PknE, a serine/threonine protein kinase from Mycobacterium tuberculosis has a role in adaptive responses

Archives of Microbiology

Volumn 195, Issue 1, 2013, Pages 75-80

  Kumar, Dinesh ^a   Palaniyandi, Kannan ^a   Challu, Vijay K ^b   Kumar, Prahlad ^b   Narayanan, Sujatha ^a  

^a NATIONAL INSTITUTE FOR RESEARCH IN TUBERCULOSIS   (India)

^b NATIONAL TUBERCULOSIS INSTITUTE   (India)

Author keywords

Mycobacterium tuberculosis; PknE and stress; STPK

Indexed keywords

ETHAMBUTOL; ETHIONAMIDE; ISONIAZID; KANAMYCIN; LYSOZYME; OFLOXACIN; PKNE PROTEIN; PROTEIN SERINE THREONINE KINASE; RIFAMPICIN; STREPTOMYCIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; CELL SIZE; CELL SURVIVAL; CELL WALL; DELETION MUTANT; GUINEA PIG; LIQUID CULTURE; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PATHOGENESIS; PH; PRIORITY JOURNAL; STRESS;

ANIMALS; ANTITUBERCULAR AGENTS; DRUG RESISTANCE, BACTERIAL; GUINEA PIGS; HYDROGEN-ION CONCENTRATION; MURAMIDASE; MYCOBACTERIUM TUBERCULOSIS; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE DELETION; SODIUM DODECYL SULFATE; STRESS, PHYSIOLOGICAL; TUBERCULOSIS;

CAVIA; MYCOBACTERIUM TUBERCULOSIS;

EID: 84872275034     PISSN: 03028933     EISSN: 1432072X     Source Type: Journal    
DOI: 10.1007/s00203-012-0848-4     Document Type: Article

References (35)

1. Arora K, Whiteford DC, Lau-Bonilla D, Davitt CM, Dahl JL (2008) Inactivation of lsr2 results in a hypermotile phenotype in Mycobacterium smegmatis. J Bacteriol 190:4291-4300
2. Bardarov S et al (2002) Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis. Microbiology 148:3007-3017
3. Blumenthal A, Trujillo C, Ehrt S, Schnappinger D (2011) Simultaneous analysis of multiple Mycobacterium tuberculosis knockdown mutants in vitro and in vivo. PLoS ONE 5:e15667
4. Buchmeier NA, Newton GL, Fahey RC (2006) A mycothiol synthase mutant of Mycobacterium tuberculosis has an altered thioldisulfide content and limited tolerance to stress. J Bacteriol 188:6245-6252
5. Chao J et al (2010) Protein kinase and phosphatase signaling in Mycobacterium tuberculosis physiology and pathogenesis. Biochim Biophys Acta 1804:620-627
6. Deol P et al (2005) Role of Mycobacterium tuberculosis Ser/Thr kinase PknF: implications in glucose transport and cell division. J Bacteriol 187:3415-3420
7. Drumm JE et al (2009) Mycobacterium tuberculosis universal stress protein Rv2623 regulates bacillary growth by ATP-Binding: requirement for establishing chronic persistent infection. PLoS Pathog 5:e1000460
8. Gao LY et al (2003) Requirement for kasB in Mycobacterium mycolic acid biosynthesis, cell wall impermeability and intra-cellular survival: implications for therapy. Mol Microbiol 49:1547-1563
9. Geiman DE, Raghunand TR, Agarwal N, Bishai WR (2006) Differential gene expression in response to exposure to antimycobacterial agents and other stress conditions among seven Mycobacterium tuberculosis whiB-like genes. Antimicrob Agents Chemother 50:2836-2841
10. Gopalaswamy R, Narayanan S, Jacobs WR Jr, Av-Gay Y (2008) Mycobacterium smegmatis biofilm formation and sliding motility are affected by the serine/threonine protein kinase PknF. FEMS Microbiol Lett 278:121-127
11. Gopalaswamy R, Narayanan S, Chen B, Jacobs WR, Av-Gay Y (2009) The serine/threonine protein kinase PknI controls the growth of Mycobacterium tuberculosis upon infection. FEMS Microbiol Lett 295:23-29
12. Jayakumar D, Jacobs WR Jr, Narayanan S (2008) Protein kinase E of Mycobacterium tuberculosis has a role in the nitric oxide stress response and apoptosis in a human macrophage model of infection. Cell Microbiol 10:365-374
13. Kana BD et al (2008) The resuscitation-promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for growth in vitro. Mol Microbiol 67:672-684
14. Kang CM, Abbott DW, Park ST, Dascher CC, Cantley LC, Husson RN (2005) The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape. Genes Dev 19:1692-1704
15. Kruuner A, Jureen P, Levina K, Ghebremichael S, Hoffner S (2003) Discordant resistance to kanamycin and amikacin in drug-resistant Mycobacterium tuberculosis. Antimicrob Agents Chemother 47:2971-2973
16. Kumar D, Narayanan S (2012) pknE, a serine/threonine kinase of Mycobacterium tuberculosis modulates multiple apoptotic paradigms. Infect Genet Evol 12(4):737-747
17. Malhotra V, Arteaga-Cortes LT, Clay G, Clark-Curtiss JE (2010) Mycobacterium tuberculosis protein kinase K confers survival advantage during early infection in mice and regulates growth in culture and during persistent infection: implications for immune modulation. Microbiology 156:2829-2841
18. Molle V, Kremer L (2010) Division and cell envelope regulation by Ser/Thr phosphorylation: mycobacterium shows the way. Mol Microbiol 75:1064-1077
19. Molle V, Girard-Blanc C, Kremer L, Doublet P, Cozzone AJ, Prost JF (2003) Protein PknE, a novel transmembrane eukaryotic-like serine/threonine kinase from Mycobacterium tuberculosis. Biochem Biophys Res Commun 308:820-825
20. Mouslim C, Hilbert F, Huang H, Groisman EA (2002) Conflicting needs for a Salmonella hypervirulence gene in host and non-host environments. Mol Microbiol 45:1019-1027
21. Ojha AK et al (2008) Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria. Mol Microbiol 69:164-174
22. Pal S, Dolai S, Yadav RK, Adak S (2010) Ascorbate peroxidase from Leishmania major controls the virulence of infective stage of promastigotes by regulating oxidative stress. PLoS One 5:e11271
23. Pang X et al (2007) Evidence for complex interactions of stress-associated regulons in an mprAB deletion mutant of Mycobacterium tuberculosis. Microbiology 153:1229-1242
24. Papavinasasundaram KG, Chan B, Chung JH, Colston MJ, Davis EO, Av-Gay Y (2005) Deletion of the Mycobacterium tuberculosis pknH gene confers a higher bacillary load during the chronic phase of infection in BALB/c mice. J Bacteriol 187:5751-5760
25. Raymond JB, Mahapatra S, Crick DC, Pavelka MS Jr (2005) Identification of the namH gene, encoding the hydroxylase responsible for the N-glycolylation of the mycobacterial peptidoglycan. J Biol Chem 280:326-333
26. Rengarajan J et al (2008) Mycobacterium tuberculosis Rv2224c modulates innate immune responses. Proc Natl Acad Sci USA 105:264-269
27. Rohde KH, Abramovitch RB, Russell DG (2007) Mycobacterium tuberculosis invasion of macrophages: linking bacterial gene expression to environmental cues. Cell Host Microbe 2:352-364
28. Sampson S, Warren R, Richardson M, van der Spuy G, van Helden P (2001) IS6110 insertions in Mycobacterium tuberculosis: predominantly into coding regions. J Clin Microbiol 39:3423-3424
29. Schaefer WB, Lewis CW Jr (1965) Effect of oleic acid on growth and cell structure of mycobacteria. J Bacteriol 90:1438-1447
30. Selvakumar N, Sudhamathi S, Duraipandian M, Frieden TR, Narayanan PR (2004) Reduced detection by Ziehl-Neelsen method of acid-fast bacilli in sputum samples preserved in cetylpyridinium chloride solution. Int J Tuberc Lung Dis 8:248-252
31. Suzuki Y et al (1998) Detection of kanamycin-resistant Mycobacterium tuberculosis by identifying mutations in the 16S rRNA gene. J Clin Microbiol 36:1220-1225
32. ten Bokum AM, Movahedzadeh F, Frita R, Bancroft GJ, Stoker NG (2008) The case for hypervirulence through gene deletion in Mycobacterium tuberculosis. Trends Microbiol 16:436-441
33. Vandal OH, Roberts JA, Odaira T, Schnappinger D, Nathan CF, Ehrt S (2009) Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment. J Bacteriol 191:625-631
34. Walburger A et al (2004) Protein kinase G from pathogenic mycobacteria promotes survival within macrophages. Science 304:1800-1804
35. Walzl G, Ronacher K, Hanekom W, Scriba TJ, Zumla A (2011) Immunological biomarkers of tuberculosis. Nat Rev Immunol 11:343-354