Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 8, 2010, Pages 2493-2496

  Beshore, Douglas C ^a   Liverton, Nigel J ^a   McIntyre, Charles J ^a   Claiborne, Christopher F ^a   Libby, Brian ^a   Culberson, J Christopher ^a   Salata, Joseph J ^a   Regan, Christopher P ^a   Lynch, Joseph J ^a   Kiss, Laszlo ^a   Spencer, Robert H ^a   Kane, Stephanie A ^a   White, Rebecca B ^a   Yeh, Suzie ^a   Hartman, George D ^a   Dinsmore, Christopher J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Arrhythmia; Atrial fibrillation; Kv1.5; TAEA; Triarylethanolamine

Indexed keywords

ETHANOLAMINE DERIVATIVE; POTASSIUM CHANNEL KV1.5;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; RAT;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; ETHANOLAMINES; HUMANS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, VOLTAGE-GATED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77950035344     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.005     Document Type: Article

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