Synthesis and evaluation of diphenylphosphinic amides and diphenylphosphine oxides as inhibitors of Kv1.5

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 3, 2013, Pages 706-710

  Olsson, Roine I ^a   Jacobson, Ingemar ^a   Boström, Jonas ^a   Fex, Tomas ^a   Björe, Annika ^a   Olsson, Christina ^a   Sundell, Johan ^a   Gran, Ulrik ^a   Öhrn, Anna ^a   Nordin, Andreas ^a   Gyll, Jonna ^a   Thorstensson, Maria ^a   Hayen, Ahlke ^a   Aplander, Karolina ^a   Hidestål, Olle ^a   Jiang, Fanyi ^a   Linhardt, Gunilla ^a   Forsström, Elin ^a   Collins, Teresa ^a   Sundqvist, Monika ^a   Lindhardt, Emma ^a   Astrand, Annika ^a   Löfberg, Boel ^a   more..

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Atrial fibrillation; Diphenylphosphine oxides; Diphenylphosphinic amides; IKs; Kv1.5

Indexed keywords

DIPHENYLPHOSPHINE OXIDE; DIPHENYLPHOSPHINIC AMIDE; PHOSPHORUS DERIVATIVE; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KV1.5; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; HEART ATRIUM FIBRILLATION; IC 50; IN VITRO STUDY; MALE; NONHUMAN; POTASSIUM CURRENT; RABBIT; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; BIPHENYL COMPOUNDS; HUMANS; INHIBITORY CONCENTRATION 50; KV1.5 POTASSIUM CHANNEL; MOLECULAR STRUCTURE; OXIDES; PHOSPHINES; PHOSPHINIC ACIDS; PROTEIN BINDING; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP;

ORYCTOLAGUS CUNICULUS;

EID: 84872294128     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.11.098     Document Type: Article

References (22)

1. C.W. Khoo, and G.Y. Lip Chest 135 2009 849
2. G.Y. Lip, and H.F. Tse Lancet 370 2007 604
3. J. Tamargo, R. Caballero, R. Gómez, and E. Delpón Expert Opin. Investig. Drugs 18 2009 399
4. Q. Yang, X. Wang, L. Du, M. Li, and Q. You Expert Opin. Ther. Pat. 17 2007 1443
5. M.T. Bilodeau, and B.W. Trotter Curr. Top. Med. Chem. 9 2009 436
6. H. Wulff, N.A. Castle, and L.A. Pardo Nat. Rev. Drug Disc. 8 2009 982
7. J.T. Milnes, D.J. Madge, and J.W. Ford Drug Discovery Today 17 2012 654
8. K.B. Dillon, F. Mathey, and J.F. Nixon Phosphorous: The Carbon Copy 1998 Wiley Chichester
9. A. Lagrutta, J. Wang, B. Fermini, and J.J. Salata J. Pharmacol. Exp. Ther. 317 2006 1054
10. D.C. Beshore, N.J. Liverton, C.J. McIntyre, C.F. Claiborne, B. Libby, J.C. Culberson, J.J. Salata, C.P. Regan, J.J. Lynch, L. Kiss, R.H. Spencer, S.A. Kane, R.B. White, S. Yeh, G.D. Hartman, and C.J. Dinsmore Bioorg. Med. Chem. Lett. 20 2010 2493
11. A. Lehmann, M. Antonsson, A.A. Holmberg, L. Blackshaw, L. Bränden, H. Bräuner-Osborne, B. Christiansen, J. Dent, T. Elebring, B-M. Jacobson, J. Jensen, J.P. Mattsson, K. Nilsson, S.S. Oja, A.J. Page, P. Saransaari, and S. von Unge J. Pharmacol. Exp. Ther. 331 2009 504
12. J. Boström ACS Med. Chem. Lett. 3 2012 769
13. ROCS, OpenEye Scientic Software, Santa Fe, NM, USA. http://www.eyesopen. com.
14. K. Schroeder, B. Neagle, D.J. Trezise, and J. Worley J. Biomol. Screen. 8 2003 50
15. J. Kutchinsky, S. Friis, M.A. Asmild, R. Taboryski, S. Pedersen, R.K. Vestergaard, R.B. Jacobsen, K. Kryzywkowski, R.L. Schröder, T. Ljungström, N. Hélix, C.B. Sörensen, M. Bech, and N.J. Willumsen Assay Drug Dev. Technol. 1 2003 685
16. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 99; International Agency for Research on Cancer: Lyon, France, 2010; p 1.
17. Trotter, W. B.; Nanda, K. K.; Wolkenberg, S.; Nolt, B. M.; Manley, P.; Kett, N. R.; Bilodeau, M. T. PCT Int. Appl. WO 2007/050348.
18. Trotter, W. B. Abstract of Papers, 234th ACS National Meeting, Boston, MA, United States, 2007, MEDI-449.
19. A.K. Bhattacharya, and G. Thyagarajan Chem. Rev. 81 1981 415
20. N. Miyaura, and A. Suzuki Chem. Rev. 95 1995 2457
21. H. Sun, J. Lloyd, H. Shi, D. Li, and P. Levesque Heart Rhythm 5 2008 213
22. A. Ollerstam, S.A.G. Visser, A.H. Persson, G. Eklund, L.B. Nilsson, T. Forsberg, S.J. Wiklund, J. Gabrielsson, G. Duker, and A. Al-Saffar J. Pharmacol. Toxicol. Methods 53 2006 174