Enhancement of corneal permeation of riboflavin-5′-phosphate through vitamin e TPGS: A promising approach in corneal trans-epithelial cross linking treatment

International Journal of Pharmaceutics

Volumn 440, Issue 2, 2013, Pages 148-153

  Ostacolo, Carmine ^a   Caruso, Ciro ^b   Tronino, Diana ^a   Troisi, Salvatore ^c   Laneri, Sonia ^a   Pacente, Luigi ^b   Del Prete, Antonio ^d   Sacchi, Antonia ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b Pellegrini Hospital   (Italy)

^c UNIVERSITY OF SALERNO   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Corneal cross linking; Electron microscopy; In vitro corneal accumulation; Riboflavin; Stress strain measurements; Vitamin E TPGS

Indexed keywords

ALPHA TOCOPHEROL; DEXTRAN; DEXTRO ALPHA TOCOPHERYL POLY(ETHYLENE GLYCOL) 1000 SUCCINATE; FLAVINE MONONUCLEOTIDE; FREE RADICAL; POLYMER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORNEA CROSS LINKING; CORNEA EPITHELIUM; CORNEA PERMEABILITY; CRITICAL MICELLE CONCENTRATION; CROSS LINKING; DIFFUSION; DRUG ACCUMULATION; DRUG PENETRATION; EYE PROTECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY;

ADMINISTRATION, OPHTHALMIC; ANIMALS; ANTIOXIDANTS; BIOLOGICAL AVAILABILITY; CORNEA; CORNEAL TOPOGRAPHY; CROSS-LINKING REAGENTS; DEXTRANS; DRUG CARRIERS; FLAVIN MONONUCLEOTIDE; HUMANS; POLYETHYLENE GLYCOLS; PRODRUGS; SWINE; VITAMIN E;

EID: 84872337509     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.09.051     Document Type: Article

References (30)

1. S. Baiocchi, C. Mazzotta, D. Cerretani, T. Caporossi, and A. Caporossi Corneal crosslinking: riboflavin concentration in corneal stroma exposed with and without epithelium J. Cataract Refract. Surg. 35 2009 893 899
2. H.B. Collin Ultrastructural changes to corneal stromal cells due to ophthalmic preservatives Acta Opthalmol. 64 1986 72 78
3. E.M. Collnot, C. Baldes, M.F. Wempe, J. Hyatt, L. Navarro, K.J. Edgar, U.F. Schaefer, and C.M. Lehr Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers J. Control. Release 111 2006 35 40
4. P.P. Constantinides, J. Han, and S.S. Davis Advances in the use of tocols as drug delivery vehicles Pharm. Res. 23 2006 243 255
5. P.P. DeLuca, and H.B. Kostenbauder Interaction of preservatives with macromolecules IV. Binding of quaternary ammonium compounds by nonionic agents J. Am. Pharm. Assoc. 49 1960 430 437
6. G.R.S. Franzco Collagen cross-linking: a new treatment paradigm in corneal diseases-a review Clin. Exp. Ophthalmol. 38 2010 141 153
7. F. Hafezi Limitation of collagen cross-linking with hypoosmolar riboflavin solution: failure in an extremely thin cornea Cornea 30 2011 917 919
8. S. Hariharan, K.G. Janoria, S. Gunda, X. Zhu, D. Pal, and A.K. Mitra Identification and functional expression of a carrier-mediated riboflavin transport system on rabbit corneal epithelium Curr. Eye Res. 31 2006 811 824
9. J. Jiao Polyoxyethylated nonionic surfactants and their applications in topical ocular drug delivery Adv. Drug Deliv. Rev. 60 2008 1663 1673
10. V. Kansara, D. Pal, R. Jain, and A.K. Mitra Identification and functional characterization of riboflavin transporter in human-derived retinoblastoma cell line (Y-79): mechanisms of cellular uptake and translocation J. Ocul. Pharmacol. Ther. 21 2005 275 287
11. S. Katragadda, R.S. Talluri, and A.K. Mitra Modulation of P-glycoprotein-mediated efflux by prodrug derivatization: an approach involving peptide transporter-mediated influx across rabbit cornea J. Ocul. Pharmacol. Ther. 22 2006 110 120
12. A. Kissner, E. Spoerl, R. Jung, K. Spekl, L.E. Pillunat, and F. Raiskup Pharmacological modification of the epithelial permeability by benzalkonium chloride in UVA/riboflavin corneal collagen cross-linking Curr. Eye Res. 35 2010 715 721
13. S.D. Klyce, and C.E. Crosson Transport processes across the rabbit corneal epithelium: a review Curr. Eye Res. 4 1985 323 331
14. M. Kohlhaas, E. Spoerl, T. Schilde, G. Unger, C. Wittig, and L.E. Pillunat Biomechanical evidence of the distribution of cross-links in corneas treated with riboflavin and ultraviolet A light J. Cataract Refract. Surg. 32 2006 279 283
15. C. Koppen, J.C. Vryghem, L. Gobin, and M.J. Tassignon Keratitis and corneal scarring after UVA/riboflavin cross-linking for keratoconus J. Refract. Surg. 25 2009 819 823
16. J.H. Krachmer, R.S. Feder, and M.W. Belin Keratoconus and related noninflammatory corneal thinning disorders Surv. Ophthalmol. 28 1984 293 322
17. A. Leccisotti, and T. Islam Transepithelial corneal collagen cross-linking in keratoconus J. Refract. Surg. 26 2010 942 948
18. J.K. Maurer, R.D. Parker, and G.J. Carr Ocular irritation: microscopic changes occurring over time in the rat with surfactants of known irritancy Toxicol. Pathol. 26 1998 217 225
19. A. Podskochy, L. Gan, and P. Fagerholm Apoptosis in UV exposed rabbit corneas Cornea 19 2000 99 103
20. M. Pollhammer, and C. Cursiefen Bacterial keratitis early after corneal crosslinking with riboflavin and ultraviolet-A J. Cataract Refract. Surg. 35 2009 588 589
21. S.W. Reeves, S. Stinnett, R.A. Adelman, and N.A. Afshari Risk factors for progression to penetrating keratoplasty in patients with keratoconus Am. J. Ophthalmol. 140 2005 607 611
22. D.Z. Reinstein, T.J. Archer, M. Gobbe, R.H. Silverman, and D.J. Coleman Epithelial thickness in the normal cornea: three-dimensional display with Artemis very high-frequency digital ultrasound J. Refract. Surg. 24 2008 571 581
23. M.F. Saettone, P. Chetoni, R. Cerbai, G. Mazzanti, and L. Braghiroli Evaluation of ocular permeation enhancers: in vitro effects on corneal transport of four β-blockers, and in vitro/in vivo toxic activity Int. J. Pharm. 142 1996 103 113
24. E. Spoerl, M. Huhle, and T. Seiler Induction of cross-links in corneal tissue Exp. Eye Res. 66 1998 97 103
25. M.G. Traber, C.A. Thellman, M.J. Rindler, and H.J. Kayden Uptake of intact TPGS (d-alpha-tocopheryl polyethylene glycol 1000 succinate) a water-miscible form of vitamin E by human cells in vitro Am. J. Clin. Nutr. 48 1988 605 611
26. P. Viñas, N. Balsalobre, C. López-Erroz, and M. Hernández-Córdoba Liquid chromatographic analysis of riboflavin vitamers in foods using fluorescence detection J. Agric. Food Chem. 52 2004 1789 1794
27. G. Wollensak, E. Spoerl, and T. Seiler Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking J. Cataract Refract. Surg. 29 2003 1780 1785
28. G. Wollensak, E. Spoerl, M. Wilsch, and T. Seiler Endothelial cell damage after riboflavin-ultraviolet-A-treatment in the rabbit J. Cataract Refract. Surg. 29 2003 1786 1790
29. G. Wollensak Crosslinking treatment of progressive keratoconus: new hope Curr. Opin. Ophthalmol. 17 2006 356 360
30. G. Wollensak, and E. Iomdina Biomechanical and histological changes after corneal crosslinking with and without epithelial debridement J. Cataract Refract. Surg. 35 2009 540 546