Cytoprotective activity of mulberry leaf extract against oxidative stress-induced cellular injury in rats

Pakistan Journal of Pharmaceutical Sciences

Volumn 26, Issue 1, 2013, Pages 163-168

  Jaruchotikamol, Atika ^a   Pannangpetch, Patchareewan ^b  

^a MAHASARAKHAM UNIVERSITY   (Thailand)

^b KHON KAEN UNIVERSITY   (Thailand)

Author keywords

Anti oxidant activity; Cytoprotective activity; Ischemia reperfusion; Morus alba Linn.; Mulberry

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 2,2' AZOBIS(2 AMIDINOPROPANE); ANTIOXIDANT; MULBERRY EXTRACT;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DAMAGE; CELL PROTECTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG SCREENING; HEMOLYSIS; IC 50; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OXIDATIVE STRESS; PLANT LEAF; RAT; STOMACH MUCOSA INJURY;

ANIMALS; ANTIOXIDANTS; BIPHENYL COMPOUNDS; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; GASTRIC MUCOSA; HEMOLYSIS; MALE; MORUS; OXIDATIVE STRESS; PICRATES; PLANT EXTRACTS; PLANT LEAVES; PLANTS, MEDICINAL; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; TIME FACTORS;

EID: 84872189329     PISSN: 1011601X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Bose PC (1989). Genetic Resources of Mulberry and Utilization. CSR and TI Mysore, India, pp.183-190.
2. Cao G, Sofic E and Prior RL (1997). Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships. Free Radic. Biol. Med., 22: 749-760.
3. Chepelev NL, Bennitz JD, Wright JS, Smith JC and Willmore WG (2009). Oxidative modification of citrate synthase by peroxyl radicals and protection with novel antioxidants. J. Enzyme Inhib. Med. Chem., 24(6): 1319-1331.
4. Chung KO, Kim BY, Lee MH, Kim YR, Chung HY, Park JH and Moon JO (2003). In-vitro and in-vivo antiinflammatory effect of oxyresveratrol from Morus alba L. J. Pharm. Pharmacol., 55(12): 1695-1700.
5. Cuzzocrea S, Riley DP, Caputi AP and Salvemini D (2001). Antioxidant therapy: A new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacol. Rev., 53:135-159.
6. Doi K, Kojima T and Fujimoto Y (2000). Mulberry leaf extract inhibits the oxidative modification of rabbit and human low density lipoprotein. Biol. Pharm. Bull., 23: 1066-1071.
7. Dugo P, Donato P, Cacciola F, Germanò MP, Rapisarda A and Mondello L (2009). Characterization of the polyphenolic fraction of Morus alba leaves extracts by HPLC coupled to a hybrid IT-TOF MS system. J. Sep. Sci., 32 (21): 3627-3634.
8. Galati G, Sabzevari O, Wilson JX and O'Brien PJ (2002). Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. Toxicology, 177: 91-104.
9. Ha HL, Shin HJ, Feitelson MA and Yu DY (2010). Oxidative stress and antioxidants in hepatic pathogenesis. World J. Gastroenterol., 16(48): 6035-6043.
10. Halliwell B and Gutteridge JMC (1999). Free radicals in biology and medicine. Clarendon Press, Oxford, pp.22-81.
11. Hanasaki Y, Ogawa S and Fukui S (1994). The correlation between ative oxygens scavenging and antioxidative effects of flavonoids. Free Radic. Biol. Med., 16: 845-850.
12. He ZD, Lau KM, Xu HX, Li PC and Pui-Hay But P (2000). Antioxidant activity of phenylethanoid glycosides from Brandisia hancei. J. Ethnopharmacol., 71: 483-486.
13. Huang TH, Teoh AW, Lin BL, Lin DS and Roufogalis B (2009). The role of herbal PPAR modulators in the treatment of cardiometabolic syndrome. Pharmacol. Res., 60(3): 195-206.
14. Ishii M, Shimizu S, Nawata S, Kiuchi Y and Yamamoto T (2000). Involvement of reactive oxygen species and nitric oxide in gastric ischemia-reperfusion injury in rats: protective effect of tetrahydrobiopterin. Dig. Dis. Sci., 45 : 93-98.
15. Iwata F, Joh T, Yokoyama Y and Itoh M (1998). Role of endogenous nitric oxide in ischaemia-reperfusion injury of rat gastric mucosa. J. Gastroenterol. Hepatol., 13(10): 997-1001.
16. Kang TH, Oh HR, Jung SM, Ryu JH, Park MW, Park YK and Kim SY (2006). Enhancement of neuroprotection of mulberry leaves (Morus alba L.) prepared by the anaerobic treatment against ischemic damage. Biol. Pharm. Bull., 29(2): 270-274.
17. Khammuang S and Sarnthima R (2011). Antioxidant and antibacterial activities of selected varieties of Thai mango seed extract. Pak. J. Pharm. Sci., 24(1): 37-42.
18. Kim SY, Gao JJ and Kang HK (2000). Two flavonoids from the leaves of Morus alba induce differentiation of the human promyelocytic leukemia (HL-60) cell line. Biol. Pharm. Bull., 23: 451-455.
19. Kim SY, Gao JJ, Lee WC, Ryu KS, Lee KR and Kim YC (1999). Antioxidative flavonoids from the leaves of Morus alba. Arch. Pharm. Res., 22: 81-85.
20. Kurose I and Granger DN (1994). Evidence implicating xanthine oxidase and neutrophils in reperfusioninduced microvascular dysfunction. Ann. N. Y. Acad. Sci., 723: 158-179.
21. Kwiecień S, Brzozowski T and Konturek SJ (2002). Effects of reactive oxygen species action on gastric mucosa in various models of mucosal injury. J. Physiol. Pharmacol., 53(1): 39-50.
22. Kwiecień S, Brzozowski T, Konturek PC, Pawlik MW, Pawlik WW, Kwiecień N and Konturek SJ (2003). The role of reactive oxygen species and capsaicin-sensitive sensory nerves in the pathomechanisms of gastric ulcers induced by stress. J. Physiol. Pharmacol., 54(3): 423-437.
23. Maricic N, Ehrlich K, Gretzer B, Schuligoi R, Respondek M and Peskar BM (1999). Selective cyclo-oxygenase-2 inhibitors aggravate ischaemia-reperfusion injury in the rat stomach. Br. J. Pharmacol., 128(8): 1659-1666.
24. Naito Y, Takagi T, Katada K, Tomatsuri N, Mizushima K, Handa O, Kokura S, Yagi N, Ichikawa H and Yoshikawa T (2011). Gastric peroxisome proliferator activator receptor-γ expression and cytoprotective actions of its ligands against ischemia-reperfusion injury in rats. J. Clin. Biochem. Nutr., 48(2): 170-177.
25. Naowaboot J, Pannangpetch P, Kukongviriyapan V, Kongyingyoes B and Kukongviriyapan U (2009a). Antihyperglycemic, Antioxidant and antiglycation activities of mulberry leaf extract in streptozotocininduced chronic diabetic rats. Plant Foods Hum. Nutr., 64: 116-121.
26. Naowaboot J, Pannangpetch P, Kukongviriyapan V, Kukongviriyapan U, Nakmareong S and Itharat A (2009b). Mulberry leaf extract restores arterial pressure in streptozotocin-induced chronic diabetic rats. Nutri. Res., 29: 602-608.
27. Sharma R, Sharma A, Shono T, Takasugi M, Shirata A, Fujimura T and Machii H (2001). Mulberry moracins: Ccavengers of UV stress-generated free radicals. Biosci. Biotechnol. Biochem., 65: 1402-1405.
28. Srivastava S, Kapoor R, Thathola A and Srivastavav RP (2006). Nutritional quality of leaves of some genotypes of mulberry (Morus alba). Int. J. Food Sci. Nutr., 57(5-6): 305-313.
29. Wada K, Kamisaki Y, Kitano M, Nakmoto K and Itoh T (1995). Protective effect of cystathionine on acute gastric mucosal injury induced by ischemia-reperfusion in rats. Eur. J. Pharmacol., 294: 377-382.
30. Wada K, Nakajima A, Takahashi H, Yoneda M, Fujisawa N, Ohsawa E, Kadowaki T, Kubota N, Terauchi Y, Matsuhashi N, Saubermann LJ, Nakajima N and Blumberg RS (2004). Protective effect of endogenous PPARγ against acute gastric mucosal lesions associated with ischemia-reperfusion. Am. J. Physiol. Gastrointest. Liver Physiol., 287: G452-G458.
31. Wallace JL, Zamuner SR, McKnight W, Dicay M, Mencarelli A, del Soldato P and Fiorucci S (2004). Aspirin, but not NO-releasing aspirin (NCX-4016), interacts with selective COX-2 inhibitors to aggravate gastric damage and inflammation. Am. J. Physiol. Gastrointest. Liver Physiol., 286: G76-G81.
32. Yu Z, Fong WP and Cheng CH (2006). The dual actions of morin (3,5,7,2′,4′-pentahydroxyflavone) as a hypouricemic agent: uricosuric effect and xanthine oxidase inhibitory activity. J. Pharmacol. Exp. Ther., 316(1): 169-175.
33. Zimmerman BJ and Granger DN (1994). Mechanism of reperfusion injury. Am. J. Med. Sci., 307: 284-292.