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77953222546
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Hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: Long-Term results of a retrospective study on behalf of the gruppo italiano trapianto midollo osseo (gitmo)
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This paper describes the outcomes of a sizeable cohort of patients who underwent HCT for PNH
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Santarone S, Bacigalupo A, Risitano AM, et al. Hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: long-Term results of a retrospective study on behalf of the Gruppo Italiano Trapianto Midollo Osseo (GITMO). Haematologica. 2010;95:983-8. This paper describes the outcomes of a sizeable cohort of patients who underwent HCT for PNH.
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Farah R, Franke G, Gregory TB. Hematopoietic cell transplantation after reduced intensity conditioning for severe paroxysmal nocturnal hemoglobinuria. Blood. 2011;118:2047. abstract.
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Allogeneic hematopoietic stem cell transplantation in paroxysmal nocturnal hemoglobinuria: A transplant versus no transplant matched comparison study on behalf of the severe aplastic anemia working party (saawp) of the european group for blood and marrow transplantation (ebmt) group and the french society of hematology (sfh
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In this abstract the authors describe an elegant matched-pair analysis comparing outcomes of patients who underwent HCT versus those who did not
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de Latour RP, Schrezenmeier H, Bacigalupo A. Allogeneic hematopoietic stem cell transplantation in paroxysmal nocturnal hemoglobinuria: A transplant versus no transplant matched comparison study on behalf of the Severe Aplastic Anemia Working Party (SAAWP) of the European Group for Blood and Marrow Transplantation (EBMT) Group and the French Society of Hematology (SFH). Blood. 2011;118:2403. In this abstract the authors describe an elegant matched-pair analysis comparing outcomes of patients who underwent HCT versus those who did not.
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This study describes the long-Term survival advantage seen with eculizumab in patients with PNH
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Kelly RJ, Hill A, Arnold LM, et al. Long-Term treatment with eculizumab in paroxysmal nocturnal hemoglobinuria: sustained efficacy and improved survival. Blood. 2011;117:6786-92. This study describes the long-Term survival advantage seen with eculizumab in patients with PNH.
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This paper describes the current experience with a novel conditioning regimen that incorporates alemtuzumab resulting in an excellent overall survival and a significantly lower incidence of GVHD
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Marsh JC, Gupta V, Lim Z, et al. Alemtuzumab with fludarabine and cyclophosphamide reduces chronic graft-versus-host disease after allogeneic stem cell transplantation for acquired aplastic anemia. Blood. 2011;118:2351-7. This paper describes the current experience with a novel conditioning regimen that incorporates alemtuzumab resulting in an excellent overall survival and a significantly lower incidence of GVHD.
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Bacigalupo A, Socié G, Schrezenmeier H, et al. Bone marrow versus peripheral blood sibling transplants in acquired aplastic anemia: survival advantage for marrow in all age groups. Haematologica. 2012;97:1142-8. This study is the most recent in a series of papers establishing bone marrow as the preferred graft source over peripheral blood in patients undergoing HCT for aplastic anemia.
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Kim H, Kim BS, Kim DH, et al. Comparison between matched related and alternative donors of allogeneic hematopoietic stem cells transplanted into adult patients with acquired aplastic anemia: multivariate and propensity score-matched analysis. Biol Blood Marrow Transplant. 2011;17:1289-98. When controlling for various factors by the use of a matched-pair analysis, the results of this study suggest that outcomes are similar in patients who have a matched donor whether they are related or unrelated.
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Schanz J, Tuchler H, Sole F, et al. New comprehensive cytogenetic scoring system for primary myelodysplastic syndromes (MDS) and oligoblastic acute myeloid leukemia after MDS derived from an international database merge. J Clin Oncol. 2012;30:820-9. This paper describes the novel cytogenetic classification system for MDS that will be incorporated into the revised IPSS. It summarizes the prognostic value of the most commonly seen cytogenetic abnormalities seen in MDS.
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Lim Z, Brand R, Martino R, et al. Allogeneic hematopoietic stemcell transplantation for patients 50 years or older with myelodysplastic syndromes or secondary acute myeloid leukemia. J Clin Oncol. 2010;28:405-11. This study analyzed the results of a large number of patients who underwent HCT for MDS. It compares the outcomes of patients who undergo high intensity versus reduced intensity conditioning regimens, and notes the heavy influence of pre-Transplant disease burden on posttransplant outcomes.
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de Lima M, Giralt S, Thall PF, et al. Maintenance therapy with low-dose azacitidine after allogeneic hematopoietic stem cell transplantation for recurrent acute myelogenous leukemia or myelodysplastic syndrome: a dose and schedule finding study. Cancer. 2010;116:5420-31. This paper describes the use of azacitidine in a prophylactic strategy after transplantation in order to reduce post-Transplant relapse in a group of high-risk patients with MDS or AML.
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