메뉴 건너뛰기




Volumn 13, Issue 2, 2013, Pages 169-182

Anti-CD20 monoclonal antibodies in chronic lymphocytic leukemia

Author keywords

anti CD20 monoclonal antibody; chronic lymphocytic leukemia; rituximab

Indexed keywords

ALEMTUZUMAB; BENDAMUSTINE; CD20 ANTIBODY; CD20 ANTIGEN; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; FLUDARABINE; LENALIDOMIDE; LUMILIXIMAB; METHYLPREDNISOLONE; MITOXANTRONE; OBINUTUZUMAB; OCRELIZUMAB; OFATUMUMAB; PENTOSTATIN; PREDNISOLONE; RITUXIMAB; VELTUZUMAB;

EID: 84872182852     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.2012.735655     Document Type: Review
Times cited : (19)

References (116)
  • 1
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the international workshop on chronic lymphocytic leukemia updating the national cancer institute-working group 1996 guidelines
    • Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood 2008;111:5446-56
    • (2008) Blood , vol.111 , pp. 5446-56
    • Hallek, M.1    Cheson, B.D.2    Catovsky, D.3
  • 2
    • 78651376557 scopus 로고    scopus 로고
    • New anti-cd20 monoclonal antibodies for the treatment of b-cell lymphoid malignancies
    • Robak T, Robak E. New anti-CD20 monoclonal antibodies for the treatment of B-cell lymphoid malignancies. BioDrugs 2011;25:13-24
    • (2011) BioDrugs , vol.25 , pp. 13-24
    • Robak, T.1    Robak, E.2
  • 3
    • 0019448991 scopus 로고
    • A unique cell surface antigen identifying lymphoid malignancies of B cell origin
    • Nadler LM, Ritz J, Hardy R, et al. A unique cell surface antigen identifying lymphoid malignancies of B cell origin. J Clin Invest 1981;67:134-40 (Pubitemid 11163165)
    • (1981) Journal of Clinical Investigation , vol.67 , Issue.1 , pp. 134-140
    • Nadler, L.M.1    Ritz, J.2    Hardy, R.3
  • 4
    • 79952720110 scopus 로고    scopus 로고
    • The future of anti-cd20 monoclonal antibodies: Are we making progress?
    • Alduaij W, Illidge TM. The future of anti-CD20 monoclonal antibodies: are we making progress? Blood 2011;117:2993-3001
    • (2011) Blood , vol.117 , pp. 2993-3001
    • Alduaij, W.1    Illidge, T.M.2
  • 5
    • 51649093353 scopus 로고    scopus 로고
    • Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia
    • Tam CS, O'Brien S, Wierda W, et al. Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia. Blood 2008;112:975-80
    • (2008) Blood , vol.112 , pp. 975-80
    • Tam, C.S.1    O'Brien, S.2    Wierda, W.3
  • 6
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
    • Landmark randomized trial showing that addition of rituximab to FC improved outcomes in untreated CLL patients.
    • Hallek M, Fischer K, Fingerle-Rowson G, et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet 2010;376:1164-74 Landmark randomized trial showing that addition of rituximab to FC improved outcomes in untreated CLL patients.
    • (2010) Lancet , vol.376 , pp. 1164-74
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3
  • 7
    • 77950502126 scopus 로고    scopus 로고
    • Ofatumumab as single-Agent cd20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia
    • Wierda WG, Kipps TJ, Mayer J, et al. Ofatumumab as single-Agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia. J Clin Oncol 2010;28:1749-54
    • (2010) J Clin Oncol , vol.28 , pp. 1749-54
    • Wierda, W.G.1    Kipps, T.J.2    Mayer, J.3
  • 8
    • 84858664440 scopus 로고    scopus 로고
    • Rituximab for chronic lymphocytic leukemia
    • Robak T. Rituximab for chronic lymphocytic leukemia. Expert Opin Biol Ther 2012;12:503-14
    • (2012) Expert Opin Biol Ther , vol.12 , pp. 503-14
    • Robak, T.1
  • 9
    • 77949423291 scopus 로고    scopus 로고
    • Strategies to enhance rituximab anti-tumor activity in the treatment of cd20-positive b-cell neoplasms
    • Riaz W, Hernandez-Ilizaliturri FJ, Czuczman MS. Strategies to enhance rituximab anti-tumor activity in the treatment of CD20-positive B-cell neoplasms. Immunol Res 2010;46:192-204
    • (2010) Immunol Res , vol.46 , pp. 192-204
    • Riaz, W.1    Hernandez-Ilizaliturri, F.J.2    Czuczman, M.S.3
  • 10
    • 41349113572 scopus 로고    scopus 로고
    • FMC7 is an epitope of CD20
    • DOI 10.1182/blood-2007-11-126243
    • Deans JP, Polyak MJ. FMC7 is an epitope of CD20. Blood 2008;111:2492; author reply 3-4 (Pubitemid 351451473)
    • (2008) Blood , vol.111 , Issue.4 , pp. 2492
    • Deans, J.P.1    Polyak, M.J.2
  • 12
    • 77950331000 scopus 로고    scopus 로고
    • Cd20 as a target for therapeutic type i and ii monoclonal antibodies
    • Beers SA, Chan CH, French RR, et al. CD20 as a target for therapeutic type I and II monoclonal antibodies. Semin Hematol 2010;47:107-14
    • (2010) Semin Hematol , vol.47 , pp. 107-14
    • Beers, S.A.1    Chan, C.H.2    French, R.R.3
  • 13
    • 0029115799 scopus 로고
    • Association of 75/80-kda phosphoproteins and the tyrosine kinases lyn, fyn, and lck with the b cell molecule cd20. Evidence against involvement of the cytoplasmic regions of cd20
    • Deans JP, Kalt L, Ledbetter JA, et al. Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20. J Biol Chem 1995;270:22632-8
    • (1995) J Biol Chem , vol.270 , pp. 22632-8
    • Deans, J.P.1    Kalt, L.2    Ledbetter, J.A.3
  • 14
    • 0031858988 scopus 로고    scopus 로고
    • The association between CD20 and Src-family tyrosine kinases requires an additional factor
    • DOI 10.1016/S0161-5890(98)00042-X, PII S016158909800042X
    • Popoff IJ, Savage JA, Blake J, et al. The association between CD20 and Src-family Tyrosine kinases requires an additional factor. Mol Immunol 1998;35:207-14 (Pubitemid 28374928)
    • (1998) Molecular Immunology , vol.35 , Issue.4 , pp. 207-214
    • Popoff, I.J.1    Savage, J.A.2    Blake, J.3    Johnson, P.4    Deans, J.P.5
  • 15
    • 79960475243 scopus 로고    scopus 로고
    • Cd20 antibodies: Doing the time warp
    • Cragg MS. CD20 antibodies: doing the time warp. Blood 2011;118:219-20
    • (2011) Blood , vol.118 , pp. 219-20
    • Cragg, M.S.1
  • 18
    • 77955300283 scopus 로고    scopus 로고
    • Ofatumumab, a novel anti-cd20 monoclonal antibody for the treatment of b-cell malignancies
    • Cheson BD. Ofatumumab, a novel anti-CD20 monoclonal antibody for the treatment of B-cell malignancies. J Clin Oncol 2010;28:3525-30
    • (2010) J Clin Oncol , vol.28 , pp. 3525-30
    • Cheson, B.D.1
  • 20
    • 0034775122 scopus 로고    scopus 로고
    • Variability in B-cell antigen expression: Implications for the treatment of B-cell lymphomas and leukemias with monoclonal antibodies
    • DOI 10.1038/sj.thj.6200119
    • Rossmann ED, Lundin J, Lenkei R, et al. Variability in B-cell antigen expression: implications for the treatment of B-cell lymphomas and leukemias with monoclonal antibodies. Hematol J 2001;2:300-6 (Pubitemid 32976373)
    • (2001) Hematology Journal , vol.2 , Issue.5 , pp. 300-306
    • Rossmann, E.D.1    Lundin, J.2    Lenkei, R.3    Mellstedt, H.4    Osterborg, A.5
  • 22
    • 58149162030 scopus 로고    scopus 로고
    • Type ii (tositumomab) anti-cd20 monoclonal antibody out performs type i (rituximab-like) reagents in b-cell depletion regardless of complement activation
    • Beers SA, Chan CH, James S, et al. Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation. Blood 2008;112:4170-7
    • (2008) Blood , vol.112 , pp. 4170-7
    • Beers, S.A.1    Chan, C.H.2    James, S.3
  • 23
    • 42149090514 scopus 로고    scopus 로고
    • Complement activation plays a key role in antibody-induced infusion toxicity in monkeys and rats
    • Tawara T, Hasegawa K, Sugiura Y, et al. Complement activation plays a key role in antibody-induced infusion toxicity in monkeys and rats. J Immunol 2008;180:2294-8
    • (2008) J Immunol , vol.180 , pp. 2294-8
    • Tawara, T.1    Hasegawa, K.2    Sugiura, Y.3
  • 24
    • 38949121647 scopus 로고    scopus 로고
    • NK-cell activation and antibody-dependent cellular cytotoxicity induced by rituximab-coated target cells is inhibited by the C3b component of complement
    • DOI 10.1182/blood-2007-02-074716
    • Wang SY, Racila E, Taylor RP, Weiner GJ. NK-cell activation and antibody-dependent cellular cytotoxicity induced by rituximab-coated target cells is inhibited by the C3b component of complement. Blood 2008;111:1456-63 (Pubitemid 351213433)
    • (2008) Blood , vol.111 , Issue.3 , pp. 1456-1463
    • Wang, S.-Y.1    Racila, E.2    Taylor, R.P.3    Weiner, G.J.4
  • 25
    • 0038518572 scopus 로고    scopus 로고
    • Apoptotic-regulatory and complement-protecting protein expression in chronic lymphocytic leukemia: Relationship to in vivo rituximab resistance
    • DOI 10.1200/JCO.2003.06.012
    • Bannerji R, Kitada S, Flinn IW, et al. Apoptotic-regulatory and complement-protecting protein expression in chronic lymphocytic leukemia: relationship to in vivo rituximab resistance. J Clin Oncol 2003;21:1466-71 (Pubitemid 46594097)
    • (2003) Journal of Clinical Oncology , vol.21 , Issue.8 , pp. 1466-1471
    • Bannerji, R.1    Kitada, S.2    Flinn, I.W.3    Pearson, M.4    Young, D.5    Reed, J.C.6    Byrd, J.C.7
  • 26
    • 3042592452 scopus 로고    scopus 로고
    • The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy
    • DOI 10.1084/jem.20040119
    • Uchida J, Hamaguchi Y, Oliver JA, et al. The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy. J Exp Med 2004;199:1659-69 (Pubitemid 38821999)
    • (2004) Journal of Experimental Medicine , vol.199 , Issue.12 , pp. 1659-1669
    • Uchida, J.1    Hamaguchi, Y.2    Oliver, J.A.3    Ravetch, J.V.4    Poe, J.C.5    Haas, K.M.6    Tedder, T.F.7
  • 27
    • 0842264005 scopus 로고    scopus 로고
    • FcγRIIIa and FcγRIIa polymorphisms do not predict response to rituximab in B-cell chronic lymphocytic leukemia
    • DOI 10.1182/blood-2003-07-2548
    • Farag SS, Flinn IW, Modali R, et al. Fc gamma RIIIa and Fc gamma RIIa polymorphisms do not predict response to rituximab in B-cell chronic lymphocytic leukemia. Blood 2004;103:1472-4 (Pubitemid 38168664)
    • (2004) Blood , vol.103 , Issue.4 , pp. 1472-1474
    • Farag, S.S.1    Flinn, I.W.2    Modali, R.3    Lehman, T.A.4    Young, D.5    Byrd, J.C.6
  • 28
    • 68849108368 scopus 로고    scopus 로고
    • Monoclonal antibodies directed to cd20 and hla-dr can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells
    • Ivanov A, Beers SA, Walshe CA, et al. Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells. J Clin Invest 2009;119:2143-59
    • (2009) J Clin Invest , vol.119 , pp. 2143-59
    • Ivanov, A.1    Beers, S.A.2    Walshe, C.A.3
  • 29
    • 77956545725 scopus 로고    scopus 로고
    • Long-lasting antitumor protection by anti-cd20 antibody through cellular immune response
    • Abes R, Gelize E, Fridman WH, Teillaud JL. Long-lasting antitumor protection by anti-CD20 antibody through cellular immune response. Blood 2010;116:926-34
    • (2010) Blood , vol.116 , pp. 926-34
    • Abes, R.1    Gelize, E.2    Fridman, W.H.3    Teillaud, J.L.4
  • 30
    • 78751564397 scopus 로고    scopus 로고
    • Preclinical studies on the mechanism of action and the anti-lymphoma activity of the novel anti-cd20 antibody ga101
    • Dalle S, Reslan L, Besseyre de Horts T, et al. Preclinical studies on the mechanism of action and the anti-lymphoma activity of the novel anti-CD20 antibody GA101. Mol Cancer Ther 2011;10:178-84
    • (2011) Mol Cancer Ther , vol.10 , pp. 178-84
    • Dalle, S.1    Reslan, L.2    Besseyre De Horts, T.3
  • 33
    • 50949166628 scopus 로고    scopus 로고
    • Radiation therapy with tositumomab (b1) anti-cd20 monoclonal antibody initiates extracellular signal-regulated kinase/mitogen-Activated protein kinase-dependent cell death that overcomes resistance to apoptosis
    • Ivanov A, Krysov S, Cragg MS, Illidge T. Radiation therapy with tositumomab (B1) anti-CD20 monoclonal antibody initiates extracellular signal-regulated kinase/mitogen-Activated protein kinase-dependent cell death that overcomes resistance to apoptosis. Clin Cancer Res 2008;14:4925-34
    • (2008) Clin Cancer Res , vol.14 , pp. 4925-34
    • Ivanov, A.1    Krysov, S.2    Cragg, M.S.3    Illidge, T.4
  • 34
    • 78651232150 scopus 로고    scopus 로고
    • Bm-ca is a newly defined type i/ii anti-cd20 monoclonal antibody with unique biological properties
    • Nishida M, Uematsu N, Kobayashi H, et al. BM-ca is a newly defined type I/II anti-CD20 monoclonal antibody with unique biological properties. Int J Oncol 2011;38:335-44
    • (2011) Int J Oncol , vol.38 , pp. 335-44
    • Nishida, M.1    Uematsu, N.2    Kobayashi, H.3
  • 38
    • 66549111370 scopus 로고    scopus 로고
    • Down-regulation of cd20 expression in b-cell lymphoma cells after treatment with rituximab-containing combination chemotherapies: Its prevalence and clinical significance
    • Hiraga J, Tomita A, Sugimoto T, et al. Down-regulation of CD20 expression in B-cell lymphoma cells after treatment with rituximab-containing combination chemotherapies: its prevalence and clinical significance. Blood 2009;113:4885-93
    • (2009) Blood , vol.113 , pp. 4885-93
    • Hiraga, J.1    Tomita, A.2    Sugimoto, T.3
  • 39
    • 32044464340 scopus 로고    scopus 로고
    • The shaving reaction: Rituximab/CD20 complexes are removed from mantle cell lymphoma and chronic lymphocytic leukemia cells by THP-1 monocytes
    • Beum PV, Kennedy AD, Williams ME, et al. The shaving reaction: rituximab/CD20 complexes are removed from mantle cell lymphoma and chronic lymphocytic leukemia cells by THP-1 monocytes. J Immunol 2006;176:2600-9 (Pubitemid 43201712)
    • (2006) Journal of Immunology , vol.176 , Issue.4 , pp. 2600-2609
    • Beum, P.V.1    Kennedy, A.D.2    Williams, M.E.3    Lindorfer, M.A.4    Taylor, R.P.5
  • 40
    • 77954679392 scopus 로고    scopus 로고
    • Antigenic modulation limits the efficacy of anti-cd20 antibodies: Implications for antibody selection
    • Beers SA, French RR, Chan HT, et al. Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection. Blood 2010;115:5191-201
    • (2010) Blood , vol.115 , pp. 5191-201
    • Beers, S.A.1    French, R.R.2    Chan, H.T.3
  • 42
    • 0028057250 scopus 로고
    • Depletion of b cells in vivo by a chimeric mouse human monoclonal antibody to cd20
    • Reff ME, Carner K, Chambers KS, et al. Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20. Blood 1994;83:435-44
    • (1994) Blood , vol.83 , pp. 435-44
    • Reff, M.E.1    Carner, K.2    Chambers, K.S.3
  • 43
    • 78650064032 scopus 로고    scopus 로고
    • Prospective analysis of hepatitis b virus reactivation in patients with diffuse large b-cell lymphoma after rituximab combination chemotherapy
    • Niitsu N, Hagiwara Y, Tanae K, et al. Prospective analysis of hepatitis B virus reactivation in patients with diffuse large B-cell lymphoma after rituximab combination chemotherapy. J Clin Oncol 2010;28:5097-100
    • (2010) J Clin Oncol , vol.28 , pp. 5097-100
    • Niitsu, N.1    Hagiwara, Y.2    Tanae, K.3
  • 44
    • 67749087489 scopus 로고    scopus 로고
    • The late adverse events of rituximab therapy-rare but there!
    • Ram R, Ben-Bassat I, Shpilberg O, et al. The late adverse events of rituximab therapy-rare but there! Leuk Lymphoma. 2009;50:1083-94
    • (2009) Leuk Lymphoma , vol.50 , pp. 1083-94
    • Ram, R.1    Ben-Bassat, I.2    Shpilberg, O.3
  • 45
    • 1842368507 scopus 로고    scopus 로고
    • Idec-c2b8 (rituximab) anti-cd20 monoclonal antibody therapy in patients with relapsed low-grade non-hodgkin's lymphoma
    • Maloney DG, Grillo-Lopez AJ, White CA, et al. IDEC-C2B8 (Rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma. Blood 1997;90:2188-94
    • (1997) Blood , vol.90 , pp. 2188-94
    • Maloney, D.G.1    Grillo-Lopez, A.J.2    White, C.A.3
  • 46
    • 0032931320 scopus 로고    scopus 로고
    • IDEC-C2B8 anti-CD20 (Rituximab) immunotherapy in patients with low- grade non-Hodgkin's lymphoma and lymphoproliferative disorders: Evaluation of response on 48 patients
    • Nguyen DT, Amess JA, Doughty H, et al. IDEC-C2B8 anti-CD20 (rituximab) immunotherapy in patients with low-grade non-Hodgkin's lymphoma and lymphoproliferative disorders: evaluation of response on 48 patients. Eur J Haematol 1999;62:76-82 (Pubitemid 29071265)
    • (1999) European Journal of Haematology , vol.62 , Issue.2 , pp. 76-82
    • Nguyen, D.T.1    Amess, J.A.2    Doughty, H.3    Hendry, L.4    Diamond, L.W.5
  • 47
    • 0026655066 scopus 로고
    • Reduced expression of cd20 antigen as a characteristic marker for chronic lymphocytic leukemia
    • Almasri NM, Duque RE, Iturraspe J, et al. Reduced expression of CD20 antigen as a characteristic marker for chronic lymphocytic leukemia. Am J Hematol 1992;40:259-63
    • (1992) Am J Hematol , vol.40 , pp. 259-63
    • Almasri, N.M.1    Duque, R.E.2    Iturraspe, J.3
  • 50
    • 79951658129 scopus 로고    scopus 로고
    • Single agent rituxan in early stage chronic lymphocytic leukemia(cll)
    • [abstract]
    • Thomas DA, O'Brien S, Giles FJ, et al. Single agent rituxan in early stage chronic lymphocytic leukemia(CLL) [abstract]. Blood 2001;98:364
    • (2001) Blood , vol.98 , pp. 364
    • Thomas, D.A.1    O'Brien, S.2    Giles, F.J.3
  • 51
    • 0038811776 scopus 로고    scopus 로고
    • Single-agent rituximab as first-line and maintenance treatment for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: A phase II trial of the Minnie Pearl Cancer Research Network
    • DOI 10.1200/JCO.2003.09.027
    • Hainsworth JD, Litchy S, Barton JH, et al. Single-Agent rituximab as first-line and maintenance treatment for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: a phase II trial of the Minnie Pearl Cancer Research Network. J Clin Oncol 2003;21:1746-51 (Pubitemid 46638587)
    • (2003) Journal of Clinical Oncology , vol.21 , Issue.9 , pp. 1746-1751
    • Hainsworth, J.D.1    Litchy, S.2    Barton, J.H.3    Houston, G.A.4    Hermann, R.C.5    Bradof, J.E.6    Greco, F.A.7
  • 52
    • 0034894958 scopus 로고    scopus 로고
    • Inhibition of interleukin 10 by Rituximab results in down-regulation of Bcl-2 and sensitization of B-cell non-Hodgkin's lymphoma to apoptosis
    • Alas S, Emmanouilides C, Bonavida B. Inhibition of interleukin 10 by rituximab results in down-regulation of bcl-2 and sensitization of B-cell non-Hodgkin's lymphoma to apoptosis. Clin Cancer Res 2001;7:709-23 (Pubitemid 32707998)
    • (2001) Clinical Cancer Research , vol.7 , Issue.3 , pp. 709-723
    • Alas, S.1    Emmanouilides, C.2    Bonavida, B.3
  • 55
    • 0037220152 scopus 로고    scopus 로고
    • Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: Results from cancer and leukemia group B 9712 (CALGB 9712)
    • DOI 10.1182/blood-2002-04-1258
    • Byrd JC, Peterson BL, Morrison VA, et al. Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712). Blood 2003;101:6-14 (Pubitemid 36025880)
    • (2003) Blood , vol.101 , Issue.1 , pp. 6-14
    • Byrd, J.C.1    Peterson, B.L.2    Morrison, V.A.3    Park, K.4    Jacobson, R.5    Hoke, E.6    Vardiman, J.W.7    Rai, K.8    Schiffer, C.A.9    Larson, R.A.10
  • 56
    • 19944429446 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: An updated retrospective comparative analysis of CALGB 9712 and CALGB 9011
    • DOI 10.1182/blood-2004-03-0796
    • Byrd JC, Rai K, Peterson BL, et al. Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: an updated retrospective comparative analysis of CALGB 9712 and CALGB 9011. Blood 2005;105:49-53 (Pubitemid 40053062)
    • (2005) Blood , vol.105 , Issue.1 , pp. 49-53
    • Byrd, J.C.1    Rai, K.2    Peterson, B.L.3    Appelbaum, F.R.4    Morrison, V.A.5    Kolitz, J.E.6    Shepherd, L.7    Hines, J.D.8    Schiffer, C.A.9    Larson, R.A.10
  • 57
    • 79954435811 scopus 로고    scopus 로고
    • Chemoimmunotherapy with fludarabine and rituximab produces extended overall survival and progression-free survival in chronic lymphocytic leukemia: Long-term followup of calgb study 9712
    • Woyach JA, Ruppert AS, Heerema NA, et al. Chemoimmunotherapy with fludarabine and rituximab produces extended overall survival and progression-free survival in chronic lymphocytic leukemia: long-term followup of CALGB study 9712. J Clin Oncol 2011;29:1349-54
    • (2011) J Clin Oncol , vol.29 , pp. 1349-54
    • Woyach, J.A.1    Ruppert, A.S.2    Heerema, N.A.3
  • 58
    • 0035179950 scopus 로고    scopus 로고
    • DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine
    • Yamauchi T, Nowak BJ, Keating MJ, Plunkett W. DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine. Clin Cancer Res 2001;7:3580-9 (Pubitemid 33069998)
    • (2001) Clinical Cancer Research , vol.7 , Issue.11 , pp. 3580-3589
    • Yamauchi, T.1    Nowak, B.J.2    Keating, M.J.3    Plunkett, W.4
  • 59
    • 77956972088 scopus 로고    scopus 로고
    • Baff serum level predicts time to first treatment in early chronic lymphocytic leukemia
    • Molica S, Digiesi G, Battaglia C, et al. Baff serum level predicts time to first treatment in early chronic lymphocytic leukemia. Eur J Haematol 2010;85:314-20
    • (2010) Eur J Haematol , vol.85 , pp. 314-20
    • Molica, S.1    Digiesi, G.2    Battaglia, C.3
  • 61
    • 84860630561 scopus 로고    scopus 로고
    • Minimal residual disease quantification is an independent predictor of progression-free and overall survival in chronic lymphocytic leukemia: A multivariate analysis from the randomized gcllsg cll8 trial
    • Bottcher S, Ritgen M, Fischer K, et al. Minimal residual disease quantification is an independent predictor of progression-free and overall survival in chronic lymphocytic leukemia: a multivariate analysis from the randomized GCLLSG CLL8 trial. J Clin Oncol 2012;30:980-8
    • (2012) J Clin Oncol , vol.30 , pp. 980-8
    • Bottcher, S.1    Ritgen, M.2    Fischer, K.3
  • 62
    • 59149090791 scopus 로고    scopus 로고
    • Chemoimmunotherapy with low-dose fludarabine and cyclophosphamide and high dose rituximab in previously untreated patients with chronic lymphocytic leukemia
    • Foon KA, Boyiadzis M, Land SR, et al. Chemoimmunotherapy with low-dose fludarabine and cyclophosphamide and high dose rituximab in previously untreated patients with chronic lymphocytic leukemia. J Clin Oncol 2009;27:498-503
    • (2009) J Clin Oncol , vol.27 , pp. 498-503
    • Foon, K.A.1    Boyiadzis, M.2    Land, S.R.3
  • 63
    • 84859344298 scopus 로고    scopus 로고
    • Long-term results of chemoimmunotherapy with low-dose fludarabine, cyclophosphamide and high-dose rituximab as initial treatment for patients with chronic lymphocytic leukemia
    • Foon KA, Mehta D, Lentzsch S, et al. Long-term results of chemoimmunotherapy with low-dose fludarabine, cyclophosphamide and high-dose rituximab as initial treatment for patients with chronic lymphocytic leukemia. Blood 2012;119:3184-4
    • (2012) Blood , vol.119 , pp. 3184-4
    • Foon, K.A.1    Mehta, D.2    Lentzsch, S.3
  • 64
    • 59149106873 scopus 로고    scopus 로고
    • Sequential therapy with fludarabine, high-dose cyclophosphamide, and rituximab in previously untreated patients with chronic lymphocytic leukemia produces high-quality responses: Molecular remissions predict for durable complete responses
    • Lamanna N, Jurcic JG, Noy A, et al. Sequential therapy with fludarabine, high-dose cyclophosphamide, and rituximab in previously untreated patients with chronic lymphocytic leukemia produces high-quality responses: molecular remissions predict for durable complete responses. J Clin Oncol 2009;27:491-7
    • (2009) J Clin Oncol , vol.27 , pp. 491-7
    • Lamanna, N.1    Jurcic, J.G.2    Noy, A.3
  • 66
    • 74549145611 scopus 로고    scopus 로고
    • Rituximab, fludarabine, cyclophosphamide, and mitoxantrone: A new, highly active chemoimmunotherapy regimen for chronic lymphocytic leukemia
    • Bosch F, Abrisqueta P, Villamor N, et al. Rituximab, fludarabine, cyclophosphamide, and mitoxantrone: a new, highly active chemoimmunotherapy regimen for chronic lymphocytic leukemia. J Clin Oncol 2009;27:4578-84
    • (2009) J Clin Oncol , vol.27 , pp. 4578-84
    • Bosch, F.1    Abrisqueta, P.2    Villamor, N.3
  • 67
    • 84866531516 scopus 로고    scopus 로고
    • Bendamustine in combination with rituximab for previously untreated patients with chronic lymphocytic leukemia: A multicenter phase ii trial of the german chronic lymphocytic leukemia study group
    • Fischer K, Cramer P, Busch R, et al. Bendamustine in combination with rituximab for previously untreated patients with chronic lymphocytic leukemia: a multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study Group. J Clin Oncol 2012;30(26):3209-16
    • (2012) J Clin Oncol , vol.30 , Issue.26 , pp. 3209-16
    • Fischer, K.1    Cramer, P.2    Busch, R.3
  • 68
    • 84861342267 scopus 로고    scopus 로고
    • Rituximab plus chlorambucil as initial treatment for elderly patients with chronic lymphocytic leukemia (cll): Effect of pre-treatment biological characteristics and gene expression patterns on response to treatment [abstract]
    • Foa R, Ciolli S, Raimondo FD, et al. Rituximab plus chlorambucil as initial treatment for elderly patients with chronic lymphocytic leukemia (CLL): effect of pre-treatment biological characteristics and gene expression patterns on response to treatment [abstract]. Blood 2011;118:1
    • (2011) Blood , vol.118 , pp. 1
    • Foa, R.1    Ciolli, S.2    Raimondo, F.D.3
  • 69
    • 84872182150 scopus 로고    scopus 로고
    • German CLL Study Group NCIN, ClinicalTrials.gov NCT00769522. Fludarabine, Cyclophosphamide, and Rituximab or Bendamustine and Rituximab in Treating Patients With Previously Untreated B-Cell Chronic Lymphocytic Leukemia. Available from:
    • German CLL Study Group NCIN, ClinicalTrials.gov NCT00769522. Fludarabine, Cyclophosphamide, and Rituximab or Bendamustine and Rituximab in Treating Patients With Previously Untreated B-Cell Chronic Lymphocytic Leukemia. Available from: http://clinicaltrialsgov/ct2/results?term=NCT00769522 2012
    • (2012)
  • 70
    • 80052180048 scopus 로고    scopus 로고
    • Frontline chemoimmunotherapy with fludarabine, cyclophosphamide, alemtuzumab, and rituximab for high-risk chronic lymphocytic leukemia
    • Parikh SA, Keating MJ, O'Brien S, et al. Frontline chemoimmunotherapy with fludarabine, cyclophosphamide, alemtuzumab, and rituximab for high-risk chronic lymphocytic leukemia. Blood 2011;118:2062-8
    • (2011) Blood , vol.118 , pp. 2062-8
    • Parikh, S.A.1    Keating, M.J.2    O'Brien, S.3
  • 71
    • 77449133613 scopus 로고    scopus 로고
    • Phase 1/2 study of lumiliximab combined with fludarabine, cyclophosphamide, and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia
    • Byrd JC, Kipps TJ, Flinn IW, et al. Phase 1/2 study of lumiliximab combined with fludarabine, cyclophosphamide, and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia. Blood 2010;115:489-94
    • (2010) Blood , vol.115 , pp. 489-94
    • Byrd, J.C.1    Kipps, T.J.2    Flinn, I.W.3
  • 72
    • 84864336293 scopus 로고    scopus 로고
    • A phase iii trial of fludarabine, cyclophosphamide, and rituximab vs. Pentostatin, cyclophosphamide, and rituximab in b-cell chronic lymphocytic leukemia
    • Reynolds C, Di Bella N, Lyons RM, et al. A phase III trial of fludarabine, cyclophosphamide, and rituximab vs. pentostatin, cyclophosphamide, and rituximab in B-cell chronic lymphocytic leukemia. Invest New Drugs 2012;30:1232-40
    • (2012) Invest New Drugs , vol.30 , pp. 1232-40
    • Reynolds, C.1    Di Bella, N.2    Lyons, R.M.3
  • 73
    • 77950478885 scopus 로고    scopus 로고
    • Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia
    • Robak T, Dmoszynska A, Solal-Celigny P, et al. Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia. J Clin Oncol 2010;28:1756-64
    • (2010) J Clin Oncol , vol.28 , pp. 1756-64
    • Robak, T.1    Dmoszynska, A.2    Solal-Celigny, P.3
  • 74
    • 80053020928 scopus 로고    scopus 로고
    • Bendamustine combined with rituximab in patients with relapsed and/or refractory chronic lymphocytic leukemia: A multicenter phase ii trial of the german chronic lymphocytic leukemia study group
    • Fischer K, Cramer P, Busch R, et al. Bendamustine combined with rituximab in patients with relapsed and/or refractory chronic lymphocytic leukemia: a multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study Group. J Clin Oncol 2011;29:3559-66
    • (2011) J Clin Oncol , vol.29 , pp. 3559-66
    • Fischer, K.1    Cramer, P.2    Busch, R.3
  • 75
    • 79953072637 scopus 로고    scopus 로고
    • Fludarabine, cyclophosphamide, and rituximab chemoimmunotherapy is highly effective treatment for relapsed patients with cll
    • Badoux XC, Keating MJ, Wang X, et al. Fludarabine, cyclophosphamide, and rituximab chemoimmunotherapy is highly effective treatment for relapsed patients with CLL. Blood 2011;117:3016-24
    • (2011) Blood , vol.117 , pp. 3016-24
    • Badoux, X.C.1    Keating, M.J.2    Wang, X.3
  • 77
    • 33749600951 scopus 로고    scopus 로고
    • Rituximab combined with cladribine or with cladribine and cyclophosphamide in heavily pretreated patients with indolent lymphoproliferative disorders and mantle cell lymphoma
    • DOI 10.1002/cncr.22196
    • Robak T, Smolewski P, Cebula B, et al. Rituximab combined with cladribine or with cladribine and cyclophosphamide in heavily pretreated patients with indolent lymphoproliferative disorders and mantle cell lymphoma. Cancer 2006;107:1542-50 (Pubitemid 44546915)
    • (2006) Cancer , vol.107 , Issue.7 , pp. 1542-1550
    • Robak, T.1    Smolewski, P.2    Cebula, B.3    Szmigielska-Kaplon, A.4    Chojnowski, K.5    Blonski, J.Z.6
  • 78
    • 70350132633 scopus 로고    scopus 로고
    • Rituximab in combination with high-dose methylprednisolone for the treatment of chronic lymphocytic leukemia
    • Castro JE, James DF, Sandoval-Sus JD, et al. Rituximab in combination with high-dose methylprednisolone for the treatment of chronic lymphocytic leukemia. Leukemia 2009;23:1779-89
    • (2009) Leukemia , vol.23 , pp. 1779-89
    • Castro, J.E.1    James, D.F.2    Sandoval-Sus, J.D.3
  • 79
    • 40849094878 scopus 로고    scopus 로고
    • High dose methylprednisolone and rituximab is an effective therapy in advanced refractory chronic lymphocytic leukemia resistant to fludarabine therapy
    • DOI 10.3324/haematol.11903
    • Dungarwalla M, Evans SO, Riley U, et al. High dose methylprednisolone and rituximab is an effective therapy in advanced refractory chronic lymphocytic leukemia resistant to fludarabine therapy. Haematologica 2008;93:475-6 (Pubitemid 351398657)
    • (2008) Haematologica , vol.93 , Issue.3 , pp. 475-476
    • Dungarwalla, M.1    Evans, S.O.2    Riley, U.3    Catovsky, D.4    Dearden, C.E.5    Matutes, E.6
  • 80
    • 37149029392 scopus 로고    scopus 로고
    • Methylprednisolone-rituximab is an effective salvage therapy for patients with relapsed chronic lymphocytic leukemia including those with unfavorable cytogenetic features
    • DOI 10.1080/10428190701724801, PII 788239125
    • Bowen DA, Call TG, Jenkins GD, et al. Methylprednisolone-rituximab is an effective salvage therapy for patients with relapsed chronic lymphocytic leukemia including those with unfavorable cytogenetic features. Leuk Lymphoma 2007;48:2412-17 (Pubitemid 350253473)
    • (2007) Leukemia and Lymphoma , vol.48 , Issue.12 , pp. 2412-2417
    • Bowen, D.A.1    Call, T.G.2    Jenkins, G.D.3    Zent, C.Z.4    Schwager, S.M.5    Van Dyke, D.L.6    Jelinek, D.F.7    Kay, N.E.8    Shanafelt, T.D.9
  • 81
    • 79957456534 scopus 로고    scopus 로고
    • Dose-dense high-dose methylprednisolone and rituximab in the treatment of relapsed or refractory high-risk chronic lymphocytic leukemia
    • Pileckyte R, Jurgutis M, Valceckiene V, et al. Dose-dense high-dose methylprednisolone and rituximab in the treatment of relapsed or refractory high-risk chronic lymphocytic leukemia. Leuk Lymphoma 2011;52:1055-64
    • (2011) Leuk Lymphoma , vol.52 , pp. 1055-64
    • Pileckyte, R.1    Jurgutis, M.2    Valceckiene, V.3
  • 82
    • 84865173645 scopus 로고    scopus 로고
    • Rituximab in combination with high-dose dexamethasone for the treatment of relapsed/refractory chronic lymphocytic leukemia
    • Smolej L, Doubek M, Panovska A, et al. Rituximab in combination with high-dose dexamethasone for the treatment of relapsed/refractory chronic lymphocytic leukemia. Leuk Res 2012;36:1278-82
    • (2012) Leuk Res , vol.36 , pp. 1278-82
    • Smolej, L.1    Doubek, M.2    Panovska, A.3
  • 83
    • 78650823247 scopus 로고    scopus 로고
    • Rituximab maintenance for 2 years in patients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (prima): A phase 3, randomised controlled trial
    • Salles G, Seymour JF, Offner F, et al. Rituximab maintenance for 2 years in patients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (PRIMA): a phase 3, randomised controlled trial. Lancet 2011;377:42-51
    • (2011) Lancet , vol.377 , pp. 42-51
    • Salles, G.1    Seymour, J.F.2    Offner, F.3
  • 84
    • 37549046061 scopus 로고    scopus 로고
    • Consolidation and maintenance immunotherapy with rituximab improve clinical outcome in patients with b-cell chronic lymphocytic leukemia
    • Del Poeta G, Del Principe MI, Buccisano F, et al. Consolidation and maintenance immunotherapy with rituximab improve clinical outcome in patients with B-cell chronic lymphocytic leukemia. Cancer 2008;112:119-28
    • (2008) Cancer , vol.112 , pp. 119-28
    • Del Poeta, G.1    Del Principe, M.I.2    Buccisano, F.3
  • 85
    • 84859719803 scopus 로고    scopus 로고
    • Rituximab maintenance in patients with chronic lymphocytic leukemia (cll) after upfront treatment with rituximab plus fludarabine, cyclophosphamide, and mitoxantrone (r-fcm): Final results of a multicenter phase ii trial on behalf of the spanish cll study group (gellc) [abstract]
    • Bosch F, Abrisqueta P, Villamor N, et al. Rituximab maintenance in patients with chronic lymphocytic leukemia (CLL) after upfront treatment with rituximab plus fludarabine, cyclophosphamide, and mitoxantrone (R-FCM): final results of a multicenter phase II trial on behalf of the Spanish CLL study group (GELLC) [abstract]. Blood 2011;118:293
    • (2011) Blood , vol.118 , pp. 293
    • Bosch, F.1    Abrisqueta, P.2    Villamor, N.3
  • 86
    • 10744230768 scopus 로고    scopus 로고
    • Anti-cd20 therapy for chronic lymphocytic leukemia-Associated autoimmune diseases
    • Zaja F, Vianelli N, Sperotto A, et al. Anti-CD20 therapy for chronic lymphocytic leukemia-Associated autoimmune diseases. Leuk Lymphoma 2003;44:1951-4
    • (2003) Leuk Lymphoma , vol.44 , pp. 1951-4
    • Zaja, F.1    Vianelli, N.2    Sperotto, A.3
  • 87
    • 68449102378 scopus 로고    scopus 로고
    • A combination of rituximab, cyclophosphamide and dexamethasone effectively treats immune cytopenias of chronic lymphocytic leukemia
    • Kaufman M, Limaye SA, Driscoll N, et al. A combination of rituximab, cyclophosphamide and dexamethasone effectively treats immune cytopenias of chronic lymphocytic leukemia. Leuk Lymphoma 2009;50:892-9
    • (2009) Leuk Lymphoma , vol.50 , pp. 892-9
    • Kaufman, M.1    Limaye, S.A.2    Driscoll, N.3
  • 88
    • 79952445044 scopus 로고    scopus 로고
    • Rituximab-cyclophosphamidedexamethasone combination in the management of autoimmune cytopenias associated with chronic lymphocytic leukemia
    • Rossignol J, Michallet AS, Oberic L, et al. Rituximab- cyclophosphamidedexamethasone combination in the management of autoimmune cytopenias associated with chronic lymphocytic leukemia. Leukemia 2011;25:473-8
    • (2011) Leukemia , vol.25 , pp. 473-8
    • Rossignol, J.1    Michallet, A.S.2    Oberic, L.3
  • 89
    • 77953199483 scopus 로고    scopus 로고
    • Treatment of autoimmune cytopenia complicating progressive chronic lymphocytic leukemia/small lymphocytic lymphoma with rituximab, cyclophosphamide, vincristine, and prednisone
    • Bowen DA, Call TG, Shanafelt TD, et al. Treatment of autoimmune cytopenia complicating progressive chronic lymphocytic leukemia/small lymphocytic lymphoma with rituximab, cyclophosphamide, vincristine, and prednisone. Leuk Lymphoma 2010;51:620-7
    • (2010) Leuk Lymphoma , vol.51 , pp. 620-7
    • Bowen, D.A.1    Call, T.G.2    Shanafelt, T.D.3
  • 90
    • 84861344593 scopus 로고    scopus 로고
    • A phase 1 study of the selective phosphatidylinositol 3-kinase-delta (pi3k) inhibitor cal-101 (gs-1101), in combination with rituximab and/or bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia (cll) [abstract]
    • Sharman J, de Vos S, Leonard JP, et al. A Phase 1 Study of the Selective Phosphatidylinositol 3-Kinase-Delta (PI3K) Inhibitor, CAL-101 (GS-1101), in Combination with Rituximab and/or Bendamustine in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) [abstract]. Blood 2011;118:1787
    • (2011) Blood , vol.118 , pp. 1787
    • Sharman, J.1    De Vos, S.2    Leonard, J.P.3
  • 91
    • 84867231194 scopus 로고    scopus 로고
    • Final analysis of a phase 2 study of lenalidomide and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia (cll) [abstract]
    • Badoux X, Keating M, O'Brien S, et al. Final Analysis of a Phase 2 Study of Lenalidomide and Rituximab in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) [abstract]. Blood 2011;118:980
    • (2011) Blood , vol.118 , pp. 980
    • Badoux, X.1    Keating, M.2    O'Brien, S.3
  • 92
    • 84867232551 scopus 로고    scopus 로고
    • A phase iii trial of fludarabine bendamustine and rituximab (fbr) chemoimmunotherapy for previously treated patients with cll [abstract]
    • Wierda W, Balakrishnan K, Ferrajoli A, et al. A Phase I/II Trial of Fludarabine, Bendamustine, and Rituximab (FBR) Chemoimmunotherapy for Previously Treated Patients with CLL [abstract]. Blood 2011;118:3901
    • (2011) Blood , vol.118 , pp. 3901
    • Wierda, W.1    Balakrishnan, K.2    Ferrajoli, A.3
  • 94
    • 84856249903 scopus 로고    scopus 로고
    • Ofatumumab demonstrates activity against rituximab-sensitive and -resistant cell lines, lymphoma xenografts and primary tumour cells from patients with b-cell lymphoma
    • Barth MJ, Hernandez-Ilizaliturri FJ, Mavis C, et al. Ofatumumab demonstrates activity against rituximab-sensitive and -resistant cell lines, lymphoma xenografts and primary tumour cells from patients with B-cell lymphoma. Br J Haematol 2012;156:490-8
    • (2012) Br J Haematol , vol.156 , pp. 490-8
    • Barth, M.J.1    Hernandez-Ilizaliturri, F.J.2    Mavis, C.3
  • 95
    • 73949084380 scopus 로고    scopus 로고
    • Characterization of a rituximab variant with potent antitumor activity against rituximab-resistant b-cell lymphoma
    • Li B, Zhao L, Guo H, et al. Characterization of a rituximab variant with potent antitumor activity against rituximab-resistant B-cell lymphoma. Blood 2009;114:5007-14
    • (2009) Blood , vol.114 , pp. 5007-14
    • Li, B.1    Zhao, L.2    Guo, H.3
  • 96
    • 38349138517 scopus 로고    scopus 로고
    • Estimation of dose requirements for sustained in vivo activity of a therapeutic human anti-cd20 antibody
    • Bleeker WK, Munk ME, Mackus WJ, et al. Estimation of dose requirements for sustained in vivo activity of a therapeutic human anti-CD20 antibody. Br J Haematol 2008;140:303-12
    • (2008) Br J Haematol , vol.140 , pp. 303-12
    • Bleeker, W.K.1    Munk, M.E.2    Mackus, W.J.3
  • 97
    • 84855814866 scopus 로고    scopus 로고
    • Combination therapy with ofatumumab and bendamustine in xenograft model of chronic lymphocytic leukaemia
    • Haskova Z, Whitacre MN, Dede KA, et al. Combination therapy with ofatumumab and bendamustine in xenograft model of chronic lymphocytic leukaemia. Br J Haematol 2012;156:402-4
    • (2012) Br J Haematol , vol.156 , pp. 402-4
    • Haskova, Z.1    Whitacre, M.N.2    Dede, K.A.3
  • 99
    • 79955870406 scopus 로고    scopus 로고
    • Final analysis from the international trial of single-Agent ofatumumab in patients with fludarabine-refractory chronic lymphocytic leukemia
    • Wierda WG, Kipps TJ, Mayer J, et al. Final Analysis From the International Trial of Single-Agent Ofatumumab In Patients with Fludarabine-Refractory Chronic Lymphocytic Leukemia. ASH Annual Meeting Abstracts; 2010. p. 116
    • (2010) ASH Annual Meeting Abstracts , pp. 116
    • Wierda, W.G.1    Kipps, T.J.2    Mayer, J.3
  • 101
    • 81055148076 scopus 로고    scopus 로고
    • Ofatumumab is active in patients with fludarabine-refractory cll irrespective of prior rituximab: Results from the phase 2 international study
    • Wierda WG, Padmanabhan S, Chan GW, Gupta IV. Ofatumumab is active in patients with fludarabine-refractory CLL irrespective of prior rituximab: results from the phase 2 international study. Blood 2011;118:5126-9
    • (2011) Blood , vol.118 , pp. 5126-9
    • Wierda, W.G.1    Padmanabhan, S.2    Chan, G.W.3    Gupta, I.V.4
  • 102
    • 84872188413 scopus 로고    scopus 로고
    • Ofatumumab retreatment and maintenance in patients with fludarabine-refractory cll
    • Osterborg A, Martin JSD, Jiri M, et al. Ofatumumab retreatment and maintenance in patients with fludarabine-refractory CLL. ASCO; 2012
    • (2012) ASCO
    • Osterborg, A.1    Martin, J.S.D.2    Jiri, M.3
  • 103
    • 84867230849 scopus 로고    scopus 로고
    • Combination therapy with ofatumumab and lenalidomide in patients with relapsed chronic lymphocytic leukemia ( cll): Results of a phase ii trial
    • Ferrajoli A, O'Brien S, Wierda W, et al. Combination Therapy with Ofatumumab and Lenalidomide in Patients with Relapsed Chronic Lymphocytic Leukemia (CLL): Results of a Phase II Trial. ASH; 2011
    • (2011) ASH
    • Ferrajoli, A.1    O'Brien, S.2    Wierda, W.3
  • 104
    • 84872486370 scopus 로고    scopus 로고
    • Efficacy of ofatumumab and high-dose methylprednisolone for the treatment of relapsed or refractory chronic lymphocytic leukemia (cll)
    • Teichman ML, Viet QH, et al. Efficacy of Ofatumumab and High-Dose Methylprednisolone for the Treatment of Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL). ASH Annual Meeting Abstracts; 2011. p. 118
    • (2011) ASH Annual Meeting Abstracts , pp. 118
    • Teichman, M.L.1    Viet, Q.H.2
  • 105
    • 84860738946 scopus 로고    scopus 로고
    • Oral high-dose glucocorticoids and ofatumumab in fludarabine-resistant chronic lymphocytic leukemia
    • Spaner DE. Oral high-dose glucocorticoids and Ofatumumab in fludarabine-resistant Chronic Lymphocytic Leukemia. Leukemia 2012;26:1144-4
    • (2012) Leukemia , vol.26 , pp. 1144-4
    • Spaner, D.E.1
  • 106
    • 84867234044 scopus 로고    scopus 로고
    • A phase ii trial of ofatumumab for older patients and patients who refuse fludarabine-based regimens with previously untreated chronic lymphocytic leukemia or small lymphocytic lymphoma
    • Flinn IW, Harwin WN, Macias-Pe'rez IM, et al. A Phase II Trial of Ofatumumab for Older Patients and Patients Who Refuse Fludarabine-Based Regimens with Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma. ASH Annual Meeting Abstracts; 2011. p. 118
    • (2011) ASH Annual Meeting Abstracts , pp. 118
    • Flinn, I.W.1    Harwin, W.N.2    Macias-Pe'rez, I.M.3
  • 107
    • 79959190996 scopus 로고    scopus 로고
    • Chemoimmunotherapy with o-fc in previously untreated patients with chronic lymphocytic leukemia
    • Wierda WG, Kipps TJ, Durig J, et al. Chemoimmunotherapy with O-FC in previously untreated patients with chronic lymphocytic leukemia. Blood 2011;117:6450-8
    • (2011) Blood , vol.117 , pp. 6450-8
    • Wierda, W.G.1    Kipps, T.J.2    Durig, J.3
  • 108
    • 84859740636 scopus 로고    scopus 로고
    • Ofatumumab based chemoimmunotherapy (cit) for patients with previously untreated cll
    • Shanafelt TD, Clive SZ, Lanasa MC, et al. Ofatumumab Based Chemoimmunotherapy (CIT) for Patients with Previously Untreated CLL. ASH Annual Meeting Abstracts; 2011. p. 118
    • (2011) ASH Annual Meeting Abstracts , pp. 118
    • Shanafelt, T.D.1    Clive, S.Z.2    Lanasa, M.C.3
  • 109
    • 84857349967 scopus 로고    scopus 로고
    • Obinutuzumab for the treatment of lymphoproliferative disorders
    • Owen C, Stewart DA. Obinutuzumab for the treatment of lymphoproliferative disorders. Expert Opin Biol Ther 2012;12:343-51
    • (2012) Expert Opin Biol Ther , vol.12 , pp. 343-51
    • Owen, C.1    Stewart, D.A.2
  • 110
    • 84861830510 scopus 로고    scopus 로고
    • A phase 1 study of obinutuzumab induction followed by 2 years of maintenance in patients with relapsed cd20-positive b-cell malignancies
    • Sehn LH, Assouline SE, Stewart DA, et al. A phase 1 study of obinutuzumab induction followed by 2 years of maintenance in patients with relapsed CD20-positive B-cell malignancies. Blood 2012;119:5118-24
    • (2012) Blood , vol.119 , pp. 5118-24
    • Sehn, L.H.1    Assouline, S.E.2    Stewart, D.A.3
  • 111
    • 80053055044 scopus 로고    scopus 로고
    • Chemoimmunotherapy with chlorambucil and the type ii cd20-Antibody ga101 in patients with chronic lymphocytic leukemia and comorbidity: Results of the run-in phase of the cll11 (bo21004) trial [abstract]
    • Valentin G, Kirsten F, Raymonde B, et al. Chemoimmunotherapy with Chlorambucil and the Type II CD20-Antibody GA101 In Patients with Chronic Lymphocytic Leukemia and Comorbidity: results of the Run-In Phase of the CLL11 (BO21004) Trial [abstract]. Blood 2010;116:1387
    • (2010) Blood , vol.116 , pp. 1387
    • Valentin, G.1    Kirsten, F.2    Raymonde, B.3
  • 112
    • 84857247431 scopus 로고    scopus 로고
    • Results from a phase ii study of obinutuzumab (ga101) monotherapy in relapsed/refractory chronic lymphocytic leukemia (cll). European hematology association annual congress [abstract]
    • Cartron G, Morschhauser F, Thieblemont C, et al. Results from a phase II study of obinutuzumab (GA101) monotherapy in relapsed/refractory chronic lymphocytic leukemia (CLL). European Hematology Association Annual Congress [abstract]. Haematologica 2011;96(s2):0101a
    • (2011) Haematologica , vol.96 , Issue.S2
    • Cartron, G.1    Morschhauser, F.2    Thieblemont, C.3
  • 113
    • 60849089338 scopus 로고    scopus 로고
    • Properties and structure-function relationships of veltuzumab (ha20), a humanized anti-cd20 monoclonal antibody
    • Goldenberg DM, Rossi EA, Stein R, et al. Properties and structure-function relationships of veltuzumab (hA20), a humanized anti-CD20 monoclonal antibody. Blood 2009;113:1062-70
    • (2009) Blood , vol.113 , pp. 1062-70
    • Goldenberg, D.M.1    Rossi, E.A.2    Stein, R.3
  • 114
    • 70249106098 scopus 로고    scopus 로고
    • Humanized anti-cd20 antibody, veltuzumab, in refractory/recurrent non-hodgkin's lymphoma: Phase i/ii results
    • Morschhauser F, Leonard JP, Fayad L, et al. Humanized anti-CD20 antibody, veltuzumab, in refractory/recurrent non-Hodgkin's lymphoma: phase I/II results. J Clin Oncol 2009;27:3346-53
    • (2009) J Clin Oncol , vol.27 , pp. 3346-53
    • Morschhauser, F.1    Leonard, J.P.2    Fayad, L.3
  • 115
    • 77955175014 scopus 로고    scopus 로고
    • Results of a phase i/ii study of ocrelizumab, a fully humanized anti-cd20 mab, in patients with relapsed/refractory follicular lymphoma
    • Morschhauser F, Marlton P, Vitolo U, et al. Results of a phase I/II study of ocrelizumab, a fully humanized anti-CD20 mAb, in patients with relapsed/refractory follicular lymphoma. Ann Oncol 2010;21:1870-6
    • (2010) Ann Oncol , vol.21 , Issue.6
    • Morschhauser, F.1    Marlton, P.2    Vitolo, U.3
  • 116
    • 56249095457 scopus 로고    scopus 로고
    • Rituximab in combination with high-dose methylprednisolone for the treatment of fludarabine refractory high-risk chronic lymphocytic leukemia
    • Castro JE, Sandoval-Sus JD, Bole J, Rassenti L. Rituximab in combination with high-dose methylprednisolone for the treatment of fludarabine refractory high-risk chronic lymphocytic leukemia. Leukemia 2008;22:2048-53
    • (2008) Leukemia , vol.22 , pp. 2048-53
    • Castro, J.E.1    Sandoval-Sus, J.D.2    Bole, J.3    Rassenti, L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.