Synthesis of novel phosphorylated guanidine derivatives from cyanamide and their anti-inflammatory activity

Chemical and Pharmaceutical Bulletin

Volumn 61, Issue 1, 2013, Pages 25-32

  Katla, Venkata Ramana ^a   Syed, Rasheed ^a   Kuruva, Chandra Sekhar ^a   Kuntrapakam, Hema Kumar ^b   Chamarthi, Naga Raju ^a  

^a SRI VENKATESWARA UNIVERSITY   (India)

^b Aptus Biosciences Private Limited   (India)

Author keywords

2 Aminopyridin 3 ol; Anti inflammatory activity; Phosphorylated guanidine

Indexed keywords

ANTIINFLAMMATORY AGENT; CYANAMIDE; DICLOFENAC; GUANIDINE DERIVATIVE; N (1,3 BENZOTHIAZOL 2 YL) N' (2 THIOXO 2,3 DIHYDRO 2LAMBDA5 PYRIDO[2,3 D][1,3,2]OXAZAPHOSPHOL 2 YL)GUANIDINE; N (1,3,4 THIADIAZOL 2 YL) N' (2 THIOXO 2,3 DIHYDRO 2LAMBDA5 PYRIDO[2,3 D][1,3,2]OXAZAPHOSPHOL 2 YL)GUANIDINE; N (2 CHLORO 4 FLUOROPHENYL) N' (2 THIOXO 2,3 DIHYDRO 2LAMBDA5 PYRIDO[2,3 D][1,3,2]OXAZAPHOSPHOL 2 YL)GUANIDINE; N (2,4 DIFLUOROPHENYL) N' (2 THIOXO 2,3 DIHYDRO 2LAMBDA5 PYRIDO[2,3 D][1,3,2]OXAZAPHOSPHOL 2 YL)GUANIDINE; N (4 CHLORO 1,3 BENZOTHIAZOL 2 YL) N' (2 THIOXO 2,3 DIHYDRO 2LAMBDA5 PYRIDO[2,3 D][1,3,2]OXAZAPHOSPHOL 2 YL)GUANIDINE; N (6 METHOXYL 1,3 BENZOTHIAZOL 2 YL) N' (2 THIOXO 2,3 DIHYDRO 2LAMBDA5 PYRIDO[2,3 D][1,3,2]OXAZAPHOSPHOL 2 YL)GUANIDINE; N (6 NITRO 1,3 BENZOTHIAZOL 2 YL) N' (2 THIOXO 2,3 DIHYDRO 2LAMBDA5 PYRIDO[2,3 D][1,3,2]OXAZAPHOSPHOL 2 YL)GUANIDINE; N [2 (1H 3 INDOLYL)ETHYL] N' (2 THIOXO 2,3 DIHYDRO 2LAMBDA5 PYRIDO[2,3 D][1,3,2]OXAZAPHOSPHOL 2 YL)GUANIDINE; N1 (2 THIOXO 2,3 DIHYDRO 2LAMBDA5 PYRIDO[2,3 D][1,3,2]OXAZAPHOSPHOL 2 YL) 4 (2 PYRIMIDINYL) 1 PIPERAZINECARBOXIMIDAMIDE; N1 (2 THIOXO 2,3 DIHYDRO 2LAMBDA5 PYRIDO[2,3 D][1,3,2]OXAZAPHOSPHOL 2 YL) 4 (4 CHLOROPHENYL) 1 PIPERAZINE CARBOXIMIDAMIDE; N1 (2 THIOXO 2,3 DIHYDRO 2LAMBDA5 PYRIDO[2,3 D][1,3,2]OXAZAPHOSPHOL 2 YL) 4 (4 FLUOROPHENYL 1 PIPERAZINECARBOXIMIDAMIDE; N1 (2 THIOXO 2,3 DIHYDRO 2LAMBDA5 PYRIDO[2,3 D][1,3,2]OXAZAPHOSPHOL 2 YL) 4 (4 NITROPHENYL) 1 PIPERAZINECARBOXIMIDAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PROTEIN DENATURATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; CYANAMIDE; EDEMA; ERYTHROCYTE MEMBRANE; FOOT; GUANIDINE; HUMANS; PHOSPHORYLATION; RATS; RATS, WISTAR;

EID: 84872197130     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.c12-00582     Document Type: Article

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