Design, synthesis, and pharmacological evaluation of conformationally constrained analogues of N,N'-diaryl- and N-aryl-N-aralkylguanidines as potent inhibitors of neuronal Na+ channels

Journal of Medicinal Chemistry

Volumn 41, Issue 16, 1998, Pages 3048-3061

  Maillard, Michel C ^a,c   Perlman, Michael E ^c   Amitay, Oved ^c   Baxter, Deborah ^c   Berlove, David ^c   Connaughton, Sonia ^c   Fischer, James B ^c   Guo, Jun Qing ^c   Hu, Lain Yen ^c   McBurney, Robert N ^d   Nagy, Peter I ^b   Subbarao, Katragadda ^c   Yost, Elizabeth A ^c   Zhang, Lu ^c   Durant, Graham J ^c  

^a Athena Neurosciences Inc   (United States)

^b MEDICAL COLLEGE OF OHIO   (United States)

^c CeNeS Pharmaceuticals plc   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BIS(4 BUTYLPHENYL) 4,5 DIHYDROIMIDAZOL 2 YLAMINE HYDROBROMIDE; 1,3 BIS(4 BUTYLPHENYL)TETRAHYDROPYRIMIDIN 2 YLIDENAMINE HYDROBROMIDE; CARBAMAZEPINE; CNS 1237; DIZOCILPINE; FOSPHENYTOIN SODIUM; GUANIDINE DERIVATIVE; ION CHANNEL; LAMOTRIGINE; LIFARIZINE; LUBELUZOLE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N,N' BIS(4 BUTYLPHENYL) N,N' DIMETHYLGUANIDINE; NEUROPROTECTIVE AGENT; RILUZOLE; SIPATRIGINE; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN PROTECTION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; LIPID BILAYER; MALE; MOUSE; NEUROPHARMACOLOGY; NONHUMAN; RECEPTOR BINDING; SEIZURE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICONVULSANTS; BIOLOGICAL TRANSPORT; BRAIN; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CHO CELLS; CRICETINAE; DRUG DESIGN; FEMALE; GUANIDINE; IMIDAZOLES; MALE; MICE; MICE, INBRED DBA; MOLECULAR CONFORMATION; NEURONS; PYRIMIDINES; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; SEIZURES; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTOSOMES;

EID: 15644366605     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980124a     Document Type: Article

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