Leveraging the biology of adversity to address the roots of disparities in health and development

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue SUPPL.2, 2012, Pages 17302-17307

  Shonkoff, Jack P ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BEHAVIOR DISORDER; CAREGIVER; CLINICAL PRACTICE; HEALTH DISPARITY; HUMAN; JOB STRESS; LEARNING DISORDER; MOTHER; PARENTING EDUCATION; PRIORITY JOURNAL; PROPHYLAXIS; REVIEW; ARTICLE; BIOLOGICAL MODEL; CHILD; CHILD DEVELOPMENT; CHILD PARENT RELATION; FEMALE; HEALTH CARE DISPARITY; LEARNING; LIFE EVENT; MALE; POLICY; PREVENTIVE MEDICINE; SOCIAL STATUS; UNITED STATES;

CHILD; CHILD DEVELOPMENT; FEMALE; HEALTHCARE DISPARITIES; HUMANS; LEARNING; LIFE CHANGE EVENTS; MALE; MODELS, BIOLOGICAL; PARENTING; PREVENTIVE MEDICINE; PUBLIC POLICY; SOCIAL CONDITIONS; UNITED STATES;

EID: 84872250056     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1121259109     Document Type: Review

References (86)

1. Fox SE, Levitt P, Nelson CA, 3rd (2010) How the timing and quality of early experiences influence the development of brain architecture. Child Dev 81:28-40.
2. Meaney MJ (2010) Epigenetics and the biological definition of gene x environment interactions. Child Dev 81:41-79.
3. Shonkoff JP, Boyce WT, McEwen BS (2009) Neuroscience, molecular biology, and the childhood roots of health disparities: Building a new framework for health promotion and disease prevention. JAMA 301:2252-2259.
4. Astuto J, Allen L (2009) Home visitation and young children: An approach worth investing in? Soc Policy Rep 23:3-21.
5. Karoly L, Kilburn M, Cannon J (2005) Early Childhood Interventions: Proven Results, Future Promise (RAND, Santa Monica, CA).
6. Shonkoff JP (2010) Building a new biodevelopmental framework to guide the future of early childhood policy. Child Dev 81:357-367.
7. Shonkoff JP, Phillips D, eds (2000) From Neurons to Neighborhoods: The Science of Early Childhood Development, Committee on Integrating the Science of Early Childhood Development, Board on Children, Youth, and Families, Institute of Medicine and National Research Council (National Academies Press, Washington, DC).
8. Knudsen EI, Heckman JJ, Cameron JL, Shonkoff JP (2006) Economic, neurobiological, and behavioral perspectives on building America's future workforce. Proc Natl Acad Sci USA 103:10155-10162. (Pubitemid 44051137)
9. Shonkoff JP, Richter L, van der Gaag J, Bhutta ZA (2012) An integrated scientific framework for child survival and early childhood development. Pediatrics 129:e460-e472.
10. Walker SP, et al. (2011) Inequality in early childhood: Risk and protective factors for early child development. Lancet 378:1325-1338.
11. Engle PL, et al.; Global Child Development Steering Group (2011) Strategies for reducing inequalities and improving developmental outcomes for young children in low-income and middle-income countries. Lancet 378:1339-1353.
12. Lewit EM, Baker LS (1995) School readiness. Future Child 5:128-139.
13. Rimm-Kaufman SE, Pianta RC, Cox MJ (2000) Teachers' judgments of problems in the transition to kindergarten. Early Child Res Q 15:147-166.
14. Diamond A (2002) Normal development of prefrontal cortex from birth to young adulthood: Cognitive functions, anatomy, and biochemistry. Principles of Frontal Lobe Function, eds Stuss DT, Knight RT (Oxford Univ Press, New York), pp 466-503.
15. Goldman-Rakic PS (1987) Circuitry of primate prefrontal cortex and regulation of behavior by representational memory. Handbooks of Physiology: A Spectrum of Physiological Knowledge and Concepts: Nervous System: Higher Functions of the Brain, ed Plum F (American Physiological Society, Bethesda), Section 1, Vol 5 (2 parts), pp 373-417.
16. Rothbart MK, Posner MI (2005) Genes and experience in the development of executive attention and effortful control. New Horizons in Developmental Theory and Research, eds Jensen LA, Larson RW (Jossey-Bass, San Francisco), pp 101-108.
17. Bush G, Luu P, Posner MI (2000) Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci 4:215-222. (Pubitemid 30332147)
18. Drevets WC, Raichle ME (1998) Reciprocal suppression of regional cerebral blood flow during emotional versus higher cognitive processes: Implications for interactions between emotion and cognition. Cogn Emotion 12:353-385. (Pubitemid 128467544)
19. Kuhl J, Kazen M (1999) Volitional facilitation of difficult intentions: Joint activation of intention memory and positive affect removes Stroop interference. J Exp Psychol Gen 128:382-399.
20. Rueda MR, Posner MI, Rothbart MK (2005) The development of executive attention: Contributions to the emergence of self-regulation. Dev Neuropsychol 28:573-594. (Pubitemid 41368243)
21. Blair C, Zelazo PD, Greenberg MT (2005) The measurement of executive function in early childhood. Dev Neuropsychol 28:561-571. (Pubitemid 41368242)
22. Lengua LJ, Honorado E, Bush NR (2007) Contextual risk and parenting as predictors of effortful control and social competence in preschool children. J Appl Dev Psychol 28:40-55.
23. Maughan A, Cicchetti D (2002) Impact of child maltreatment and interadult violence on children's emotion regulation abilities and socioemotional adjustment. Child Dev 73:1525-1542. (Pubitemid 41692403)
24. O'Connor TG, Rutter M, Beckett C, Keaveney L, Kreppner JM English and Romanian Adoptees Study Team (2000) The effects of global severe privation on cognitive competence: Extension and longitudinal follow-up. Child Dev 71:376-390.
25. Center on the Developing Child at Harvard University (2011) Building the Brain's "Air Traffic Control" System: How Early Experiences Shape the Development of Executive Function, Working Paper No. 11 (Cambridge, MA). Available at http://developingchild.harvard.edu.
26. Raver CC, et al. (2011) CSRP's impact on low-income preschoolers' preacademic skills: Self-regulation as a mediating mechanism. Child Dev 82:362-378.
27. Best JR, Miller PH (2010) A developmental perspective on executive function. Child Dev 81:1641-1660.
28. Kishiyama MM, Boyce WT, Jimenez AM, Perry LM, Knight RT (2009) Socioeconomic disparities affect prefrontal function in children. J Cogn Neurosci 21:1106-1115.
29. Li-Grining CP (2007) Effortful control among low-income preschoolers in three cities: Stability, change, and individual differences. Dev Psychol 43:208-221.
30. Noble KG, McCandliss BD, Farah MJ (2007) Socioeconomic gradients predict individual differences in neurocognitive abilities. Dev Sci 10:464-480.
31. Noble KG, Norman MF, Farah MJ (2005) Neurocognitive correlates of socioeconomic status in kindergarten children. Dev Sci 8:74-87. (Pubitemid 40166847)
32. Mezzacappa E (2004) Alerting, orienting, and executive attention: Developmental properties and sociodemographic correlates in an epidemiological sample of young, urban children. Child Dev 75:1373-1386.
33. Rothman EF, Edwards EM, Heeren T, Hingson RW (2008) Adverse childhood experiences predict earlier age of drinking onset: Results from a representative US sample of current or former drinkers. Pediatrics 122:e298-e304.
34. Anda RF, et al. (1999) Adverse childhood experiences and smoking during adolescence and adulthood. JAMA 282:1652-1658. (Pubitemid 29513972)
35. Scherrer JF, et al. (2007) Association between exposure to childhood and lifetime traumatic events and lifetime pathological gambling in a twin cohort. J Nerv Ment Dis 195:72-78. (Pubitemid 46104904)
36. Hertzman C (1999) The biological embedding of early experience and its effects on health in adulthood. Ann N Y Acad Sci 896:85-95.
37. Kuh D, Ben-Shlomo Y (2004) A Life Course Approach to Chronic Disease Epidemiology (Oxford Univ Press, Oxford).
38. McEwen BS (1998) Stress, adaptation, and disease. Allostasis and allostatic load. Ann N Y Acad Sci 840:33-44.
39. Frodl T, Reinhold E, Koutsouleris N, Reiser M, Meisenzahl EM (2010) Interaction of childhood stress with hippocampus and prefrontal cortex volume reduction in major depression. J Psychiatr Res 44:799-807.
40. Shonkoff JP, Garner AS Committee on Psychosocial Aspects of Child and Family Health; Committee on Early Childhood, Adoption, and Dependent Care; Section on Developmental and Behavioral Pediatrics (2012) The lifelong effects of early childhood adversity and toxic stress. Pediatrics 129:e232-e246.
41. Bierhaus A, et al. (2003) A mechanism converting psychosocial stress into mononuclear cell activation. Proc Natl Acad Sci USA 100:1920-1925. (Pubitemid 36254549)
42. Miller GE, Chen E (2010) Harsh family climate in early life presages the emergence of a proinflammatory phenotype in adolescence. Psychol Sci 21:848-856.
43. Miller GE, Chen E, Parker KJ (2011) Psychological stress in childhood and susceptibility to the chronic diseases of aging: Moving toward a model of behavioral and biological mechanisms. Psychol Bull 137:959-997.
44. Araújo JP, et al. (2009) Prognostic value of high-sensitivity C-reactive protein in heart failure: A systematic review. J Card Fail 15:256-266.
45. Galkina E, Ley K (2009) Immune and inflammatory mechanisms of atherosclerosis (*). Annu Rev Immunol 27:165-197.
46. Ward JR, Wilson HL, Francis SE, Crossman DC, Sabroe I (2009) Translational minireview series on immunology of vascular disease: Inflammation, infections and Toll-like receptors in cardiovascular disease. Clin Exp Immunol 156:386-394.
47. Heydtmann M, Adams DH (2009) Chemokines in the immunopathogenesis of hepatitis C infection. Hepatology 49:676-688.
48. Berasain C, et al. (2009) Inflammation and liver cancer: New molecular links. Ann N Y Acad Sci 1155:206-221.
49. Chen E, Miller GE (2007) Stress and inflammation in exacerbations of asthma. Brain Behav Immun 21:993-999. (Pubitemid 47484388)
50. Yao H, Rahman I (2009) Current concepts on the role of inflammation in COPD and lung cancer. Curr Opin Pharmacol 9:375-383.
51. Li M, Zhou Y, Feng G, Su SB (2009) The critical role of Toll-like receptor signaling pathways in the induction and progression of autoimmune diseases. Curr Mol Med 9:365-374.
52. Poulton R, et al. (2002) Association between children's experience of socioeconomic disadvantage and adult health: A life-course study. Lancet 360:1640-1645. (Pubitemid 35379736)
53. Danese A, et al. (2008) Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Arch Gen Psychiatry 65:409-415.
54. Danese A, Pariante CM, Caspi A, Taylor A, Poulton R (2007) Childhood maltreatment predicts adult inflammation in a life-course study. Proc Natl Acad Sci USA 104:1319-1324. (Pubitemid 46184002)
55. Howren MB, Lamkin DM, Suls J (2009) Associations of depression with C-reactive protein, IL-1, and IL-6: A meta-analysis. Psychosom Med 71:171-186.
56. Garner AS, Shonkoff JP Committee on Psychosocial Aspects of Child and Family Health; Committee on Early Childhood, Adoption, and Dependent Care; Section on Developmental and Behavioral Pediatrics (2012) Early childhood adversity, toxic stress, and the role of the pediatrician: Translating developmental science into lifelong health. Pediatrics 129:e224-e231.
57. Halfon N, DuPlessis H, Inkelas M (2007) Transforming the U.S. child health system. Health Aff (Millwood) 26:315-330.
58. Snow C, Burns MS, Griffin P, eds (1998) Preventing Reading Difficulties in Young Children, Committee on the Prevention of Reading Difficulties in Young Children, National Research Council (National Academies Press, Washington, DC).
59. Lyons DM, Parker KJ (2007) Stress inoculation-induced indications of resilience in monkeys. J Trauma Stress 20:423-433. (Pubitemid 47475493)
60. Ellis BJ, Boyce WT (2011) Differential susceptibility to the environment: Toward an understanding of sensitivity to developmental experiences and context. Dev Psychopathol 23:1-5.
61. Obradović J, Bush NR, Stamperdahl J, Adler NE, Boyce WT (2010) Biological sensitivity to context: The interactive effects of stress reactivity and family adversity on socioemotional behavior and school readiness. Child Dev 81:270-289.
62. Lupien SJ, McEwen BS, Gunnar MR, Heim C (2009) Effects of stress throughout the lifespan on the brain, behavior, and cognition. Nat Rev Neurosci 10:1-12.
63. McEwen BS, Gianaros PJ (2010) Central role of the brain in stress and adaptation: Links to socioeconomic status, health, and disease. Ann N Y Acad Sci 1186:190-222.
64. Jolles DD, van Buchem MA, Rombouts SA, Crone EA (2012) Practice effects in the developing brain: A pilot study. Dev Cogn Neurosci 2(Suppl 1):S180-S191.
65. Shonkoff JP (2011) Protecting brains, not simply stimulating minds. Science 333:982-983.
66. Olesen PJ, Westerberg H, Klingberg T (2004) Increased prefrontal and parietal activity after training of working memory. Nat Neurosci 7:75-79. (Pubitemid 38032171)
67. Rabiner DL, Murray DW, Skinner AT, Malone PS (2010) A randomized trial of two promising computer-based interventions for students with attention difficulties. J Abnorm Child Psychol 38:131-142.
68. Rueda MR, Rothbart MK, McCandliss BD, Saccomanno L, Posner MI (2005) Training, maturation, and genetic influences on the development of executive attention. Proc Natl Acad Sci USA 102:14931-14936. (Pubitemid 41457158)
69. Stevens C, Fanning J, Coch D, Sanders L, Neville H (2008) Neural mechanisms of selective auditory attention are enhanced by computerized training: Electrophysiological evidence from language-impaired and typically developing children. Brain Res 1205:55-69.
70. Diamond A, Barnett WS, Thomas J, Munro S (2007) Preschool program improves cognitive control. Science 318:1387-1388. (Pubitemid 350208940)
71. Brooks-Gunn J, Duncan G, Aber JL, eds (1997) Neighborhood Poverty: Context and Consequences for Children: Policy Implications in Studying Neighborhoods (Russell Sage Foundation Press, New York), Vols 1 and 2.
72. Sampson RJ, Raudenbush SW, Earls F (1997) Neighborhoods and violent crime: A multilevel study of collective efficacy. Science 277:918-924. (Pubitemid 27366670)
73. Wilson WJ (1990) The Truly Disadvantaged: The Inner City, the Underclass, and Public Policy (Univ of Chicago Press, Chicago).
74. Wilson WJ (1997) When Work Disappears: The World of the New Urban Poor (Vintage, New York).
75. Bronfenbrenner U (1979) The Ecology of Human Development: Experiments by Nature and Design (Harvard Univ Press, Cambridge, MA).
76. Sameroff A (2010) A unified theory of development: A dialectic integration of nature and nurture. Child Dev 81:6-22.
77. Radner J, Shonkoff J (2012) Mobilizing science to reduce intergenerational poverty. Investing in What Works for America's Communities: Essays on People, Place & Purpose, eds Andrews NO, Erickson DJ, Galloway IJ, Seidman ES (Federal Reserve Bank of San Francisco and the Low Income Investment Fund, San Francisco), pp 338-350.
78. Snow C, Van Hemel S, eds (2008) Early Childhood Assessment: Why, What, and How, Committee on Developmental Outcomes and Assessments for Young Children, Board on Children, Youth, and Families, Board on Testing and Assessment, Division of Behavioral and Social Sciences and Education, National Research Council (National Academies Press, Washington, DC).
79. Center on the Developing Child at Harvard University (2010) The Foundations of Lifelong Health Are Built in Early Childhood (Cambridge, MA). Available at http://developingchild.harvard.edu.
80. US Department of Health and Human Services, Agency for Healthcare Research and Quality (2008) Total expenses and percent distribution for selected conditions by type of service (United States, 2008). Medical Expenditure Panel Survey Household Component Data. Available at http://meps.ahrq.gov/mepsweb/data- stats/tables-compendia-hh-interactive.jsp?-SERVICE=MEPSSocket0&-PROGRAM= MEPSPGM.TC.SAS&File=HCFY2008&Table=HCFY2008-CNDXP-C&-Debug=.
81. Fairchild AL, Bayer R (1999) Uses and abuses of Tuskegee. Science 284:919-921. (Pubitemid 29288421)
82. Gould SJ (1981) The Mismeasure of Man (Norton, New York).
83. Skloot R (2010) The Immortal Life of Henrietta Lacks (Crown Publishing Group, New York).
84. Keuroghlian AS, Knudsen EI (2007) Adaptive auditory plasticity in developing and adult animals. Prog Neurobiol 82:109-121. (Pubitemid 46829606)
85. Buonomano DV, Merzenich MM (1998) Cortical plasticity: From synapses to maps. Annu Rev Neurosci 21:149-186. (Pubitemid 28150662)
86. Karmarkar UR, Dan Y (2006) Experience-dependent plasticity in adult visual cortex. Neuron 52:577-585. (Pubitemid 44750569)