Sinonasal epithelial cells synthesize active vitamin D, augmenting host innate immune function

International Forum of Allergy and Rhinology

Volumn 3, Issue 1, 2013, Pages 26-30

  Sultan, Babar ^a   Ramanathan, Murugappan ^a   Lee, Joan ^a   May, Lindsey ^a   Lane, Andrew P ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

1 hydroxylase; Cathelicidin; Innate immunity; Rhinosinusitis; Sinonasal; Vitamin D

Indexed keywords

1 ALPHA HYDROXYLASE; CATHELICIDIN; OXYGENASE; UNCLASSIFIED DRUG; VITAMIN D;

ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; INNATE IMMUNITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SINONASAL EPITHELIAL CELL; STIMULATION;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; ANTIMICROBIAL CATIONIC PEPTIDES; CALCITRIOL; CHRONIC DISEASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; HUMANS; IMMUNITY, INNATE; NASAL MUCOSA; PARANASAL SINUSES; REAL-TIME POLYMERASE CHAIN REACTION; RHINITIS; SINUSITIS;

EID: 84872280157     PISSN: 20426976     EISSN: 20426984     Source Type: Journal    
DOI: 10.1002/alr.21087     Document Type: Article

References (26)

1. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266-281.
2. Giovannucci E, Liu Y, Rimm EB, et al. Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst. 2006;98:451-459.
3. Davies PD, Brown RC, Woodhead JS. Serum concentrations of vitamin D metabolites in untreated tuberculosis. Thorax. 1985;40:187-190.
4. Bouillon R. Vitamin D: from photosynthesis, metabolism, and action to clinical applications. In: DeGroot LJ, Jameson JL, eds. Endocrinology. 4 ed. Philadelphia: W.B. Saunders; 2001:1009-1028.
5. Bikle DD, Nemanic MK, Gee E, Elias P. 1, 25-Dihydroxyvitamin D3 production by human keratinocytes. Kinetics and regulation. J Clin Invest. 1986;78:557-566.
6. Hansdottir S, Monick MM, Hinde SL, Lovan N, Look DC, Hunninghake GW. Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense. Immunology. 2008;181:7090-7099.
7. Adams JS, Sharma OP, Gacad MA, Singer FR. Metabolism of 25-hydroxyvitamin D3 by cultured pulmonary alveolar macrophages in sarcoidosis. J Clin Invest. 1983;72:1856-1860.
8. Christakos S, Raval-Pandya M, Wernyj RP, Yang W. Genomic mechanisms involved in the pleiotropic actions of 1, 25-dihydroxyvitamin D3. Biochem J. 1996;316(Pt 2):361-371.
9. Liu PT, Stenger S, Tang DH, Modlin RL. Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J Immunol. 2007;179:2060-2063.
10. Zanetti M, Gennaro R, Scocchi M, Skerlavaj B. Structure and biology of cathelicidins. Adv Exp Med Biol. 2000;479:203-218.
11. Durr UH, Sudheendra US, Ramamoorthy A. LL-37, the only human member of the cathelicidin family of antimicrobial peptides. Biochim Biophys Acta. 2006;1758:1408-1425.
12. Chennupati SK, Chiu AG, Tamashiro E, et al. Effects of an LL-37-derived antimicrobial peptide in an animal model of biofilm Pseudomonas sinusitis. Am J Rhinol Allergy. 2009;23:46-51.
13. Vonk MJ, Hiemstra PS, Grote JJ. An antimicrobial peptide modulates epithelial responses to bacterial products. Laryngoscope. 2008;118:816-820.
14. Holick MF. Calcium and vitamin D. Diagnostics and therapeutics. Clin Lab Med. 2000;20:569-590.
15. Ramanathan M, Jr, Lee WK, Spannhake EW, Lane AP. Th2 cytokines associated with chronic rhinosinusitis with polyps down-regulate the antimicrobial immune function of human sinonasal epithelial cells. Am J Rhinol. 2008;22:115-121.
16. Benninger MS, Ferguson BJ, Hadley JA, et al. Adult chronic rhinosinusitis: definitions, diagnosis, epidemiology, and pathophysiology. Otolaryngol Head Neck Surg. 2003;129(3 Suppl):S1-S32.
17. Ramanathan M, Jr, Lane AP. A comparison of experimental methods in molecular chronic rhinosinusitis research. Am J Rhinol. 2007;21:373-377.
18. Pittas AG, Chung M, Trikalinos T, et al. Systematic review: vitamin D and cardiometabolic outcomes. Ann Intern Med. 2010;152:307-314.
19. Wang L, Manson JE, Song Y, Sesso HD. Systematic review: vitamin D and calcium supplementation in prevention of cardiovascular events. Ann Intern Med. 2010;152:315-323.
20. Takeyama K, Kitanaka S, Sato T, Kobori M, Yanagisawa J, Kato S. 25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis. Science. 1997;277:1827-1830.
21. Jo EK. Innate immunity to mycobacteria: vitamin D and autophagy. Cell Microbiol. 2010;12:1026-1035.
22. Wang TT, Dabbas B, Laperriere D, et al. Direct and indirect induction by 1, 25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease. J Biol Chem. 2010;285:2227-2231.
23. Laws PM, Young HS. Topical treatment of psoriasis. Expert Opin Pharmacother. 2010;11:1999-2009.
24. Xystrakis E, Kusumakar S, Boswell S, et al. Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. J Clin Invest. 2006;116:146-155.
25. Pinto JM, Schneider J, Perez R, DeTineo M, Baroody FM, Naclerio RM. Serum 25-hydroxyvitamin D levels are lower in urban African American subjects with chronic rhinosinusitis. J Allergy Clin Immunol. 2008;122:415-417.
26. Rostkowska-Nadolska B, Fraczek M, Gawron W, Latocha M. Influence of vitamin D(3) analogues in combination with budesonid R on proliferation of nasal polyp fibroblasts. Acta Biochim Pol. 2009;56:235-242.