Extracellular DNA within a nontypeable haemophilus influenzae-induced biofilm binds human beta defensin-3 and reduces its antimicrobial activity

Journal of Innate Immunity

Volumn 5, Issue 1, 2013, Pages 24-38

  Jones, Eric A ^a   McGillivary, Glen ^a   Bakaletz, Lauren O ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Cationic host defense peptides; Extracellular DNA; Innate immunity; Middle ear; Nontypeable Haemophilus influenzae; Otitis media

Indexed keywords

BACTERIAL DNA; BETA DEFENSIN 3; DEOXYRIBONUCLEASE I; GENOMIC DNA; RECOMBINANT PROTEIN; DNA; EXTRACELLULAR DNA; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BIOFILM; CHILD; CHINCHILLA; CONTROLLED STUDY; HAEMOPHILUS INFLUENZAE; HUMAN; IN VITRO STUDY; INFANT; INNATE IMMUNITY; MIDDLE EAR; NONHUMAN; OTITIS MEDIA; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DNA INTERACTION; PROTEIN LOCALIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; NONTYPEABLE HAEMOPHILUS INFLUENZAE; THICKNESS;

ANIMALS; BETA-DEFENSINS; BIOFILMS; CHILD, PRESCHOOL; CHINCHILLA; DEOXYRIBONUCLEASE I; DNA, BACTERIAL; FEMALE; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; HUMANS; IMMUNITY, INNATE; IMMUNOSUPPRESSION; INFANT; INFANT, NEWBORN; MALE; OTITIS MEDIA; PROTEIN BINDING; RECOMBINANT PROTEINS;

EID: 84872267848     PISSN: 1662811X     EISSN: 16628128     Source Type: Journal    
DOI: 10.1159/000339961     Document Type: Article

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