Ocular irritation: Microscopic changes occurring over time in the rat with surfactants of known irritancy

Toxicologic Pathology

Volumn 26, Issue 2, 1998, Pages 217-225

  Maurer, James K ^a   Parker, Ronald D ^a   Carr, Gregory J ^a  

^a PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

Conjunctiva; Cornea; Eye testing; Histopathology; Pathobiology; Wound healing

Indexed keywords

ALKYLBENZENESULFONIC ACID; ANIONIC SURFACTANT; CATIONIC SURFACTANT; CETRIMIDE; DODECYL SULFATE SODIUM; IRRITANT AGENT; NONIONIC SURFACTANT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONJUNCTIVA EPITHELIUM; CONTROLLED STUDY; CORNEA CELL; CORNEA EDEMA; CORNEA EPITHELIUM; CORNEA STROMA; EYE IRRITATION; EYELID; IRIS; KERATITIS; MALE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0031981119     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262339802600205     Document Type: Article

References (16)

1. Bailer AJ (1988). Testing for the equality of area under the curves when using destructive measurement techniques. J. Pharmacokinet. Biopharm. 16: 303-309.
2. Bruner LH (1992). Ocular irritation. In: In Vitro Toxicity Testing. Applications to Safety Evaluation, JM Frazier (ed). Marcel Dekker, New York, pp. 149-190.
3. Draize JH, Woodard G, and Calvery HO (1944). Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. J. Pharmacol. Exp. Ther. 82: 377-390.
4. Green K (1992). A brief history of ocular toxicology. Lens Eye Tox. Res. 9: 153-159.
5. Green S (1992). In vitro test validation and regulatory animal testing: A house built on sand versus a house of cards? Altern. Lab. Anim. 20: 567-570.
6. Green S, Chambers WA, Gupta KC, Hill RN, Hurley PM, Lambert LA, Lee CC, Lee JK, Liu PT, Lowther DK, Roberts CD, Seabaugh VM, Springer JA, and Wilcox NL (1993). Criteria for in vitro alternatives for the eye irritation test. Food Chem. Toxicol. 31: 81-85.
7. Heywood R and James RW (1978). Towards objectivity in the assessment of eye irritation. J. Soc. Cosmet. Chem. 29: 25-29.
8. Jester JV, Maurer JK, Petroll WM, Wilkie DA, Parker RD, and Cavanagh HD (1996). Application of in vivo confocal microscopy to the understanding of surfactant-induced ocular irritation. Toxicol. Pathol. 24: 412-428.
9. Martins T, Pauluhn J, and Machemer L (1992). Analysis of alternative methods for determining ocular irritation. Food Chem. Toxicol. 30: 1061-1067.
10. Maurer JK, Li HF, Petroll WM, Parker RD, Cavanagh HD, and Jester JV (1997). Confocal microscopic characterization of initial corneal changes of surfactant-induced eye irritation in the rabbit. Toxicol. Appl. Pharmacol. 143: 291-300.
11. Maurer JK and Parker RD (1996). Light microscopic comparison of surfactant-induced eye irritation in rabbits and rats at 3 hours and recovery/day 35. Toxicol. Pathol. 24: 403-411.
12. Muller-Decker K, Furstenberger G, and Marks F (1994). Keratin-ocyte-derived proinflammatory key mediators and cell viability as in vitro parameters of irritancy: A possible alternative to the Draize skin irritation test. Toxicol Appl. Pharmacol. 127: 99-108.
13. Organization for Economic Co-operation and Development (1996). Final Report of the OECD Workshop on Harmonization of Validation and Acceptance Criteria for Alternative Toxicologic Test Methods. Solna, Sweden, 22-24 January 1996. Document: ENV/ MC/CHEM/TG(96)9, OECD, Paris.
14. US Department of Health and Human Services (1985). Guide for the Care and Use of Laboratory Animals. Animal Resources Program, Division of Research Resources, National Institute of Health, Bethesda, Maryland.
15. Weil CS and Scala RA (1971). Study of intra- and interlaboratory variability in the results of rabbit eye and skin irritation tests. Toxicol. Appl. Pharmacol. 19: 276-360.
16. Williams SJ, Graepel GJ, and Kennedy GL (1982). Evaluation of ocular irritancy potential: Intralaboratory variability and effect of dosage volume. Toxicol. Lett. 12: 235-241.