Safety and efficacy of therapeutic early onset granulocyte transfusions in pediatric patients with neutropenia and severe infections

Transfusion

Volumn 46, Issue 11, 2006, Pages 1909-1914

  Sachs, Ulrich J H ^a   Reiter, Alfred ^a   Walter, Tobias ^a   Bein, Gregor ^a   Woessmann, Wilhelm ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; FOSCARNET SODIUM; GRANULOCYTE COLONY STIMULATING FACTOR;

ADOLESCENT; ADULT; ARTICLE; ASPERGILLOSIS; BACTERIAL INFECTION; CHILD; CHILL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; DYSPNEA; EOSINOPHILIA; FEMALE; GRANULOCYTE TRANSFUSION; HUMAN; HUMAN CELL; HYPOXEMIA; IMMUNE DEFICIENCY; INFANT; LEUKAPHERESIS; MALE; MYCOSIS; NEUTROPENIA; NEWBORN; PHASE 2 CLINICAL TRIAL; PNEUMONIA; TRACHEOBRONCHIAL TOILET;

ADOLESCENT; BACTERIAL INFECTIONS; CHILD; CHILD, PRESCHOOL; FEMALE; GRANULOCYTE COLONY STIMULATING FACTOR, RECOMBINANT; GRANULOCYTES; HUMANS; IMMUNOCOMPROMISED HOST; INFANT; INFANT, NEWBORN; LEUKOCYTE TRANSFUSION; MALE; MYCOSES; NEOPLASMS; NEUTROPENIA; SAFETY MANAGEMENT; SEVERITY OF ILLNESS INDEX;

EID: 33750322246     PISSN: 00411132     EISSN: 15372995     Source Type: Journal    
DOI: 10.1111/j.1537-2995.2006.00996.x     Document Type: Article

References (20)

1. Denning DW. Treatment of invasive aspergillosis. J Infect 1994;28:25-33.
2. Hughes WT, Armstrong D, Bodey GP, et al. Guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever. Clin Infect Dis 1997;25:551.
3. Engels EA, Ellis CA, Supran SE, et al. Early infection in bone marrow transplantation: quantitative study of clinical factors that affect risk. Clin Infect Dis 1999;28:256.
4. Vamvakas EC, Pineda AA. Meta-analysis of clinical studies of the efficacy of granulocyte transfusions in the treatment of bacterial sepsis. J Clin Apher 1996;11:1-9.
5. Bensinger WI, Price TH, Dale DC, et al. The effects of daily recombinant human granulocyte colony-stimulating factor administration on normal granulocyte donors undergoing leukapheresis. Blood 1993;81:1883-8.
6. Caspar CB, Seger RA, Burger J, Gmur J. Effective stimulation of donors for granulocyte transfusions with recombinant methionyl granulocyte colony-stimulating factor. Blood 1993;81:2866-71.
7. Peters C, Minkov M, Matthes-Martin S, et al. Leucocyte transfusions from rhG-CSF or prednisolone stimulated donors for treatment of severe infections in immunocompromised neutropenic patients. Br J Haematol 1999;106:689-96.
8. Price TH, Bowden RA, Boeckh M, et al. Phase I/II trial of neutrophil transfusions from donors stimulated with G-CSF and dexamethasone for treatment of patients with infections in hematopoietic stem cell transplantation. Blood 2000;95:3302-9.
9. Dignani MC, Anaissie EJ, Hester JP, et al. Treatment of neutropenia-related fungal infections with granulocyte colony-stimulating factor-elicited white blood cell transfusions: a pilot study. Leukemia 1997;11:1621-30.
10. Auffermann S, Herzog R, Hebart H, et al. Granulocyte transfusions in neutropenic patients with life threatening infections: prophylactic and therapeutic use. Bone Marrow Transplant 1999;23:S110.
11. Verheugt FW, van dem Borne AE, Decary F, et al. The detection of granulocyte alloantibodies with an indirect immunofluorescence test. Br J Haematol 1977;36:533-44.
12. Lalezari O, Jiang A, Lee S. A microagglutination technique for the detection of leukocyte agglutinins. In: Ray JG, editor. NIAID manual of tissue typing techniques. Bethesda: NIAID; 1979. p. 20-2.
13. Bux J, Cassens U, Dielschneider T, et al. Tolerance of granulocyte donors towards granulocyte colony-stimulating factor stimulation and of patients towards granulocyte transfusions: results of a multicentre study. Vox Sang 2003;85:322-5.
14. Cesaro S, Chinello P, De Silvestro G, et al. Granulocyte transfusions from G-CSF-stimulated donors for the treatment of severe infections in neutropenic patients with onco-hematological diseases. Support Care Cancer 2003;11:101-6.
15. Lee JJ, Chung IJ, Park MR, et al. Clinical efficacy of granulocyte transfusion therapy in patients with neutropenia-related infections. Leukemia 2001;15:203-7.
16. Seeger W, Schneider U, Kreusler B, et al. Reproduction of transfusion-related acute lung injury in an ex vivo lung model. Blood 1990;76:1438-44.
17. Sachs UJ, Hattar K, Weissmann N, et al. Antibody-induced neutrophil activation as a trigger for transfusion-related acute lung injury in an ex vivo rat lung model. Blood 2006;107:1217-9.
18. McCullough J, Clay M, Hurd D, et al. Effect of leukocyte antibodies and HLA matching on the intravascular recovery, survival, and tissue localization of 111-indium granulocytes. Blood 1986;67:522-8.
19. Illerhaus G, Wirth K, Dwenger A, et al. Treatment and prophylaxis of severe infections in neutropenic patients by granulocyte transfusions. Ann Hematol 2002;81:273-81.
20. Hester JP, Dignani MC, Anaissie EJ, et al. Collection and transfusion of granulocyte concentrates from donors primed with granulocyte stimulating factor and response of myelosuppressed patients with established infection. J Clin Apher 1995;10:188-93.