Pharmacological Inhibition of mTORC1 Prevents Over-Activation of the Primordial Follicle Pool in Response to Elevated PI3K Signaling

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Adhikari, Deepak ^a   Risal, Sanjiv ^a   Liu, Kui ^a   Shen, Yan ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN MTORC1; RAPAMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVATION; ENZYME INHIBITION; MOUSE; MOUSE MUTANT; NONHUMAN; OVARIAN RESERVE; OVARY FOLLICLE; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION;

ANIMALS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GERM CELLS; MICE; MUTATION; OOCYTES; OVARIAN FOLLICLE; PHOSPHATIDYLINOSITOL 3-KINASES; PRIMARY OVARIAN INSUFFICIENCY; PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; SIROLIMUS;

MAMMALIA; MUS;

EID: 84872243014     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053810     Document Type: Article

References (28)

1. Zhang H, Zheng W, Shen Y, Adhikari D, Ueno H, et al. (2012) Experimental evidence showing that no mitotically active female germline progenitors exist in postnatal mouse ovaries. Proc Natl Acad Sci U S A. 109: 12580-12585.
2. Adhikari D, Liu K, (2009) Molecular mechanisms underlying the activation of mammalian primordial follicles. Endocr Rev 30: 438-464.
3. Reddy P, Zheng W, Liu K, (2010) Mechanisms maintaining the dormancy and survival of mammalian primordial follicles. Trends Endocrinol Metab 21: 96-103.
4. Broekmans FJ, Knauff EAH, te Velde ER, Macklon NS, Fauser BC, (2007) Female reproductive ageing: current knowledge and future trends. Trends in Endocrinology & Metabolism 18: 58-65.
5. Hansen KR, Knowlton NS, Thyer AC, Charleston JS, Soules MR, et al. (2008) A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause. Hum Reprod 23: 699-708.
6. Beck-Peccoz P, Persani L, (2006) Premature ovarian failure. OrphanetJ Rare Dis 1: 9.
7. Jagarlamudi K, Reddy P, Adhikari D, Liu K, (2010) Genetically modified mouse models for premature ovarian failure (POF). Mol Cell Endocrinol 315: 1-10.
8. Reddy P, Liu L, Adhikari D, Jagarlamudi K, Rajareddy S, et al. (2008) Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool. Science 319: 611-613.
9. Reddy P, Adhikari D, Zheng W, Liang S, Hamalainen T, et al. (2009) PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles. Hum Mol Genet 18: 2813-2824.
10. Laplante M, Sabatini DM, (2012) mTOR signaling in growth control and disease. Cell 149: 274-293.
11. Magnuson B, Ekim B, Fingar DC, (2012) Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks. Biochem J 441: 1-21.
12. Adhikari D, Liu K, (2010) mTOR signaling in the control of activation of primordial follicles. Cell Cycle 9: 1673-1674.
13. Adhikari D, Zheng W, Shen Y, Gorre N, Hamalainen T, et al. (2010) Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles. Hum Mol Genet 19: 397-410.
14. Adhikari D, Flohr G, Gorre N, Shen Y, Yang H, et al. (2009) Disruption of Tsc2 in oocytes leads to overactivation of the entire pool of primordial follicles. Mol Hum Reprod 15: 765-770.
15. Cantley LC, (2002) The phosphoinositide 3-kinase pathway. Science 296: 1655-1657.
16. Wullschleger S, Loewith R, Hall MN, (2006) TOR signaling in growth and metabolism. Cell 124: 471-484.
17. Manning BD, Cantley LC, (2007) AKT/PKB signaling: navigating downstream. Cell 129: 1261-1274.
18. Morgan S, Anderson RA, Gourley C, Wallace WH, Spears N, (2012) How do chemotherapeutic agents damage the ovary? Hum Reprod Update 18: 525-535.
19. Ben-Aharon I, Shalgi R, (2012) What lies beyond chemotherapy induced ovarian toxicity? Reproduction 144: 153-163.
20. Meirow D, Biederman H, Anderson RA, Wallace WH, (2010) Toxicity of chemotherapy and radiation on female reproduction. Clin Obstet Gynecol 53: 727-739.
21. Durlinger AL, Kramer P, Karels B, de Jong FH, Uilenbroek JT, et al. (1999) Control of primordial follicle recruitment by anti-Mullerian hormone in the mouse ovary. Endocrinology 140: 5789-5796.
22. Sobinoff AP, Mahony M, Nixon B, Roman SD, McLaughlin EA, (2011) Understanding the Villain: DMBA-induced preantral ovotoxicity involves selective follicular destruction and primordial follicle activation through PI3K/Akt and mTOR signaling. Toxicol Sci 123: 563-575.
23. Sobinoff AP, Nixon B, Roman SD, McLaughlin EA, (2012) Staying Alive: PI3K Pathway Promotes Primordial Follicle Activation and Survival in Response to 3MC-Induced Ovotoxicity. Toxicol Sci 128: 258-271.
24. Braun M, Young J, Reiner CS, Poster D, Wüthrich RP, et al. (2012) Ovarian Toxicity from Sirolimus. New England Journal of Medicine 366: 1062-1064.
25. Yu J, Yaba A, Kasiman C, Thomson T, Johnson J, (2011) mTOR Controls Ovarian Follicle Growth by Regulating Granulosa Cell Proliferation. PLoS One 6: e21415.
26. Lan ZJ, Xu X, Cooney AJ, (2004) Differential oocyte-specific expression of Cre recombinase activity in GDF-9-iCre, Zp3cre, and Msx2Cre transgenic mice. Biol Reprod 71: 1469-1474.
27. Pedersen T, Peters H, (1968) Proposal for a classification of oocytes and follicles in the mouse ovary. J Reprod Fertil 17: 555-557.
28. Johnson J, Canning J, Kaneko T, Pru JK, Tilly JL, (2004) Germline stem cells and follicular renewal in the postnatal mammalian ovary. Nature 428: 145-150.