Generating mouse models of degenerative diseases using Cre/lox-mediated in vivo mosaic cell ablation

Journal of Clinical Investigation

Volumn 121, Issue 6, 2011, Pages 2462-2469

  Fujioka, Masato ^a,b,c   Tokano, Hisashi ^a,b   Fujioka, Keiko Shiina ^a,b   Okano, Hideyuki ^c   Edge, Albert S B ^a,b,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

^c KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CRE RECOMBINASE; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CELL TYPE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DIMERIZATION; DISEASE MODEL; ENZYME REGULATION; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; IMPAIRED GLUCOSE TOLERANCE; MOSAICISM; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; TRANSGENIC MOUSE; WOUND HEALING;

ALOPECIA; ANIMALS; APOPTOSIS; CASPASE 3; CELL LINEAGE; DIMERIZATION; DISEASE MODELS, ANIMAL; EPIDERMIS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GENES, TRANSGENIC, SUICIDE; GLUCOSE INTOLERANCE; HAIR CELLS, AUDITORY, INNER; HEARING LOSS, BILATERAL; HEARING LOSS, SENSORINEURAL; HOMEODOMAIN PROTEINS; INSULIN; ISLETS OF LANGERHANS; KERATIN-14; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOSAICISM; ORGAN SPECIFICITY; PHENOTYPE; TACROLIMUS; TRANSCRIPTION FACTOR BRN-3C; TRANSGENES; WOUND HEALING;

EID: 79957909838     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI45081     Document Type: Article

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