Ovarian toxicity from sirolimus

New England Journal of Medicine

Volumn 366, Issue 11, 2012, Pages 1062-1064

  Braun, Matthias ^a   Young, James ^b   Reiner, Cäcilia S ^a   Poster, Diane ^a   Wüthrich, Rudolf P ^a   Serra, Andreas L ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b Biometrical Practice BIOP   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

RAPAMYCIN;

ACCURACY; CLINICAL FEATURE; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG SAFETY; DRUG TOLERABILITY; HUMAN; INTERMETHOD COMPARISON; KIDNEY GRAFT REJECTION; KIDNEY POLYCYSTIC DISEASE; LETTER; LOW DRUG DOSE; NUCLEAR MAGNETIC RESONANCE IMAGING; OLIGOMENORRHEA; OUTCOME ASSESSMENT; OVARY CYST; OVARY DISEASE; PATIENT MONITORING; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; RISK ASSESSMENT; RISK FACTOR; TUMOR VOLUME;

EID: 84858257135     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc1113145     Document Type: Letter

References (5)

1. Alam H, Maizels ET, Park Y, et al. Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of follicular differentiation. J Biol Chem 2004;279:19431-40. (Pubitemid 38623376)
2. Cure P, Pileggi A, Froud T, et al. Alterations of the female reproductive system in recipients of islet grafts. Transplantation 2004;78:1576-81. (Pubitemid 39648428)
3. Serra AL, Poster D, Kistler AD, et al. Sirolimus and kidney growth in autosomal dominant polycystic kidney disease. N Engl J Med 2010;363:820-9.
4. Stamm ER, Townsend RR, Johnson AM, Garg K, Manco-Johnson M, Gabow PA. Frequency of ovarian cysts in patients with autosomal dominant polycystic kidney disease. Am J Kidney Dis 1999;34:120-4. (Pubitemid 29318805)
5. Heinonen PK, Vuento M, Maunola M, Ala-Houhala I. Ovarian manifestations in women with autosomal dominant polycystic kidney disease. Am J Kidney Dis 2002;40:504-7. (Pubitemid 34971278)