Gastric peroxisome proliferator activator receptor-γ expression and cytoprotective actions of its ligands against ischemia-reperfusion injury in rats

Journal of Clinical Biochemistry and Nutrition

Volumn 48, Issue 2, 2011, Pages 170-177

  Naito, Yuji ^a   Takagi, Tomohisa ^a   Katada, Kazuhiro ^a   Tomatsuri, Naoya ^a   Mizushima, Katsura ^a   Handa, Osamu ^a   Kokura, Satoshi ^a   Yagi, Nobuaki ^a   Ichikawa, Hiroshi ^a   Yoshikawa, Toshikazu ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

DNA microarray; Inflammation; Ischemia reperfusion; Peroxisome proliferator activated receptor (PPAR ); Transcriptome

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; 2 CHLORO 5 NITROBENZANILIDE; CALNEXIN; CXCL1 CHEMOKINE; CYTOKINE; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 60; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; PROTEIN CINC1; PROTEIN ERP70; PROTEIN HSPA5; PROTEIN HSPCA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; DOWN REGULATION; DRUG EFFECT; GENE EXPRESSION; GENE IDENTIFICATION; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH MUCOSA; STOMACH MUCOSA INJURY; UPREGULATION; WESTERN BLOTTING;

RATTUS;

EID: 79952432482     PISSN: 09120009     EISSN: None     Source Type: Journal    
DOI: 10.3164/jcbn.10-81     Document Type: Article

References (29)

1. Zinner MJ, Turtinen L, Gurll NJ. The role of acid and ischemia in production of stress ulcers during canine hemorrhagic shock. Surgery 1975; 77: 807-816.
2. Kitajima M, Shimizu A, Sakai N, and et al. Gastric microcirculation and its regulating factors in stress. J Clin Gastroenterol 1991; 13 Suppl 1: S9-S17.
3. Takeuchi K, Ueshima K, Hironaka Y, Fujioka Y, Matsumoto J, Okabe S. Oxygen free radicals and lipid peroxidation in the pathogenesis of gastric mucosal lesions induced by indomethacin in rats. Relation to gastric hypermotility. Digestion 1991; 49: 175-184.
4. Murakami M, Asagoe K, Kusaka S, Kita T. Effect of gastric mucosal blood flow on the pathogenesis of ammonia in Helicobacter pylori-induced gastric mucosal injury. Eur J Gastroenterol Hepatol 1994; 6 Suppl 1: S45-S47.
5. Perry MA, Wadhwa S, Parks DA, Pickard W, Granger DN. Role of oxygen radicals in ischemia-induced lesions in the cat stomach. Gastroenterology 1986; 90: 362-367. (Pubitemid 16136677)
6. Yoshikawa T, Ueda S, Naito Y, and et al. Role of oxygen-derived free radicals in gastric mucosal injury induced by ischemia or ischemia-reperfusion in rats. Free Radic Res Commun 1989; 7: 285-291. (Pubitemid 19281977)
7. Naito Y. Role of superoxide anion radical in acute gastric mucosal and vascular injury induced by ischemia-reperfusion in rats. J Kyoto Pref Univ Med 1993; 102: 87-106.
8. Itoh M, Guth PH. Role of oxygen-derived free radicals in hemorrhagic shock-induced gastric lesion in the rats. Gastroenterology 1985; 88: 1162-1167. (Pubitemid 15087618)
9. Lemberger T, Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid phisiology. Ann Rev Cell Dev Biol 1996; 12: 335-363. (Pubitemid 26422717)
10. Schoonjans K, Martin G, Staels B, Auwerx J. Peroxisome proliferator-activated receptors, orphans with ligands and functions. Curr Opin Lipidol 1997; 8: 159-166. (Pubitemid 27290462)
11. Jiang C, Ting AT, Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 1998; 391: 82-86. (Pubitemid 28079219)
12. Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 1998; 391: 79-82. (Pubitemid 28079218)
13. Naito Y, Yoshikawa T. Thiazolidinediones: a new class of drugs for the therapy of ischemia-reperfusion injury. Drugs Today (Barc) 2004; 40: 423-430. (Pubitemid 38858909)
14. Ichikawa H, Naito Y, Takagi T, Tomatsuri N, Yoshida N, Yoshikawa T. A specific peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligand, pioglitazone, ameliorates gastric mucosal damage induced by is chemia and reperfusion in rats. Redox Rep 2002; 7: 343-346. (Pubitemid 36032930)
15. Konturek PC, Brzozowski T, Kania J, and et al. Pioglitazone, a specific ligand of the peroxisome proliferator-activated receptor gamma reduces gastric mucosal injury induced by ischaemia/reperfusion in rat. Scand J Gastroenterol 2003; 38: 468-476. (Pubitemid 36609849)
16. Villegas I, Martin AR, Toma W, de la Lastra CA. Rosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma, protects against gastric ischemia-reperfusion damage in rats: role of oxygen free radicals generation. Eur J Pharmacol 2004; 505: 195-203. (Pubitemid 39535692)
17. Wada K, Nakajima A, Takahashi H, and et al. Protective effect of endogenous PPARgamma against acute gastric mucosal lesions associated with ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol 2004; 287: G452-G458. (Pubitemid 38955266)
18. Takagi T, Naito Y, Ichikawa H, and et al. A PPAR-gamma ligand, 15-deoxy-Delta12,14-prostaglandin J(2), inhibited gastric mucosal injury induced by ischemia-reperfusion in rats. Redox Rep 2004; 9: 376-381.
19. Naito Y, Takagi T, Matsuyama K, Yoshida N, Yoshikawa T. Pioglitazone, a specific PPAR-gamma ligand, inhibits aspirin-induced gastric mucosal injury in rats. Aliment Pharmacol Ther 2001; 15: 865-873. (Pubitemid 32500433)
20. Slomiany BL, Slomiany A. Suppression of gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide by peroxisome proliferator-activated receptor gamma activation. IUBMB Life 2002; 53: 303-308. (Pubitemid 34951411)
21. Nakajima A, Wada K, Miki H, and et al. Endogenous PPAR gamma mediates anti-inflammatory activity in murine ischemia-reperfusion injury. Gastroenterology 2001; 120: 460-469. (Pubitemid 32147643)
22. Kobayashi I, Kawano S, Tsuji S, and et al. RGM1, a cell line derived from normal gastric mucosa of rat. In Vitro Cell Dev Biol -Animal 1996; 32: 259-261.
23. Inauen W, Granger DN, Meininger CJ, Schelling ME, Granger HJ, Kvietys PR. An in vitro model of ischemia/reperfusion-induced microvascular injury. Am J Physiol 1990; 259: G134-G139. (Pubitemid 20233163)
24. Katada K, Naito Y, Shimozawa M, and et al. Gene expression analysis following hypoxia-reoxygenation in rat gastric epithelial cells using a high-density oligonucleotide array. Redox Rep 2004; 9: 337-342. (Pubitemid 40185439)
25. Naito Y, Uchiyama K, Kuroda M, and et al. Laser capture microdissection/GeneChip analysis of gene expression in glomerular cells in diabetic db/db mice. Redox Rep 2004; 9: 307-312. (Pubitemid 40185433)
26. Matsuyama M, Yoshimura R, Hase T, and et al. Expression of peroxisome proliferator-activated receptor-gamma in renal ischemia-reperfusion injury. Transplant Proc 2005; 37: 1684-1685. (Pubitemid 40790795)
27. Yoshikawa T, Naito Y. The role of neutrophils and inflammation in gastric mucosal injury. Free Radic Res 2000; 33: 785-794. (Pubitemid 32208486)
28. Ellgaard L, Frickel EM. Calnexin, calreticulin, and ERp57: teammates in glycoprotein folding. Cell Biochem Biophys 2003; 39: 223-247. (Pubitemid 41270793)
29. Weber SM, Chambers KT, Bensch KG, Scarim AL, Corbett JA. PPARgamma ligands induce ER stress in pancreatic beta-cells: ER stress activation results in attenuation of cytokine signaling. Am J Physiol Endocrinol Metab 2004; 287: E1171-E1177. (Pubitemid 39491959)