The serine/threonine protein kinase PknI controls the growth of Mycobacterium tuberculosis upon infection

FEMS Microbiology Letters

Volumn 295, Issue 1, 2009, Pages 23-29

  Gopalaswamy, Radha ^a,b,c   Narayanan, Sujatha ^b   Chen, Bing ^c   Jacobs, William R ^c   Av Gay, Yossef ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b NATIONAL INSTITUTE FOR RESEARCH IN TUBERCULOSIS   (India)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Infection; Macrophage; PknI; STPKs; Tuberculosis

Indexed keywords

OXYGEN; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE PKNI; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GROWTH; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; BACTERIUM MUTANT; CONTROLLED STUDY; GROWTH REGULATION; HOST; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SPACE; MACROPHAGE; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OXYGEN SUPPLY; PRIORITY JOURNAL; SEVERE COMBINED IMMUNODEFICIENCY; SIGNAL TRANSDUCTION; SURVIVAL TIME; TUBERCULOSIS; WILD TYPE;

ANIMALS; CELL LINE; COLONY COUNT, MICROBIAL; GENE DELETION; HUMANS; MACROPHAGES; MICE; MICE, SCID; MYCOBACTERIUM TUBERCULOSIS; PROTEIN-SERINE-THREONINE KINASES; SURVIVAL ANALYSIS; TRANSDUCTION, GENETIC; VIRULENCE;

MUS; MYCOBACTERIUM TUBERCULOSIS;

EID: 65449134732     PISSN: 03781097     EISSN: 15746968     Source Type: Journal    
DOI: 10.1111/j.1574-6968.2009.01570.x     Document Type: Article

References (22)

1. Av-Gay Y Deretic V (2005) Two-component systems, protein kinases and signal transduction. Mycobacterium tuberculosis (Cole ST, Eisenach KD, McMurray DN Jacobs WRJ, eds), pp. 359 367. ASM Press, Washington, DC.
2. Av-Gay Y Everett M (2000) The eukaryotic-like Ser/Thr protein kinases of Mycobacterium tuberculosis. Trends Microbiol 8 : 238 244. (Pubitemid 30236245)
3. Bach H, Papavinasasundaram KG, Wong D, Hmama Z Av-Gay Y (2008) Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B. Cell Host Microbe 3 : 316 322.
4. Bardarov S, Bardarov S Jr., Pavelka MS Jr. et al 2002) Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis. Microbiology 148 : 3007 3017. (Pubitemid 35243700)
5. Cowley S, Ko M, Pick N et al 2004) The Mycobacterium tuberculosis protein serine/threonine kinase PknG is linked to cellular glutamate/glutamine levels and is important for growth in vivo. Mol Microbiol 52 : 1691 1702. (Pubitemid 38822678)
6. Fisher MA, Plikaytis BB Shinnick TM (2002) Microarray analysis of the Mycobacterium tuberculosis transcriptional response to the acidic conditions found in phagosomes. J Bacteriol 184 : 4025 4032. (Pubitemid 34705461)
7. Flynn JL Chan J (2001) Tuberculosis: latency and reactivation. Infect Immun 69 : 4195 4201. (Pubitemid 32574413)
8. Gopalaswamy R, Narayanan PR Narayanan S (2004) Cloning, overexpression, and characterization of a serine/threonine protein kinase pknI from Mycobacterium tuberculosis H37Rv. Protein Expres Purif 36 : 82 89. (Pubitemid 38836768)
9. Hatfull GF Jacobs WR Jr. (2000) Molecular Genetics of Mycobacteria. ASM Press, Washington, DC.
10. Hestvik AL, Hmama Z Av-Gay Y (2005) Mycobacterial manipulation of the host cell. FEMS Microbiol Rev 29 : 1041 1050. (Pubitemid 41416849)
11. Honer zu Bentrup K Russell DG (2001) Mycobacterial persistence: adaptation to a changing environment. Trends Microbiol 9 : 597 605. (Pubitemid 33135416)
12. Hu Y, Movahedzadeh F, Stoker NG Coates AR (2006) Deletion of the Mycobacterium tuberculosis α-crystallin-like hspX gene causes increased bacterial growth in vivo. Infect Immun 74 : 861 868. (Pubitemid 43185518)
13. Papavinasasundaram KG, Chan B, Chung JH, Colston MJ, Davis EO Av-Gay Y (2005) Deletion of the Mycobacterium tuberculosis pknH gene confers a higher bacillary load during the chronic phase of infection in BALB/c mice. J Bacteriol 187 : 5751 5760. (Pubitemid 41134312)
14. Parish T, Smith DA, Kendall S, Casali N, Bancroft GJ Stoker NG (2003) Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis. Infect Immun 71 : 1134 1140. (Pubitemid 36254293)
15. Rao V, Gao F, Chen B, Jacobs WR Jr. Glickman MS (2006) Trans-cyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis-induced inflammation and virulence. J Clin Invest 116 : 1660 1667. (Pubitemid 43911020)
16. Sassetti CM, Boyd DH Rubin EJ (2003) Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol 48 : 77 84. (Pubitemid 36411469)
17. Sauton B (1912) Sur la nutrition minerale du bacille tuberculeux. C R Acad Sci Ser III Sci Vie 135 : 860 863.
18. Saviola B, Woolwine SC Bishai WR (2003) Isolation of acid-inducible genes of Mycobacterium tuberculosis with the use of recombinase-based in vivo expression technology. Infect Immun 71 : 1379 1388. (Pubitemid 36254324)
19. Shimono N, Morici L, Casali N, Cantrell S, Sidders B, Ehrt S Riley LW (2003) Hypervirulent mutant of Mycobacterium tuberculosis resulting from disruption of the mce1 operon. P Natl Acad Sci USA 100 : 15918 15923. (Pubitemid 38021090)
20. Singh A, Singh Y, Pine R, Shi L, Chandra R Drlica K (2005) Protein kinase I of Mycobacterium tuberculosis: cellular localization and expression during infection of macrophage-like cells. Tuberculosis 86 : 28 33.
21. Smith DA, Parish T, Stoker NG Bancroft GJ (2001) Characterization of auxotrophic mutants of Mycobacterium tuberculosis and their potential as vaccine candidates. Infect Immun 69 : 1142 1150. (Pubitemid 32109583)
22. Stover CK, de la Cruz VF, Fuerst TR et al 1991) New use of BCG for recombinant vaccines. Nature 351 : 456 460. (Pubitemid 21896614)