro G, Marson P, Picco G, Varotto S, Pittalis S, Zanesco L (2003) Granulocyte transfusions from G-CSF-stimulated donors for the treatment of severe infections in neutropenic pediatric patients with onco-hematological diseases. Support Care Cancer 11:101-106
6. Goldstein B, Giroir B, Randolph A (2005) International consensus conference on pediatric sepsis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 6(1):2-8
7. Grigull L, Schrauder A, Schmitt-Thomssen A, Sykora K, Welte K (2002) Efficacy and safety of G-CSF mobilized granulocyte transfusions in four neutropenic children with sepsis and invasive fungal infection. Infection 30:267-271
8. Haase R, Mathony U, Lieser U, Nagel F, Sitka U, Burdach S (2003) Oncology patients in a pediatric intensive care unit - a 7-year experience. Klin Padiatr 215(4):234-240
9. Hann I, Viscoli C, Paesmans M, Gaya H, Glauser M (1997) A comparison of outcome from febrile neutropenic episodes in children compared with adults: results from four EORTC studies. International antimicrobial Therapy Cooperative Group (IATCG) of the European Organization for Research and Treatment of Cancer (EORTC). Br J Haematol 99:580-588
10. Hester JP, Dignani MC, Anaissie EJ, Kantarjian HM, O'Brien S, Freireich EJ (1995) Collection and transfusion of granulocyte concentrates from donors primed with granulocyte stimulating factor and response of myelosuppressed patients with established infection. J Clin Apheresis 10:188-193
11. Heuft HG, Goudeva L, Pulver N, Grigull L, Schwella N, Blasczyk R (2005) A dose-response analysis of lenograstim plus dexamethasone for neutrophil mobilization and collection. Transfusion 45(4):604-612
12. Hübel K, Engert A (2003) Granulocyte transfusion therapy for treatment of infections after cytotoxic chemotherapy. Onkologie 26:73-79
13. Jacobe SJ, Hassan A, Veys P, Mok Q (2003) Outcome of children requiring admission to an intensive care unit after bone marrow transplantation. Crit Care Med 31(5):1299-1305
14. Kerr JP, Liakopolou E, Brown J, Cornish, JM, Fleming, D, Massey, E, Oakhill, A, Pamphilon DH, Robinson SP, Totem A, Valencia AM, Marks DI (2003) The use of stimulated granulocyte transfusions to prevent recurrence of past severe infections after allogeneic stem cell transplantation. Br J Haematol 123:114-118
15. Kutko MC, Calarco MP, Flaherty MB, Helmrich RF, Ushay HM, Pon S, Greenwald BM (2003) Mortality rates in pediatric septic shock with and without multiple organ system failure. Pediatr Crit Care Med 4(3):333-337
16. Larche J, Azoulay E, Fieux F, Mesnard L, Moreau D, Thiery G, Darmon M, Le Gall JR, Schlemmer B (2003) Improved survival of critically ill cancer patients with septic shock. Intensive Care Med 29(10):1688-1695
17. Lee JJ, Chung IJ, Park MR, Kook H, Hwang TJ, Ryang DW, Kim HJ (2001) Clinical efficacy of granulocyte transfusion therapy in patients with neutropenia-related infections. Leukemia 15:203-207
18. Lehrnbecher T, Chanock SJ (1998) Controversies in the treatment of neutropenia in cancer patients. Curr Opin Hematol 5:26-32
19. Liang DC (2003) The role of colony-stimulating factors and granulocyte transfusion in treatment options for neutropenia in children with cancer. Paediatr Drugs 5:673-684
20. Ozsahin H, von Planta M, Muller I, Steinert HC, Nadal D, Lauener R, Tuchschmid P, Willi UV, Ozsahin M, Crompton NE, Seger RA (1998) Successful treatment of invasive aspergillosis in chronic granulomatous disease by bone marrow transplantation, granulocyte colony-stimulating factor-mobilized granulocytes, and liposomal amphotericin-B. Blood 92:2719-2724
21. Peters C, Minkov M, Matthes-Martin S, Potschger U, Witt V, Mann, G, Höcker, P, Worel N, Stary J, Klingebiel T, Gadner H (1999) Leucocyte transfusions from rhG-CSF or prednisolone stimulated donors for treatment of severe infections in immunocompromised neutropenic patients. Br J Haematol 106:689-696
22. Price TH, Bowden RA, Boeckh M, Bux J, Nelson K, Liles WC, Dale DC (2000) Phase I/II trial of neutrophil transfusions from donors stimulated with G-CSF and dexamethasone for treatment of patients with infections in hematopoietic stem cell transplantation. Blood 95:3302-3309
23. Rossi C, Klastersky J (1996) Initial empirical antibiotic therapy for neutropenic fever:analysis of the causes of death. Support Care Cancer 4(3):207-212
24. Schneider DT, Lemburg P, Sprock I, Heying R, Gobel U, Nurnberger W (2000) Introduction of the oncological pediatric risk of mortality score (O-PRISM) for ICU support following stem cell transplantation in children. Bone Marrow Transplant 25:1079-1086
25. Tomaske M, Bosk A, Eyrich M, Bader P, Niethammer D (2003) Risks of mortality in children admitted to the paediatric intensive care unit after haematopoietic stem cell transplantation. Br J Haematol 121(6):886-891
26. van Burik JA, Weisdorf DJ (2002) Is it time for a new look at granulocyte transfusions? Transfusion 42:1393-1395